Cost-effectiveness of the Floodlight MS app in Austria. Unlocking the mystery of costs and outcomes of a digital health application for patients with multiple sclerosis by Evelyn Walter, Matthäus Traunfellner, Franz Meyer, Christian Enzinger, Michael Guger, Christian Bsteh, Patrick Altmann, Harald Hegen, Christoph Goger, Veronika Mikl

“…These patients experienced fewer relapses and slower disability progression, translating to a quality-of-life improvement of 4.5 months in perfect health and an incremental-cost-effectiveness-ratio (ICER) of 7,071 €. …”
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A systematic review of the clinical use of a single-layer bovine collagen-elastin acellular dermal matrix by David M. Hill

“…Manuscripts were excluded if they were primarily animal models, in vitro studies, reviews, expert opinion articles, or lacked sufficient detail. Google Translate was utilized when necessary. Results: Five hundred and thirty-five manuscripts containing potential details of CEM usage were identified. …”
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Liver cancer risk and changes in lifestyle habits after successful hepatitis C virus therapy post-DAA HCV therapy: lifestyle changes and liver cancer risk by Núria Granel, Gemma Iserte, Concepció Bartres, Neus Llarch, Anna Pla, Víctor Sapena, Zoe Mariño, Sabela Lens, Ramón Vilana, Isabel Nuñez, Anna Darnell, Ernest Belmonte, Ángeles García-Criado, Alba Díaz, Marco Sanduzzi-Zamparelli, Carla Fuster, Sergio Muñoz-Martínez, Carmen Ayuso, Jordi Rimola, Alejandro Forner, Alexandre Soler, Ferran Torres, José Ríos, Jordi Bruix, Andrew M. Moon, Xavier Forns, María Reig

“…Conclusions In this prospective cohort, successful HCV therapy was followed by significant changes in lifestyle habits translating into increases in BMI and alcohol consumption. …”
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New Resinogalea species from Araucaria araucana resin in Chile and reclassification of the genus in the Cryptocaliciomycetidae by Felipe Balocchi, Irene Barnes, Michael J. Wingfield, Rodrigo Ahumada, Cobus M. Visagie

“…Further analyses applying the Genealogical Concordance Phylogenetic Species Recognition (GCPSR) based on ITS, mini chromosome maintenance protein complex (MCM7), RNA polymerase II second largest subunit (RPB2) and translation elongation factor 1-alpha (TEF) gene regions, confirmed that strains represent two new species. …”
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FORCE platform overcomes barriers of oligonucleotide delivery to muscle and corrects myotonic dystrophy features in preclinical models by Timothy Weeden, Tyler Picariello, Brendan Quinn, Sean Spring, Pei-Yi Shen, Qifeng Qiu, Benjamin F. Vieira, Lydia Schlaefke, Ryan J. Russo, Ya-An Chang, Jin Cui, Monica Yao, Aiyun Wen, Nelson Hsia, Tama Evron, Katy Ovington, Pei-Ni Tsai, Nicholas Yoder, Bo Lan, Reshmii Venkatesan, John Hall, Cody A. Desjardins, Mo Qatanani, Scott Hilderbrand, John Najim, Zhenzhi Tang, Matthew K. Tanner, Romesh Subramanian, Charles A. Thornton, Oxana Ibraghimov-Beskrovnaya, Stefano Zanotti

“…Cynomolgus monkeys were used to determine translatability of DYNE-101 pharmacology to higher species. …”
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Advances in tissue engineering of peripheral nerve and tissue innervation – a systematic review by Jayson Sueters, Rowan van Heiningen, Ralph de Vries, Zeliha Guler, Judith Huirne, Theo Smit

“…In response, tissue-engineered solutions have been developed, yet clinical translations is rare. In this study, a systematic review was performed on tissue-engineered advancements for peripheral nerves and tissues, to aid future developments in bridging the gap toward the clinic by identifying high-potential solutions and unexplored areas. …”
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From physical activity patterns to cognitive status: development and validation of novel digital biomarkers for cognitive assessment in older adults by Ling-Jie Fan, Feng-Yi Wang, Jun-Han Zhao, Jun-Jie Zhang, Yang-An Li, Jia Tang, Tao Lin, Quan Wei

“…Based on these findings, we developed a proof-of-concept application that demonstrates the feasibility of translating these PA analytics into practical monitoring tools in real-world settings.…”
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Integrative deep immune profiling of the elderly reveals systems-level signatures of aging, sex, smoking, and clinical traitsResearch in context by Lennart Riemann, Rodrigo Gutierrez, Ivan Odak, Joana Barros-Martins, Lennart M. Roesner, Ximena Leon Lara, Christine Falk, Thomas F. Schulz, Gesine Hansen, Thomas Werfel, Reinhold Förster, Berislav Bošnjak, Felix Jenniches, Norman Klopp, Till Robin Lesker, Martin Stangel

“…Our findings highlight clinically relevant immune signatures that enhance our understanding of aging-related diseases and could guide future research into new treatments, offering translational insights into human health and aging. Funding: Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy—EXC 2155—project number 390874280.…”
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Characterization and Probiotic Potential of <i>Levilactobacillus brevis</i> DPL5: A Novel Strain Isolated from Human Breast Milk with Antimicrobial Properties Against Biofilm-Formi... by Ivan Iliev, Galina Yahubyan, Elena Apostolova-Kuzova, Mariyana Gozmanova, Daniela Mollova, Iliya Iliev, Lena Ilieva, Mariana Marhova, Velizar Gochev, Vesselin Baev

