Editorial: Five grand challenges in toxicology by Bengt Fadeel, Jan Alexander, Sara C. Antunes, Kim Dalhoff, Ellen Fritsche, Ellen Fritsche, Helena T. Hogberg, François Huaux, Stina Oredsson, Antonio Pietroiusti, Terje Svingen, Martin F. Wilks, Martin F. Wilks

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Research progress of Management of acute skin failure in critically ill patients (重症患者急性皮肤衰竭管理的研究进展) by YUAN Yingying (袁迎迎), GAO Qian (高倩)

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C-Reactive Protein Is Not the Driver Factor in Ulcerative Colitis by Zhong-Bo Ge, Xin-Yun Zhang, Chun-Miao Zhang, Tao-Tao Xu, Si-Yi Li, Meng-Xiao Wei, Xin-Yuan Ding, Cai-Juan Bai, Han Wang, Hai-Hong Zhou, Ming-Yu Wang

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Development Status of TCM Nursing Clinic (中医护理门诊建设发展现状) by DENG Jianhua (邓建华), ZHANG Jing (张敬), TANG Ling (唐玲)

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Stability and optimal control for some classes of tritrophic systems by Luca Galbusera, Sara Pasquali, Gianni Gilioli

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Second-line treatment patterns and outcomes in advanced HCC after progression on atezolizumab/bevacizumab by Meng Wu, Claudia A.M. Fulgenzi, Antonio D’Alessio, Alessio Cortellini, Ciro Celsa, Giulia F. Manfredi, Bernardo Stefanini, Y. Linda Wu, Yi-Hsiang Huang, Anwaar Saeed, Angelo Pirozzi, Tiziana Pressiani, Lorenza Rimassa, Martin Schoenlein, Kornelius Schulze, Johann von Felden, Yehia Mohamed, Ahmed O. Kaseb, Arndt Vogel, Natascha Roehlen, Marianna Silletta, Naoshi Nishida, Masatoshi Kudo, Caterina Vivaldi, Lorenz Balcar, Bernhard Scheiner, Matthias Pinter, Amit G. Singal, Joshua Glover, Susanna Ulahannan, Fredrich Foerster, Arndt Weinmann, Peter R. Galle, Neehar D. Parikh, Wei-Fan Hsu, Alessandro Parisi, Hong Jae Chon, David J. Pinato, Celina Ang

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Analysis of fatty acid-derived lipids in critically ill patients after cardiac surgery yields novel pathophysiologically relevant mediators with possible relevance for systemic inf... by Holger Neb, Verena Roth, Jessica Roos, Jessica Roos, Tom Bauer, Anja Urbschat, Ulrike Heinicke, Carlo Angioni, Dieter Steinhilber, Dieter Steinhilber, Matthias Piesche, Matthias Piesche, Nerea Ferreirós, Robert Gurke, Robert Gurke, Gerd Geisslinger, Gerd Geisslinger, Edith Utech, Kai Zacharowski, Patrick Meybohm, Patrick Meybohm, Patrick Paulus, Elke Schmitt, Elke Schmitt, Thorsten Jürgen Maier, Thorsten Jürgen Maier

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Men’s Attitudes Towards Participation in Organised Prostate Cancer Testing: An Abductive Thematic Analysis by Markus Arvendell, Lottie Phillips, Sara Delilovic, Moa Backman Enelius, Karin Olsson, Anetta Bolejko, Olof Akre, Sigrid Carlsson, Anne Richter, Anna Lantz

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Efficacy and safety of surufatinib plus toripalimab in treatment-naive, PD-L1-positive, advanced or metastatic non-small-cell lung cancer and previously treated small-cell lung can... by Ying Cheng, Panpan Zhang, Ming Lu, Zhendong Chen, Lijie Song, Si Shi, Feng Ye, Xing Zhang, Baorui Liu, Dongmei Ji, Yanqiao Zhang, Weiguo Su, Michael Shi, Songhua Fan, Panfeng Tan, Chen Zhong

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Kinematics Analysis and Performance Optimization of Low Coupling PRPaR/2CRR Parallel Mechanism by Zhang Li, Zhu Lei, Xu Dong

“…Based on the topological structure synthesis method, a batch of spatial triple translational parallel mechanisms were synthesized, and a PRPaR/2CRR parallel mechanism with spatial triple translational motion was optimized. …”
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A New MEN2 Syndrome with Clinical Features of Both MEN2A and MEN2B Associated with a New RET Germline Deletion by Carlotta Giani, Teresa Ramone, Cristina Romei, Raffaele Ciampi, Alessia Tacito, Laura Valerio, Laura Agate, Clara Ugolini, Michele Marinò, Fulvio Basolo, Alessandro Franchi, Simona Borsari, Angela Michelucci, Cesare Selli, Gabriele Materazzi, Filomena Cetani, Rossella Elisei

