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4601
Investigation on Nonlinear Flow Behavior through Rock Rough Fractures Based on Experiments and Proposed 3-Dimensional Numerical Simulation
Published 2020-01-01“…Reservoir sandstones as a case study, four splitting groups of fractures with different roughness were scanned to get the geometric features, and then the seepage experiments were taken to analyze the relationship of the pressure gradient ∇Pand flow rate Q, and the critical Reynolds number(Rec) and wall friction factor (f) were determined to explain the translation of linear seepage to nonlinear seepage condition. …”
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4602
Examining the integration of refugees into the national health system in Uganda: an analysis using the policy triangle framework
Published 2025-01-01“…The findings shed light on the importance of collaboration between stakeholders, mobilization of legal and political frameworks to shape the integration of refugee health services into the national health system, and the importance of ensuring that high-level commitments translate to action and development plans at local levels.…”
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4603
Backtranslation of human RNA biosignatures of tuberculosis disease risk into the preclinical pipeline is condition dependent
Published 2025-01-01“…Human-derived COR signatures offer an opportunity for high-throughput preclinical endpoint criteria of vaccine and drug therapy evaluations.IMPORTANCEUnderstanding the strengths or limitations of back-translating human-derived correlate of risk (COR) RNA signatures into the preclinical pipeline may help streamline down-selection of therapeutic vaccine and drug candidates and better align preclinical models with proposed clinical trial efficacy endpoints.…”
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4604
Targeted CQA analytical control strategy for commercial antibody products: Replacing ion-exchange chromatography methods for charge heterogeneity with multi-attribute monitoring
Published 2024-12-01“…Historically, peptide mapping monitors post-translational modifications (PTMs) of protein products and process intermediates during development. …”
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4605
Molecular Mechanisms of Neurodegeneration Related to C9orf72 Hexanucleotide Repeat Expansion
Published 2019-01-01“…However, many more cellular processes are affected by pathological processes in C9FTD/ALS, including nucleocytoplasmic transport, RNA processing, normal function of nucleolus, formation of membraneless organelles, translation, ubiquitin proteasome system, Notch signalling pathway, granule transport, and normal function of TAR DNA-binding protein 43 (TDP-43). …”
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4606
MODERN STATE LANGUAGE POLICY
Published 2015-11-01“…The perspective directions of the state language policy in the field of the Russian language and literature are specified and formulated: the analysis of the programs and projects aimed at the development, distribution and support of the Russian language; providing coordination of actions of executive authorities in the presented study; improvement of the Russian language studying quality in schools in accordance with features of the general education in the national republics; professional level improvement of teachers of the Russian language; preservation of national languages of Russia; scientific studying and codification of the modern language, promoting of scientific knowledge of Russian and languages of the people of the Russian Federation; support expansion of the private initiatives connected with preservation and development of Russian in neighboring countries; creation of base for studying of Russian by foreign experts and labor migrants; cooperation with foreign specialists in the Russian philology, translators of the Russian literature and teachers of Russian.…”
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4607
The process and logical mechanism of agricultural production space contraction in mountainous areas based on actor-network theory:A case study of Lishi Village in Longde County, Ni...
Published 2025-01-01“…[Results] The study found that: (1) The translation of actor networks at different stages, the entry and exit of heterogeneous actors within the networks, and the transformation of the actor networks goals comprehensively contributed to the contraction of agricultural production space through the combined effects of human and non-human actors. (2) During the transformation of the actor network in Lishi Village, the key actor changed from the local government to the young labor force, and the obligatory point of passage (OPP) changed from “returning farmland to forest and grassland” to “developing specialty farming to maximize economic income”. (3) The agricultural production space in Lishi Village has gone through two stages: explicit contraction under the ecological objective and implicit contraction under the economic objective. (4) The contraction of agricultural production space in mountainous areas follows the mechanisms of environmental logic, policy-driven logic, and multi-subject logic. …”
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4608
Validation of Spanish Version of the Spirituality and Spiritual Care Rating Scale (SSCRS‐Sp) in Nursing Professionals
Published 2024-12-01“…Methods The sample consisted of N = 325 nursing professionals from various healthcare settings, including hospitals, clinics and community healthcare centres. Following translation and cultural adaption of the SSCRS, the scale underwent psychometric assessment of its construct validity through exploratory and confirmatory factor analysis. …”
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4609
