Trace amine-associated receptors (TAARs)2-9 knockout mice exhibit reduced wakefulness and disrupted REM sleep by Sunmee Park, Jasmine Heu, Gavin Scheldrup, Ryan K. Tisdale, Yu Sun, Meghan Haire, Shun-Chieh Ma, Marius C. Hoener, Thomas S. Kilduff

Get full text

The Binding of BF-227-Like Benzoxazoles to Human α-Synuclein and Amyloid β Peptide Fibrils by Lee Josephson PhD, Nancy Stratman MS, YuTing Liu MS, Fang Qian MS, Steven H. Liang PhD, Neil Vasdev PhD, Shil Patel PhD

Get full text

Automatic summarization of cooking videos using transfer learning and transformer-based models by P. M. Alen Sadique, R. V. Aswiga

“…Effective summary is necessary in order to translate the abundance of culinary knowledge found in videos into text recipes that are easy to read and follow. …”
Get full text

Substrains of Inbred Mice Differ in Their Physical Activity as a Behavior by Dario Coletti, Emanuele Berardi, Paola Aulino, Eleonora Rossi, Viviana Moresi, Zhenlin Li, Sergio Adamo

Get full text

Discordance, accuracy and reproducibility study of pathologists’ diagnosis of melanoma and melanocytic tumors by Sarah Haggenmüller, Christoph Wies, Julia Abels, Jana T. Winterstein, Lukas Heinlein, Carina Nogueira Garcia, Jochen S. Utikal, Sebastian A. Wohlfeil, Friedegund Meier, Sarah Hobelsberger, Frank F. Gellrich, Mildred Sergon, Axel Hauschild, Lars E. French, Lucie Heinzerling, Justin G. Schlager, Kamran Ghoreschi, Max Schlaak, Franz J. Hilke, Gabriela Poch, Sören Korsing, Cosimo Sarfert, Carola Berking, Markus V. Heppt, Michael Erdmann, Sebastian Haferkamp, Konstantin Drexler, Dirk Schadendorf, Wiebke Sondermann, Matthias Goebeler, Bastian Schilling, Jakob Nikolas Kather, Stefan Fröhling, Mar Llamas-Velasco, Luis C. Requena, Gerardo Ferrara, Maite Fernandez-Figueras, Sylvie Fraitag, Cornelia S. L. Müller, Hans Starz, Heinz Kutzner, Raymond Barnhill, Richard Carr, Kenneth S. Resnik, Stephan Alexander Braun, Tim Holland-Letz, Titus J. Brinker

Get full text

Mesenchymal stromal cells-derived extracellular vesicles in cartilage regeneration: potential and limitations by María Piñeiro-Ramil, Iván Gómez-Seoane, Ana Isabel Rodríguez-Cendal, Isaac Fuentes-Boquete, Silvia Díaz-Prado

“…Further research is necessary to elucidate the mechanisms underlying sEVs-mediated cartilage regeneration and to facilitate their translation into effective OA therapies.…”
Get full text

Shrub encroachment alters the diversity of soil fungal communities in topsoil, but not in subsoil under alpine grassland of the Qinghai-Tibetan plateau by Wenming Ma, Tenzing Droma, Changting Wang, Xiangli Ma

“…A total of 48 samples were collected. The Fourier Translation Infrared spectroscopy (FTIR) was conducted to assess the soil organic carbon (SOC) chemical composition. …”
Get full text

Knowledge, attitude and practice of community pharmacy personnel in tuberculosis patient detection: a multicentre cross-sectional study in a high-burden tuberculosis setting by Rovina Ruslami, Rizky Abdulah, Rob E Aarnoutse, Ivan Surya Pradipta, Khairunnisa Khairunnisa, Muh Akbar Bahar, Mersa Nurain Kausar, Efi Fitriana

“…Several factors significantly associated with performing the TBPD practice (p<0.05), such as TB training experience (p<0.001), provision of a drug consultation service (p<0.001), male gender (p<0.05), a positive attitude towards TBPD (p<0.001), short working hours (p<0.001) and central city location of the pharmacy (p<0.05).Conclusions Most participants had good knowledge and attitude, which did not translate into actual TBPD practice. We identified that TB educational programmes are essential in improving the KAP. …”
Get full text

