Implementation and evaluation of a complex outpatient oral antimicrobial therapy program (COpAT) in Canada by Maggie Wong, Davie Wong

“…Compared to outpatient intravenous therapy, the total cost savings from COpAT were estimated to be $255,000 Canadian dollars (CAD), which translated to an average cost savings of $2500 CAD per patient per year. …”
Get full text

Cartilage structure-inspired nanofiber-hydrogel composite with robust proliferation and stable chondral lineage-specific differentiation function to orchestrate cartilage regenerat... by Yaqiang Li, Xiaowei Xun, Liang Duan, Erji Gao, Jiaxin Li, Lei Lin, Xinping Li, Aijuan He, Haiyong Ao, Yong Xu, Huitang Xia

“…Overall, the biomaterial system developed in this study provides a promising strategy for engineering transplantable, high-quality cartilage substitutes, with translational potential for artificial trachea construction.…”
Get full text

An In silico Approach towards Finding the Cancer-Causing Mutations in Human MET Gene by Fayeza Sadia Laskar, Md. Nazmul Islam Bappy, Md. Sowrov Hossain, Zenifer Alam, Dilruba Afrin, Sudeb Saha, Kazi Md. Ali Zinnah

“…Moreover, these nsSNPs exhibited substantial effects on structure, binding affinity with ligand, phylogenetic conservation, secondary structure, and post-translational modification sites of MET, which were evaluated using MutPred2, RaptorX, ConSurf, PSIPRED, and MusiteDeep, respectively. …”
Get full text

Evaluation of the cardiotoxicity of Echinochrome A using human induced pluripotent stem cell-derived cardiac organoids by Su-Jin Lee, Eunji Kim, Yeeun Jeong, Jae Boum Youm, Hyoung Kyu Kim, Jin Han, Elena A. Vasileva, Natalia P. Mishchenko, Sergey A. Fedoreyev, Valentin A. Stonik, Sung Joon Kim, Hyang-Ae Lee

“…This study fills a critical gap and highlights the translational relevance of hCOs for cardiotoxicity assessment, demonstrating EchA's cardiac safety and supporting its potential therapeutic and environmental applications.…”
Get full text

Bullying victimization and mental health before and during the COVID-19 pandemic by Ann H. Farrell, Heather Brittain, Amanda Krygsman, Tracy Vaillancourt, Tracy Vaillancourt

“…It is unclear whether the decrease in bullying victimization early in the pandemic translated to weaker associations between bullying victimization and mental health difficulties.MethodsUsing a population-based design, we examined whether the correlations between bullying victimization and mental health difficulties were significantly weaker in magnitude during the COVID-19 pandemic compared to before the pandemic in a sample of 6,578 Canadian students in grades 4–12. …”
Get full text

JNK1 Deficient Insulin-Producing Cells Are Protected against Interleukin-1β-Induced Apoptosis Associated with Abrogated Myc Expression by Michala Prause, Christopher Michael Mayer, Caroline Brorsson, Klaus Stensgaard Frederiksen, Nils Billestrup, Joachim Størling, Thomas Mandrup-Poulsen

“…INS-1 cells express JNK1α1, JNK1α2, JNK1β1, JNK1β2, JNK2α1, JNK2α2, JNK3α1, and JNK3α2 mRNA isoform transcripts translating into 46 and 54 kDa isoform JNK proteins. …”
Get full text

Landscape composition and orchard management effects on bat assemblages and bat foraging activity in apple crops by Marcos Miñarro, Daniel García

“…Little is known, however, on how bat assemblages respond to the gradients imposed by anthropogenic landscapes and farming practices and how these environmental effects translate into changes in bat foraging. In this study, we use cider apple crop in northern Spain as a model to address the filtering effects of landscape composition and orchard management on, simultaneously, quantitative and qualitative characteristics of bat local assemblages and their foraging activity. …”
Get full text

Challenges and Barriers Faced by People with TB and Healthcare Workers Providing TB Care and Management – A Qualitative Study by S. Suseendar, Akhil Dhanesh Goel, T. Pritish Baskaran, V. R. Rehana, Pankaj Bhardwaj, Manoj Kumar Gupta, S. Srikanth, Suman Saurabh

“…Interviews were carried out in the Hindi language, audio recorded, and translated to English. Participants were asked about their experiences of challenges and barriers faced during TB care and management. …”
Get full text

Molecular hydrogen reduces dermatitis-induced itch, diabetic itch and cholestatic itch by inhibiting spinal oxidative stress and synaptic plasticity via SIRT1-β-catenin pathway in... by Linlin Zhang, Fangshi Zhao, Yize Li, Zhenhua Song, Lingyue Hu, Yuanjie Li, Rui Zhang, Yonghao Yu, Guolin Wang, Chunyan Wang

“…Taken together, this study uncovers that molecular hydrogen protects against chronic pruritus and spinal pruriceptive sensitization by reducing oxidative damage via up-regulation of SIRT1-dependent β-catenin deacetylation in mice, implying a promising strategy in translational development for itch control.…”
Get full text

Adipose-Derived Stem Cells in Bone Tissue Engineering: Useful Tools with New Applications by Gabriele Storti, Maria Giovanna Scioli, Bong-Sung Kim, Augusto Orlandi, Valerio Cervelli

“…All these advancements are ultimately intended for a faster translational and clinical application of BTE.…”
Get full text

