International initiatives for the study of the human brain: EBRAINS and its Spanish node by Teris Duran, David Ezpeleta, Gemma Aragonès, Javier Mínguez, Emma Muñoz-Moreno, Maria V. Sanchez-Vives, Guillermo Velasco

“…Moreover, the global challenges on neurological and mental disorders, their incidence and prevalence, increasingly require R&D projects directed towards translational and personalized medicine. In an effort to advance these approaches, EBRAINS offers the medical and research sector tools such as The Virtual Epileptic Patient, The Virtual Brain, Medical Informatics Platform, Perturbational Complexity Index, Virtual Research Environment, among others; with the potential to move to clinical practice in the future, as well as other innovations in the spectrum of consciousness disorders or blindness. …”
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Distinguishing rheumatoid arthritis from psoriatic arthritis by Joseph F Merola, Luis R Espinoza, Roy Fleischmann

“…Differences in the pathogenesis of RA and PsA translate into some variances in the specificity and efficacy of therapies.…”
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Amur Softshell Turtle (<i>Pelodiscus maackii</i>) Population Size, Structure, and Spatial Distribution by Xiaochen Hou, Haitao Shi

“…The estimated population size in the study area was 40.79 ± 9.75 (95% confidence interval, 95% CI = 27–65), translating to 0.663 ± 0.158 turtles/ha (95% CI = 0.44–1.06 individuals/ha). …”
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The N-Terminal Domain of Y-Box Binding Protein-1 Induces Cell Cycle Arrest in G2/M Phase by Binding to Cyclin D1 by Payal Khandelwal, Mythili K. Padala, John Cox, Ramareddy V. Guntaka

“…Y-box binding protein YB-1 is a multifunctional protein involved in cell proliferation, regulation of transcription and translation. Our previous study indicated that disruption of one allele of Chk-YB-1b gene in DT-40 cells resulted in major defects in the cell cycle. …”
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Adaptive Fuzzy Control for Attitude Stabilization of Spacecraft with Deployable Composite Laminated Solar Array by Wei Zhang, Weibing Zhu, Shijie Zhang, Xiangtian Zhao

“…The solar array deployment causes obvious translational and rotational motions of the spacecraft. …”
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A Compliant Active Roller Gripper with High Positional Offset Tolerance for Delicate Spherical Fruit Handling by Haoran Zhu, Huanhuan Qin, Zicheng Qiu, Xinwen Chen, Jinlin Xue, Xingjian Gu, Mingzhou Lu

“…A flexible active roller is configured at the end of each finger, allowing fruit translation with just a gentle touch. An integrated pressure sensor within the active roller further enhances the gripper’s compliance. …”
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Kinematics and Mechanical Properties of Knees following Patellar Replacing and Patellar Retaining Total Knee Arthroplasty by Rongying Huang, Yanqiang Liu, Jun Zhu

“…By contrast, patellar replacement had a significant influence on the patellofemoral joint; patellar internal rotation, external rotation, and medial-lateral translation were all increased. Moreover, the stress distribution on patellar prostheses was altered, resulting in an increased surface maximal equivalent stress on the corresponding area. …”
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Inkjet-printed electronics for rapid and low-cost prototyping of digital microfluidic devices using an off-the-shelf printer by Babak Kamali Doust Azad, Amirhossein Roozbahani, Seyed Mohammad Tabatabaei, Amirali Valinejad, Alireza Fazelian, Kimia Shahmoradi, Fatemeh Khatami, Seyed Mohammad Kazem Aghamir, Mohammadreza Kolahdouz

“…Abstract Digital microfluidics (DMF) is revolutionizing point-of-care diagnostics by advancing lab-on-a-chip technology. To accelerate translation to real-life applications, it is crucial to devise rapid and low-cost methods for prototyping to test various design ideas. …”
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The Safety of Digital Mental Health Interventions: Findings and Recommendations From a Qualitative Study Exploring Users’ Experiences, Concerns, and Suggestions by Rayan Taher, Daniel Stahl, Sukhi Shergill, Jenny Yiend

“…MethodsWe included individuals aged 18 years old or older, having experience in using a DMHI, and can speak and understand English without the need for a translator. Fifteen individual interviews were conducted. …”
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Harnessing nanotechnology for cancer treatment by Jiajun Zhu, Jiajun Zhu, HaeJu Lee, HaeJu Lee, Ruotong Huang, Ruotong Huang, Jianming Zhou, Jingjun Zhang, Xiaoyi Yang, Wenhan Zhou, Wangqing Jiang, Shuying Chen

