Systematic preclinical evaluation of CD33-directed chimeric antigen receptor T cell immunotherapy for acute myeloid leukemia defines optimized construct design by Haiying Qin, Nirali N Shah, Terry J Fry, Lila Yang, John A Chukinas, Samiksha Tarun, Marie Pouzolles, Christopher D Chien, Lisa M Niswander, Anthony R Welch, Sarah K Tasian, Naomi A Taylor

“…A ‘best-in-class’ lintuzumab-CD28/CD3ζ CAR construct was thus selected for clinical translation.Conclusions CD33 is a critical antigen for potential immunotherapeutic targeting in patients with AML. …”
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Response mechanism of ethanol-tolerant Saccharomyces cerevisiae strain ES-42 to increased ethanol during continuous ethanol fermentation by Xue-Xue Ji, Quan Zhang, Bai-Xue Yang, Qing-Ran Song, Zhao-Yong Sun, Cai-Yun Xie, Yue-Qin Tang

“…Results During continuous fermentation, as ethanol concentration increased, the expression of genes associated with cytoplasmic ribosomes, translation, and fatty acid biosynthesis progressively declined, while the expression of genes related to heat shock proteins (HSPs) and ubiquitin-mediated protein degradation gradually increased. …”
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Hotspots in peril: Misalignment of conservation efforts and ecological values in a shallow coastal sea by Kasper J. Meijer, Oscar Franken, Sterre Witte, Sander J. Holthuijsen, Tjisse van der Heide, Laura L. Govers, Han Olff

“…We first spatially overlay and translate the different protection measures to international standards. …”
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Predictors of a Good Outcome after Endovascular Stroke Treatment with Stent Retrievers by Ozcan Ozdemir, Semih Giray, Zulfikar Arlier, Demet Funda Baş, Yusuf Inanc, Ertugrul Colak

“…Successful recanalization after endovascular stroke therapy (EVT) did not translate into a good clinical outcome in randomized trials. …”
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Comparative analysis of dominant gut microbiota in Inflammatory Bowel Disease patients and healthy individuals: A case-control study by Alireza Ahmadi, Ebrahim Kouhsari, Shabnam Razavi, Nima Mohamadzadeh, Sima Besharat, Mohammad Ali Vakili, Taghi Amiriani

“…Further research is needed to translate these insights into targeted therapeutic strategies and to explore their effectiveness in clinical settings.…”
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Improved primary stability and load transfer of a customized osseointegrated transfemoral prosthesis compared to a commercial one by Giulia Galteri, Valentina Betti, Domenico Alesi, Stefano Zaffagnini, Marco Palanca, Emanuele Gruppioni, Luca Cristofolini

“…To measure the pull-out force, a tensile force was applied to the prostheses. Results The translational inducible micromotions during the compression-flexion test of the OsteoCustom stem were more than 4 times smaller than the commercial one (p < 0.05). …”
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Establishment and characterization of a new mouse gastric carcinoma cell line, MCC by Yushen Wang, Xianju Li, Yi Wang, Jun Qin

“…Its exceptional tumorigenic capacity and strong concordance with clinical proteomic profiles underscore its significance in translational research, facilitating the discovery of novel therapeutic targets and elucidation of molecular pathways critical for developing effective treatment strategies.…”
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Effects of early maternal care on anxiety and threat learning in adolescent nonhuman primates by Elyse L. Morin, Erin R. Siebert, Brittany R. Howell, Melinda Higgins, Tanja Jovanovic, Andrew M. Kazama, Mar M. Sanchez

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Trifluridine/tipiracil regimen in combination with bevacizumab for metastatic colorectal cancer in the third line: an expert opinion by Carmine Pinto, Sara Lonardi, Evaristo Maiello, Erika Martinelli, Michele Prisciandaro, Lisa Salvatore, Lisa Salvatore, Andrea Sartore-Bianchi, Andrea Sartore-Bianchi, Mario Scartozzi, Giuseppe Aprile, Chiara Cremolini, Alberto Sobrero