Mini review of spatially fractionated radiation therapy for cancer management by Shrikant B. Mali

“…A consensus on dose prescription, technical administration, and clinical and translational design parameters for SFRT trials is essential to enable broad participation and successful accrual to rigorously test the SFRT approach. …”
Get full text

Development of quality indicators for hand osteoarthritis care – Results from an European consensus study by Daniel H. Bordvik, Yeliz Prior, Rachael Bamford, Francis Berenbaum, Mathilda Björk, Thalita Blanck, Barbara Slatkowsky Christensen, Krysia Dziedzic, John Edwards, Nazemin Gilanliogullari, Carol Graham, Ida K. Haugen, Margreet Kloppenburg, Hellen Laheij, Marco J.P.F. Ritt, Tanja Stamm, Anne Therese Tveter, Nina Østerås, Ingvild Kjeken

“…The adapted questionnaire was translated from English into Norwegian. Cognitive debriefing interviews with Norwegian and UK hand OA patients were conducted to ensure clarity. …”
Get full text

Harnessing marine bacteria for next-gen antibiotics: potent inhibition of S. aureus and Riemerella anatipestifer through in vitro, omics, and chemoinformatics approach with enhance... by Syed Shams ul Hassan, Huizi Jin

“…A transcriptome analysis of active compound 4 showed its antibacterial effect on R. anatipestifer by inhibiting 30S and 50S ribosomal subunits, resistance mechanisms, and gliding motility proteins IX secretion system (T9SS) and interfering with protein translations process, secretion system, defense and resistance mechanisms, ultimately resulting in effective inhibition of normal bacterial growth and its motility. …”
Get full text

In situ natural radioactivity and radiological hazard assessments of granite gneiss outcrops in parts of the Southwestern Basement Complex of Nigeria by Adedibu Sunny Akingboye, Omowumi Ademila

“…However, increase in estimated mean of AGDE and ELCR; 525.620 and 1.273 above the world permissible standards of 300 and respectively does not translate to significant radiological threats. Therefore, control measure by constant monitoring of the radioactivity levels of the area and rocks should be practiced.…”
Get full text

MetaRange.jl: A Dynamic and Metabolic Species Range Model for Plant Species by Jana Blechschmidt, Juliano Sarmento Cabral

“…A promising research direction is to expand demographically explicit metapopulation models by integrating metabolic constraints. We translated and expanded a previously developed R metapopulation model to Julia language and published it as a Julia module. …”
Get full text

The fibronectin-targeting PEG-FUD imaging probe shows enhanced uptake during fibrogenesis in experimental lung fibrosis by Thomas J. Harr, Nikesh Gupta, Babita Rahar, Kristen Stott, Yadira Medina-Guevara, Metti K. Gari, Angie T. Oler, Ivy Sohee McDermott, Hye Jin Lee, Morteza Rasoulianboroujeni, Ashley M. Weichmann, Amir Forati, Kelsey Holbert, Trevor S. Langel, Kade W. Coulter, Brian M. Burkel, Bianca R. Tomasini-Johansson, Suzanne M. Ponik, Jonathan W. Engle, Reinier Hernandez, Glen S. Kwon, Nathan Sandbo, Ksenija Bernau

“…These data suggest that PEG-FUD targets fibronectin associated with active fibrogenesis in this model, making it a promising candidate for a clinically translatable molecular imaging probe to non-invasively determine pulmonary fibrosis disease activity, enabling accelerated therapeutic decision-making.…”
Get full text

On the Work of Cartan and Münzner on Isoparametric Hypersurfaces by Thomas E. Cecil, Patrick J. Ryan

“…These papers of Cartan and Münzner have been the foundation of the extensive field of isoparametric hypersurfaces, and they have all been recently translated into English by T. Cecil. The paper concludes with a brief survey of the recently completed classification of isoparametric hypersurfaces in spheres.…”
Get full text

Renouveler les connaissances sur les risques liés aux sports de montagne : l’exemple d’un laboratoire collaboratif d’accidentologie by Maud Vanpoulle, Bastien Soulé, Eric Boutroy, Brice Lefèvre

“…At its source, the SERAC project has two complementary but also divergent aims: that of collaborative action research to support social innovation, and the production of contextualized knowledge that can ideally be translated into accident prevention recommendations and a better understanding of risky alpine practices.…”
Get full text

Continuous Sign Language Recognition With Multi-Scale Spatial-Temporal Feature Enhancement by Zhen Wang, Dongyuan Li, Renhe Jiang, Manabu Okumura

“…Continuous Sign Language Recognition (CSLR) seeks to interpret the gestures used by people who are hard of hearing-mute individuals and translate them into natural language, thereby enhancing communication and interaction. …”
Get full text

Phase I clinical trial testing the dose escalation and expansion of Pressurized IntraThoracic Hyperthermic Aerosol Cisplatin administration (PITHAC) for the management of pleural c... by Louis-Emmanuel Chriqui, Etienne Abdelnour-Berchtold, Edoardo Zanfrini, Severine Devesa-Perez, Michel Gonzalez, Thorsten Krueger, Kim Ellefsen, Alice Destaillats, David Bonnet, Martin Hübner, Hasna Bouchaab, Michal Bassani-Sternberg, Solange Peters, Sabrina Cavin, Jean Y Perentes

“…The secondary and translational endpoints are adverse events and the immune response directed against cancer following PITHAC. …”
Get full text