Evaluating comparative effectiveness of psychosocial interventions for persons receiving opioid agonist therapy for opioid use disorder: protocol for a systematic review by Brian Hutton, Beverley Shea, Kimberly Corace, David Moher, Danielle B Rice, Becky Skidmore, Kednapa Thavorn, Sheena Taha, Dianna Wolfe, Fatemeh Yazdi, Beth A Sproule, Melanie Willows, Patricia Poulin, Gary Garber, Amy Porath, Leila Esmaeilisaraji

“…The search will be conducted in MEDLINE and translated for Embase, PsycINFO and the Cochrane Central Register of Controlled Trials. …”
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Approbation of the stochastic group virus protection model by R. Y. Sharykin

“…We propose a method of translating a system specification in the SHYMaude language, intended for the specification and analysis of DOBSHS models in the rewriting logic framework, into the corresponding Java implementation. …”
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Genetic and neurochemical profiles underlying cortical morphometric vulnerability to Parkinson’s disease by Su Yan, Jun Lu, Bingfang Duan, Hongquan Zhu, Tian Tian, Yuanyuan Qin, Yuanhao Li, Wenzhen Zhu

“…The related genes were enriched for the glucose metabolism, mitochondrial function, and post-translational histone modifications processes. In addition, the serotonin and norepinephrine transporter devoted more to gray matter properties alterations while the dopamine, gamma-aminobutyric acid receptors, and norepinephrine transporter were strong contributors of curvature abnormalities in PD. …”
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Diego Velázquez's Kings, Buffoons and Philosophers in the Context of His Religious Paintings: the View from Russia (Philosophical-Anthropological Analysis) by M. Silantieva

“…At that one should not think that the images are "translated" into "the text of words" - on the contrary, philosophical reconstruction implies not as "verbalization" of visual line as coherent to it logical mastering of the picture's sense (in this case) against the background of historical and historical-philosophical "scenery". …”
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MDTR: a knowledge-guided interpretable representation for quantifying liver toxicity at transcriptomic level by Inyoung Sung, Sangseon Lee, Dongmin Bang, Dongmin Bang, Jungseob Yi, Sunho Lee, Sun Kim, Sun Kim, Sun Kim, Sun Kim

“…In addition, the mechanisms of drug toxicity are known only as literature information, not in a computable form.MethodsTo address these challenges, we propose a Multi-Dimensional Transcriptomic Ruler (MDTR) that quantifies the degree of DILI at the transcriptome level. To translate transcriptome data to toxicity-related mechanisms, MDTR incorporates KEGG pathways as representatives of mechanisms, mapping transcriptome data to biological pathways and subsequently aggregating them for each of the five hepatotoxicity mechanisms. …”
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The CHK1 inhibitor prexasertib in BRCA wild-type platinum-resistant recurrent high-grade serous ovarian carcinoma: a phase 2 trial by Elena Giudice, Tzu-Ting Huang, Jayakumar R. Nair, Grant Zurcher, Ann McCoy, Darryl Nousome, Marc R. Radke, Elizabeth M. Swisher, Stanley Lipkowitz, Kristen Ibanez, Duncan Donohue, Tyler Malys, Min-Jung Lee, Bernadette Redd, Elliot Levy, Shraddha Rastogi, Nahoko Sato, Jane B. Trepel, Jung-Min Lee

“…Toxicity was manageable. Translational research was an exploratory endpoint. Potential biomarkers were investigated using pre-treatment fresh biopsies and serial blood samples. …”
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Transcriptomic and proteomic profiling identifies feline fibrosarcoma as clinically amenable model for aggressive sarcoma subtypes by Mikiyo Weber, Daniel Fuchs, Amiskwia Pöschel, Erin Beebe, Zuzana Garajova, Armin Jarosch, Laura Kunz, Witold Wolski, Lennart Opitz, Franco Guscetti, Mirja C. Nolff, Enni Markkanen

“…However, a lack of molecular characterization of FSA and adjacent normal tissue (NT) in both species hinders identification of tumor-specific targets and undermines the translational potential of feline FSA. Combining laser-capture microdissection, RNAsequencing and liquid chromatography-tandem mass spectrometry, we perform comprehensive profiling of 30 feline FSA and matched skeletal muscle, adipose and connective tissue. …”
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Health workers knowledge, attitudes and practices towards youth-friendly sexual and reproductive health service delivery in Calabar Metropolis, South-South, Nigeria by Felicity Nneoma Ike, Elvis Anyaehiechukwu Okolie, Phillip Etabee Bassey

“…Conclusion: Moderate to high levels of knowledge and positive attitudes among health workers did not translate into desired practices in YFSRH service delivery. …”
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Multi-criteria group decision-making with extended ELECTRE III method and regret theory based on probabilistic interval-valued intuitionistic hesitant fuzzy information by Chuanyang Ruan, Shicheng Gong, Xiangjing Chen

“…To develop a suitable MCGDM model for dynamic environments, this paper develops a new MCGDM model based on probabilistic interval-valued intuitionistic hesitant fuzzy sets (PIVIHFSs), regret theory, and the extended ELimination Et Choice Translating Reality (ELECTRE) III method. Firstly, this paper proposes two new aggregation operators, including the generalized probabilistic interval-valued intuitionistic hesitant fuzzy weighted averaging (GPIVIHFWA) operator and the generalized probabilistic interval-valued intuitionistic hesitant fuzzy weighted geometric (GPIVIHFWG) operator. …”
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Structural insights into dynamics of the BMV TLS aminoacylation by Wen Yang, Ran Yi, Jing Yao, Yongxiang Gao, Shanshan Li, Qingguo Gong, Kaiming Zhang

