Ticam2 ablation facilitates monocyte exhaustion recovery after sepsis by Blake A. Caldwell, Susanti Ie, Amy Lucas, Liwu Li

“…To determine the impact of TICAM2 ablation on innate epigenetic memory in sepsis, we measured genome-wide DNA methylation in bone marrow monocytes and found that Ticam2 -/- cells exhibit a unique profile of altered methylation at CEBPE binding sites and regulatory features for key immune genes such as Dmkn and Btg1. Bearing human translational relevance, a case study of time course blood samples collected from a sepsis patient presenting with SIRS and a positive qSOFA revealed a similar effect in human monocytes, which steadily transition into an exhausted memory characterized by a CD38high; CX3CR1low; HLA-DRlow state within four days of hospital admittance. …”
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A Beam of Light on the Dark Side of the Moon: A Critical Review on the Book Women in Ancient Persia by Ehsan Ahmadinya

“…This article reviews and criticizes this book along with one of its Persian translations.…”
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Adverse Events of Antiepileptic Drugs Using Indonesian Version of Liverpool Adverse Events Profile by Astri Budikayanti, Lubna Muhammad Qadri, Zakiah Syeban, Luh Ari Indrawati, Fitri Octaviana

“…The questionnaire was translated from English into Indonesian version. The validity and reliability were tested using Spearman correlation and Cronbach’s alpha measurement. …”
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A High-Throughput Method as a Diagnostic Tool for HIV Detection in Patient-Specific Induced Pluripotent Stem Cells Generated by Different Reprogramming Methods by Daniela Hübscher, Sabine Rebs, Luis Haupt, Thomas Borchert, Celina Isabell Guessoum, Franziska Treu, Steffen Köhne, Andreas Maus, Mario Hambrecht, Samuel Sossalla, Ralf Dressel, Angela Uy, Mark Jakob, Gerd Hasenfuss, Katrin Streckfuss-Bömeke

“…Induced pluripotent stem cells (iPSCs) provide a unique opportunity for generation of patient-specific cells for use in translational purposes. We aimed to compare iPSCs generated by different reprogramming methods regarding their reprogramming efficiency, pluripotency capacity, and the possibility to use high-throughput PCR-based methods for detection of human pathogenic viruses. iPSCs from skin fibroblasts (FB), peripheral blood mononuclear cells (PBMCs), or mesenchymal stem cells (MSCs) were generated by using three different reprogramming systems including chromosomal integrating and nonintegrating methods. …”
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Double diffusive MHD stagnation point flow of second grade fluid in non-Darcy porous media under radiation effects by Walid Aich, Amir Abbas, Adebowale Martins Obalalu, Walid Hassen, Lotfi Ben Said, Rejab Hajlaoui, Lioua Kolsi

“…Mathematical models are developed for the current situation and translated into a set of ordinary differential equations that are solved using MATLAB’s bvp4c. …”
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Carte, autor şi model uman în Predosloviile vechi româneşti by Laura Lazăr Zăvăleanu

“…The prefaces of the Romanian ancient texts often feature the dialectic relation between the book and the writer – in the wide connotation of the term, including the editor of the text, the copyist, the translator, the type-setter and, of course, the original author of the ‘escort text’ – and configures, from various typologies, an ideal human model upon which the entire motivation of writing is being set up. …”
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Lower urinary dysfunction as a long-term effect of childhood vincristine treatment, with potential influences by sex and dose by Nao Iguchi, Ali Teimouri, Duncan T. Wilcox, Anna P. Malykhina, Nicholas G. Cost

“…Our initial clinical and translational investigations suggest a sex-specific influence of childhood VCR exposure on LUT function. …”
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IONPs-induced neurotoxicity via cascade of neuro-oxidative stress, parthanatos-mediated cell death, neuro-inflammation and neurodegenerative changes: Ameliorating effect of rosemar... by Arwa A. Elsheikh, Noha Ali Abd-Almotaleb, Mona Mostafa Ahmed, Eman El-Sayed Khayal

“…Consequently, the current data provide evidence that RO supplementation during IONP administration holds promise to minimize potential health risks, which should be corroborated by translational studies.…”
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rule4ml: an open-source tool for resource utilization and latency estimation for ML models on FPGA by Mohammad Mehdi Rahimifar, Hamza Ezzaoui Rahali, Audrey C Therrien

“…We leverage HLS4ML, a tool-flow that helps translate NNs into high-level synthesis (HLS) code, to synthesize a diverse dataset of NN architectures and train resource utilization and inference latency predictors. …”
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Evolution of the RNA alternative decay cis element into a high-affinity target for the immunomodulatory protein Roquin by Jan-Niklas Tants, Katharina Friedrich, Jasmina Neumann, Andreas Schlundt

