Early assessment of IL8 and PD1+ Treg predicts response and guides treatment monitoring in cemiplimab-treated cutaneous squamous cell carcinoma by Teresa Troiani, Fabiana Napolitano, Luigi Formisano, Roberto Bianco, Daniela Russo, Daniela Esposito, Giuseppe Ercolano, Angela Ianaro, Alberto Servetto, Daniela Claudia Maresca, Marcella Scala, Annarita Amato, Stefania Belli, Claudia Maria Ascione, Angela Vallefuoco, Giovanna Attanasio, Fabio Somma, Silvia Varricchio, Massimo Mascolo, Claudia Costa, Alessia Villani, Massimiliano Scalvenzi, Gianfranco Orlandino

“…However, reliable biomarkers for patient selection are still lacking.Experimental design In this translational study, clinical annotations, tissue and liquid biopsies were acquired to investigate the association between sustained objective responses and transcriptional profiles, immune cell dynamics in tumor tissue and peripheral blood samples, as well as circulating cytokine levels.Results First, we investigated the baseline characteristics of the immune landscape of cSCC biopsies. …”
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Computational pathology assessments of cardiac stromal remodeling: Clinical correlates and prognostic implications in heart transplantation by Eliot G. Peyster, MD, MSc, Cai Yuan, PhD, Sara Arabyarmohammadi, PhD, Priti Lal, MD, Michael D. Feldman, MD, PhD, Pingfu Fu, PhD, Kenneth B. Margulies, MD, MS, Anant Madabhushi, PhD, FAIMBE, FIEEE, FNAI

“…Computational pathology analysis of allograft stroma yields translationally relevant biomarkers, identifying accelerated remodeling before adverse outcomes occur. …”
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The SUPERCOLD-CGM Survey. II. [C i](1–0) Emission and the Physical Conditions of Cold Gas in Enormous Lyα Nebulae at z ∼ 2 by Jianan Li, Bjorn H. C. Emonts, Zheng Cai, Jianrui Li, Ran Wang, Montserrat Villar-Martín, Fabrizio Arrigoni Battaia, Mingyu Li, Yunjing Wu, Ilsang Yoon, Matthew D. Lehnert, Kyle Massingill, Craig Sarazin, Jason X Prochaska, Mark Lacy, Brian Mason

“…The 3 σ mass limits of molecular CGM for the remaining QSO fields are (0.2–1.4) × 10 ^10 M _☉ . This translates into a baryon fraction of <0.4%–3% in the molecular CGM relative to the total baryonic halo mass. …”
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Repeated social defeat in male mice induced unique RNA profiles in projection neurons from the amygdala to the hippocampus by Rebecca G. Biltz, Wenyuan Yin, Ethan J. Goodman, Lynde M. Wangler, Amara C. Davis, Braedan T. Oliver, Jonathan P. Godbout, John F. Sheridan

“…Next, pan-neuronal (Baf53 b-Cre) RiboTag mice were generated to capture ribosomal bound mRNA (i.e., active translation) activated by RSD in the hippocampus. RNAseq revealed that there were 1694 differentially expressed genes (DEGs) in hippocampal neurons after RSD. …”
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Development and validation of a predictive model for lymph node metastases in peripheral non-small cell lung cancer with a tumor diameter ≤ 2.0 cm and a consolidation-to-tumor rati... by Dongyu Li, Dongyu Li, Shaolei Li, Hongbing Zhang, Chunqiu Xia, Xiaoyong Nan, Hongyu Liu, Jun Chen, Jun Chen

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EVALUATING THE IMPACT OF MASS TOURISM ON THE HOSPITALITY INDUSTRY AND TOURISM DESTINATION DEVELOPMENT OF CROSS RIVER STATE, NIGERIA by Nnana Okoi OFEM, Chinasa UTTAH, Ndem Samuel ETIM, Queen Olubukola AYENI, Josephat Owan EMEKA, Agnes Awoli EWURU, Maxwell-Borjor Achuk EBA, Eja Iwara EJA, Jeremiah ABANBESHIE, Daniel Daniel JAMES, Ayuk Awunghe ACHU, Michael Takim OTU, Fidelis Ngaji AKWAJI, Etta Oyen ETTA

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Exploring the association between pro-inflammatory diets and chronic liver diseases: evidence from the UK Biobank by Lili Pan, Lili Pan, Zhengrong Xu, Yining Li, Guoen Cai, Haibing Gao, Shenglong Lin

