Pancreatic resection with perioperative drug repurposing of propranolol and etodolac: trial protocol of the phase-II randomised placebo controlled PROSPER trial by Phillip Knebel, Thilo Hackert, Markus W Büchler, Ilse Rooman, Markus K Diener, Felix J Hüttner, André L Mihaljevic, Oliver Strobel, Gauthier Bouche, Johannes Hüsing

“…The clinical trial is accompanied by a translational study investigating the mechanisms of action of the combined therapy on a molecular basis.Ethics and dissemination The PROSPER-trial has been approved by the German Federal Institute for Drugs and Medical Devices (reference number 4042875) and the Ethics Committee of the Medical Faculty of the University of Heidelberg (reference number AFmo-385/2018). …”
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Integrative deep immune profiling of the elderly reveals systems-level signatures of aging, sex, smoking, and clinical traitsResearch in context by Lennart Riemann, Rodrigo Gutierrez, Ivan Odak, Joana Barros-Martins, Lennart M. Roesner, Ximena Leon Lara, Christine Falk, Thomas F. Schulz, Gesine Hansen, Thomas Werfel, Reinhold Förster, Berislav Bošnjak, Felix Jenniches, Norman Klopp, Till Robin Lesker, Martin Stangel

“…Our findings highlight clinically relevant immune signatures that enhance our understanding of aging-related diseases and could guide future research into new treatments, offering translational insights into human health and aging. Funding: Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy—EXC 2155—project number 390874280.…”
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Characterization and Probiotic Potential of <i>Levilactobacillus brevis</i> DPL5: A Novel Strain Isolated from Human Breast Milk with Antimicrobial Properties Against Biofilm-Formi... by Ivan Iliev, Galina Yahubyan, Elena Apostolova-Kuzova, Mariyana Gozmanova, Daniela Mollova, Iliya Iliev, Lena Ilieva, Mariana Marhova, Velizar Gochev, Vesselin Baev

“…The genome also contains multiple biosynthetic gene clusters such as lanthipeptide class IV, Type III polyketide synthase (T3PKS), and ribosomally synthesized, and post-translationally modified peptides (RiPP-like compounds), all of which are associated with antibacterial properties. …”
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INTRASPECIFIC VARIABILITY OF THE Sus1 SUCROSE SYNTHASE GENE IN Pisum sativum ACCESSIONS by E. A. Dyachenko, M. A. Slugina

“…All the conservative motifs and active sites were detected in the translated amino acid sequences. It was shown that their sequences were invariable in all the tested accessions. …”
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Investigating assumptions in motivational interviewing among general practitioners: a qualitative study by Paul Aujoulat, Amélie Manac’h, Catherine Le Reste, Delphine Le Goff, Jean Yves Le Reste, Marie Barais

“…Focused efforts are needed to translate MI’s potential into routine clinical use.…”
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Formaldehyde and propionic acid do not reduce starch gelatinization within a laboratory setting and may not contribute to reduced pellet quality by K.M. Bowen, L.E. Knarr, E.B. Estanich, S.R. Estep, J.S. Moritz

“…The increase in starch gelatinization with increased heating time may translate to increasing pellet quality.…”
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Bacterial nanocellulose and its oxidized form as functional carriers for pomegranate peel extract: A sustainable approach to bioactive delivery by Vuk Filipovic, Jasmina Nikodinovic-Runic, Katarina Savikin, Jelena Zivkovic, Jelena Mudric, Nemanja Krgovic, Marijana Ponjavic

“…Compared to unmodified BNC, a wider range of bioactive compounds was incorporated on o-BNC due to enhanced binding capacity and porosity, which translated into material stronger antioxidant activity, attributed to presence of additional phenolics like gallic acid and ellagitannins. …”
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A reproducible representation of healthy tibiofemoral kinematics during stair descent using REFRAME – part I: REFRAME foundations and validation by Ariana Ortigas-Vásquez, William R. Taylor, Barbara Postolka, Pascal Schütz, Allan Maas, Matthias Woiczinski, Thomas M. Grupp, Adrian Sauer

“…Here, building on previous work that introduced a frame orientation optimisation method and demonstrated its potential to induce convergence towards a consistent kinematic signal, we present the REference FRame Alignment MEthod (REFRAME) that addresses both rotational and translational kinematics, is validated here for a healthy tibiofemoral joint, and allows flexible selection of optimisation criteria to fittingly address specific research questions. …”
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Information modelling of dynamic impacts on a unique building of a multifunctional complex of parametric architecture by E. K. Agahanov, M. K. Agahanov, E. V. Trufanova

“…The change in design solutions allowed to make the first and second forms of oscillations translational, the third — torsional. The obtained nature of the dynamic response shows the efficiency of the adopted design solutions of the unique building frame. …”
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Piloting an external quality assurance program (QAP) for COVID-19 antigen rapid diagnostic tests (Ag-RDTs): findings and lessons learned from Cambodia by Vonthanak Saphonn, John Kaldor, Deborah Williamson, Sothavireak Bory, Philip Cunningham, Jessica Markby, Kennarey Seang, Jacqueline Prestedge, Chan Leakhena Phoeung, Marilyn Ninan, Kanika Heng, Andrew Valley

