MCT1 lactate transporter blockade re-invigorates anti-tumor immunity through metabolic rewiring of dendritic cells in melanoma by Camille Niveau, Mélanie Cettour-Cave, Stéphane Mouret, Eleonora Sosa Cuevas, Mylene Pezet, Benoît Roubinet, Hugo Gil, Florence De Fraipont, Ludovic Landemarre, Julie Charles, Philippe Saas, Caroline Aspord

“…Here we explore metabolic features of human DC subsets (cDC2s, cDC1s, pDCs) in melanoma, at single cell level, using the flow cytometry-based SCENITH (Single-Cell ENergetIc metabolism by profiling Translation inHibition) method. We demonstrate that circulating and tumor-infiltrating DC subsets from melanoma patients are characterized by altered metabolism, which is linked to their activation status and profile of immune checkpoint expression. …”
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Dutch Validation of the Self-Evaluation of Negative Symptoms Scale (SNS) by Tim van Brouwershaven, Anika Poppe, Gerdina Hendrika Maria Pijnenborg, André Aleman, Nynke Boonstra, Shiral Gangadin, Sonia Dollfus, Wim Veling, Stynke Castelein, Jan Alexander de Vos, Edith Liemburg, PHAMOUS-researchers, Lisette van der Meer

“…Here, we aim to evaluate the psychometric properties of the Dutch translation of the SNS and the relationship between the SNS and functional outcomes. …”
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Preclinical optimization of a GPC2-targeting CAR T-cell therapy for neuroblastoma by Nan Li, Haiying Qin, Rosa Nguyen, Mitchell Ho, Ming Sun, Eytan Ruppin, Michael C Kelly, Yingying Cao, Reona Okada, Jeyshka M Reyes-González, Hannah G Stack, Charlie Seibert, Carol J Thiele

“…We developed a new chimeric antigen receptor (CAR) targeting glypican-2 (GPC2) and conducted iterative preclinical engineering of the CAR structure to maximize its anti-tumor efficacy before clinical translation.Methods We evaluated different GPC2-CAR constructs by measuring the CAR activity in vitro. …”
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β-Caryophyllene and Statins in Bone Fracture Healing – A Narrative Review by Marom H, Khan MA, Darvish N, Tornetta III P, Khoury A, Weil YA, Skelley NW, Allison DC, Meiron S, Ehrmann Barr T

“…While individual effects are supported preclinically, further studies investigating synergies, formulations, and clinical translation are needed to develop this promising novel therapeutic approach for improving fracture repair outcomes.Keywords: bone regeneration, fracture repair, osteoblast, osteogenesis, piezoelectric effect…”
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Considering best practice standards for routine whole-genome sequencing for TB care and control by J.T. Denholm, G. de Vries, R. Anthony, E. Robinson, M. Backx, I.F. Laurenson, A.L. Seagar, H. Modestil, L. Trieu, J.S. Meissner, D.H.L. Ng, J.Y. Tay, H.H. Lin, R. Lee, V. Sintchenko, B.J. Marais, E.J. Donnan

“…Optimal structures and approaches are needed to support the rapid translation of genomic information into practice and to evaluate outcomes and impact. …”
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Ferroptosis: A novel cell death modality as a synergistic therapeutic strategy with photodynamic therapy by Yuqing Wang, Yiting Xu, Yong Qu, Yifang Jin, Juanmei Cao, Jinshan Zhan, Zhuoxia Li, Chuxing Chai, Changzheng Huang, Min Li

“…Furthermore, given the current research dilemma, we propose potential therapeutic strategies to advance the combined usage of PDT and ferroptosis inducers, providing the basis and guidelines for prospective clinical translation and research directionality with regard to PDT.…”
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Biphasic Modulation of NOS Expression, Protein and Nitrite Products by Hydroxocobalamin Underlies Its Protective Effect in Endotoxemic Shock: Downstream Regulation of COX-2, IL-1β,... by André L. F. Sampaio, Jesmond Dalli, Vincenzo Brancaleone, Fulvio D'Acquisto, Mauro Perretti, Carmen Wheatley

“…During the immune response, pro-inflammatory phase, parenteral hydroxocobalamin (HOCbl) treatment partially inhibits hepatic, but not lung, iNOS mRNA and promotes lung eNOS mRNA, but attenuates the LPS hepatic rise in eNOS mRNA, whilst paradoxically promoting high iNOS/eNOS protein translation, but relatively moderate •NO production. …”
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Antipsychotic prescribing practices and patient, family member and healthcare professional perceptions of antipsychotic prescribing in acute care settings: a scoping review protoco... by Zahinoor Ismail, Daniel Niven, Kirsten Fiest, Lisa Burry, Karla D Krewulak, Natalia Jaworska, Stephana Julia Moss, Zara Stelfox

“…The results of this scoping review will inform integrated knowledge translation initiatives aimed at in-hospital antipsychotic medication deprescribing.…”
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From the history of Lithuanian picture books (1900-1930) by Ingrida Korsakaitė

“…Binkis assisted with the translation. Mažylis karaliukas (The Little Prince) (Kaunas, 1923) by F. …”
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Preliminary analysis of the role of small hepatitis B surface proteins mutations in the pathogenesis of occult hepatitis B infection via the endoplasmic reticulum stress-induced UP... by Huang Chengrong, Zhang Hao, Wang Jing, Li Jianfei, Liu Qian, Zong Qiyin, Zhang Yunyun, Wang Qin, Zhou Qiang

