Genetic and neurochemical profiles underlying cortical morphometric vulnerability to Parkinson’s disease by Su Yan, Jun Lu, Bingfang Duan, Hongquan Zhu, Tian Tian, Yuanyuan Qin, Yuanhao Li, Wenzhen Zhu

“…The related genes were enriched for the glucose metabolism, mitochondrial function, and post-translational histone modifications processes. In addition, the serotonin and norepinephrine transporter devoted more to gray matter properties alterations while the dopamine, gamma-aminobutyric acid receptors, and norepinephrine transporter were strong contributors of curvature abnormalities in PD. …”
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Augmenter of Liver Regeneration Crotonylation Assists in Mitochondria-ER Contact to Alleviate Hepatic SteatosisSummary by Xiao-lin Wang, Jia-hao He, Ping Xie, Yuan Wu, Ling-yue Dong, Wei An

“…Background & Aims: Crotonylation (Kcr), a newly identified post-translation modification (PTM), has been confirmed to be involved in diverse biological processes and human diseases as well. …”
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MDTR: a knowledge-guided interpretable representation for quantifying liver toxicity at transcriptomic level by Inyoung Sung, Sangseon Lee, Dongmin Bang, Dongmin Bang, Jungseob Yi, Sunho Lee, Sun Kim, Sun Kim, Sun Kim, Sun Kim

“…In addition, the mechanisms of drug toxicity are known only as literature information, not in a computable form.MethodsTo address these challenges, we propose a Multi-Dimensional Transcriptomic Ruler (MDTR) that quantifies the degree of DILI at the transcriptome level. To translate transcriptome data to toxicity-related mechanisms, MDTR incorporates KEGG pathways as representatives of mechanisms, mapping transcriptome data to biological pathways and subsequently aggregating them for each of the five hepatotoxicity mechanisms. …”
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Current Trends in Biomaterial Utilization for Cardiopulmonary System Regeneration by Adegbenro Omotuyi John Fakoya, David Adeiza Otohinoyi, Joshua Yusuf

“…Stem cell therapy alone appears not to be sufficient to provide the desired tissue regeneration and hence the drive for biomaterials that can support its transplantation and translation, providing not only physical support to seeded cells but also chemical and physiological cues to the cells to facilitate tissue regeneration. …”
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Semi-automated Generation of Geometric Digital Twin for Bridge Based on Terrestrial Laser Scanning Data by Kaixin Hu, Daguang Han, Guocheng Qin, Yin Zhou, Long Chen, Chunli Ying, Tong Guo, Yanhui Liu

“…For cross sections that lack point clouds, a translation strategy is used to supplement the unknown line segment. …”
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The CHK1 inhibitor prexasertib in BRCA wild-type platinum-resistant recurrent high-grade serous ovarian carcinoma: a phase 2 trial by Elena Giudice, Tzu-Ting Huang, Jayakumar R. Nair, Grant Zurcher, Ann McCoy, Darryl Nousome, Marc R. Radke, Elizabeth M. Swisher, Stanley Lipkowitz, Kristen Ibanez, Duncan Donohue, Tyler Malys, Min-Jung Lee, Bernadette Redd, Elliot Levy, Shraddha Rastogi, Nahoko Sato, Jane B. Trepel, Jung-Min Lee

“…Toxicity was manageable. Translational research was an exploratory endpoint. Potential biomarkers were investigated using pre-treatment fresh biopsies and serial blood samples. …”
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Transcriptomic and proteomic profiling identifies feline fibrosarcoma as clinically amenable model for aggressive sarcoma subtypes by Mikiyo Weber, Daniel Fuchs, Amiskwia Pöschel, Erin Beebe, Zuzana Garajova, Armin Jarosch, Laura Kunz, Witold Wolski, Lennart Opitz, Franco Guscetti, Mirja C. Nolff, Enni Markkanen

“…However, a lack of molecular characterization of FSA and adjacent normal tissue (NT) in both species hinders identification of tumor-specific targets and undermines the translational potential of feline FSA. Combining laser-capture microdissection, RNAsequencing and liquid chromatography-tandem mass spectrometry, we perform comprehensive profiling of 30 feline FSA and matched skeletal muscle, adipose and connective tissue. …”
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Role of astrocytes and microglia in hepatic encephalopathy associated with advanced chronic liver disease: lessons from animal studies by Wouter Claeys, Anja Geerts, Lien Van Hoecke, Christophe Van Steenkiste, Roosmarijn E. Vandenbroucke

“…Microglia, the brain resident macrophages, have been linked to the translation of systemic inflammation to the brain microenvironment. …”
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Health workers knowledge, attitudes and practices towards youth-friendly sexual and reproductive health service delivery in Calabar Metropolis, South-South, Nigeria by Felicity Nneoma Ike, Elvis Anyaehiechukwu Okolie, Phillip Etabee Bassey

“…Conclusion: Moderate to high levels of knowledge and positive attitudes among health workers did not translate into desired practices in YFSRH service delivery. …”
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Multi-criteria group decision-making with extended ELECTRE III method and regret theory based on probabilistic interval-valued intuitionistic hesitant fuzzy information by Chuanyang Ruan, Shicheng Gong, Xiangjing Chen