“…Furthermore, Electrophoretic Mobility Shift Assay (EMSA) demonstrated that BMV TLS binds elongation factors EF1α and EF2, suggesting a multifaceted strategy to exploit host translational machinery. These findings not only enhance our knowledge of virus-host interactions but also offer potential targets for antiviral drug development.…”
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Contemporary decongestant practices of Canadian otolaryngologists for endoscopic sinus surgery by Jonathan W. Reid, Brian W. Rotenberg, Leigh J Sowerby

“…Methods A cross-sectional survey design using a 24-item electronic questionnaire was distributed to actively practicing members of the Canadian Society of Otolaryngology-Head and Neck Surgery via email. A French translated version of the survey was also available. …”
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Engineered ipilimumab variants that bind human and mouse CTLA-4 by Brett Robison, SJ Diong, Anusha Kumar, Thomas M. Moon, Olin Chang, Bryant Chau, Christine Bee, Ishita Barman, Arvind Rajpal, Alan J. Korman, Sean West, Pavel Strop, Peter S. Lee

“…These cross-reactive ipilimumab variants may facilitate improved translatability and future mechanism-of-action studies for anti-CTLA-4 targeting in murine models.…”
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Keratoconus Diagnosis: Validation of a Novel Parameter Set Derived from IOP-Matched Scenario by Dan Lin, Lei Tian, Shu Zhang, Like Wang, Ying Jie, Yongjin Zhou

“…Our study shows that NPS indeed offers comparable performance in keratoconus diagnosis. Translational Relevance. Determining a parameter set after eliminating the influence from IOP is useful in revealing the essential differences between keratoconus and normal corneas and possibly facilitating further progress in keratoconus diagnosis.…”
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A meta-analysis of sex differences in neonatal rodent ultrasonic vocalizations and the implication for the preclinical maternal immune activation model by Alison M. Randell, Stephanie Salia, Lucas F. Fowler, Toe Aung, David A. Puts, Ashlyn Swift-Gallant

“…We discuss how analyzing USV call types and incorporating sex as a biological variable can enhance our understanding of neonatal ultrasonic communication and its translational value in NDD research.…”
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Employing visual thinking skills in the techniques of advertising art by Bydaa Sabih Al-Gharawi

“…It also works on enhancing current education methods to reach excellence in the process of teaching advertisement art techniques, where the research aims to take on skills of visual thinking and adopt them in preparing teaching units that represent weekly lectures for the students of the Department of Printing Design Techniques / First Grade, and develop their abilities in translating visual language carried in advertisements to a written phonic language that requires training on visual thinking skills. …”
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Synergistic impact of temperature and pore saturation on corrosion in carbonated reinforced concrete by Li Soon Wan, Mayuko Hirata, Toshinori Oyamoto, Tetsushi Kanda, Kang Hai Tan

“…For concrete with a water-to-cement ratio of 0.65, severe corrosion occurred at substantially lower pore saturation levels at higher temperatures, with even lower thresholds for more porous concrete. To translate these findings into practical tools, multiple linear regression analysis yielded predictive equations relating temperature and pore saturation effects to corrosion rates. …”
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Expanding the structural resolution of glycosylation microheterogeneity in therapeutic proteins by salt-free hydrophilic interaction liquid chromatography tandem mass spectrometry by Yutian Gan, Steffen Lippold, John Stobaugh, Christian Schöneich, Feng Yang

“…Glycosylation is a highly complex post-translational modification (PTM) due to its structural heterogeneity, i.e. glycosylation site occupancy, glycan compositions, modifications, and isomers. …”
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Kaempferol enhances ER-mitochondria coupling and protects motor neurons from mitochondrial dysfunction and ER stress in C9ORF72-ALS by Federica Pilotto, Paulien Hermine Smeele, Olivier Scheidegger, Rim Diab, Martina Schobesberger, Julieth Andrea Sierra-Delgado, Smita Saxena

“…Importantly, in vivo, chronic kaempferol administration ameliorated pathological motor dysfunction and inhibited motor neuron degeneration, highlighting the translational potential of kaempferol. Lastly, in silico modelling identified a novel kaempferol target and mechanistically the neuroprotective mechanism of kaempferol is through the iP3R-VDAC1 pathway via the modulation of GRP75 expression. …”
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Bidimensional Increment Entropy for Texture Analysis: Theoretical Validation and Application to Colon Cancer Images by Muqaddas Abid, Muhammad Suzuri Hitam, Rozniza Ali, Hamed Azami, Anne Humeau-Heurtier

“…In our proposed method, increments are translated into two-letter words, encoding both the size (magnitude) and direction (sign) of the increments calculated from an image. …”
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Lymphocytic Esophagitis: Navigating an Uncharted Territory by Ahmad Jradi MD, Kaline Maya Khoury MD, Karam Karam MD, Dr. Ihab I. El Hajj MD, Elias Fiani MD

“…This case plays an instrumental role in changing the way physicians translate unexplained chest pain, adding LE to their list of differential diagnosis as prompt detection slows us to start management with PPIs quicker and lessen the burden of symptoms on the patient. …”
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