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Specificity of psychological readiness for changes and psychological resilience in the employees of the State Criminal-Executive Service of Ukraine by O. V. Mitroshkina

“…Heather, M. Gold, C. Hull (translation and adaptation by N. A. Bazhanova and G. …”
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Advances in Cardiovascular Multimodality Imaging in Patients with Marfan Syndrome by Marco Alfonso Perrone, Sara Moscatelli, Giulia Guglielmi, Francesco Bianco, Deborah Cappelletti, Amedeo Pellizzon, Andrea Baggiano, Enrico Emilio Diviggiano, Maria Ricci, Pier Paolo Bassareo, Akshyaya Pradhan, Giulia Elena Mandoli, Andrea Cimini, Giuseppe Caminiti

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Risk Factors for Excessive Gestational Weight Gain in a Healthy, Nulliparous Cohort by Antonia Restall, Rennae S. Taylor, John M. D. Thompson, Deralie Flower, Gustaaf A. Dekker, Louise C. Kenny, Lucilla Poston, Lesley M. E. McCowan

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Estimasi Gender Berbasis Sidik Jari dengan Wavelet dan Support Vector Machine by Sri Suwarno, Aditya Wikan Mahastama

“…The difficulty in digital fingerprint examination is determining reliable features unaffected by translation or rotation. In addition, some preprocessing is required on the dataset to obtain high accuracy. …”
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Replacement of Dietary Fishmeal Protein with Degossypolized Cottonseed Protein on Growth Performance, Nonspecific Immune Response, Antioxidant Capacity, and Target of Rapamycin Pat... by Sheng Chen, Yuhang Tang, Zhou Zhang, Jichang Zheng, Yuliang He, Zhen Wang, Kangsen Mai, Qinghui Ai

“…As to the target of rapamycin (TOR) pathway, the transcription of hepatic target of rapamycin (tor) and ribosomal protein (s6) was significantly up-regulated, while the transcription of hepatic eukaryotic translation initiation factor 4E binding protein 1 (4e-bp1) gene was significantly downregulated in the DCP group compared with the control group (P<0.05). …”
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Is Lateral Ligament Complex Repair Necessary in All Unstable Elbow Injuries with Coronoid Fractures? A Comparative Study: A Case Series by Nishaanth Ragavan, Rex Chandrabose

“…The coronoid is prone to fracture as a result of axial stress and it serves as an anterior buttress that prevents the posterior ulna translation. In order to restore the bone and ligamentous components and allow for early mobilization, the protocol was formulated. …”
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Association Analysis of Polymorphisms with Aspirin-Exacerbated Respiratory Disease in a Korean Population by Jin Sol Lee, Joon Seol Bae, Byung-Lae Park, Hyun Sub Cheong, Jeong-Hyun Kim, Jason Yongha Kim, Suhg Namgoong, Ji-On Kim, Choon-Sik Park, Hyoung Doo Shin

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Classification of Nanomaterial Drug Delivery Systems for Inflammatory Bowel Disease by Wang H, Zhou F, Shen M, Ma R, Yu Q

“…This review contributes to a deeper understanding of how the physicochemical properties of NDDS influence pharmacological behavior in vivo and can expedite their clinical translation.Keywords: inflammatory bowel disease, nanomaterials, drug delivery, nano-delivery systems, nanomedicine applications…”
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An insight into brucellosis in wild boar and domestic pigs in Europe: A systematic review by Zita Martins Ruano, Teresa Letra Mateus, Madalena Vieira-Pinto

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Esophageal Impedance-pH Monitoring and Pharyngeal pH Monitoring in the Diagnosis of Extraesophageal Reflux in Children by Anna Plocek, Beata Gębora-Kowalska, Jakub Białek, Wojciech Fendler, Ewa Toporowska-Kowalska

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Ipsilateral concomitant fractures of the clavicle and coracoid process of the scapula: incidence, characteristics, and outcomes by Nan Zhang, Guoyang Bai, Xiaomin Kang, Yangjun Zhu, Dongxu Feng

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A remarkable and durable response to tislelizumab treatment of an anaplastic thyroid carcinoma without targetable genomic alterations: a case report by Jingjing Chai, Jiaqi Lv, Jian Xiong, Xiuwen Chen, Senyuan Luo, Zhiguo Luo, Zhiguo Luo, Ming Luo

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