Phase I clinical trial testing the dose escalation and expansion of Pressurized IntraThoracic Hyperthermic Aerosol Cisplatin administration (PITHAC) for the management of pleural c... by Louis-Emmanuel Chriqui, Etienne Abdelnour-Berchtold, Edoardo Zanfrini, Severine Devesa-Perez, Michel Gonzalez, Thorsten Krueger, Kim Ellefsen, Alice Destaillats, David Bonnet, Martin Hübner, Hasna Bouchaab, Michal Bassani-Sternberg, Solange Peters, Sabrina Cavin, Jean Y Perentes

“…The secondary and translational endpoints are adverse events and the immune response directed against cancer following PITHAC. …”
Get full text

Adverse Events of Antiepileptic Drugs Using Indonesian Version of Liverpool Adverse Events Profile by Astri Budikayanti, Lubna Muhammad Qadri, Zakiah Syeban, Luh Ari Indrawati, Fitri Octaviana

“…The questionnaire was translated from English into Indonesian version. The validity and reliability were tested using Spearman correlation and Cronbach’s alpha measurement. …”
Get full text

A High-Throughput Method as a Diagnostic Tool for HIV Detection in Patient-Specific Induced Pluripotent Stem Cells Generated by Different Reprogramming Methods by Daniela Hübscher, Sabine Rebs, Luis Haupt, Thomas Borchert, Celina Isabell Guessoum, Franziska Treu, Steffen Köhne, Andreas Maus, Mario Hambrecht, Samuel Sossalla, Ralf Dressel, Angela Uy, Mark Jakob, Gerd Hasenfuss, Katrin Streckfuss-Bömeke

“…Induced pluripotent stem cells (iPSCs) provide a unique opportunity for generation of patient-specific cells for use in translational purposes. We aimed to compare iPSCs generated by different reprogramming methods regarding their reprogramming efficiency, pluripotency capacity, and the possibility to use high-throughput PCR-based methods for detection of human pathogenic viruses. iPSCs from skin fibroblasts (FB), peripheral blood mononuclear cells (PBMCs), or mesenchymal stem cells (MSCs) were generated by using three different reprogramming systems including chromosomal integrating and nonintegrating methods. …”
Get full text

Lower urinary dysfunction as a long-term effect of childhood vincristine treatment, with potential influences by sex and dose by Nao Iguchi, Ali Teimouri, Duncan T. Wilcox, Anna P. Malykhina, Nicholas G. Cost

“…Our initial clinical and translational investigations suggest a sex-specific influence of childhood VCR exposure on LUT function. …”
Get full text

IONPs-induced neurotoxicity via cascade of neuro-oxidative stress, parthanatos-mediated cell death, neuro-inflammation and neurodegenerative changes: Ameliorating effect of rosemar... by Arwa A. Elsheikh, Noha Ali Abd-Almotaleb, Mona Mostafa Ahmed, Eman El-Sayed Khayal

“…Consequently, the current data provide evidence that RO supplementation during IONP administration holds promise to minimize potential health risks, which should be corroborated by translational studies.…”
Get full text

rule4ml: an open-source tool for resource utilization and latency estimation for ML models on FPGA by Mohammad Mehdi Rahimifar, Hamza Ezzaoui Rahali, Audrey C Therrien

“…We leverage HLS4ML, a tool-flow that helps translate NNs into high-level synthesis (HLS) code, to synthesize a diverse dataset of NN architectures and train resource utilization and inference latency predictors. …”
Get full text

Non3 is an essential Drosophila gene required for proper nucleolus assembly by E. N. Andreyeva, A. A. Ogienko, A. A. Yushkova, J. V. Popova, G. A. Pavlova, E. N. Kozhevnikova, A. V. Ivankin, M. Gatti, A. V. Pindyurin

“…We also demonstrate that the Non3 protein localizes to the nucleolus of larval brain cells and it is required for proper nucleolar localization of Fibrillarin, a protein important for post-translational modification and processing of rRNAs. In summary, we generated a number of genetic and biochemical tools that were exploited for an initial characterization of Non3, and will be instrumental for future functional studies on this gene and its protein product.…”
Get full text

Antioxidant Effect of Beer Polyphenols and Their Bioavailability in Dental-Derived Stem Cells (D-dSCs) and Human Intestinal Epithelial Lines (Caco-2) Cells by Marina Di Domenico, Antonia Feola, Pasqualina Ambrosio, Federica Pinto, Giovanni Galasso, Armando Zarrelli, Giovanni Di Fabio, Marina Porcelli, Salvatore Scacco, Francesco Inchingolo, Lucio Quagliuolo, Andrea Ballini, Mariarosaria Boccellino

“…Finally, our results demonstrated that the bioavailability of polyphenols is greater in beer than in the control standards used, supporting the future clinical application of these compounds as potential therapeutic tools in precision and translational medicine.…”
Get full text

<i>Macrostomum lignano</i> as a model to study the genetics and genomics of parasitic flatworms by K. V. Ustyantsev, V. Yu. Vavilova, A. G. Blinov, E. V. Berezikov

“…Due to the availability of an increasing number of genome and transcriptome assemblies of different parasitic flatworm species, new knowledge generated by studying M. lignano can be easily translated to parasitic f latworms with the help of modern bioinformatic methods of comparative genomics and transcriptomics. …”
Get full text

On the time spent preparing grant proposals: an observational study of Australian researchers by Nicholas Graves, Adrian G Barnett, Philip Clarke, Danielle L Herbert

“…An estimated 550 working years of researchers' time (95% CI 513 to 589) was spent preparing the 3727 proposals, which translates into annual salary costs of AU$66 million. …”
Get full text

Identification of Inequities in Green Visibility and Ways to Increase Greenery in Neighborhoods: A Case Study of Wuhan, China by Xiaohua Guo, Chang Liu, Shibo Bi, Yuling Tang

“…However, this improvement did not translate into better spatial equity, as the Gini coefficient consistently ranged between 0.4 and 0.5. …”
Get full text

Easy, fast and reproducible Stochastic Cellular Automata with chouca by Génin, Alexandre, Dupont, Guillaume, Valencia, Daniel, Zucconi, Mauro, Ávila-Thieme, M. Isidora, Navarrete, Sergio A., Wieters, Evie A.

