Targeting protein-protein interactions in drug discovery: Modulators approved or in clinical trials for cancer treatment by Cristina Camps-Fajol, Debora Cavero, Jordi Minguillón, Jordi Surrallés

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Perioperative care of a patient with zygomatic implant placement assisted by a dynamic real-time navigation system (动态导航引导下行穿颧种植术1例的围手术期护理)... by GUAN Zhaolan (管兆兰), YIN Xiaoqing (尹小青), XIE Lingling (谢玲玲)

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A Proteomic Study Based on Home Quarantine Model Identifies NQO1 and Inflammation Pathways Involved in Adenoid Hypertrophy by Chen P, Hou S, Pang X, Li L, Wei W

“…Penghui Chen,1– 3,* Shule Hou,1– 3,* Xiuhong Pang,4 Lei Li,1– 3 Wei Wei1– 3 1Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 2Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 3Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 4Department of Otolaryngology-Head and Neck Surgery, the Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, Jiangsu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wei Wei; Lei Li, Department of Otolaryngology-Head & Neck Surgery, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Yangpu District, Shanghai, 200082, People’s Republic of China, Tel +86-21-25078893, Fax +86-21-65152394, Email weiwei8319@xinhuamed.com.cn; xyyh2711@126.comBackground: Adenoid hypertrophy is a common disorder of childhood, and has an unclear pathogenesis. …”
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Surgical cooperation of laparoscopic oral mucosa repair and ureteral reconstruction with robotic assistance (机器人辅助腹腔镜下口腔黏膜修复重建输尿管的手术配合)... by ZHAO Yanan (赵雅楠), ZUO Jing (左静), WU Heyu (吴荷玉)

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Application of cupping therapy with buffalo horns for patients with cervical spondylosis (牛角罐法在颈型颈椎病患者中的应用) by HE Shuiwen (何水文), JIANG Haijun (蒋海军), YU Yuxiu (于玉秀), OU Jinshi (欧金石)

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An Assessment of Microfinance Institution Services and Performance of Small and Medium Enterprises in Kabale Municipality. by Mugarura, Elijah

“…In conclusion, the study further confirmed that microfinance institution services (financial literacy, development of managerial skills and marketing facilitation) positively influenced performance of SMEs and recommended that more managerial trainings should be given to the SMEs by the MFI so as to equip them with more knowledge on running their enterprise which would translate into better management of funds and enhance performance in a long run. …”
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Invasive fungal diseases in patients with autoimmune diseases: a case series from the French RESSIF network by Vincent Poindron, Benjamin Terrier, François Maillot, Jean-Pierre Gangneux, Nassim Kamar, Valéry Salle, Lilia Hasseine, François Danion, Lilia Merabet, Guillaume Desoubeaux, Éric Bailly, Milène Sasso, Antoine Néel, Simon Galmiche, Benjamin Thoreau, Stéphane Bretagne, Alexandre Alanio, André Paugam, Valérie Letscher-Bru, Sophie Cassaing, Hélène Guegan, Loïc Favennec, Alida Minoza, Florent Morio, Julie Bonhomme, Odile Eloy, Laurence Millon, Anne-Pauline Bellanger, Philippe Poirier, Maxime Moniot, Taieb Chouaki, Antoine Huguenin, Frédéric Dalle, Bernard Bouteille, Muriel Nicolas, Nicole Desbois-Nogard, Marie-Elisabeth Bougnoux, Karine Boukris-Sitbon, Fanny Lanternier, Caroline Mahinc, Marc Pihet, Magalie Demar, Céline Damiani, Marie-Fleur Durieux, Elena Charpentier, Cécile Nourrisson, Benoit Suzon

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Gestational exposure to arsenic reduces female offspring fertility by impairing the repair of DNA double-strand breaks and synapsis formation in oocytes by Cong Ma, Kaiqin Hu, Xueke Zhang, Yaru Yu, Zuying Xu, Tian Ma, Hongzhen Ruan, Yingying Zhang, Jiajia Wang, Xinyu Yue, Chunmei Liang, Huifen Xiang, Rui Guo, Yunxia Cao, Zhiming Ding

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Status of Digital Health Technology Adoption in 5 Vietnamese Hospitals: Cross-Sectional Assessment by Duc Minh Tran, Nguyen Thanh Dung, Chau Minh Duc, Huynh Ngoc Hon, Le Minh Khoi, Nguyen Phuc Hau, Duong Thi Thu Huyen, Huynh Thi Le Thu, Tran Van Duc, Lam Minh Yen, C Louise Thwaites, Chris Paton

“…As projects such as the Vietnam ICU Translational Applications Laboratory are seeking to integrate new digital technologies in the Vietnamese critical care settings, it is important to understand the current status of DHT adoption in Vietnamese hospitals. …”
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Preclinical model for evaluating human TCRs against chimeric syngeneic tumors by Olivier Michielin, Philippe Guillaume, Melita Irving, Patrick Reichenbach, Vincent Zoete, Elise Gray-Gaillard, Evangelos Stefanidis, Aikaterini Semilietof, Julien Pujol, Alessia D'Esposito

