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A perfusion-independent high-throughput method to isolate liver sinusoidal endothelial cells
Published 2025-01-01Get full text
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Effectiveness of Electronic Quality Improvement Activities to Reduce Cardiovascular Disease Risk in People With Chronic Kidney Disease in General Practice: Cluster Randomized Trial...
Published 2025-02-01“…ConclusionsFHT harnesses the data stored within EMRs to translate guidelines into practice through quality improvement activities and active clinical decision support. …”
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Investigating knowledge and attitudes toward genetic testing and counseling among palestinians
Published 2025-02-01“…Despite the relatively good knowledge of genetic testing, this has not translated into appropriate practice. Genetic testing is still not widely practiced and the most common for performing it is pre-marriage testing rather than medical reasons. …”
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Unveiling the Mechanisms of a Remission in Major Depressive Disorder (MDD)-like Syndrome: The Role of Hippocampal Palmitoyltransferase Expression and Stress Susceptibility
Published 2025-01-01“…Post-translational modifications of proteins via palmitoylation, a thioester linkage of a 16-carbon fatty acid to a cysteine residue, reversibly increases their affinity for cholesterol-rich lipid rafts in membranes, changing their function. …”
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Subtyping Social Determinants of Health in the "All of Us" Program: Network Analysis and Visualization Study
Published 2025-02-01“…ConclusionsThis study identified SDoH subtypes that had statistically significant biclusteredness and replicability, each of which had significant associations with specific adverse health outcomes and with translational implications for targeted SDoH interventions and health care policies. …”
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Impact of Financial Literacy on Saving Decisions: Insight from Aseman Project Operated by Barkat Foundation
Published 2024-06-01“…This suggested that while the program had been successful in enhancing financial literacy and positive saving-related mindsets, it had not yet translated into tangible changes in saving practices and outcomes.Despite the lack of a direct impact on saving behavior, the findings indicated that Aseman Plan had ancillary benefits in terms of improving financial knowledge and attitudes among participants. …”
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Mannan-Binding Lectin Suppresses Peptidoglycan-Induced TLR2 Activation and Inflammatory Responses
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Inflammatory and Redox Blood Gene Expression Fingerprint of Severe Obstructive Sleep Apnoea in Patients With Mild Alzheimer’s Disease
Published 2025-02-01“…Leila Romero-ElKhayat,1 Farida Dakterzada,1 Raquel Huerto,1 Anna Carnes-Vendrell,1 Olga Mínguez,2 Montserrat Pujol Sabaté,2 Adriano Targa,3,4 Ferran Barbé,3,4 Elena Milanesi,5,6 Maria Dobre,5 Gina Manda,5 Antonio Cuadrado,5,7– 10 Gerard Piñol-Ripoll1,11 1Unitat de Trastorns Cognitius, Cognition and Behavior Study Group, Universitat de Lleida, IRBLleida, Lleida, 25198, Spain; 2Unitat de Son, Hospital Universitari Santa Maria de Lleida, Lleida, Spain; 3Group of Translational Research in Respiratory Medicine, Hospital Universitari Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain; 4Center for Biomedical Research in Respiratory Diseases Network (CIBERES), Madrid, Spain; 5“Victor Babes” National Institute of Pathology, Bucharest, 050096, Romania; 6Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, 050474, Romania; 7Department of Endocrine Physiology and Nervous System, Instituto de Investigaciones Biomédicas “Alberto Sols” UAM-CSIC, Madrid, 28029, Spain; 8Department of Biochemistry, Faculty of Medicine, Autonomous University of Madrid, Madrid, 28049, Spain; 9Neuroscience Section, Instituto de Investigación Sanitaria La Paz (Idipaz), Madrid, 28046, Spain; 10Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), ISCIII, Madrid, 28031, Spain; 11Alzheimer’s Disease and Other Cognitive Disorders Unit, Hospital Clínic de Barcelona, Fundació de Recerca Clínic Barcelona – Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, SpainCorrespondence: Gerard Piñol-Ripoll, Cognitive Disorders Unit, Hospital Universitari Santa Maria, Rovira Roure no. 44, Lleida, 25198, Spain, Tel +34-937-727222, Ext. 173, Fax +34-976-727366, Email gerard_437302@hotmail.comIntroduction: Obstructive sleep apnoea (OSA) is the sleep disorder most frequently found in patients with Alzheimer’s disease (AD). …”
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Identification of EARS2 as a Potential Biomarker with Diagnostic, Prognostic, and Therapeutic Implications in Colorectal Cancer
Published 2025-01-01“…Ling Wang,1,2,* Xuemei Deng,1,* Jiaxi Tang,3 Yi Gong,2 Shaojin Bu,4 Zuli Li,1 Bin Liao,2 Yao Ding,2 Tingting Dai,1,5 Yong Liao,1 Yongsheng Li2,6 1Department of Infectious Diseases, Second Affiliated Hospital, Chongqing Medical University, Chongqing, People’s Republic of China; 2Department of Phase I Clinical Trial Ward, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing, People’s Republic of China; 3Department of Anesthesiology, Chongqing University Cancer Hospital, Chongqing, China; 4Department of Anesthesiology, Fengdu People’s Hospital, Chongqing, People’s Republic of China; 5Department of Medical Oncology, Chongqing University Fuling Hospital, Chongqing, China; 6Department of Medical Oncology, Chongqing University Cancer Hospital, Chongqing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yong Liao, Department of Infectious Diseases, Second Affiliated Hospital, Chongqing Medical University, NO. 288 Chayuan Astronomy Avenue, Nanan District, Chongqing, 401336, People’s Republic of China, Email yongliao@cqmu.edu.cn Yongsheng Li, Department of Medical Oncology, Chongqing University Cancer Hospital, No. 181 hanyu Road, Shapingba District, Chongqing, 400030, People’s Republic of China, Email yongshengli2005@163.comPurpose: Colorectal cancer (CRC) is a prevalent malignancy, and lactate metabolism significantly influences tumorigenesis and progression. …”
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Protective effects and possible mechanisms of mesenchymal stem cells and mesenchymal stem cell-derived extracellular vesicles against kidney fibrosis in animal models: a systematic...
Published 2025-01-01“…Although this study still suffers from three shortcomings: sample size, methodological consistency and translational challenges, the hUCB MSC and MSC-Exos have been demonstrated to reduce tubular apoptosis and inhibit fibrotic progression. …”
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