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  6. 5326

    Chemogenomic Screening in a Patient‐Derived 3D Fatty Liver Disease Model Reveals the CHRM1‐TRPM8 Axis as a Novel Module for Targeted Intervention by Sonia Youhanna, Aurino M. Kemas, Shane C. Wright, Yi Zhong, Britta Klumpp, Kathrin Klein, Aikaterini Motso, Maurice Michel, Nicole Ziegler, Mingmei Shang, Pierre Sabatier, Aimo Kannt, Hongda Sheng, Nuria Oliva‐Vilarnau, Florian A. Büttner, Brinton Seashore‐Ludlow, Jonas Schreiner, Maike Windbergs, Martin Cornillet, Niklas K. Björkström, Andreas J. Hülsmeier, Thorsten Hornemann, Jesper V. Olsen, Yi Wang, Roberto Gramignoli, Michael Sundström, Volker M. Lauschke

    Published 2025-01-01
    “…Abstract Metabolic dysfunction‐associated steatohepatitis (MASH) is a leading cause of chronic liver disease with few therapeutic options. To narrow the translational gap in the development of pharmacological MASH treatments, a 3D liver model from primary human hepatocytes and non‐parenchymal cells derived from patients with histologically confirmed MASH was established. …”
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  7. 5327

    Clinical and molecular outcomes from the 5-Year natural history study of SSADH Deficiency, a model metabolic neurodevelopmental disorder by Itay Tokatly Latzer, Jean-Baptiste Roullet, Wardiya Afshar-Saber, Henry H. C. Lee, Mariarita Bertoldi, Gabrielle E. McGinty, Melissa L. DiBacco, Erland Arning, Melissa Tsuboyama, Alexander Rotenberg, Thomas Opladen, Kathrin Jeltsch, Àngels García-Cazorla, Natalia Juliá-Palacios, K. Michael Gibson, Mustafa Sahin, Phillip L. Pearl

    Published 2024-04-01
    “…Abstract Background Succinic semialdehyde dehydrogenase deficiency (SSADHD) represents a model neurometabolic disease at the fulcrum of translational research within the Boston Children’s Hospital Intellectual and Developmental Disabilities Research Centers (IDDRC), including the NIH-sponsored natural history study of clinical, neurophysiological, neuroimaging, and molecular markers, patient-derived induced pluripotent stem cells (iPSC) characterization, and development of a murine model for tightly regulated, cell-specific gene therapy. …”
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  8. 5328

    KINEMATICS AND SIMULATION ANALYSIS OF A PARALLEL LEG HEXAPOD AGRICULTURAL ROBOT by XIE DongFu, LUO YuFeng, SHI ZhiXin, LIU YanDe, XIE JinFa

    Published 2021-01-01
    “…In view of the problems such as poor bearing capacity and large motion error of hexapod robot with series leg structure and plane multi-link structure,The parallel leg hexapod agricultural robot mechanism with one translational and two rotations( 1 T2 R) was proposed. …”
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  9. 5329

    « Caroline » et la montagne. Ces albums populaires pour enfants qui construisent la montagne by Christophe Meunier

    Published 2016-07-01
    “…These two picture books, despite being situated in a particular temporality and spatiality, have been republished and translated many times over. This article seeks to show how the two works can be considered as geographical and cultural products and to study the iconotextual processes that make it possible to build mountain areas and to provide practical examples, which I shall call spatiality.…”
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  10. 5330

    Experimental and Theoretical Investigations of Terahertz Spectra of the Structural Isomers: Mannose and Galactose by Tongjun Zhang, Shasha Yan, Jianjun Hao, Dehua Li

    Published 2021-01-01
    “…According to the calculated results of PBE, the observed spectral features were assigned as primarily external lattice translations, deformations, and rotations with lesser contributions due to intramolecular motion of pyranose ring, CH2OH group, and hydroxyl groups.…”
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  11. 5331

    Trauma, Romance, and the Diasporic Memory Keepers of the Holodomor in Erin Litteken’s The Memory Keeper of Kyiv by Mateusz Świetlicki

