Molecular Mechanisms of Breast Cancer Drug Resistance and CRISPR/Cas9 Strategies to Overcome by Bashdar Mahmud Hussen, Bnar Saleh Ismael, Saman S. Abdulla, Noor Haval Jamal, Suhad Asad Mustafa, Zana Baqi Najmalddin, Mohammed Fatih Rasul

“…Successful clinical translation depends on methods to improve the specificity and effectiveness of CRISPR/Cas9 editing and to solve these constraints. …”
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The N-Terminal Domain of Y-Box Binding Protein-1 Induces Cell Cycle Arrest in G2/M Phase by Binding to Cyclin D1 by Payal Khandelwal, Mythili K. Padala, John Cox, Ramareddy V. Guntaka

“…Y-box binding protein YB-1 is a multifunctional protein involved in cell proliferation, regulation of transcription and translation. Our previous study indicated that disruption of one allele of Chk-YB-1b gene in DT-40 cells resulted in major defects in the cell cycle. …”
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Adaptive Fuzzy Control for Attitude Stabilization of Spacecraft with Deployable Composite Laminated Solar Array by Wei Zhang, Weibing Zhu, Shijie Zhang, Xiangtian Zhao

“…The solar array deployment causes obvious translational and rotational motions of the spacecraft. …”
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A Compliant Active Roller Gripper with High Positional Offset Tolerance for Delicate Spherical Fruit Handling by Haoran Zhu, Huanhuan Qin, Zicheng Qiu, Xinwen Chen, Jinlin Xue, Xingjian Gu, Mingzhou Lu

“…A flexible active roller is configured at the end of each finger, allowing fruit translation with just a gentle touch. An integrated pressure sensor within the active roller further enhances the gripper’s compliance. …”
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Kinematics and Mechanical Properties of Knees following Patellar Replacing and Patellar Retaining Total Knee Arthroplasty by Rongying Huang, Yanqiang Liu, Jun Zhu

“…By contrast, patellar replacement had a significant influence on the patellofemoral joint; patellar internal rotation, external rotation, and medial-lateral translation were all increased. Moreover, the stress distribution on patellar prostheses was altered, resulting in an increased surface maximal equivalent stress on the corresponding area. …”
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Historiography in Samanid’s Period by Maryam Doalatraftar Haghighi, Mohammad Sepehri

“…Some other things that we can see in the historical compilations of this period are: starting to translate (Balamy historiography), avoiding the methods of news compilation based on the principles and traditions of Hadith records and also the appearance of new methods of historiography (local history like history of Bokhara). …”
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Inkjet-printed electronics for rapid and low-cost prototyping of digital microfluidic devices using an off-the-shelf printer by Babak Kamali Doust Azad, Amirhossein Roozbahani, Seyed Mohammad Tabatabaei, Amirali Valinejad, Alireza Fazelian, Kimia Shahmoradi, Fatemeh Khatami, Seyed Mohammad Kazem Aghamir, Mohammadreza Kolahdouz

“…Abstract Digital microfluidics (DMF) is revolutionizing point-of-care diagnostics by advancing lab-on-a-chip technology. To accelerate translation to real-life applications, it is crucial to devise rapid and low-cost methods for prototyping to test various design ideas. …”
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Systematic and comprehensive insights into HIF-1 stabilization under normoxic conditions: implications for cellular adaptation and therapeutic strategies in cancer by Jiayi Zhang, Mingxuan Yao, Shiting Xia, Fancai Zeng, Qiuyu Liu

“…Thus, the review delves into the mechanisms by which HIF-1 maintains its stability under normoxia including but not limited to giving insights into transcriptional, translational, as well as posttranslational regulation to underscore the pivotal role of HIF-1 in cellular adaptation and malignancy. …”
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Harnessing nanotechnology for cancer treatment by Jiajun Zhu, Jiajun Zhu, HaeJu Lee, HaeJu Lee, Ruotong Huang, Ruotong Huang, Jianming Zhou, Jingjun Zhang, Xiaoyi Yang, Wenhan Zhou, Wangqing Jiang, Shuying Chen

“…Nevertheless, despite these progressions, obstacles still persist, particularly in the clinical translation of these technologies. Issues such as nanoparticle toxicity, biocompatibility, and the complexity of regulatory approval hinder the widespread adoption of nanomedicine in oncology. …”
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Intravenous Administration of Adipose-Derived Stem Cell Protein Extracts Improves Neurological Deficits in a Rat Model of Stroke by Kai Zhao, Rui Li, Changcong Gu, Long Liu, Yulong Jia, Xize Guo, Wanping Zhang, Chunying Pei, Linlu Tian, Bo Li, Jianrong Jia, Huakun Cheng, Hongwei Xu, Lixian Li