“…RNA cis elements play pivotal roles in regulatory processes, e.g. in transcriptional and translational regulation. Two stem-looped cis elements, the constitutive and alternative decay elements (CDE and ADE, respectively) are shape-specifically recognized in mRNA 3’ untranslated regions (UTRs) by the immune-regulatory protein Roquin. …”
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Fluorescent Nanoparticle Imaging Allows Noninvasive Evaluation of Immune Cell Modulation in Esophageal Dysplasia by Peiman Habibollahi, Todd Waldron, Pedram Heidari, Hoon Sung Cho, David Alcantara, Lee Josephson, Timothy C. Wang, Anil K. Rustgi, Umar Mahmood

“…Our observations suggest that this translatable technology may be used for the early detection of dysplastic changes and the serial assessment of immunomodulatory therapy and to visualize changes in MDSCs in the esophageal tumor microenvironment.…”
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Non3 is an essential Drosophila gene required for proper nucleolus assembly by E. N. Andreyeva, A. A. Ogienko, A. A. Yushkova, J. V. Popova, G. A. Pavlova, E. N. Kozhevnikova, A. V. Ivankin, M. Gatti, A. V. Pindyurin

“…We also demonstrate that the Non3 protein localizes to the nucleolus of larval brain cells and it is required for proper nucleolar localization of Fibrillarin, a protein important for post-translational modification and processing of rRNAs. In summary, we generated a number of genetic and biochemical tools that were exploited for an initial characterization of Non3, and will be instrumental for future functional studies on this gene and its protein product.…”
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Antioxidant Effect of Beer Polyphenols and Their Bioavailability in Dental-Derived Stem Cells (D-dSCs) and Human Intestinal Epithelial Lines (Caco-2) Cells by Marina Di Domenico, Antonia Feola, Pasqualina Ambrosio, Federica Pinto, Giovanni Galasso, Armando Zarrelli, Giovanni Di Fabio, Marina Porcelli, Salvatore Scacco, Francesco Inchingolo, Lucio Quagliuolo, Andrea Ballini, Mariarosaria Boccellino

“…Finally, our results demonstrated that the bioavailability of polyphenols is greater in beer than in the control standards used, supporting the future clinical application of these compounds as potential therapeutic tools in precision and translational medicine.…”
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<i>Macrostomum lignano</i> as a model to study the genetics and genomics of parasitic flatworms by K. V. Ustyantsev, V. Yu. Vavilova, A. G. Blinov, E. V. Berezikov

“…Due to the availability of an increasing number of genome and transcriptome assemblies of different parasitic flatworm species, new knowledge generated by studying M. lignano can be easily translated to parasitic f latworms with the help of modern bioinformatic methods of comparative genomics and transcriptomics. …”
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On the time spent preparing grant proposals: an observational study of Australian researchers by Nicholas Graves, Adrian G Barnett, Philip Clarke, Danielle L Herbert

“…An estimated 550 working years of researchers' time (95% CI 513 to 589) was spent preparing the 3727 proposals, which translates into annual salary costs of AU$66 million. …”
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Identification of Inequities in Green Visibility and Ways to Increase Greenery in Neighborhoods: A Case Study of Wuhan, China by Xiaohua Guo, Chang Liu, Shibo Bi, Yuling Tang

“…However, this improvement did not translate into better spatial equity, as the Gini coefficient consistently ranged between 0.4 and 0.5. …”
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Network-based transfer of pan-cancer immunotherapy responses to guide breast cancer prognosis by Xiaobao Ding, Lin Zhang, Ming Fan, Lihua Li

“…Abstract graph of network-based insights translating pan-cancer immunotherapy responses to breast cancer prognosis. …”
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Easy, fast and reproducible Stochastic Cellular Automata with chouca by Génin, Alexandre, Dupont, Guillaume, Valencia, Daniel, Zucconi, Mauro, Ávila-Thieme, M. Isidora, Navarrete, Sergio A., Wieters, Evie A.

“…To provide a unifying, well-tested technical basis to this class of models and facilitate their implementation, we built chouca, an R package that translates definitions of SCA models into compiled code, and runs simulations in an efficient way. chouca supports SCA based on rectangular grids where transition probabilities are defined for each cell, with performance typically two to three orders of magnitude above typical implementations in interpreted languages (e.g. …”
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Exploring the Physical and Mental Health Challenges of Teenage Pregnancy: A Qualitative Study in the Tamale Metropolis, Ghana by Rafatu Tahiru, Comfort Kona, Abiba Nyari, Tawfik Mohammed, Dorothy Anukem Pwamang

“…Discussions, guided by the socioecological model, were transcribed, translated, and thematically analyzed using NVivo software. …”
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Tuzūkāt-i Tīmūrī as a Source on Chagatai Military Tactics, Late Fourteenth to Early Fifteenth Centuries by Leonid A. Bobrov, Aibolat K. Kushkumbayev, Zhaksylyk М. Sabitov, Myltykbayuly

“…The study discovers The Code is a composite work compiled from a text allegedly found in Arabia by Abu TalibTurbati in the early seventeenth century, subsequent comments of a translator and a copyist, some fragments of Timurid writings dated from the early fifteenth century, and corrections introduced by the Mughal historian Muhammad Ashraf Bukhari. …”
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