“…The genome also contains multiple biosynthetic gene clusters such as lanthipeptide class IV, Type III polyketide synthase (T3PKS), and ribosomally synthesized, and post-translationally modified peptides (RiPP-like compounds), all of which are associated with antibacterial properties. …”
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Investigating assumptions in motivational interviewing among general practitioners: a qualitative study by Paul Aujoulat, Amélie Manac’h, Catherine Le Reste, Delphine Le Goff, Jean Yves Le Reste, Marie Barais

“…Focused efforts are needed to translate MI’s potential into routine clinical use.…”
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Formaldehyde and propionic acid do not reduce starch gelatinization within a laboratory setting and may not contribute to reduced pellet quality by K.M. Bowen, L.E. Knarr, E.B. Estanich, S.R. Estep, J.S. Moritz

“…The increase in starch gelatinization with increased heating time may translate to increasing pellet quality.…”
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A reproducible representation of healthy tibiofemoral kinematics during stair descent using REFRAME – part I: REFRAME foundations and validation by Ariana Ortigas-Vásquez, William R. Taylor, Barbara Postolka, Pascal Schütz, Allan Maas, Matthias Woiczinski, Thomas M. Grupp, Adrian Sauer

“…Here, building on previous work that introduced a frame orientation optimisation method and demonstrated its potential to induce convergence towards a consistent kinematic signal, we present the REference FRame Alignment MEthod (REFRAME) that addresses both rotational and translational kinematics, is validated here for a healthy tibiofemoral joint, and allows flexible selection of optimisation criteria to fittingly address specific research questions. …”
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Impact of English proficiency on use of Glasgow Coma Scale in geriatric patients with traumatic brain injury by Veronica Layrisse-Landaeta, Gabriela R Dincheva, Shahenda Khedr, Andrew Geng, Michele Schombs, Kazi Maisha, Steven Y Chao, Chun-Cheng Chen

“…Moreover, GCS remained effective for predicting ICH in LEP individuals, highlighting its value with suitable translation resources.Level of evidence This is a Level III evidence restrospective comparative study.…”
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Neuron-Specific Glycine Metabolism Links Transfer RNA Epitranscriptomic Regulation to Complex Behaviors by Jennifer Blaze, Viviana Dolores Evans, Jessica Abigail Feria Pliego, Petr Unichenko, Behnam Javidfar, Soeren Heissel, Hanan Alwaseem, Zachary Pennington, Denise Cai, Henrik Molina, Christian Henneberger, Schahram Akbarian

“…Methods: To link specific molecular alterations resulting from neuronal Nsun2 ablation to neuropsychiatric phenotypes, we used drug-induced phosphoactivation of stress response translation initiation factors together with disruption of NSUN2-regulated glycine tRNAs and cell type–specific ablation of the glycine cleavage system modeling the excessive upregulation of this amino acid in the Nsun2-deficient brain. …”
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A Hybrid Contextual Embedding and Hierarchical Attention for Improving the Performance of Word Sense Disambiguation by Robbel Habtamu Yigzaw, Beakal Gizachew Assefa, Elefelious Getachew Belay

“…It plays a crucial role in natural language applications such as machine translation, question-answering, chatbots, information retrieval, sentiment analysis, and overall language comprehension. …”
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Dutch Validation of the Self-Evaluation of Negative Symptoms Scale (SNS) by Tim van Brouwershaven, Anika Poppe, Gerdina Hendrika Maria Pijnenborg, André Aleman, Nynke Boonstra, Shiral Gangadin, Sonia Dollfus, Wim Veling, Stynke Castelein, Jan Alexander de Vos, Edith Liemburg, PHAMOUS-researchers, Lisette van der Meer

“…Here, we aim to evaluate the psychometric properties of the Dutch translation of the SNS and the relationship between the SNS and functional outcomes. …”
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Implementing Machine Learning for Supply-Demand Shifts and Price Impacts in Farmer Market for Tool and Equipment Sharing by Manik Rakhra, Amitabh Bhargava, Deepshikha Bhargava, Ramandeep Singh, Astha Bhanot, Abdul Wahab Rahmani

“…The third category is particularly prevalent in underdeveloped nations such as India, owing to a lack of competence, a lack of effective translation, and most crucially, a lack of financial resources. …”
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Preclinical optimization of a GPC2-targeting CAR T-cell therapy for neuroblastoma by Nan Li, Haiying Qin, Rosa Nguyen, Mitchell Ho, Ming Sun, Eytan Ruppin, Michael C Kelly, Yingying Cao, Reona Okada, Jeyshka M Reyes-González, Hannah G Stack, Charlie Seibert, Carol J Thiele

“…We developed a new chimeric antigen receptor (CAR) targeting glypican-2 (GPC2) and conducted iterative preclinical engineering of the CAR structure to maximize its anti-tumor efficacy before clinical translation.Methods We evaluated different GPC2-CAR constructs by measuring the CAR activity in vitro. …”
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Policy analysis of the Global Financing Facility in Uganda by Phillip Wanduru, Doris Kwesiga, Mary Kinney, Asha George, Peter Waiswa

“…Conclusion The learnings from this study provide insights into the translation of globally conceived health initiatives at country level, highlighting enablers and challenges. …”
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An Open‐Label Phase II Trial of Pembrolizumab, an Immune Checkpoint Inhibitor Alone or in Combination With Oral Azacitidine as Second‐Line Therapy for Advanced Head and Neck Squamo... by Vinod K. Ramani, Srimonta Gayen, Radheshyam Naik

“…Conclusion The findings of this trial will have translational implications, in terms of immune reprogramming induced by epigenetic therapy among a subset of advanced H & N cancer patients in a clinical setting.…”
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