“…To provide a unifying, well-tested technical basis to this class of models and facilitate their implementation, we built chouca, an R package that translates definitions of SCA models into compiled code, and runs simulations in an efficient way. chouca supports SCA based on rectangular grids where transition probabilities are defined for each cell, with performance typically two to three orders of magnitude above typical implementations in interpreted languages (e.g. …”
Get full text

Tuzūkāt-i Tīmūrī as a Source on Chagatai Military Tactics, Late Fourteenth to Early Fifteenth Centuries by Leonid A. Bobrov, Aibolat K. Kushkumbayev, Zhaksylyk М. Sabitov, Myltykbayuly

“…The study discovers The Code is a composite work compiled from a text allegedly found in Arabia by Abu TalibTurbati in the early seventeenth century, subsequent comments of a translator and a copyist, some fragments of Timurid writings dated from the early fifteenth century, and corrections introduced by the Mughal historian Muhammad Ashraf Bukhari. …”
Get full text

Bicarbonate Within: A Hidden Modulator of Antibiotic Susceptibility by Selvi C. Ersoy, Warren E. Rose, Richard A. Proctor

“…This “NaHCO₃-responsive” phenotype is widespread among US MRSA USA300/CC8 bloodstream and skin and soft tissue infection isolates. Translationally, β-lactam therapy has proven effective against NaHCO₃-responsive MRSA in both ex vivo simulated endocarditis vegetation (SEV) and in vivo rabbit infective endocarditis (IE) models. …”
Get full text

Chat GPT 4o vs residents: French language evaluation in ophthalmology by Leah Attal, Elad Shvartz, Nakhoul Nakhoul, Daniel Bahir

“…Therefore, this study's aim is to evaluate ChatGPT 4o's accuracy to MCQs from the national ophthalmology residency examination in French language, compared to residents and other leading AI chatbots Methods: A set of 600 questions from the national ophthalmology examination was translated into French and submitted to ChatGPT 4o, ChatGPT 4, and Gemini Advanced. …”
Get full text

Carnitine palmitoyltransferase 1C promotes EMT-associated cisplatin resistance in non-small cell lung cancer cells by Renjie Chen, Jiahui Wang, Shuoyu Huang, Xuefeng Hu, Xinran He, Tiange Zhang, Yunhan Hu, Huijun Wei, Sihui Nian, Yushu Huang, Zhihao Wu

“…Moreover, CPT1C was shown to be regulated at the post-translational level and an E3-ubiquitin ligase, NEDD4L, was shown to be a major regulator of CPT1C stability and activity. …”
Get full text

A rare case of double pituitary prolactinomas: the diagnostic application of intraoperative ultrasonography and DNA methylation markers by Jared C. Reese, Thomas M. Zervos, Jack Rock, Abeer Tabbarah, Houtan Noushmehr, Grayson Herrgott, Ana Valeria Castro

“…This case illustrates the translational use of methylation-based liquid biopsy methodologies in detecting and monitoring PTs through the detection of tumor-specific markers in blood specimens. …”
Get full text

Unraveling the pathogenesis of Barrett’s esophagus and esophageal adenocarcinoma: the “omics” era by Alberto Barchi, Giuseppe Dell’Anna, Giuseppe Dell’Anna, Luca Massimino, Luca Massimino, Francesco Vito Mandarino, Edoardo Vespa, Edi Viale, Sandro Passaretti, Vito Annese, Vito Annese, Alberto Malesci, Alberto Malesci, Silvio Danese, Silvio Danese, Federica Ungaro

“…The implementation of transcriptomic and proteomic analysis, even at the single-cell level, has widened the horizons, complementing the genomic alterations with their transcriptional and translational bond. Increasing interest has been gathered around small circulating genetic traces (circulating-free DNA and micro-RNAs) with a potential role as blood biomarkers. …”
Get full text

TEC-mediated tRF-31R9J regulates histone lactylation and acetylation by HDAC1 to suppress hepatocyte ferroptosis and improve non-alcoholic steatohepatitis by Juanjuan Zhu, Xian Wu, Mao Mu, Quan Zhang, Xueke Zhao

“…Recent discoveries have revealed that histone lactylation and acetylation play a crucial role in connecting cellular metabolism and epigenetic regulation through post-translational modification of histones. However, it is unclear whether TEC improves NASH by regulating histone lactylation, acetylation and hepatocyte ferroptosis through tRFs. …”
Get full text

Synergistic Antibacterial Action of Norfloxacin-Encapsulated G4 Hydrogels: The Role of Boronic Acid and Cyclodextrin by Monica-Cornelia Sardaru, Irina Rosca, Simona Morariu, Elena-Laura Ursu, Alexandru Rotaru

“…Nevertheless, further in vivo studies and long-term stability assessments are needed to fully establish clinical relevance, safety, and scalability before these systems can be translated into routine healthcare applications.…”
Get full text