“…To develop a suitable MCGDM model for dynamic environments, this paper develops a new MCGDM model based on probabilistic interval-valued intuitionistic hesitant fuzzy sets (PIVIHFSs), regret theory, and the extended ELimination Et Choice Translating Reality (ELECTRE) III method. Firstly, this paper proposes two new aggregation operators, including the generalized probabilistic interval-valued intuitionistic hesitant fuzzy weighted averaging (GPIVIHFWA) operator and the generalized probabilistic interval-valued intuitionistic hesitant fuzzy weighted geometric (GPIVIHFWG) operator. …”
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Structural insights into dynamics of the BMV TLS aminoacylation by Wen Yang, Ran Yi, Jing Yao, Yongxiang Gao, Shanshan Li, Qingguo Gong, Kaiming Zhang

“…Furthermore, Electrophoretic Mobility Shift Assay (EMSA) demonstrated that BMV TLS binds elongation factors EF1α and EF2, suggesting a multifaceted strategy to exploit host translational machinery. These findings not only enhance our knowledge of virus-host interactions but also offer potential targets for antiviral drug development.…”
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Fibrin Glue Enhances Adipose-Derived Stromal Cell Cytokine Secretion and Survival Conferring Accelerated Diabetic Wound Healing by Ursula Hopfner, Matthias M. Aitzetmueller, Philipp Neßbach, Michael S. Hu, Hans-Guenther Machens, Zeshaan N. Maan, Dominik Duscher

“…By demonstrating the ability of fibrin glue to act as a carrier vehicle for ASCs, while simultaneously enhancing cellular regenerative function and viability, this study is a proponent of clinical translation for ASC-based therapies.…”
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A new taxonomy of neuroprotective agents for stroke appropriate for the reperfusion era by Mersedeh Bahr-Hosseini, Jeffrey L. Saver

“…This updated taxonomy may accelerate the translation of cerebroprotective agents from bench to bedside.…”
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Development and Evaluation of the Immunogenic Potential of an Unmodified Nucleoside mRNA Vaccine for Herpes Zoster by Shun Zhang, Xiaojie Wang, Tongyi Zhao, Chen Yang, Lulu Huang

“…Background/Objectives: Approved mRNA vaccines commonly use sequences modified with pseudouridine to enhance translation efficiency and mRNA stability. However, this modification can result in ribosomal frameshifts, reduced immunogenicity, and higher production costs. …”
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Leveraging Single-Cell Multi-Omics to Decode Tumor Microenvironment Diversity and Therapeutic Resistance by Hussein Sabit, Borros Arneth, Timothy M. Pawlik, Shaimaa Abdel-Ghany, Aysha Ghazy, Rawan M. Abdelazeem, Amany Alqosaibi, Ibtesam S. Al-Dhuayan, Jawaher Almulhim, Noof A. Alrabiah, Ahmed Hashash

“…Future studies will incorporate multi-omics data, spatial relationships in tumor micro-environments, and their translation into personalized cancer therapies. This review emphasizes how single-cell multi-omics can provide insights into the cellular and molecular heterogeneity of the TME, revealing immune evasion mechanisms, metabolic reprogramming, and stromal cell influences. …”
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Engineered ipilimumab variants that bind human and mouse CTLA-4 by Brett Robison, SJ Diong, Anusha Kumar, Thomas M. Moon, Olin Chang, Bryant Chau, Christine Bee, Ishita Barman, Arvind Rajpal, Alan J. Korman, Sean West, Pavel Strop, Peter S. Lee

“…These cross-reactive ipilimumab variants may facilitate improved translatability and future mechanism-of-action studies for anti-CTLA-4 targeting in murine models.…”
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Keratoconus Diagnosis: Validation of a Novel Parameter Set Derived from IOP-Matched Scenario by Dan Lin, Lei Tian, Shu Zhang, Like Wang, Ying Jie, Yongjin Zhou

“…Our study shows that NPS indeed offers comparable performance in keratoconus diagnosis. Translational Relevance. Determining a parameter set after eliminating the influence from IOP is useful in revealing the essential differences between keratoconus and normal corneas and possibly facilitating further progress in keratoconus diagnosis.…”
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A meta-analysis of sex differences in neonatal rodent ultrasonic vocalizations and the implication for the preclinical maternal immune activation model by Alison M. Randell, Stephanie Salia, Lucas F. Fowler, Toe Aung, David A. Puts, Ashlyn Swift-Gallant

“…We discuss how analyzing USV call types and incorporating sex as a biological variable can enhance our understanding of neonatal ultrasonic communication and its translational value in NDD research.…”
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Employing visual thinking skills in the techniques of advertising art by Bydaa Sabih Al-Gharawi

“…It also works on enhancing current education methods to reach excellence in the process of teaching advertisement art techniques, where the research aims to take on skills of visual thinking and adopt them in preparing teaching units that represent weekly lectures for the students of the Department of Printing Design Techniques / First Grade, and develop their abilities in translating visual language carried in advertisements to a written phonic language that requires training on visual thinking skills. …”
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Deep Learning for Traffic Scene Understanding: A Review by Parya Dolatyabi, Jacob Regan, Mahdi Khodayar

“…It examines fundamental techniques such as classification, object detection, and segmentation, and extends to more advanced applications like action recognition, object tracking, path prediction, scene generation and retrieval, anomaly detection, Image-to-Image Translation (I2IT), and person re-identification (Person Re-ID). …”
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