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  1. 4161

    Comprehensive analysis of lncRNAs and mRNAs revealed potential participants in the process of avian reovirus infection by Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Jinkang Li, Mingshu Wang, Mingshu Wang, Mingshu Wang, Mingshu Wang, Renyong Jia, Renyong Jia, Renyong Jia, Renyong Jia, Shun Chen, Shun Chen, Shun Chen, Shun Chen, Mafeng Liu, Mafeng Liu, Mafeng Liu, Mafeng Liu, Dekang Zhu, Dekang Zhu, Dekang Zhu, Dekang Zhu, Xinxin Zhao, Xinxin Zhao, Xinxin Zhao, Xinxin Zhao, Ying Wu, Ying Wu, Ying Wu, Ying Wu, Qiao Yang, Qiao Yang, Qiao Yang, Qiao Yang, Juan Huang, Juan Huang, Juan Huang, Juan Huang, Xumin Ou, Xumin Ou, Xumin Ou, Xumin Ou, Di Sun, Di Sun, Di Sun, Di Sun, Bin Tian, Bin Tian, Bin Tian, Bin Tian, Yu He, Yu He, Yu He, Yu He, Zhen Wu, Zhen Wu, Zhen Wu, Zhen Wu, Anchun Cheng, Anchun Cheng, Anchun Cheng, Anchun Cheng

    Published 2025-02-01
    “…Notably, our study identified a novel functional lncRNA, MSTRG.9284.1 (It was named linc000889 in the present study), which inhibits the replication of ARV at the transcriptional, translational levels and viral titer. Overall, this study has identified numerous ARV-induced differentially expressed mRNAs and lncRNAs, including the functional lncRNA linc000889 that inhibits ARV replication. …”
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  2. 4162

    What Drives Innovation and How Its Relevance is Established. A Perspective on Electric Vehicle Promotion in La Rochelle and Gothenburg : 1989-2000 by Marika Rupeka

    Published 2018-01-01
    “…On all three levels by means of motivations, attitudes, vocabularies, and methods corporate cultures and agendas translate into the narratives arguing the relevance of territorial innovation.…”
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  3. 4163

    Benchmarking the identification of a single degraded protein to explore optimal search strategies for ancient proteins by Rodriguez Palomo, Ismael, Nair, Bharath, Chiang, Yun, Dekker, Joannes, Dartigues, Benjamin, Mackie, Meaghan, Evans, Miranda, Macleod, Ruairidh, Olsen, Jesper V., Collins, Matthew J.

    Published 2024-11-01
    “…However, there is a lack of a systematic exploration of how these affect the identification of peptides, post-translational modifications (PTMs), proteins and their significance (through the False Discovery Rate) and correctness. …”
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  4. 4164

    Exploring BCL2 regulation and upstream signaling transduction in venetoclax resistance in multiple myeloma: potential avenues for therapeutic intervention by Rodrigo Fonseca, Yuan Xiao Zhu, Laura A. Bruins, Joseph Ahmann, Cecilia de Bonolo Campos, Esteban Braggio, Xianfeng Chen, Mariano Arribas, Susie Darvish, Seth Welsh, Erin Meermeier, Kiran K. Mangalaparthi, Richard K. Kandasamy, Greg Ahmann, J. Erin Wiedmeier-Nutor, Akhilesh Pandey, Marta Chesi, P. Leif Bergsagel, Rafael Fonseca

    Published 2025-02-01
    “…Simultaneous inhibition of MCL-1, BCL-XL, and upstream PI3K, RTK (FGF, EGF, and IGF1) mediated signaling enhanced VTX sensitivity. Post-translational modifications of MCL-1, particularly its stabilization via acetylation and phosphorylation, were investigated, although their inhibition only marginally increased VTX sensitivity. …”
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  5. 4165

    Association between previous work experience in general healthcare and recovery orientation among mental health professionals during the COVID-19 pandemic in Japan by Miharu Nakanishi, Tomohiro Takahashi, Keita Toshi, Mai Sakai, Hatsumi Yoshii

    Published 2025-01-01
    “…Working with primary care helps professionals learn and translate the concept of recovery into practice. In Japan where primary care system is not established yet, previous work experience in general healthcare may substitute for the absence of primary care work experience. …”
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  6. 4166

    Targeting PPARγ Signaling Cascade for the Prevention and Treatment of Prostate Cancer by Sakshi Sikka, Luxi Chen, Gautam Sethi, Alan Prem Kumar

    Published 2012-01-01
    “…These TZD-derived novel therapeutic agents, alone or in combination with other anticancer drugs, have translational relevance in fostering effective strategies for cancer treatment. …”
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  7. 4167

    Comprehensive transcriptome and proteome analysis revealed the molecular mechanisms of melatonin priming and waterlogging response in peach by Xianbin Gu, Linghong Lu, Jing Gao, Fei Fan, Genhua Song, Huiqin Zhang

    Published 2025-02-01
    “…A correlation analysis between differentially expressed genes and proteins highlighted the regulation of numerous genes at both the transcriptional and translational levels. Furthermore, core DEGs/DEPs, including heat shock proteins and stress-related proteins, were identified. …”
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  8. 4168

    Enhancing magnetic hyperthermia: Investigating iron oxide nanoparticle coating and stability by Joana Santos, Jorge Carvalho Silva, Manuel A. Valente, Tânia Vieira, Paula I.P. Soares

    Published 2025-01-01
    “…Further research is essential for a better understanding of the cell death mechanism induced by MH and for its clinical translation.…”
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  9. 4169

    Optimization of Conditions for Production of Soluble <i>E. coli</i> Poly(A)-Polymerase for Biotechnological Applications by Igor P. Oscorbin, Maria S. Kunova, Maxim L. Filipenko