“…Nevertheless, despite these progressions, obstacles still persist, particularly in the clinical translation of these technologies. Issues such as nanoparticle toxicity, biocompatibility, and the complexity of regulatory approval hinder the widespread adoption of nanomedicine in oncology. …”
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Intravenous Administration of Adipose-Derived Stem Cell Protein Extracts Improves Neurological Deficits in a Rat Model of Stroke by Kai Zhao, Rui Li, Changcong Gu, Long Liu, Yulong Jia, Xize Guo, Wanping Zhang, Chunying Pei, Linlu Tian, Bo Li, Jianrong Jia, Huakun Cheng, Hongwei Xu, Lixian Li

“…Together these data provide translational evidence for using protein extracts from ADSC for treating stroke.…”
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A practical approach to building a calcareous nannofossil knowledge graph by Hongyi Zhao, Bin Hu, Chao Ma, Shijun Jiang, Yi Zhang, Xin Li, Lirong Chen, Can Cai, Longgang Ye, Shengjian Zhou, Chengshan Wang

“…The knowledge graph, as a key technology for semantic translation and data fusion, offers a possible solution to these challenges. …”
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Recent advances in recombinant production of soluble proteins in E. coli by Ario de Marco

“…Nevertheless, the majority of the published papers aimed at identifying the conditions for optimal control of the translation process to achieve maximal yields of functional exogenous proteins. …”
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PEPITEM, its tripeptide pharmacophores and their peptidomimetic analogues regulate the inflammatory response through parenteral and topical dosing in models of peritonitis and psor... by Anella Saviano, Bonita Apta, Samantha Tull, Laleh Pezhman, Areeba Fatima, Mustafa Sevim, Antonio Mete, Myriam Chimen, Anna Schettino, Noemi Marigliano, Helen M. McGettrick, Asif J. Iqbal, Francesco Maione, G. Ed Rainger

“…Taken together with other reports on the efficacy of PEPITEM, this study paves the way for the development and translation of a novel class of anti-inflammatory agents which may have utility in a broad range of autoimmune and chronic inflammatory diseases.…”
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A comparative study of the developability of full-length antibodies, fragments, and bispecific formats reveals higher stability risks for engineered constructs by Itzel Condado-Morales, Fabian Dingfelder, Isabel Waibel, Oliver M. Turnbull, Bhargav Patel, Zheng Cao, Jais Rose Bjelke, Susanne Nedergaard Grell, Anja Bennet, Alissa M. Hummer, Matthew I. J. Raybould, Charlotte M. Deane, Thomas Egebjerg, Nikolai Lorenzen, Paolo Arosio

“…Engineered antibody formats, such as antibody fragments and bispecifics, have the potential to offer improved therapeutic efficacy compared to traditional full-length monoclonal antibodies (mAbs). However, the translation of these non-natural molecules into successful therapeutics can be hampered by developability challenges. …”
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PEBP1 amplifies mitochondrial dysfunction-induced integrated stress response by Ling Cheng, Ian Meliala, Yidi Kong, Jingyuan Chen, Christopher G Proud, Mikael Björklund

“…Depletion of PEBP1 impaired mitochondrial ISR activation by reducing eukaryotic translation initiation factor 2α (eIF2α) phosphorylation and subsequent ISR gene expression, which was independent of PEBP1’s role in inhibiting the RAF/MEK/ERK pathway. …”
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Teaching responsible chemistry: a challenge-based learning framework for the implementation of RRI courses in tertiary chemistry education by Mehlich Jan

“…This paper proposes a course concept that aims at filling a gap in the translation of RRI principles into tertiary chemistry education practice. …”
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Tirosin Kinase Inhibitors in Chronic Graft versus Host Disease: From Bench to Bedside by Jacopo Olivieri, Sabrina Coluzzi, Imma Attolico, Attilio Olivieri

“…Moreover accumulating in vitro data confirm that TKIs, interacting with the TCR and other signalling molecules, carry potent immunomodulatory effects, being involved in both T-cell and B-cell response. Translation to the clinical setting revealed that treatment with Imatinib can achieve encouraging responses in patients with autoimmune diseases and steroid-refractory cGVHD, showing a favourable toxicity profile. …”
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Curcumin-Based Nanoparticles: Advancements and Challenges in Tumor Therapy by Hicham Wahnou, Riad El Kebbaj, Bertrand Liagre, Vincent Sol, Youness Limami, Raphaël Emmanuel Duval

“…Finally, the review addresses the current challenges and future perspectives in the clinical translation of CNPs, emphasizing the need for further research to optimize their design for targeted delivery and to enhance their therapeutic outcomes. …”
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Epigenetic regulation of bone remodeling and its role in the pathogenesis of primary osteoporosis by B. I. Yalaev, R. I. Khusainova

“…The results of epigenetic studies have significantly increased the understanding of the role of post-translational modifications of histones, DNA methylation and RNA interference in the osteoporosis pathogenesis and in bone remodelling. …”
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