Multi-Omics and Network-Based Drug Repurposing for Septic Cardiomyopathy by Pei-Pei Liu, Xin-Yue Yu, Qing-Qing Pan, Jia-Jun Ren, Yu-Xuan Han, Kai Zhang, Yan Wang, Yin Huang, Tao Ban

“…Conclusions: This study provides a robust platform for drug repurposing in SCM, identifying acetaminophen and pyridoxal phosphate as promising candidates for clinical translation, with the potential to improve treatment outcomes in septic patients with cardiac complications.…”
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Combination of rapamycin and adipose-derived mesenchymal stromal cells enhances therapeutic potential for osteoarthritis by Damien Veret, Gautier Tejedor, Esther Perez, Alison Chomette, Maylis Farno, Rosanna Ferreira-Lopez, Louis Dagneaux, Yves-Marie Pers, Christian Jorgsensen, Claire Gondeau, Jean-Marc Brondello

“…However, despite the promising regenerative properties documented in preclinical studies, for instance in osteoarthritis (OA), the therapeutic translation of these results in patients has not been fully conclusive. …”
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Glutamine missense suppressor transfer RNAs inhibit polyglutamine aggregation by Rasangi Tennakoon, Teija M.I. Bily, Farah Hasan, Sunidhi Syal, Aaron Voigt, Tugce B. Balci, Kyle S. Hoffman, Patrick O’Donoghue

“…HD-causative polyQ alleles lead to protein aggregation, which is a prerequisite for disease. Translation fidelity modifies protein aggregation, and several studies suggest that mutating one or two glutamine (Gln) residues in polyQ reduces aggregation. …”
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Refining prognostic assessment of diffuse large B-cell lymphoma: insights from multi-omics and single-cell analysis unveil SRM as a key target for regulating immunotherapy by Xiaojie Liang, Jia Guo, Baiwei Luo, Weixiang Lu, Qiumin Chen, Yeling Deng, Yunong Yang, Liang Wang

“…Finally, for eventual clinical translation, we integrated the model with other clinical features to develop a comprehensive database for DLBCL. …”
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Finite Element Analysis of Horizontal Bearing Capacity for the Composite Diaphragm Wall Anchor Foundation by Qian Yin, Leyong Wei, Xiaojuan Li, Weiming Gong, Xueying Yang, Guoliang Dai, Shunkai Peng

“…The results reveal that under external loads, the CDWAF experiences both rigid-body translation and rotational displacement, with the rotation center shifting dynamically to the upper right with the increase in load. …”
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Minimal clinical data sets for spine-related musculoskeletal disorders in primary care and outpatient settings: a scoping review protocol by Pierre Côté, Andrea C Tricco, Cesar A Hincapié, Léonie Hofstetter, Jérémie Mikhail, Isabelle Pagé

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An Efficient 3D Convolutional Neural Network for Dose Prediction in Cancer Radiotherapy from CT Images by Lam Thanh Hien, Pham Trung Hieu, Do Nang Toan

“…Before the training phase, preprocessing and augmentation techniques, such as standardization, translation, and flipping, are applied to the training set. …”
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Quality of Life among Persons with HIV/AIDS in Iran: Internal Reliability and Validity of an International Instrument and Associated Factors by Pedram Razavi, Kaveh Hajifathalian, Behtash Saeidi, Gholamreza Esmaeeli Djavid, Mehrnaz Rasoulinejad, Mahboube Hajiabdolbaghi, Koosha Paydary, Parastoo Kheirandish, Mahsa Foroughi, SeyedAhmad SeyedAlinaghi, Minoo Mohraz, Willi McFarland

“…The purpose of this cross-sectional study on 191 HIV/AIDS patient was to prepare the first Persian translation of complete WHOQOL-HIV instrument, evaluate its reliability and validity, and apply it to determine quality of life and its associated factors in Tehran, Iran. …”
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A Body‐Temperature‐Triggered In Situ Softening Peripheral Nerve Electrode for Chronic Robust Neuromodulation by Xueyang Ren, Wenjie Tang, Yuehui Yuan, Shisheng Chen, Fangzhou Lu, Jinyang Mao, Jidan Fan, Xufeng Wei, Ming Chu, Benhui Hu

“…The central core is altered from the tri‐arm crosslinker to the star‐branched monomer to kill two birds (close the translation temperature to 37 °C and decrease the modulus after implantation) with one stone. …”
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Molecular Mechanisms Underlying Neuroinflammation Intervention with Medicinal Plants: A Critical and Narrative Review of the Current Literature by Sandra Maria Barbalho, Beatriz Leme Boaro, Jéssica da Silva Camarinha Oliveira, Jiří Patočka, Caroline Barbalho Lamas, Masaru Tanaka, Lucas Fornari Laurindo

“…While the anti-inflammatory potential of these plants is significant, the variability in dosages and phytochemical compositions limits clinical translation. Here, we highlight that medicinal plants are effective modulators of neuroinflammation, underscoring their therapeutic potential. …”
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Advances in Pure Drug Self-Assembled Nanosystems: A Novel Strategy for Combined Cancer Therapy by Runyan Niu, Xuexue Liu, Xian Yang, Xiao Du, Siliang Wang, Xiaolong Ma, Shaoping Yin, Lihua Shao, Jinping Zhang