CONSORT-DEFINE explanation and elaboration: recommendations for enhancing reporting quality and impact of early phase dose-finding clinical trialsResearch in context
Published 2025-01-01“…Summary: Early phase dose-finding (EPDF) trials are key in the development of novel therapies, with their findings directly informing subsequent clinical development phases and providing valuable insights for reverse translation. Comprehensive and transparent reporting of these studies is critical for their accurate and critical interpretation, which may improve and expedite therapeutic development. …”
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4610
Measuring the condition of Tehran Metropolitan based on Ubiquitous city indicators
Published 2022-12-01“…<link href="moz-extension://e82f9c05-bf9c-4e25-87b0-684d37ab5915/skin/s3gt_tooltip_mini.css" rel="stylesheet" type="text/css" > #s3gt_translate_tooltip_mini { display: none !important; }…”
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4611
Languages of Written and Oral Communication between Russian Emperors and Electors of the Holy Roman Empire, 1725–1799
Published 2024-12-01“…Conversely, Russian monarchs adhered to tradition, drafting official correspondence in Russian with German translations attached.The article concludes that the choice of language serves as a formal indicator of the nature of relationships between rulers, highlighting the distinction between sovereign monarchs and electors, who, de jure, remained vassals. …”
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4612
The ArcB kinase sensor participates in the phagocyte-mediated stress response in Salmonella Typhimurium
Published 2025-02-01“…Our results show that ArcB influences the expression of genes associated with fatty acid degradation, protein secretion, cysteine and H2S biosynthesis, and translation, both in vitro and under conditions found within neutrophils. …”
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4613
Proposal for a predictive scale of cognitive impairment in adult patients with neurocysticercosis
Published 2022-07-01“…<span class="VIiyi" lang="en"><span class="JLqJ4b ChMk0b" data-language-for-alternatives="en" data-language-to-translate-into="es" data-phrase-index="0" data-number-of-phrases="1"><span class="Q4iAWc">Through data provided by previous research, the variables related to the appearance of cognitive impairment were selected in the bivariate analysis (p<0.05).…”
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4614
A nociceptor-specific RNAi screen in Drosophila larvae identifies RNA-binding proteins that regulate thermal nociception
Published 2025-01-01“…Some of the genes identified have well-understood roles in the regulation of translation initiation and regulation of nociceptor sensitization in vertebrate and invertebrate animal models, suggesting an evolutionarily conserved role for these mechanisms in regulating nociceptor sensitivity. …”
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4615
Caption Generation Based on Emotions Using CSPDenseNet and BiLSTM with Self-Attention
Published 2022-01-01“…They are BiLingual Evaluation Understudy (BLEU), Metric for Evaluation of Translation with Explicit Ordering (METEOR), Recall-Oriented Understudy for Gisting Evaluation (ROGUE), Consensus-based Image Description Evaluation (CIDEr), and Semantic Propositional Image Caption Evaluation (SPICE). …”
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4616
Partial replacement of soybean meal with cottonseed meal in diets of broiler chicken sustains performance by upregulating the expression of nutrient transporter genes in small inte...
Published 2025-03-01“…The study suggests that inclusion of HF-CSM by replacing 10-15 % of SBM on a weight-to-weight basis, which translates into 2.5–3 % inclusion of the former in the whole ration, may sustain the performance of broiler chickens…”
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4617
Exploring avocado consumption and health: a scoping review and evidence map
Published 2025-02-01“…The results have been made public and freely available, and a visual, interactive map was created to aid in science translation. This evidence map should enable future meta-analyses, enhance communication and transparency in avocado research, and serve as a resource for policy guidance.…”
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4618
Looking beyond the ER, PR, and HER2: what’s new in the ARsenal for combating breast cancer?
Published 2025-01-01“…From the settings of developing nations, this may provide useful insight by integrating recent advances in AR-targeted therapies and exploring their translational potential, emphasizing the critical need for further research to optimize AR-based therapeutic strategies for breast cancer management.…”
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4619
Effects of Enterocytozoon hepatopenaei infection on intestinal immune defense and physiological processes of Penaeus vannamei
Published 2025-01-01“…Moreover, the expression levels of key genes involved in nutrient absorption, transport and synthesis, such as glucose transporter 1, Na+-K+ATPase, fatty acid synthase, acetyl-CoA carboxylase, rapamycin kinase, mTOR regulation-related protein, eukaryotic translation initiation factor 4E binding protein, ribosomal protein S6 kinase, were significantly up-regulated. …”
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4620
Тransplastomic tobacco plants producing the hydrophilic domain of the sheep pox virus coat protein L1R
Published 2020-12-01“…Subsequent Northern and Western blot analysis showed the gene expression at the transcriptional and translational levels. The recombinant protein yields reached up to 0.9 % of total soluble protein. …”
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