Psychometric evaluation of the exercise-related cognitive errors questionnaire among Chinese emerging adults by Mengyao Guo, Jin Kuang, Ting Wang, Fabian Herold, Alyx Taylor, Jonathan Leo Ng, Jonathan Leo Ng, M. Mahbub Hossain, M. Mahbub Hossain, Arthur F. Kramer, Arthur F. Kramer, Robert Schinke, Zhihui Cheng, Liye Zou

“…Thus, this study aims to validate the Chinese version of the Exercise-related Cognitive Errors Questionnaire (E-CEQ-C) among Chinese emerging adults, a self-report measure to evaluate cognitive errors of context-relevant information related to exercise.MethodsFollowing a forward-backward translation of the E-CEQ (N = 24 items), the E-CEQ-C and the Chinese version of the Cognitive Distortions Questionnaire (CD-Quest-C) for gathering evidence of criterion-related validity were administered among a sample of Chinese emerging adults (N = 376, 29.0% male) through an online survey. …”
Get full text

Clinical management of community-acquired meningitis in adults in the UK and Ireland in 2017: a retrospective cohort study on behalf of the National Infection Trainees Collaborativ... by Amy Robinson, Kamaljit Khalsa, Arjun Chandna, John Bowen, Viva Levee, Jan Coebergh, Tom Solomon, Clive Graham, David Turner, Robert Tilley, Tim Jones, Susan Hopkins, Matthew Stevens, Daniel White, Celestine Eshiwe, Anna Goodman, Ramandeep Singh, Robert S Heyderman, Nicholas Davies, Joseph Thompson, Ed Moran, Martin Williams, Rhea O’Regan, Simon Tiberi, Jonathan Lambourne, Naomi Bulteel, Susan Larkin, Ruth McEwen, Hassan Paraiso, Aarti Shah, Martin Wiselka, Sylviane Defres, Ernest Mutengesa, Maria Krutikov, Ruth Owen, David Griffith, David Harvey, Trupti Patel, Brendan Davies, Emma Mclean, Joanna Allen, Ali Khan, Alastair Miller, Ashutosh Deshpande, Christopher Green, Lewis Jones, Mark Melzer, Fiona McGill, Amanda Fife, Nimal Wickramasinghe, Stephanie Harris, Ewan Hunter, Jayne Ellis, Benedict Rogers, Imogen Fordham, Elen Vink, Victoria Ward, Anna Smith, Andrew Rosser, Alison Muir, Ken Woodhouse, John Shone, Iain Crossingham, Ryan Jayesinghe, Eavan Muldoon, Avneet Shahi, Terry John Evans, Jeremy Wong, Eloisa MacLachlan, Amy Chue, Karishma Gokani, Katherine Ajdukiewicz, Lucinda Barrett, Frances Edwards, Adam Usher, Mairi McLeod, Su su Htwe, Grace Duane, Nicholas Wong, Jennifer Poyner, Jenni Crane, Ollie Lloyd, Emma Chisholm, Ildiko Kustos, Sam Sutton, M. Estee Torok, Isobel Ramsay, Monica Ivan, Joshua York, Jennifer Ansett, Maithili Varadarajan, Priya Sekhon, James Cruise, Shivani Kanabar, Mirella Ling, Charlotte Milne, Jayanta Sarma, Aline Wilson, Lynn Urquhart, Sahar Eldirdiri, Leila White, Jody Aberdein, Phillip Simpson, Hnin Hay Mar, Keying Tan, Eint Shwe Zin thein, Mahmoud Aziz, Anthony Cadwgan, Natasha Weston, Salman Zeb, Angela Houston, Louise Wootton, Iona Willingham, Aimee Johnson, Ashley Horsley, Eamonn Trainor, Olivier Gaillemin, Nicholas J Norton, Katie Cheung, Megan Duxbury, Emilie Bellhouse, Helena Brezovjakova, Kanitkar Tanmay, Alexsander Dawidziuk, Razan Saman, Hugh Adler, Elshadai Ejere, Yiwen Soo, Wendy Beadles, Heather Sturgeon, Brodie Cameron, David Chadwick Ben Tomlinson, Claire McGoldrick, Katie McDowell, Mpho Molosiwa, Katherine FlackAdrian Kennedy, Phoebe Cross, Fay Perry, Vithusha Inpadhas, Sarathy Selvam, Vhairi Bateman, Henry Wu, Monika Pasztor, Ajanthiha Karunakaran, Basma Soliman, Andrew Blanshard, Harish Reddy, Helen Chesterfield, Ben Schroeder, Tee Keat Teoh, Sathyavani Subbarao, Caryn RosmarinLucy Bell, Emma McGuire, Robert Serafino, Ishaan Bhide, Karanjeet Sagoo, Indran Balakrishnan, Kajal Patel, Barzo Faris, Graeme Calver, Ricky Singh, Hazel Sanghvi, Mohamed Eltayeb, Rathur Haris