“…However, their clinical translation remains hindered by several significant challenges, including intricate preparation processes, limited drug loading capacity, and concerns regarding potential toxicity. …”
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Protecting the American dream for socially vulnerable families: An evaluation of state-level policies to improve housing security and protect mobile home communities by Morgan Clennin, Denise Hartsock, Olivia Goodman, Stacie Daugherty, Cheryl Kelly

“…Among mobile home park residents, fear of retaliation from property owners, park management, and oversight agencies remained a significant barrier to policy effectiveness despite the new protections offered by the state-level policies. Conclusions: Translation of policies into practice takes time and resources. …”
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Neo-BCV: A Novel Bacterial Liquid Complex Vaccine for Enhancing Dendritic Cell-Mediated Immune Responses Against Lung Cancer by Zilong Zhu, Zhuze Chu, Fei Fei, Chenxi Wu, Zhengyue Fei, Yuxia Sun, Yun Chen, Peihua Lu

“…Conclusions: These findings highlight Neo-BCV’s potential as a safe and effective therapeutic strategy, offering a novel avenue for clinical translation in lung cancer immunotherapy.…”
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Soil data from the Barbastro-Balaguer gypsum belt, NE SpainMendeley Data by Juan Herrero, María Tierra, Carmen Castañeda

“…The dataset [1] also presents a .xlsx file with an English translation of all figure captions of [16], including those of micrographs, and two more .xlsx files with analytical data. …”
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Development and Testing of a Patient Outcome Measure for Interprofessional Tuberculosis Care: A Delphi Study by Bau D. Ardyansyah, Reinie Cordier, Margo Brewer, Dave Parsons

“…Methods: The study involved four phases: 1) developing a conceptual framework and creating items, 2) evaluating the construct through Delphi studies to obtain international consensus, 3) back-to-back translation into Indonesian, and 4) re-evaluating the construct with Delphi study to obtain Indonesian consensus. …”
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Cross-species comparisons between pigs and mice reveal conserved sex-specific intraspinal inflammatory responses after spinal cord injury by Reena Kumari, Gabrielle V. Hammers, Robert H. Hammons, Andrew N. Stewart, Steven M. MacLean, Tracy Niedzielko, Lonnie E. Schneider, Candace L. Floyd, John C. Gensel

“…Abstract Objective Therapeutic translation is challenging in spinal cord injury (SCI) and large animal models with high clinical relevance may accelerate therapeutic development. …”
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Development and preclinical testing of a naloxone prodrug depot for extended protection against opioid overdose by Hala Aldawod, Arjun D. Patel, Rasha Emara, Dengpan Liang, Joshua S. Ho, Toufiq Ul Amin, Md Tariqul Haque Tuhin, Abdulmalek Balgoname, Avishan Kiani, Jumana M. Ajlouny, Melanie A. Felmlee, Miki S. Park, Bhaskara R. Jasti, William K. Chan, James A. Uchizono, Mamoun M. Alhamadsheh

“…Although monkey efficacy was not assessed, combined rat efficacy and monkey pharmacokinetics suggest strong potential for successful human translation.…”
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Neuroprotection against Amyloid-β-Induced DNA Double-Strand Breaks Is Mediated by Multiple Retinoic Acid-Dependent Pathways by Julien Colas, Natacha Chessel, Allaeddine Ouared, Emmanuelle Gruz-Gibelli, Pascale Marin, François R. Herrmann, Armand Savioz

“…Whereas Aβ1-42 needs transcription and translation for DSB production, RA protects against Aβ1-42-induced DSBs at the posttranslational level through both the RARα/β/γ and PPARβ/δ receptors as demonstrated by using specific antagonists. …”
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Development of an Evidence-Based First Aid Guideline for First Responders in Sub-Saharan Africa by Bert Avau

“…Ce manuel est disponible en libre accès à toute personne intéressée (https://www.rodekruis.be/en/what-do-we-do/first-aid-and-support/first-aid-for-first-responders/).   [Translation by: Aurélia Feyssaguet Voluntary translator for the Global First Aid Reference Centre]   Resumo Enquadramento: Muitos países da África Subsariana carecem de serviços médicos de emergência eficazes. …”
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Enhanced effects of slowly co-released TGF-β3 and BMP-2 from biomimetic calcium phosphate-coated silk fibroin scaffolds in the repair of osteochondral defects by Jiping Chen, Yanyi Wang, Tianyi Tang, Baochao Li, Banani Kundu, Subhas C. Kundu, Rui L. Reis, Xingnan Lin, Huang Li

“…These findings indicate that the biomimetic calcium-phosphate coated silk fibroin scaffolds with slowly co-released TGF-β3 and BMP-2 effectively promote the repair of OC defects, hence facilitating the future clinical translation of controlled drug delivery in tissue engineering. …”
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