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Role of Cannabis in the Management of Chronic Non-Cancer Pain: A Narrative Review by Lou’i Al-Husinat, Shrouq Obeidat, Saif Azzam, Yara Al-Gwairy, Fatima Obeidat, Sarah Al Sharie, Deema Haddad, Fadi Haddad, Martina Rekatsina, Matteo Luigi Giuseppe Leoni, Giustino Varrassi

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Effects of Mating and Social Exposure on Cell Proliferation in the Adult Male Prairie Vole (Microtus ochrogaster) by A. E. Castro, L. J. Young, F. J. Camacho, R. G. Paredes, N. F. Diaz, W. Portillo

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Lymphatic-derived oxysterols promote anti-tumor immunity and response to immunotherapy in melanoma by Mengzhu Sun, Laure Garnier, Romane Chevalier, Martin Roumain, Chen Wang, Julien Angelillo, Julien Montorfani, Robert Pick, Dale Brighouse, Nadine Fournier, David Tarussio, Stéphanie Tissot, Jean-Marc Lobaccaro, Tatiana V. Petrova, Camilla Jandus, Daniel E. Speiser, Manfred Kopf, Caroline Pot, Christoph Scheiermann, Krisztian Homicsko, Giulio G. Muccioli, Abhishek D. Garg, Stéphanie Hugues

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Investigation on extended care needs of patients with hypertensive intracerebral hemorrhage (高血压性脑出血患者延续性护理服务需求调查) by QIU Yajiao (邱亚娇), LIANG Hui (梁慧), WANG Fang (王芳)

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Application of deep learning models on single-cell RNA sequencing analysis uncovers novel markers of double negative T cells by Tian Xu, Qin Xu, Ran Lu, David N. Oakland, Song Li, Liwu Li, Christopher M. Reilly, Xin M. Luo

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The Class III PI3K/Beclin-1 Autophagic Pathway Participates in the mmLDL-Induced Upregulation of ETA Receptor in Mouse Mesenteric Arteries by Xi Xie, Chen Chen, Cang-Bao Xu, Jie Lin, Lei Cao, Gen Chen, Jie Li

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Reference Intervals (RIs) of the Bone Turnover Markers (BTMs) in Children and Adolescents: A Proposal for Effective Use by Vincenzo Brescia, Roberto Lovero, Antonietta Fontana, Roberta Zerlotin, Silvia Concetta Colucci, Maria Grano, Angela Pia Cazzolla, Francesca Di Serio, Vito Crincoli, Maria Felicia Faienza

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A New Device Improves Signs and Symptoms of TMD by Ruggero Cattaneo, Davide Pietropaoli, Barry C. Cooper, Dino Capparè, Eleonora Ortu, Annalisa Monaco

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Lasater clinical judgment rubric in nursing education: a Turkish validity and reliability study by Esra Sezer, Hilal Yıldız Çelik, Ükke Karabacak, Kathie Lasater

“…The language validity of the rubric was performed according to the 10-step translation and cultural adaptation guide of the International Society for Pharmacoeconomics and Outcomes Research; expert opinions were obtained for content validity. …”
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Deciphering the heterogeneity and plasticity of the tumor microenvironment in liver cancer provides insights for prognosis by Yihao Sun, Yihao Sun, Guojuan Shi, Jian Yang, Chun-Zhong Zhou, Chuhan Peng, Yu-Hong Luo, Ying Pan, Rui-Qi Wang

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Definition of clinical immunology around the globe by José C. Crispín, José C. Crispín, José C. Crispín, Tineke Cantaert, Tineke Cantaert, Alberto Pinzon-Charry, Alberto Pinzon-Charry, Alberto Pinzon-Charry, Domenico Mavilio, Domenico Mavilio, Domenico Mavilio, Ahmed Seri, Ahmed Seri, Pierre Miossec, Pierre Miossec

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