“…Work should be done to improve the impact of guidelines, understand why they are not followed and, once published, ensure they translate into changed practice.…”
Get full text

APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology by Kristine M. Tran, Nellie E. Kwang, Claire A. Butler, Angela Gomez-Arboledas, Shimako Kawauchi, Cassandra Mar, Donna Chao, Rocio A. Barahona, Celia Da Cunha, Kate I. Tsourmas, Zechuan Shi, Shuling Wang, Sherilyn Collins, Amber Walker, Kai-Xuan Shi, Joshua A. Alcantara, Jonathan Neumann, Duc M. Duong, Nicholas T. Seyfried, Andrea J. Tenner, Frank M. LaFerla, Lindsay A. Hohsfield, Vivek Swarup, Grant R. MacGregor, Kim N. Green

“…Bulk proteomics show upregulated mitochondrial protein abundance with ApoeCh in 5xFAD mice, but reductions in mitochondrial and translation associated proteins in PS19 mice. Conclusions These findings highlight the ability of the ApoeCh variant to modulate microglial responses based on the type of pathology, enhancing DAM reactivity in amyloid models and dampening neuroinflammation to promote protection in tau models. …”
Get full text

A bibliometric analysis of publications in 3D printing in surgery from the web of science database by Bitesh Kumar, Anjan Kumar Dhua, Mohit Garg, Vishesh Jain, Devendra Kumar Yadav, Prabudh Goel, Sachit Anand, Divya Jain

“…Leading countries and institutions are crucial in driving scientific discoveries and translating research into clinical practice.…”
Get full text

Validation of a data-driven motion-compensated PET brain image reconstruction algorithm in clinical patients using four radiotracers by Ole L. Munk, Anders B. Rodell, Patricia B. Danielsen, Josefine R. Madsen, Mie T. Sørensen, Niels Okkels, Jacob Horsager, Katrine B. Andersen, Per Borghammer, Joel Aanerud, Judson Jones, Inki Hong, Sven Zuehlsdorff

“…Results The Hoffman brain phantom study demonstrated the algorithm’s capability to detect and correct for even minimal movements, 1-mm translations and 1⁰ rotations, applied to the phantom. …”
Get full text

Willingness to donate eyes and associated factors among adults in Addis Ababa City, Ethiopia: a mixed-methods approach by Ejigu Gebeye Zeleke, Merkineh Markos Lorato, Wubalem Addis Tefera, Hirut Gebremeskel Mengistu

“…Qualitative data were analysed through thematic content analysis using code software, which included transcription, translation, coding and thematisation, ultimately enriching the quantitative findings.Results and conclusion The study found that 47.2% (95% CI 44.7, 50.0) participants were willing to donate their eyes. …”
Get full text

Genotyped cluster investigations versus standard contact tracing: comparative impact on latent tuberculosis infection cascade of care in a low-incidence region by Michael Asare-Baah, Marie Nancy Séraphin, LaTweika A.T. Salmon-Trejo, Lori Johnston, Lina Dominique, David Ashkin, Krishna Vaddiparti, Awewura Kwara, Anthony T. Maurelli, Michael Lauzardo