“…Together these data provide translational evidence for using protein extracts from ADSC for treating stroke.…”
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A practical approach to building a calcareous nannofossil knowledge graph by Hongyi Zhao, Bin Hu, Chao Ma, Shijun Jiang, Yi Zhang, Xin Li, Lirong Chen, Can Cai, Longgang Ye, Shengjian Zhou, Chengshan Wang

“…The knowledge graph, as a key technology for semantic translation and data fusion, offers a possible solution to these challenges. …”
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Recent advances in recombinant production of soluble proteins in E. coli by Ario de Marco

“…Nevertheless, the majority of the published papers aimed at identifying the conditions for optimal control of the translation process to achieve maximal yields of functional exogenous proteins. …”
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PEPITEM, its tripeptide pharmacophores and their peptidomimetic analogues regulate the inflammatory response through parenteral and topical dosing in models of peritonitis and psor... by Anella Saviano, Bonita Apta, Samantha Tull, Laleh Pezhman, Areeba Fatima, Mustafa Sevim, Antonio Mete, Myriam Chimen, Anna Schettino, Noemi Marigliano, Helen M. McGettrick, Asif J. Iqbal, Francesco Maione, G. Ed Rainger

“…Taken together with other reports on the efficacy of PEPITEM, this study paves the way for the development and translation of a novel class of anti-inflammatory agents which may have utility in a broad range of autoimmune and chronic inflammatory diseases.…”
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Cropland Suitability Prediction Method Based on Biophysical Variables from Copernicus Data and Machine Learning by Dorijan Radočaj, Mateo Gašparović, Mladen Jurišić

“…Four machine learning regression algorithms, including random forest (RF), support vector machine (SVM), and extreme gradient boosting (XGB), as well as their combination, were evaluated for predicting the peak LAI and FAPAR on the entire agricultural land in the study area, with RF producing the highest prediction accuracy with an R² in the range of 0.250–0.590. The translation from K-means classes to the FAO land suitability standard was performed using a relative-based approach, ranking five resulting classes based on their relative mean sums of LAI and FAPAR values. …”
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A comparative study of the developability of full-length antibodies, fragments, and bispecific formats reveals higher stability risks for engineered constructs by Itzel Condado-Morales, Fabian Dingfelder, Isabel Waibel, Oliver M. Turnbull, Bhargav Patel, Zheng Cao, Jais Rose Bjelke, Susanne Nedergaard Grell, Anja Bennet, Alissa M. Hummer, Matthew I. J. Raybould, Charlotte M. Deane, Thomas Egebjerg, Nikolai Lorenzen, Paolo Arosio

“…Engineered antibody formats, such as antibody fragments and bispecifics, have the potential to offer improved therapeutic efficacy compared to traditional full-length monoclonal antibodies (mAbs). However, the translation of these non-natural molecules into successful therapeutics can be hampered by developability challenges. …”
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PEBP1 amplifies mitochondrial dysfunction-induced integrated stress response by Ling Cheng, Ian Meliala, Yidi Kong, Jingyuan Chen, Christopher G Proud, Mikael Björklund

“…Depletion of PEBP1 impaired mitochondrial ISR activation by reducing eukaryotic translation initiation factor 2α (eIF2α) phosphorylation and subsequent ISR gene expression, which was independent of PEBP1’s role in inhibiting the RAF/MEK/ERK pathway. …”
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SOCIAL ECONOMIC CHANGE AS A PRECONDITION OF ETHNIC CONFLICTS: THE CASES OF OSH CONFLICTS IN 1990 AND 2010 by K. Hyunjung

“…The economic difficulties soon translated into institutional instability. Massive public demonstrations “framed” as an ethnic conflict by political elites intensified the battle, adding to it an “ethnic” dimension.…”
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Pushing the boundaries of anticipatory action using machine learning by Alexander Kjærum, Bo S. Madsen

“…In this article, we will detail how the model works, the accuracy and limitations of the model, and how we are translating the forecasts into action by using them for anticipatory action in South Sudan and Burkina Faso, including concrete examples of activities that can be implemented ahead of displacement in the place of origin, along routes and in place of destination.…”
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Pi bon fason pou timoun piti (ki gen laj pou ale lekòl) lave men yo by Amy Simonne, Nicole Monval, Emmanuel Jean Claude Duvalsaint

“…Written by Amy Simonne, translated and reviewed by Emmanuel Jean Claude Duvalsaint and Nicole Monval, and published by the UF/IFAS Department of Family, Youth and Community Sciences, March 2020. …”
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Teaching responsible chemistry: a challenge-based learning framework for the implementation of RRI courses in tertiary chemistry education by Mehlich Jan

“…This paper proposes a course concept that aims at filling a gap in the translation of RRI principles into tertiary chemistry education practice. …”
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