Pregnancy-Associated Plasma Protein A Induces Inflammatory Cytokine Expression by Activating IGF-I/PI3K/Akt Pathways by Weiping Li, Hongwei Li, Li Zhou, Zijian Wang, Bing Hua

“…Results showed that PAPP-A significantly stimulated the expression of MCP-1, TNF-α, and IL-6 at both transcriptional and translational levels in a dose-dependent and time-dependent manner. …”
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A current review on animal models of anti-asthmatic drugs screening by Shivam Singh, Sunita Kularia, Shivakshi Shukla, Mithilesh Singh, Manish Kumar, Ashish Kumar Sharma

“…Conclusion: This review focusses on the benefits and limitations of current animal models in asthma research, emphasising the need for more sophisticated, predictive models to decrease translational failures. By critically evaluating these models, the review emphasises their importance in directing anti-asthmatic drug development and highlights the urgent need for innovation to bridge the gap between preclinical success and clinical efficacy.…”
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Altered Atlas of Exercise-Responsive MicroRNAs Revealing miR-29a-3p Attacks Armored and Cold Tumors and Boosts Anti-B7-H3 Therapy by Jie Mei, Zhiwen Luo, Yun Cai, Renwen Wan, Zhiwen Qian, Jiahui Chu, Yaying Sun, Yuxin Shi, Ying Jiang, Yan Zhang, Yongmei Yin, Shiyi Chen

“…Single-cell RNA sequencing (scRNA-seq) and cytometry by time-of-flight (CyTOF) demonstrated that miR-29a-3p attacked the armored and cold tumors, thereby shaping an immuno-hot tumor microenvironment (TME). Translationally, liposomes were developed and loaded with miR-29a-3p (lipo@miR-29a-3p), and lipo@miR-29a-3p exhibited promising antitumor effects in a mouse model with great biocompatibility. …”
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Gene regulatory patterning codes in early cell fate specification of the C. elegans embryo by Alison G Cole, Tamar Hashimshony, Zhuo Du, Itai Yanai

“…This classic model however does not translate directly to species that lack a syncytium – such as Caenorhabditis elegans – where cell fate is specified by cell-autonomous cell lineage programs and their inter-signaling. …”
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Normative Values of Brainstem Auditory-Evoked Responses in Sheep by Katharina Suntinger, Adrian Dalbert, Lukas Prochazka, Milena Tegelkamp, Peter Kronen, Karina Klein, Christof Röösli, Alexander Huber, Flurin Pfiffner

“…However, normative data for BAERs in sheep, which represent an adequate large animal model for translational and basic otological research, are lacking. …”
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Cross-cultural adaptation: South African Gestational Diabetes Mellitus Knowledge Questionnaire by Lorisha Manas, Tawanda Chivese, Ankia Coetzee, Magda Conradie, Linzette D. Morris

“…The aim of this study was to translate and cross-culturally adapt and test the preliminary internal consistency and test-retest reliability of the South African English, Afrikaans and isiXhosa versions of the GDM Knowledge Questionnaire (GDMKQ). …”
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Examining the integration of refugees into the national health system in Uganda: an analysis using the policy triangle framework by Henry Komakech, Shatha Elnakib, Lama Bou Karroum, Evelyn Nyachwo, Winnie Adoch, Sarah Sali, Godfrey Goddie Okeny, Christopher Garimoi Orach

“…The findings shed light on the importance of collaboration between stakeholders, mobilization of legal and political frameworks to shape the integration of refugee health services into the national health system, and the importance of ensuring that high-level commitments translate to action and development plans at local levels.…”
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Backtranslation of human RNA biosignatures of tuberculosis disease risk into the preclinical pipeline is condition dependent by Hannah Painter, Sasha E. Larsen, Brittany D. Williams, Hazem F. M. Abdelaal, Susan L. Baldwin, Helen A. Fletcher, Andrew Fiore-Gartland, Rhea N. Coler

“…Human-derived COR signatures offer an opportunity for high-throughput preclinical endpoint criteria of vaccine and drug therapy evaluations.IMPORTANCEUnderstanding the strengths or limitations of back-translating human-derived correlate of risk (COR) RNA signatures into the preclinical pipeline may help streamline down-selection of therapeutic vaccine and drug candidates and better align preclinical models with proposed clinical trial efficacy endpoints.…”
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Targeted CQA analytical control strategy for commercial antibody products: Replacing ion-exchange chromatography methods for charge heterogeneity with multi-attribute monitoring by Adam R. Evans, Joseph Mulholland, Michael J. Lewis, Ping Hu

“…Historically, peptide mapping monitors post-translational modifications (PTMs) of protein products and process intermediates during development. …”
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MODERN STATE LANGUAGE POLICY by Olga B. Akimova, Tatyana S. Tabachenko

“…The perspective directions of the state language policy in the field of the Russian language and literature are specified and formulated: the analysis of the programs and projects aimed at the development, distribution and support of the Russian language; providing coordination of actions of executive authorities in the presented study; improvement of the Russian language studying quality in schools in accordance with features of the general education in the national republics; professional level improvement of teachers of the Russian language; preservation of national languages of Russia; scientific studying and codification of the modern language, promoting of scientific knowledge of Russian and languages of the people of the Russian Federation; support expansion of the private initiatives connected with preservation and development of Russian in neighboring countries; creation of base for studying of Russian by foreign experts and labor migrants; cooperation with foreign specialists in the Russian philology, translators of the Russian literature and teachers of Russian.…”
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Airborne lidar intensity correction for mapping snow cover extent and effective grain size in mountainous terrain by Chelsea Ackroyd, Christopher P. Donahue, Brian Menounos, S. McKenzie Skiles