“…Although genotyped cluster investigations may be superior to contact investigations in generating additional epidemiological links, this may not necessarily translate into reducing infections. Here, we investigated the impact of genotyped cluster investigations compared to standard contact investigations on the LTBI care cascade in a low incidence setting. …”
Get full text

Emergency volunteering willingness and participation: a cross-sectional survey of residents in northern China by Hong Sun, Chaojie Liu, Wei Xu, Ye Li, Qunhong Wu, Lijun Gao, Zheng Kang, Yanhua Hao, Ning Ning, Mingli Jiao, Libo Liang, Yu Cui, Mengli Shi, Chao Liang, Xiaowen Zhao, Jie Fei, Qiuyu Wei, Ming Yi

“…Efforts should be made to translate willingness into effective contributions to the emergency response system. …”
Get full text

Understanding ICU Nursing Knowledge, Perceived Barriers, and Facilitators of Sepsis Recognition and Management: A Cross-Sectional Study by Katherine A. Kissel, MN, RN, Karla D. Krewulak, PhD, Thérèse G. Poulin, BSc, Ken Kuljit S. Parhar, MD, MSc, Daniel J. Niven, MD, PhD, Vanessa M. Doiron, MScHQ, RN, Kirsten M. Fiest, PhD

“…Nursing workforce changes, knowledge translation gaps, and environmental/organizational barriers may impact sepsis recognition and management within the ICU. …”
Get full text

Qualitative evaluation of the Rehabilitation Exercise and psycholoGical support After COVID-19 InfectioN (REGAIN) randomised controlled trial (RCT): ‘you are not alone’ by Gordon McGregor, Susanne Finnegan, Martin Underwood, Joyce Yeung, James Mason, Peter Heine, Nigel Edwards, Julie Bruce, Kate Seers, Harbinder Kaur Sandhu, Helen Atherton, Sharisse Alleyne, Katie Booth, Ranjit Lall, Vivien P Nichols, Stuart Ennis, Scott McGuire, Rachel Potter, Jessica Smith, Chen Ji, Shilpa Patel, Henry Nwankwo, Kate Evans, Susie Hennings, Alastair Canaway, Grace Lobley, David Mcwilliams, Christina Jones, Emma Padfield, David Montgomery, Beatriz Lara, Becky Haley, Francesca Denton, Bartholomew Sheehan, Mariam Ratna, Elaine Fairbrother, Zoe Noakes, Bogdan Zutic, Lee Austin, Tom Forsyth, Anne Bush, Alan Bush, Patrick Sawdon, Jonathon Prosser, Lee Tompkins, Jonathon Guck, Danielle Hale, Juwairia Said, Georgie Ray, Rowena Williams, Gail Evans, Thillini Hettiarachchi, Abeesh Panicker

“…The themes from group exercise were: (1) monitoring and modification of the online exercise; (2) catering for differing abilities; (3) feeling safe and confident to exercise; (4) progression of fitness; (5) optimal timing in the recovery trajectory; (6) group effect; (7) initial apprehension about exercise group; (8) gauging exercise capabilities; (9) translating exercises into life; and (10) on-demand supplementary videos. …”
Get full text

Refining prognostic assessment of diffuse large B-cell lymphoma: insights from multi-omics and single-cell analysis unveil SRM as a key target for regulating immunotherapy by Xiaojie Liang, Jia Guo, Baiwei Luo, Weixiang Lu, Qiumin Chen, Yeling Deng, Yunong Yang, Liang Wang

“…Finally, for eventual clinical translation, we integrated the model with other clinical features to develop a comprehensive database for DLBCL. …”
Get full text

Finite Element Analysis of Horizontal Bearing Capacity for the Composite Diaphragm Wall Anchor Foundation by Qian Yin, Leyong Wei, Xiaojuan Li, Weiming Gong, Xueying Yang, Guoliang Dai, Shunkai Peng

“…The results reveal that under external loads, the CDWAF experiences both rigid-body translation and rotational displacement, with the rotation center shifting dynamically to the upper right with the increase in load. …”
Get full text