    Published 2025-01-01
    “…Rosetta 2 (DE3) and Rosetta Blue (DE3) hosting the pRARE plasmid exhibited the lowest solubility, likely due to excessive translation efficiency. Higher induction temperatures (>18 °C) exacerbated PAP 1’s insolubility. …”
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  10. 4170

    Dysfunction of G Protein-Coupled Receptor Kinases in Alzheimer's Disease by William Z. Suo, Longxuan Li

    Published 2010-01-01
    “…Therefore, continuous efforts in this direction are necessary before translating the knowledge to any therapeutic strategies.…”
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  11. 4171

    Genetic advancements in breast cancer treatment: a review by Marzieh Shokoohi, Sadaf Sedaghatshoar, Homaira Arian, Milad Mokarami, Fatemeh Habibi, Fatemeh Bamarinejad

    Published 2025-02-01
    “…Continued collaboration between researchers and clinicians is essential to translate these innovations into clinical practice, ultimately improving BC patients' survival rates and quality of life.…”
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  12. 4172

    The role of epigenetics in plant pathogens interactions under the changing environments: A systematic review by Wenhao Wu, Guoqiang Fan

    Published 2025-03-01
    “…RNA methylation, particularly N6-methyladenosine (m6A), adds another layer of regulation, controlling the stability and translation of transcripts involved in host immunity and pathogen virulence. …”
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  13. 4173

    Automated Detection of Macular Diseases by Optical Coherence Tomography and Artificial Intelligence Machine Learning of Optical Coherence Tomography Images by Soichiro Kuwayama, Yuji Ayatsuka, Daisuke Yanagisono, Takaki Uta, Hideaki Usui, Aki Kato, Noriaki Takase, Yuichiro Ogura, Tsutomu Yasukawa

    Published 2019-01-01
    “…Among them, 1,100 images were used for deep learning training, augmented to 59,400 by horizontal flipping, rotation, and translation. The remaining 100 images were used to evaluate the trained convolutional neural network (CNN) model. …”
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  14. 4174

    RNA N4‐acetylcytidine modification and its role in health and diseases by Qiang Wang, Yixiao Yuan, Qiang Zhou, YingDong Jia, Jing Liu, GuangJun Xiao, Chunhong Li, Xiulin Jiang

    Published 2025-01-01
    “…This review first outlines the key regulatory enzyme mediating ac4C modification, N‐acetyltransferase 10 (NAT10), including its critical roles in regulating RNA stability, transcriptional efficiency, and translational fidelity. Additionally, it systematically summarizes the essential functions and mechanisms of ac4C modification in normal biological processes, including stem cell fate determination, spermatogenesis and oogenesis, embryonic development, cellular senescence, and bone remodeling. …”
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  15. 4175

    On the Suitability of Vibration Acceptance Criteria of Process Pipework by Omar Tawfik Shady, Jamil Renno, M. Shadi Mohamed, Sadok Sassi, Asan G. A. Muthalif

    Published 2022-01-01
    “…The mainline supporting conditions will be varied using translational and rotational springs. The finite element models will be excited using a point load resembling flow-induced forces (with varying flow velocity and fluid composition). …”
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  16. 4176

    Diffusion Tensor Imaging in Alzheimer’s Disease and Mild Cognitive Impairment by G. T. Stebbins, C. M. Murphy

    Published 2009-01-01
    “…Based on increases in translational diffusion (mean diffusivity: MD) and decreases directional diffusion (fractional anisotropy: FA) damage to white matter can be assessed. …”
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  17. 4177

    Negative effects of humor in marketing communications by Baltezarević Ivana, Baltezarević Radoslav

    Published 2023-01-01
    “…Famous brands have a global presence, and often translate their advertising messages, but this does not always work as planned. …”
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  18. 4178

    Generation of iPSCs by Nonintegrative RNA-Based Reprogramming Techniques: Benefits of Self-Replicating RNA versus Synthetic mRNA by Heidrun Steinle, Marbod Weber, Andreas Behring, Ulrike Mau-Holzmann, Christian Schlensak, Hans Peter Wendel, Meltem Avci-Adali

    Published 2019-01-01
    “…Moreover, the incorporation of a GFP encoding sequence into the srRNA enabled a direct and convenient monitoring of the reprogramming procedure and the successful detection of srRNA translation in the transfected cells. Nevertheless, the use of a single srRNA to induce pluripotency was less time consuming, faster, and more efficient than the daily transfection of cells with synthetic mRNAs. …”
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  19. 4179

    PfFBXO1 is essential for inner membrane complex formation in Plasmodium falciparum during both asexual and transmission stages by Sreelakshmi K. Sreenivasamurthy, Carlos Gustavo Baptista, Christopher M. West, Ira J. Blader, Jeffrey D. Dvorin

    Published 2025-02-01
    “…We hypothesize that PfFBXO1 is necessary for IMC biogenesis, chromosomal maintenance, vesicular transport, and ubiquitin-mediated translational regulation of proteins in both sexual and asexual stages of P. falciparum.…”
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  20. 4180

    Advancing Alzheimer's Therapy: Computational strategies and treatment innovations by Jibon Kumar Paul, Abbeha Malik, Mahir Azmal, Tooba Gulzar, Muhammad Talal Rahim Afghan, Omar Faruk Talukder, Samar Shahzadi, Ajit Ghosh

    Published 2025-06-01
    “…Collaborative efforts between computational biologists, pharmacologists, and clinicians are essential to translate computational insights into clinically actionable interventions, ultimately improving patient outcomes and addressing the unmet medical needs of individuals affected by AD. …”
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    Article