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Imaging flow cytometry-based cellular screening elucidates pathophysiology in individuals with Variants of Uncertain Significance by Irena Josephina Johanna Muffels, Hans R. Waterham, Giuseppina D’Alessandro, Guido Zagnoli-Vieira, Michael Sacher, Dirk J. Lefeber, Celine Van der Vinne, Chaim M. Roifman, Koen L. I. Gassen, Holger Rehmann, Desiree Y. Van Haaften-Visser, Edward S. S. Nieuwenhuis, Stephen P. Jackson, Sabine A. Fuchs, Femke Wijk, Peter van Hasselt

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Genome-wide association analysis of composite sleep health scores in 413,904 individuals by Matthew O. Goodman, Tariq Faquih, Valentina Paz, Pavithra Nagarajan, Jacqueline M. Lane, Brian Spitzer, Matthew Maher, Joon Chung, Brian E. Cade, Shaun M. Purcell, Xiaofeng Zhu, Raymond Noordam, Andrew J. K. Phillips, Simon D. Kyle, Kai Spiegelhalder, Michael N. Weedon, Deborah A. Lawlor, Jerome I. Rotter, Kent D. Taylor, Carmen R. Isasi, Tamar Sofer, Hassan S. Dashti, Martin K. Rutter, Susan Redline, Richa Saxena, Heming Wang

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Exosome proteomic analyses identify inflammatory phenotype and novel biomarkers in African American prostate cancer patients by Gati K. Panigrahi, Prakash P. Praharaj, Hiroki Kittaka, Asit R. Mridha, Olen M. Black, Rakesh Singh, Roger Mercer, Adrie van Bokhoven, Kathleen C. Torkko, Chapla Agarwal, Rajesh Agarwal, Zakaria Y. Abd Elmageed, Hariom Yadav, Santosh K. Mishra, Gagan Deep

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Exome sequencing reveals a rare damaging variant in GRIN2C in familial late-onset Alzheimer's disease by Elisa Rubino, Maria Italia, Elisa Giorgio, Silvia Boschi, Paola Dimartino, Tommaso Pippucci, Fausto Roveta, Clara Maria Cambria, Gabriella Elia, Andrea Marcinnò, Salvatore Gallone, Ekaterina Rogaeva, Flavia Antonucci, Alfredo Brusco, Fabrizio Gardoni, Innocenzo Rainero

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Total and High Molecular Weight Adiponectin Levels and Prediction of Cardiovascular Risk in Diabetic Patients by Dagmar Horáková, Kateřina Azeem, Radka Benešová, Dalibor Pastucha, Vladimír Horák, Lenka Dumbrovská, Arnošt Martínek, Dalibor Novotný, Zdeněk Švagera, Milada Hobzová, Dana Galuszková, Vladimír Janout, Sandra Doněvská, Jana Vrbková, Helena Kollárová

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Mixed-methods evaluation of a behavioural intervention package to identify and amend incorrect penicillin allergy records in UK general practice by Sarah Tonkin-Crine, Robert West, Sinisa Savic, Jonathan Sandoe, Ly-Mee Yu, Sue Pavitt, Ushma Galal, Christopher C Butler, Marta Wanat, Bethany Shinkins, Mina Davoudianfar, Emily Bongard, Sue H Pavitt, Philip Howard, Catherine Porter, Mandy East, Marta Santillo, Louise Savic, Joanne Fielding, Jenny Boards, Catherine E Porter, Jonathan AT Sandoe

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Nursing of a patient with multiple fractures complicated with lower extremity deep venous thrombosis (1例多发性骨折并发下肢深静脉血栓患者的护理体会) by WANG Wei (王伟)

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The Neurometabolic Function of the Dopamine–Aminotransferase System by Sergey A. Apryatin

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Editorial: Clinical trial design and development in neonatal and perinatal medicine by Mohamed E. Abdel-Latif, Mohamed E. Abdel-Latif, Mohamed E. Abdel-Latif, Yogavijayan Kandasamy, Yogavijayan Kandasamy, Yogavijayan Kandasamy, Sabita Uthaya, Sabita Uthaya, Dirk Bassler, Dirk Bassler, Jonathan M. Davis, Jonathan M. Davis

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