    Published 2023-11-01
    “…A few months after its publication in North America, Erin Litteken’s bestselling historical novel The Memory Keeper of Kyiv (2022) has already been translated into fourteen languages. Thus, it is plausible that for many readers the novel will be the first encounter with the complex topic of the Great Famine of 1932-1933 in Soviet Ukraine. …”
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  12. 5332

    The Materialist Foundations of Politics: A Critique of the Book State and Civil Society by Hamid Malekzadeh, Ahmad Khaleghi damghani

    Published 2021-08-01
    “…A collection for Persian speakers entitled State and Civil Society, translated by Abbas Milani, has been presented to the market by Akhtaran Publications. …”
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  13. 5333

    Bifurcation of time crystals in driven and dissipative Rydberg atomic gas by Bang Liu, Li-Hua Zhang, Yu Ma, Qi-Feng Wang, Tian-Yu Han, Jun Zhang, Zheng-Yuan Zhang, Shi-Yao Shao, Qing Li, Han-Chao Chen, Guang-Can Guo, Dong-Sheng Ding, Bao-Sen Shi

    Published 2025-02-01
    “…Abstract A time crystal is an exotic phase of matter where time-translational symmetry is broken; this phase differs from the spatial symmetry breaking induced in conventional crystals. …”
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  14. 5334

    Multi-objective Optimization of Dimensional Parameter for 4-PRP<sub>a</sub>R Parallel Mechanism by Jian Yi, Bing He, Linxian Che, Jie Li

    Published 2021-07-01
    “…Taking a 4-PRPaR parallel mechanism with three translational and one rotational as the research object, the evolutionary multi-objective algorithm is applied to solve the dimensional synthesis problem of mechanism. …”
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  15. 5335

    Functional Evaluations in the Monitoring of the River Ecosystem Processes: The Adige River as a Case Stu by M.G. Braioni, G. Salmoiraghi, F. Bracco, M. Villani, A. Braioni, L. Girelli

    Published 2002-01-01
    “…The results achieved were then translated into five classes of functional evaluation. …”
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  16. 5336

    Aura phenomenon: a proposal for an etiology-based clinical classification by Umberto Pensato, Andrew M. Demchuk, Jens P. Dreier, Kevin C. Brennan, Simona Sacco, Michele Romoli

    Published 2025-01-01
    “…Moreover, it could promote effective communication and translational mechanistic research.…”
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  17. 5337

    Chemoresistance, Cancer Stem Cells, and miRNA Influences: The Case for Neuroblastoma by Alfred Buhagiar, Duncan Ayers

    Published 2015-01-01
    “…This review focuses on highlighting the recent, important implications of miRNAs within the context of neuroblastoma basic research efforts, particularly concerning miRNA influences on cancer stem cell pathology and chemoresistance pathology for this condition, together with development of translational medicine approaches for novel diagnostic tools and therapies for this neuroblastoma.…”
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  18. 5338

    AUTOMATED ALPHABETIC SUBJECT INDEX GENERATION FOR UNIVERSAL DECIMAL CLASSIFICATION IN BELARUSIAN by S. I. Lysy, H. R. Stanislavenka, Yu. S. Hetsevich

    Published 2018-06-01
    “…Universal Decimal Classification (UDC) is an international classification system that corresponds to the essential classification requirements: internationalism, universality, expansiveness. UDC Tables were translated and published fully or partially in more than 40 languages. …”
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  19. 5339

    Heat Transfer in Boundary Layer Magneto-Micropolar Fluids with Temperature-Dependent Material Properties over a Stretching Sheet by Ephesus O. Fatunmbi, Samuel S. Okoya

    Published 2020-01-01
    “…With the aid of similarity conversion analysis, the formulated equations of the flow and heat transfer have been translated into a system of nonlinear ordinary differential equations. …”
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  20. 5340

    JózefWolski’s Writings on the Arsacid History and Culture: A Critique by Farshid Naderi

    Published 2018-12-01
    “…To this end, many of his most important papers were translated or summarized. Among the most important achievements of this study in introducing his works is that the Persian domestic sources gained prominence and were changed into canonical works. …”
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