“…The preimplementation training including the Khmer-translated documentation was conducted virtually for Tier 1 laboratories and in-person for Tier 2 laboratories. …”
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Tools to improve discharge equity: Protocol for the pilot TIDE trial by Kirsten Austad, Cecilia Thai, Alegna Zavatti, Nhi Nguyen, Diana Bautista-Hurtado, Patrick Kenney, Noelia Lugo, Joo H. Lee, Howard Lanney, Ziming Xuan, Erika G. Cordova-Ramos, Mari-Lynn Drainoni, Brian Jack

“…The TIDE intervention includes a translated medication calendar, pictographs, and an audio recording of the discharge instructions in the patient's preferred language. …”
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Temperature- and ontogeny-dependent metabolism in invasive early juvenile round goby (Neogobius melanostomus) by Hunter A. Herron, Sina Zarini, William Andrew Thompson, Andy J. Turko, Sigal Balshine

“…We also found that the bioenergetics models previously developed for adults do not effectively translate to juveniles; the current models underestimated observed RMR values by ~20–60% depending on temperature. …”
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Integrated Business and Engineering Educational Experience for Medical Students in the Development of Pediatric Medical Devices by Jennifer J. Li, Jonathan Lee, Mayilone Sathialingam, Nhi Ha, Tamara Galoyan, Ethan Faye, Michael Kim, Tara Shelby, Rishabh Shah, Yelim Lee, Melissa Bent, Juan C. Espinoza

“…METHODS An internship program was developed by the Keck Translational Biotechnology Association and the West Coast Consortium for Technology & Innovation in Pediatrics (CTIP), a Food and Drug Administration-funded pediatric medical device accelerator. …”
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An Open‐Label Phase II Trial of Pembrolizumab, an Immune Checkpoint Inhibitor Alone or in Combination With Oral Azacitidine as Second‐Line Therapy for Advanced Head and Neck Squamo... by Vinod K. Ramani, Srimonta Gayen, Radheshyam Naik

“…Conclusion The findings of this trial will have translational implications, in terms of immune reprogramming induced by epigenetic therapy among a subset of advanced H & N cancer patients in a clinical setting.…”
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Semantic and Syntactic Dimensional Analysis of Rural Wooden Mosque Architecture in Borçka by Birgül Çakıroğlu, Reyhan Akat, Evren Osman Çakıroğlu, Taner Taşdemir

“…These analyses provide practical strategies for translating abstract religious principles into tangible design elements, enhancing their applicability in both educational and professional contexts. …”
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A comparison of development methods used to define portion sizes in food-based dietary guidelines around the world by Fanny Salesse, Fanny Salesse, Alison L. Eldridge, Tsz Ning Mak, Eileen R. Gibney, Eileen R. Gibney

“…Recommended portions in grams per day were extracted for 15 food categories to enable comparison across development methods and global regions.ResultsFBDGs from 96 countries were accessed and translated. Of these, n = 83 were based on consensus/review, n = 15 used data-based approaches, and n = 30 included other minor calculations. …”
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Exploring the anti-inflammatory effects of phytochemicals in attenuating interstitial cystitis-a literature review by Irfan Anjum, Ayesha Nasir, Faiza Naseer, Faiza Naseer, Ahsan Ibrahim, Bisma Rehman, Fawad Bashir, Qura Tul Ain

“…The coupling of phytotherapy with novel drug delivery systems such as nanoparticles, liposomes, nanotubes, quantum dots, etc. can help translate these beneficial effects of phytochemicals into clinical practice. …”
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The Effect of Kidney Transplantation on Pulmonary Hypertension in End-stage Kidney Disease Patients on Hemodialysis by Christine Mary Jane, K. Vinod Kumar, R. Anil Kumar, V. Narayanan Unni, Bipi K. Prasannan, Jojo K. Pullockara, U. R. S. Vishnu Dev

“…There is also improvement in overall cardiac functions, serum hemoglobin, and calcium levels. This translates to better physical endurance as evidenced by improvement in NYHA class post KT.…”
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Sequential or simultaneous-integrated boost in early-stage breast cancer patients: trade-offs between skin toxicity and risk of compromised coverage by Changyou Zhong, Minfeng Huang, Haidong Yu, Jun Yuan, Ruilian Xie, Zhenzhen Lai, Shanzhou Niu, Chunbo Tang

“…Rotations of 0.5°, 1°, and 2° coupled with translationals of 0.5 mm, 1.0 mm, and 2.0 mm were applied along three orthogonal axes. …”
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The Probe for Renal Organic Cation Secretion (4-Dimethylaminostyryl)-N-Methylpyridinium (ASP+)) Shows Amplified Fluorescence by Binding to Albumin and Is Accumulated In Vivo by Jacob Schade Engbjerg, Vincenzo Costanzo, Donato Sardella, Luca Bordoni, Steen Jakobsen, Luciano D'Apolito, Jørgen Frøkiær, Francesco Trepiccione, Giovambattista Capasso, Sebastian Frische

“…The renal pattern of fluorescence observed from ASP+ in vivo is likely affected by the local concentration of albumin, and quantification of ASP+ fluorescent signals in vivo cannot be directly translated to ASP+ concentrations.…”
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