A Novel Minimal Invasive Mouse Model of Extracorporeal Circulation by Shuhua Luo, Menglin Tang, Lei Du, Lina Gong, Jin Xu, Youwen Chen, Yabo Wang, Ke Lin, Qi An

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Spinal Cord Stimulation for Refractory Angina Pectoris: Current Status and Future Perspectives, a Narrative Review by Roberto Gazzeri, Jacopo Mosca, Felice Occhigrossi, Marco Mercieri, Marcelo Galarza, Matteo Luigi Giuseppe Leoni

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One size does not fit all: revising traditional paradigms for assessing accuracy of QSAR models used for virtual screening by James Wellnitz, Sankalp Jain, Joshua E. Hochuli, Travis Maxfield, Eugene N. Muratov, Alexander Tropsha, Alexey V. Zakharov

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Deciphering the regulatory programs of RNA binding proteins in rheumatoid arthritis through single-cell transcriptome analysis by Hongbin Luo, Qunya Zheng, Youzheng Zhou, Weipeng Lai, Nanwen Zhang, Peng Chen

“…Single-cell RNA sequencing (scRNA-seq) data from published datasets were obtained to investigate the expression and dysregulation of RNA-binding proteins (RBPs), which are critical for alternative mRNA splicing and translational control in rheumatoid arthritis (RA). How RBP regulation differs between RA and osteoarthritis (OA) was examined using RBP for single-cell sub-clustering. …”
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A novel approach to analyzing the evolution of SARS-CoV-2 based on visualization and clustering of large genetic data compactly represented in operative memory by A. Yu. Palyanov, N. V. Palyanova

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Recent advances in pancreatic α-cell transdifferentiation for diabetes therapy by Yanjiao Li, Yanjiao Li, Jinyu Zhu, Congyang Yue, Siyuan Song, Limin Tian, Yi Wang, Yi Wang, Yi Wang

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Single-cell transcriptome atlas of male mouse pituitary across postnatal life highlighting its stem cell landscape by Silke De Vriendt, Emma Laporte, Berkehür Abaylı, Julie Hoekx, Florian Hermans, Diether Lambrechts, Hugo Vankelecom

“…Finally, we show translatability of mouse atlas-based findings to humans, particularly regarding aging-associated profile. …”
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Inhibition of P38 MAPK Downregulates the Expression of IL-1β to Protect Lung from Acute Injury in Intestinal Ischemia Reperfusion Rats by De-Yi Zheng, Min Zhou, Jiao Jin, Mu He, Yi Wang, Jiao Du, Xiang-Yang Xiao, Ping-Yang Li, Ai-Zhu Ye, Jia Liu, Ting-Hua Wang

“…And rats with II/R have the highest translation level for IL-1β and phosphorylation of P38 MAPK in lung tissues at 16hpo compared with 8hpo and sham groups. …”
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Lack of HLH in FMF by Ozge Basaran, Erdal Sag, Elif Arslanoglu Aydın, Busra Aydın, Nur Kübra Tasdemir, Elif Celikel, Yagmur Bayındır, Semanur Özdel, Yelda Bilginer, Alexei A Grom, Seza Ozen

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Digital health technologies and self-efficacy in Parkinson’s: a scoping review by Victoria Allgar, Edward Meinert, Camille B Carroll, Andrew Michael Hall

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Ethnicity-specific distribution of <em>TRPM8</em> gene variants in Eurasian populations: signs of selection by T. A. Potapova, A. G. Romashchenko, N. S. Yudin, M. I. Voevoda

“…Sequence analysis demonstrates that they are transcribed from major H1 variant of the TRPM8 gene but contain different translation start codons, which are generated by alternative splicing from pro-mRNA.…”
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Chromosome-level genome reference of the Caucasian dwarf goby Knipowitschia cf. caucasica, a new alien Gobiidae invading the River Rhine by Schoenle, Alexandra, Guiglielmoni, Nadège, Mainz, Tobias, Greve, Carola, Hamadou, Alexander Ben, Heermann, Lisa, Borcherding, Jost, Waldvogel, Ann-Marie

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Pharmacological Characterization of the Mechanisms Involved in Delayed Calcium Deregulation in SH-SY5Y Cells Challenged with Methadone by Sergio Perez-Alvarez, Maria E. Solesio, Maria D. Cuenca-Lopez, Raquel M. Melero-Fernández de Mera, Carlos Villalobos, Hanna Kmita, Maria F. Galindo, Joaquin Jordán

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Squamous Cell Carcinomas of the Skin Explore Angiogenesis-Independent Mechanisms of Tumour Vascularization by Ievgenia Pastushenko, Tamara Gracia-Cazaña, Sandra Vicente-Arregui, Gert G. Van den Eynden, Mariano Ara, Peter B. Vermeulen, Franciso José Carapeto, Steven J. Van Laere

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Implication of tumor morphology and MRI characteristics on the accuracy of automated versus human segmentation of GBM areas by Valeria Cerina, Chiara Benedetta Rui, Andrea Di Cristofori, Davide Ferlito, Giorgio Carrabba, Carlo Giussani, Gianpaolo Basso, Elisabetta De Bernardi

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Multiple Sclerosis Nursing to Improve Care and Education (MSNICE): an observational study by Liesbeth Van Hijfte, Melissa Cambron, Roel Crols, Gino De La Meilleure, Nelly Govers, Ludo Vanopdenbosch, Guy Laureys, Barbara Willekens, for the MSNICE Study Group

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High-sensitivity colorimetric sensor based on oxidase-like Mn3O4 nanozyme for Cys detection by Junting Liang, Dihan Duan, Lubing Sun, Jinming Li, Mengke Wang, Ziyi Chang, Rick F. Thorne, Chuanliang Chen, Demin Duan

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Examining the mental health of siblings of children with a mental disorder: A scoping review protocol. by John E Krzeczkowski, Terrance J Wade, Brendan F Andrade, Dillon Browne, Busra Yalcinoz-Ucan, Negin A Riazi, Elizabeth Yates, Andrea Tagalakis, Karen A Patte

“…Finally, in section vi) we describe our integrative knowledge translation plan that aims to include knowledge users in interpretating and translating evidence gathered from the proposed review.…”
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Liver diseases: epidemiology, causes, trends and predictions by Can Gan, Yuan Yuan, Haiyuan Shen, Jinhang Gao, Xiangxin Kong, Zhaodi Che, Yangkun Guo, Hua Wang, Erdan Dong, Jia Xiao

“…Recent advances in understanding the pathogenesis of liver diseases hold critical implications and translational value for the development of novel therapeutic strategies.…”
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Quantification of Eosinophilic Granule Protein Deposition in Biopsies of Inflammatory Skin Diseases by Automated Image Analysis of Highly Sensitive Immunostaining by Peter Kiehl, Katrin Falkenberg, Markus Vogelbruch, Alexander Kapp

“…Image analysis of immunostaining was performed by colour translation, linear combination and automated thresholding. …”
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