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4161
Comprehensive analysis of lncRNAs and mRNAs revealed potential participants in the process of avian reovirus infection
Published 2025-02-01“…Notably, our study identified a novel functional lncRNA, MSTRG.9284.1 (It was named linc000889 in the present study), which inhibits the replication of ARV at the transcriptional, translational levels and viral titer. Overall, this study has identified numerous ARV-induced differentially expressed mRNAs and lncRNAs, including the functional lncRNA linc000889 that inhibits ARV replication. …”
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4162
What Drives Innovation and How Its Relevance is Established. A Perspective on Electric Vehicle Promotion in La Rochelle and Gothenburg : 1989-2000
Published 2018-01-01“…On all three levels by means of motivations, attitudes, vocabularies, and methods corporate cultures and agendas translate into the narratives arguing the relevance of territorial innovation.…”
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4163
Benchmarking the identification of a single degraded protein to explore optimal search strategies for ancient proteins
Published 2024-11-01“…However, there is a lack of a systematic exploration of how these affect the identification of peptides, post-translational modifications (PTMs), proteins and their significance (through the False Discovery Rate) and correctness. …”
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4164
Exploring BCL2 regulation and upstream signaling transduction in venetoclax resistance in multiple myeloma: potential avenues for therapeutic intervention
Published 2025-02-01“…Simultaneous inhibition of MCL-1, BCL-XL, and upstream PI3K, RTK (FGF, EGF, and IGF1) mediated signaling enhanced VTX sensitivity. Post-translational modifications of MCL-1, particularly its stabilization via acetylation and phosphorylation, were investigated, although their inhibition only marginally increased VTX sensitivity. …”
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4165
Association between previous work experience in general healthcare and recovery orientation among mental health professionals during the COVID-19 pandemic in Japan
Published 2025-01-01“…Working with primary care helps professionals learn and translate the concept of recovery into practice. In Japan where primary care system is not established yet, previous work experience in general healthcare may substitute for the absence of primary care work experience. …”
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4166
Targeting PPARγ Signaling Cascade for the Prevention and Treatment of Prostate Cancer
Published 2012-01-01“…These TZD-derived novel therapeutic agents, alone or in combination with other anticancer drugs, have translational relevance in fostering effective strategies for cancer treatment. …”
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4167
Comprehensive transcriptome and proteome analysis revealed the molecular mechanisms of melatonin priming and waterlogging response in peach
Published 2025-02-01“…A correlation analysis between differentially expressed genes and proteins highlighted the regulation of numerous genes at both the transcriptional and translational levels. Furthermore, core DEGs/DEPs, including heat shock proteins and stress-related proteins, were identified. …”
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4168
Enhancing magnetic hyperthermia: Investigating iron oxide nanoparticle coating and stability
Published 2025-01-01“…Further research is essential for a better understanding of the cell death mechanism induced by MH and for its clinical translation.…”
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4169
Optimization of Conditions for Production of Soluble <i>E. coli</i> Poly(A)-Polymerase for Biotechnological Applications
Published 2025-01-01“…Rosetta 2 (DE3) and Rosetta Blue (DE3) hosting the pRARE plasmid exhibited the lowest solubility, likely due to excessive translation efficiency. Higher induction temperatures (>18 °C) exacerbated PAP 1’s insolubility. …”
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4170
Dysfunction of G Protein-Coupled Receptor Kinases in Alzheimer's Disease
Published 2010-01-01“…Therefore, continuous efforts in this direction are necessary before translating the knowledge to any therapeutic strategies.…”
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4171
Genetic advancements in breast cancer treatment: a review
Published 2025-02-01“…Continued collaboration between researchers and clinicians is essential to translate these innovations into clinical practice, ultimately improving BC patients' survival rates and quality of life.…”
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4172
The role of epigenetics in plant pathogens interactions under the changing environments: A systematic review
Published 2025-03-01“…RNA methylation, particularly N6-methyladenosine (m6A), adds another layer of regulation, controlling the stability and translation of transcripts involved in host immunity and pathogen virulence. …”
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4173
Automated Detection of Macular Diseases by Optical Coherence Tomography and Artificial Intelligence Machine Learning of Optical Coherence Tomography Images
Published 2019-01-01“…Among them, 1,100 images were used for deep learning training, augmented to 59,400 by horizontal flipping, rotation, and translation. The remaining 100 images were used to evaluate the trained convolutional neural network (CNN) model. …”
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4174
RNA N4‐acetylcytidine modification and its role in health and diseases
Published 2025-01-01“…This review first outlines the key regulatory enzyme mediating ac4C modification, N‐acetyltransferase 10 (NAT10), including its critical roles in regulating RNA stability, transcriptional efficiency, and translational fidelity. Additionally, it systematically summarizes the essential functions and mechanisms of ac4C modification in normal biological processes, including stem cell fate determination, spermatogenesis and oogenesis, embryonic development, cellular senescence, and bone remodeling. …”
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4175
On the Suitability of Vibration Acceptance Criteria of Process Pipework
Published 2022-01-01“…The mainline supporting conditions will be varied using translational and rotational springs. The finite element models will be excited using a point load resembling flow-induced forces (with varying flow velocity and fluid composition). …”
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4176
Diffusion Tensor Imaging in Alzheimer’s Disease and Mild Cognitive Impairment
Published 2009-01-01“…Based on increases in translational diffusion (mean diffusivity: MD) and decreases directional diffusion (fractional anisotropy: FA) damage to white matter can be assessed. …”
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4177
Negative effects of humor in marketing communications
Published 2023-01-01“…Famous brands have a global presence, and often translate their advertising messages, but this does not always work as planned. …”
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4178
Generation of iPSCs by Nonintegrative RNA-Based Reprogramming Techniques: Benefits of Self-Replicating RNA versus Synthetic mRNA
Published 2019-01-01“…Moreover, the incorporation of a GFP encoding sequence into the srRNA enabled a direct and convenient monitoring of the reprogramming procedure and the successful detection of srRNA translation in the transfected cells. Nevertheless, the use of a single srRNA to induce pluripotency was less time consuming, faster, and more efficient than the daily transfection of cells with synthetic mRNAs. …”
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4179
PfFBXO1 is essential for inner membrane complex formation in Plasmodium falciparum during both asexual and transmission stages
Published 2025-02-01“…We hypothesize that PfFBXO1 is necessary for IMC biogenesis, chromosomal maintenance, vesicular transport, and ubiquitin-mediated translational regulation of proteins in both sexual and asexual stages of P. falciparum.…”
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4180
Advancing Alzheimer's Therapy: Computational strategies and treatment innovations
Published 2025-06-01“…Collaborative efforts between computational biologists, pharmacologists, and clinicians are essential to translate computational insights into clinically actionable interventions, ultimately improving patient outcomes and addressing the unmet medical needs of individuals affected by AD. …”
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