“…Moreover, with our chimeric syngeneic tumor model, we were able to track dynamic and favorable changes in the TME upon DMβ-T cell transfer.Conclusions We have developed a robust, simple, and inexpensive preclinical strategy for evaluating human TCRs in the context of a fully competent murine immune system that can aid in the development of coengineered TCR-T cells and combination treatments translated to the clinic.…”
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Delays in health care seeking for diarrheal disease and associated factors among caregivers of under five children in health centers of northwest Ethiopia: a mixed-method study by Asnakech Marew, Zenebe Jebero Zaza, Shiferaw Birhanu, Amare Belachew, Tsehaynew Kasse

“…The qualitative data were transcribed, translated, coded, thematized, and interpreted accordingly. …”
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Evaluation of guided reporting: quality and reading time of automatically generated radiology report in breast magnetic resonance imaging using a dedicated software solution by Martin H. Maurer, Daniel Lorenz, Maximilian Clemens Otterbach, Igor Toker, Alexander Huppertz

“…No non-sense, omission/commission, or translational errors were detected with the GR method. …”
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Poly (ADP-ribose) (PAR) levels in Peripheral Blood Mononuclear Cells (PBMC) during peri-implantation and early pregnancy in buffalo cows by Giovanna De Matteis, Anna Reale, Michele Zampieri, Emanuela Rossi, Federica Signorelli, Olimpia Barbato, Vittoria Lucia Barile

“… Poly(ADP-ribosyl)ation (PAR) is a reversible post-translational protein modification catalyzed by enzyme  members of the poly(ADP-ribose) polymerases (PARPs) family. …”
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Evaluation of circulating tumor DNA as a prognostic and predictive biomarker in BRAF V600E mutated colorectal cancer—results from the FIRE‐4.5 study by Susanne Klein‐Scory, Alexander Baraniskin, Wolff Schmiegel, Thomas Mika, Roland Schroers, Swantje Held, Kathrin Heinrich, David Tougeron, Dominik P. Modest, Ingo Schwaner, Jan Eucker, Rudolf Pihusch, Martina Stauch, Florian Kaiser, Christoph Kahl, Meinolf Karthaus, Christian Müller, Christof Burkart, Sebastian Stintzing, Volker Heinemann

“…This study was accompanied by a prospective translational project analyzing cell‐free circulating tumor DNA (ctDNA) in plasma to test whether ctDNA analysis may help to guide clinical treatment decision making. …”
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Selection of terminal Piétrain pigs improves vitality and prevalence of congenital defects in crossbred piglets by Wim Gorssen, Wim Gorssen, Carmen Winters, Roel Meyermans, Léa Chapard, Katrijn Hooyberghs, Jaro De Kort, Alice Van den Broeke, Jürgen Depuydt, Steven Janssens, Nadine Buys

“…A joint analysis of the datasets showed a moderate to high genetic correlation (rg=0.52 to 0.84) for porcine congenital splay leg syndrome and pre-weaning mortality, indicating the translatability of estimated breeding values for terminal sires to new farms, specifically for these traits. …”
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Role of Gut and Urinary Microbiome in Children with Urinary Tract Infections: A Systematic Review by Anjali Srivastava, Omprakash Shete, Annu Gulia, Sumit Aggarwal, Tarini Shankar Ghosh, Vineet Ahuja, Sachit Anand

“…Further studies with larger cohorts, standardized healthy controls, and longitudinal profiling are essential to validate these observations and translate them into clinical practice.…”
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Sodium Butyrate: A Multifaceted Modulator in Colorectal Cancer Therapy by Alexandra Laura Mederle, Alexandra Semenescu, George Andrei Drăghici, Cristina Adriana Dehelean, Nicolae-Valentin Vlăduț, Dragoş Vasile Nica

“…<i>Results:</i> This study provides the first exploration of <i>MCL-1</i> and <i>PCNA</i> modulation by NaB in the context of CRC and HCT-116 cells, offering significant translational insights. All treatments reduced cell viability, confluence, and number in a dose-dependent manner (<i>p</i> < 0.0001). …”
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N88S seipin-related seipinopathy is a lipidopathy associated with loss of iron homeostasis by Mariana O. Ribeiro, Mafalda Oliveira, Verónica Nogueira, Vítor Costa, Vitor Teixeira

“…Altered cellular processes, as well as potential therapeutic targets and biomarkers, were identified and can be explored in translational studies using human cell models.…”
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Scoping review of infectious disease prevention, mitigation and management in passenger ships and at ports: mapping the literature to develop comprehensive and effective public hea... by Lemonia Anagnostopoulos, Sotirios Vasileiadis, Leonidas Kourentis, Zacharoula Bogogiannidou, Ioanna Voulgaridi, Gordon Nichols, Fani Kalala, Matthaios Speletas, Christos Hadjichristodoulou, Varvara A. Mouchtouri, the EU HEALTHY SAILING project

“…New evidence for infection PMM must be translated into guidance for governmental authorities and the passenger ship industry. …”
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Influence of spine biomechanics and sagittal balance on the outcome of lumbar discectomy by José Poblete Carrizo, José Poblete Carrizo, Jesús Martínez, Julio González, Alejandra Mosteiro, Ramon Torné, Ramon Torné, Alberto Di Somma, Alberto Di Somma, José Ríos, Joaquim Enseñat, Joaquim Enseñat, Salvador Fuster, Salvador Fuster

“…PurposeSpine biomechanics, particularly sagittal balance and spino-pelvic angulation are determinant factors in the understanding of lumbar degenerative disease. These concepts translated into objective measurements are progressively being integrated into clinical practice. …”
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