“…These results suggest that proteins harboring OBI-related mutations may tend to accumulate in the ER, thereby triggering an ERS response and impairing the transcription and translation of HBsAg via the activation of the unfolded protein response and ER-associated protein degradation pathway. …”
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Molecular switch of the dendrite-to-spine transport of TDP-43/FMRP-bound neuronal mRNAs and its impairment in ASD by Pritha Majumder, Biswanath Chatterjee, Khadiza Akter, Asmar Ahsan, Su Jie Tan, Chi-Chen Huang, Jen-Fei Chu, Che-Kun James Shen

“…Abstract Background Regulation of messenger RNA (mRNA) transport and translation in neurons is essential for dendritic plasticity and learning/memory development. …”
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Mass‐Guided Single‐Cell MALDI Imaging of Low‐Mass Metabolites Reveals Cellular Activation Markers by James L. Cairns, Johanna Huber, Andrea Lewen, Jessica Jung, Stefan J. Maurer, Tobias Bausbacher, Stefan Schmidt, Pavel A. Levkin, Daniel Sevin, Kerstin Göpfrich, Philipp Koch, Oliver Kann, Carsten Hopf

“…The utility of PRISM‐MS is demonstrated through the characterization of complex metabolome changes in lipopolysaccharide (LPS)‐stimulated microglial cells and human‐induced pluripotent stem cell‐derived microglia. Translation of single cell results to endogenous microglia in organotypic hippocampal slice cultures indicates that LPS‐activation involves changes of the itaconate‐to‐taurine ratio and alterations in neuron‐to‐glia glutamine‐glutamate shuttling. …”
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Evidence-informed language: interpretation and impact on intentions to treat – results of an online survey of medical students and specialists in German-speaking countries by Sven Benson, Reinhard Griebenow, Justine Schmidt, Henrik Herrmann

“…Objectives Currently, there is no generally accepted consensus on how to translate strength of evidence into language. Against this background, we here investigated how widely used verbal descriptors of evidence grades and clinical practice recommendations, respectively, are understood, interpreted and transferred into intentions to treat. …”
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Reproducibility and Consistency of Isolation Protocols for Fibroblasts, Smooth Muscle Cells, and Epithelial Cells from the Human Vagina by Jayson Sueters, Rogier Schipperheijn, Judith Huirne, Theo Smit, Zeliha Guler

“…These findings aid the clinical translation of cell-based tissue engineering for the reconstruction and support of vaginas, fulfilling unmet medic needs.…”
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The responsiveness of surgical research to Māori in Aotearoa, New Zealand—a scoping reviewResearch in context by Jamie-Lee Rahiri, Noah Appleby, Makayla Kahi, Annaliese Wheeler, Jason Tuhoe, Shanthi Ameratunga, Rachelle Love, Wiremu MacFater, Matire Harwood

“…Funding: This study was supported by a Health Research Council of New Zealand Health Delivery Research Activation Grant (21/860) and Māori Health Knowledge Translation Grant (25/234). The funders had no role in the study design, conception, data collection, analysis, interpretation, or report writing. …”
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Bilateral alterations in sensorimotor function and altered sensory strategy in individuals with unilateral chronic ankle instability by Xiaomei Hu, Xihe Hou, Lin Wang

“…The delayed latency of MCT with medium-backward translation was also observed in both sides of unilateral CAI (uninjured: ES = 0.74; injured: ES = 0.92). …”
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Psychometric evaluation of the study interest questionnaire-short form among Chinese nursing students based on classical test theory and item response theory by Yue Yi Li, Lai Kun Tong, Mio Leng Au, Wai I. Ng, Si Chen Wang, Yongbing Liu, Liqiang Zhong, Yi Shen, Xichenhui Qiu

“…Considering the good reliability, validity, and widespread applicability of the Study Interest Questionnaire-Short Form (SIQ-SF), the objective of this study was to validate its usage among Chinese nursing students. Methods The translation and cross-cultural adaptation rigorously followed the modified Brislin model. …”
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The Legionella pneumophila effector PieF modulates mRNA stability through association with eukaryotic CCR4−NOT by Harley O'Connor Mount, Malene L. Urbanus, Francesco Zangari, Anne-Claude Gingras, Alexander W. Ensminger

“…With a host range that spans billions of years of evolution (from protists to humans), the interaction between L. pneumophila and its hosts frequently involves conserved eukaryotic pathways (protein translation, ubiquitination, membrane trafficking, autophagy, and the cytoskeleton). …”
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The interaction network and potential clinical effectiveness of dimensional psychopathology phenotyping based on EMR: a Bayesian network approach by Jianqing Qiu, Ting Zhu, Ke Qin, Wei Zhang

“…Therefore, we employed unsupervised learning to translate five domains of eRDoC scores derived from electronic medical records (EMR) of patients diagnosed with Major Depressive Disorder (MDD), Schizophrenia (SCZ), and Bipolar Disorder (BD) at West China Hospital between 2008 and 2021. …”
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Results of Cultural Adaptation of Cognitive Stimulation Therapy (CST) for Elderly and Old Age People with Cognitive Impairment in Russia by A.A. Shvedovskaya, I.F. Roshchina, M.V. Kalantarova, A.I. Khromov

“…The study used the official Russian translation of the manual for specialists conducting group classes “Making a Difference.…”
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