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4381
Synergistic impact of temperature and pore saturation on corrosion in carbonated reinforced concrete
Published 2025-07-01“…For concrete with a water-to-cement ratio of 0.65, severe corrosion occurred at substantially lower pore saturation levels at higher temperatures, with even lower thresholds for more porous concrete. To translate these findings into practical tools, multiple linear regression analysis yielded predictive equations relating temperature and pore saturation effects to corrosion rates. …”
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4382
Expanding the structural resolution of glycosylation microheterogeneity in therapeutic proteins by salt-free hydrophilic interaction liquid chromatography tandem mass spectrometry
Published 2024-12-01“…Glycosylation is a highly complex post-translational modification (PTM) due to its structural heterogeneity, i.e. glycosylation site occupancy, glycan compositions, modifications, and isomers. …”
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4383
DNA-loaded targeted nanoparticles as a safe platform to produce exogenous proteins in tumor B cells
Published 2025-01-01“…The targeting mechanism facilitated the interaction of NPs with target cells, thereby enhancing their internalization and subsequent exogenous plasmid DNA (pDNA) translation and protein expression. In the human/zebrafish lymphoma xenograft model, no evidence of toxicity was observed, and targeted NPs demonstrated the capacity to enhance exogenous pDNA expression.ConclusionOur findings provide a rationale for the use of targeted NPs as a DNA delivery system for the local expression of therapeutic proteins.…”
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4384
Turkish validity and reliability study of the psychological food involvement scale: PFIS-TR
Published 2025-01-01“…The PFIS underwent a six-stage translation and cultural adaptation process. Data collection was carried out via Google Forms, with participants completing a general information form, PFIS, and the Addiction-like Eating Behavior Scale (ALEBS). …”
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4385
Kaempferol enhances ER-mitochondria coupling and protects motor neurons from mitochondrial dysfunction and ER stress in C9ORF72-ALS
Published 2025-02-01“…Importantly, in vivo, chronic kaempferol administration ameliorated pathological motor dysfunction and inhibited motor neuron degeneration, highlighting the translational potential of kaempferol. Lastly, in silico modelling identified a novel kaempferol target and mechanistically the neuroprotective mechanism of kaempferol is through the iP3R-VDAC1 pathway via the modulation of GRP75 expression. …”
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4386
The role of the pAbp gene encoding the cytoplasmic poly(A)-binding protein in spermatogenesis of Drosophila melanogaster
Published 2017-11-01“…Cytoplasmic PABPs participate in the metabolic pathways of the mRNA: translation initiation and termination, cytoplasmic polyadenylation/deadenylation, mRNA stability, mRNA degradation. …”
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4387
Lymphocytic Esophagitis: Navigating an Uncharted Territory
Published 2025-01-01“…This case plays an instrumental role in changing the way physicians translate unexplained chest pain, adding LE to their list of differential diagnosis as prompt detection slows us to start management with PPIs quicker and lessen the burden of symptoms on the patient. …”
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4388
Proteomics and Its Current Application in Biomedical Area: Concise Review
Published 2024-01-01“…Keeping abreast of the latest developments in proteomics applications becomes paramount for the development of therapeutics, translational research, and study of diverse diseases. …”
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4389
Seasonal Changes in Climate Variables in Rainfed Crop Areas in the Lerma-Chapala-Santiago Basin, Mexico
Published 2021-01-01“…The remaining RCAs were smaller (14.6%) but presented greater variation: the amplitude of the Tmin decreased in addition to showing a phase shift, whereas Tmax increased in addition to showing a phase shift. These results translate into a delay in the characteristic temperatures of the spring and summer seasons, which can impact the rainfed crop cycle. …”
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4390
Early versus late surgical stabilisation of unstable thoracolumbar spine fractures in adult polytrauma patients: A systematic review and meta-analysis
Published 2025-03-01“…Further high-level prospective studies are recommended to investigate whether the short-term gains shown can translate to superior long-term functional outcomes.…”
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4391
Semiautomatic volumetry of the temporal lobes of the brain and correlation with electroencephalography results in dogs with assumed idiopathic epilepsy
Published 2025-01-01“…Objectives This study aimed to develop an automatic volumetry method, translate the outcomes into the assessment of temporal lobe volumes in dogs with idiopathic epilepsy, and correlate the results with the electroencephalography (EEG) data of epileptiform discharges (EDs). …”
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4392
Investigating Factors and Drivers of Livelihoods Change in Rural Households in Border Regions (Case Study: Minan district, Sarbaz township)
Published 2018-03-01“…<link href="moz-extension://8b922523-7922-435a-ac74-8ddb59e9beaf/skin/s3gt_tooltip_mini.css" rel="stylesheet" type="text/css" > #s3gt_translate_tooltip_mini { display: none !important; }…”
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4393
Curcumin Improves Epithelial Barrier Integrity of Caco-2 Monolayers by Inhibiting Endoplasmic Reticulum Stress and Subsequent Apoptosis
Published 2021-01-01“…Furthermore, curcumin administration greatly blocked the protein kinase-like endoplasmic reticulum kinase- (PERK-) eukaryotic translation initiation factor 2α- (eIF2α-) activating transcription factor 4- (ATF4-) CHOP signaling pathway. …”
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4394
Exploring a high-level programming model for the NWP domain using ECMWF microphysics schemes
Published 2025-01-01“…The library achieves high performance by translating the application into targeted low-level coding implementations. …”
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4395
Helicobacter pylori Management: How to Improve the Therapeutic Confusion in Practice
Published 2003-01-01“…Even in peptic ulcer disease, where most clinicians both in primary and in secondary care believe H pylori should be eradicated, there is often a breakdown in the translation of this belief into practice. There is also confusion in terms of treatment regimens applied for H pylori eradication. …”
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4396
Clinically Relevant Solution for the Hypothermic Storage and Transportation of Human Multipotent Mesenchymal Stromal Cells
Published 2019-01-01“…The obtained results together with the confirmed therapeutic properties of trehalose previously described provide sufficient evidence that the developed trehalose medium can be applied as a low-cost and efficient solution for the hypothermic storage of MSC suspensions, with a high potential for translation into clinical practice.…”
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4397
In silico identification of switching nodes in metabolic networks
Published 2024-10-01“…Additionally, switch metabolites are deeply involved in post-translational modification of proteins, showing their importance in cellular regulation. …”
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4398
Publication of studies registered in Clinical Trials Registry of India: An audit of mood disorder research protocols from 2009-2019
Published 2023-01-01“…Conclusions: Two out of three mood disorder research protocols registered in India do not translate into published research. These findings from a low- and middle-income country with limited spending on health care research and development represent wastage of resources and raise scientific and ethical concerns about unpublished data and futile patient participation in research.…”
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4399
How quality conventions shape the governance of the dairy value chains of Senegal
Published 2024-07-01“…We argue that value chain governance is not only determined by transaction characteristics, but also by how “lead firms” incorporate different quality conventions and translate these into value chain governance mechanisms. …”
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4400
Development and Testing of a Patient Outcome Measure for Interprofessional Tuberculosis Care: A Delphi Study
Published 2025-02-01“…Methods: The study involved four phases: 1) developing a conceptual framework and creating items, 2) evaluating the construct through Delphi studies to obtain international consensus, 3) back-to-back translation into Indonesian, and 4) re-evaluating the construct with Delphi study to obtain Indonesian consensus. …”
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