“…The lidar-derived grain size retrievals had a MAE of 32 µm compared to those from field spectroscopy, which translated to a 1% error in snow albedo. We found high incidence angles yielded an overcorrection in intensity that introduced a high bias in the grain size distribution and, therefore, suggest using an incidence angle threshold (40°). …”
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How can cervical screening meet the needs of vulnerable women? A qualitative comparative study with stakeholder perspectives from seven European countries by Partha Basu, Martin McKee, Adriana Băban, Marc Bardou, Ana Fernandes, Margarida Teixeira, Rebecca Moore, Nuno Lunet, David Ritchie, Romeu Mendes, Eric Lucas, Paolo Giorgi Rossi, Rosa Legood, Berit Andersen, Diana Taut, Keitly Mensah, João Firmino-Machado, Mariana Amorim, Mette Tranberg, Laura Bonvicini, Anneli Uusküla, Pia Kirkegaard, Paola Mantellini, Ines Baia, Liu Sun, Lise Rochaix, Camilla Fiorina, Luca Ghirotto, Anna Tisler, Firmino Machado, Rikke Buus Bøje, Raquel Rico Berrocal, Noemi Auzzi, Kerli Reintamm, Yulia Panayotova, Tatyana Kotzeva, Anna Foss, Rachel Greenley, Letizia Bartolini, Giusy Iorio, Cláudia Gouvinhas, Florian Nicula, Alexandra Tolnai, Vanessa Moore, Isabel Mosquera Metcalfe, Violette Delisle, Irina Todorova, Helena Ros Comesana, Meritxel Mallafré-Larrosa, Ginevra Papi, Nicoleta-Monica Pașca, Christiane Dascher-Nadel, Olivra Djuric

“…The meetings were audio or video recorded, transcribed and translated into English for qualitative framework analysis.Results We engaged 120 participants in the Collaborative User Boards. …”
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Measuring the condition of Tehran Metropolitan based on Ubiquitous city indicators by Haniyeh Asadzadeh, Afshar Hatami, Farzaneh Sasanpour

“…<link href="moz-extension://e82f9c05-bf9c-4e25-87b0-684d37ab5915/skin/s3gt_tooltip_mini.css" rel="stylesheet" type="text/css" > #s3gt_translate_tooltip_mini { display: none !important; }…”
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Naming the untouchable – environmental sequences and niche partitioning as taxonomical evidence in fungi by Faheema Kalsoom Khan, Kerri Kluting, Jeanette Tångrot, Hector Urbina, Tea Ammunet, Shadi Eshghi Sahraei, Martin Rydén, Martin Ryberg, Anna Rosling

“…While environmental sequences cannot be automatically translated to species, they can be used to generate phylogenetically distinct species hypotheses that can be further tested using sequences as ecological evidence. …”
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PCA and PSO based optimized support vector machine for efficient intrusion detection in internet of things by Mutkule Prasad Raghunath, Shyam Deshmukh, Poonam Chaudhari, Sunil L. Bangare, Kishori Kasat, Mohan Awasthy, Batyrkhan Omarov, Rajesh R. Waghulde

“…Conversely, all numerical features are translated back into symbolic form at the conclusion of the procedure. …”
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Languages of Written and Oral Communication between Russian Emperors and Electors of the Holy Roman Empire, 1725–1799 by M. A. Petrova

“…Conversely, Russian monarchs adhered to tradition, drafting official correspondence in Russian with German translations attached.The article concludes that the choice of language serves as a formal indicator of the nature of relationships between rulers, highlighting the distinction between sovereign monarchs and electors, who, de jure, remained vassals. …”
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Acceptability of telemedicine for early surgical site infection diagnosis after cesarean delivery in rural Rwanda: a qualitative study by Laban Bikorimana, Eve Hiyori Estrada, Anne Niyigena, Robert Riviello, Fredrick Kateera, Bethany Hedt-Gauthier, Vincent K. Cubaka

“…The interviews were transcribed verbatim and translated into English. Thematic analysis was applied and parallel inductive coding was used to develop English and Kinyarwanda codebooks. …”
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Proposal for a predictive scale of cognitive impairment in adult patients with neurocysticercosis by Jorge Luis Anaya González, Francisco López-Muñoz, Erlen Carmona Alvarez-Builla, Adriana Edit Miniet Castillo, Laudelina Moreira Tusell

“…<span class="VIiyi" lang="en"><span class="JLqJ4b ChMk0b" data-language-for-alternatives="en" data-language-to-translate-into="es" data-phrase-index="0" data-number-of-phrases="1"><span class="Q4iAWc">Through data provided by previous research, the variables related to the appearance of cognitive impairment were selected in the bivariate analysis (p&lt;0.05).…”
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Partial replacement of soybean meal with cottonseed meal in diets of broiler chicken sustains performance by upregulating the expression of nutrient transporter genes in small inte... by S. Haldar, S.S. Arora, A.K. Dhara, A. Debnath

“…The study suggests that inclusion of HF-CSM by replacing 10-15 % of SBM on a weight-to-weight basis, which translates into 2.5–3 % inclusion of the former in the whole ration, may sustain the performance of broiler chickens…”
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Looking beyond the ER, PR, and HER2: what’s new in the ARsenal for combating breast cancer? by Tryambak Pratap Srivastava, Ruby Dhar, Subhradip Karmakar

“…From the settings of developing nations, this may provide useful insight by integrating recent advances in AR-targeted therapies and exploring their translational potential, emphasizing the critical need for further research to optimize AR-based therapeutic strategies for breast cancer management.…”
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