ClaPEPCK4: target gene for breeding innovative watermelon germplasm with low malic acid and high sweetness by Congji Yang, Jiale Shi, Yuanyuan Qin, ShengQi Hua, Jiancheng Bao, Xueyan Liu, Yuqi Peng, Yige Gu, Wei Dong

“…The ClaPEPCK4 expression was inversely proportional to malate content variations in fruits. In transgenic watermelon plants, overexpressing the ClaPEPCK4 gene, malic acid content markedly decreased. …”
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Identification of a potential homeodomain-like gene governing leaf size and venation architecture in birch by Xiuyan Bian, Xiuyan Bian, Chen Chen, Chen Chen, Yang Wang, Yang Wang, Chang Qu, Chang Qu, Jing Jiang, Yao Sun, Guifeng Liu

“…Among them, a potential HD-like gene (BpPHD4) of GARP family served as a negative factor in governing leaf size and venation patterning. Compared to non-transgenic plants, BpPHD4 repression transgenic plants showed increased leaf length, leaf width, leaf area, leaf thickness, spongy tissue thickness, stomata number, epidermal cell size, primary vein length, the distance between the secondary veins, and primary vein diameter, which was opposite to those of BpPHD4 overexpression transgenic plants. …”
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HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo. by Yorifumi Satou, Jun-Ichirou Yasunaga, Tiejun Zhao, Mika Yoshida, Paola Miyazato, Ken Takai, Kei Shimizu, Koichi Ohshima, Patrick L Green, Naganari Ohkura, Tomoyuki Yamaguchi, Masahiro Ono, Shimon Sakaguchi, Masao Matsuoka

“…In HBZ-transgenic mice, CD4+Foxp3+ T(reg) cells and effector/memory CD4+ T cells increased in vivo. …”
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Rodent Models for Investigating the Dysregulation of Immune Responses in Type 1 Diabetes by Feng-Cheng Chou, Heng-Yi Chen, Shyi-Jou Chen, Mei-Cho Fang, Huey-Kang Sytwu

“…Because the genetic manipulation of mice is well developed (transgenic, knockout, and conditional knockout/transgenic), most studies are performed using the nonobese diabetic (NOD) mouse model. …”
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Ethylene Response Factor Sl-ERF.B.3 Is Responsive to Abiotic Stresses and Mediates Salt and Cold Stress Response Regulation in Tomato by Imen Klay, Julien Pirrello, Leila Riahi, Anne Bernadac, Ameur Cherif, Mondher Bouzayen, Sadok Bouzid

“…To get more insight into the role of Sl-ERF.B.3 in plant response to separate salinity and cold, a comparative study between wild type and two Sl-ERF.B.3 antisense transgenic tomato lines was achieved. Compared with wild type, Sl-ERF.B.3 antisense transgenic plants exhibited a salt stress dependent growth inhibition. …”
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Oncolytic Immunotherapy: Where Are We Clinically? by Akseli Hemminki

“…Thus, the relative contribution of “pure” oncolysis, the immune response resulting from oncolysis, and the added benefit of adding a transgene remain poorly understood. Here, the available clinical data on oncolytic viruses is reviewed, with emphasis on immunological aspects.…”
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Host-Induced Gene Silencing of the <i>Aspergillus flavus O</i>-Methyl Transferase Gene Enhanced Maize Aflatoxin Resistance by Olanike Omolehin, Yenjit Raruang, Dongfang Hu, Zhu-Qiang Han, Surassawadee Promyou, Robert L. Brown, Qijian Wei, Kanniah Rajasekaran, Jeffrey W. Cary, Kan Wang, Dan Jeffers, Zhi-Yuan Chen

“…In order to develop commercial maize lines with enhanced aflatoxin resistance, the <i>omtA</i> transgene in OmtA-7 was introduced into three elite inbred lines through crossing, and the resulting crosses also exhibited significantly lower aflatoxin accumulation compared to crosses with non-transgenic controls (<i>p</i> < 0.04). …”
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La problématique éthique du développement de l’aquaculture industrielle au Canada : analyse mésologique d’un nouveau rapport possible à l’océan by Louis-Etienne Pigeon, Lyne Létourneau

“…Nevertheless, the introduction of high-tech methods such as transgenic manipulations can reduce the quality and the diversity of these relations because they are essentially modern techniques.…”
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PPARgamma-Dependent Control of Renin Expression: Molecular Mechanisms and Pathophysiological Relevance by Vladimir T. Todorov

“…Furthermore, I discuss the need for generating of additional transgenic animal models which are more appropriate with regard to the role of the PPARgamma-dependent regulation of the renin gene expression in human diseases such as arterial hypertension and metabolic syndrome.…”
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Functional Characterization of Sesquiterpene Synthase from Polygonum minus by Su-Fang Ee, Zeti-Azura Mohamed-Hussein, Roohaida Othman, Noor Azmi Shaharuddin, Ismanizan Ismail, Zamri Zainal

“…The transgenic plants demonstrated smaller basal rosette leaves, shorter and fewer flowering stems, and fewer seeds compared to wild type plants. …”
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Heterologous expression of SpsTAC2 in Arabidopsis affected branch angle and secondary vascular system development by Fangshu Niu, Mengru Yuan, Hongxia Zhao, Zhi Pang, Jie Yan, RuiXie Ning, Lin Shi, Fengqiang Yu, Dongshan Wei, Rong Yang, Runming Zhang, Haifeng Yang

“…Phenotypic characterization of SpsTAC2 overexpressing Arabidopsis strains revealed that the branching angle of the transgenic strains was significantly greater than that of the wild type, and the anatomical structures of the stems and hypocotyls of the transgenic strains indicated that the vascular system of the transgenic strains developed more slowly than did that of the wild type. …”
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Evaluating the Accumulation of Grain Mercury in Engineered Rice Lines Containing <i>merA</i> and <i>merB</i> Genes Under an Organic Mercury-Enriched Condition by Deyao Meng, Zhaoze Song, Jinyuan Liu, Liyang Ji, Chen Chen, Changhu Wang

“…In this study, <i>merA</i> and <i>merB</i> transgenic rice lines were cultivated in organic mercury-contaminated soil to evaluate their grain mercury accumulation. …”
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Protocol for generating splice isoform-specific mouse mutants using CRISPR-Cas9 and a minigene splicing reporter by Yudong Teng, Kelsey Arbogast, Harald Junge, Zhe Chen

“…We describe steps for designing guide RNA to direct Cas9 endonuclease to consensus splice sites, producing transgenic mice through pronuclear injection, and screening for desired mutations in cultured mammalian cells using a minigene splicing reporter. …”
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A central role for Foxp3+ regulatory T cells in K-Ras-driven lung tumorigenesis. by Courtney A Granville, Regan M Memmott, Andria Balogh, Jacopo Mariotti, Shigeru Kawabata, Wei Han, Jaclyn Lopiccolo, Jason Foley, David J Liewehr, Seth M Steinberg, Daniel H Fowler, M Christine Hollander, Phillip A Dennis

“…Likewise, mutant K-Ras transgenic mice lacking Foxp3+ cells developed 75% fewer lung tumors than littermates with Foxp3+ cells.…”
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Overexpression of a Vesicle Trafficking Gene, OsRab7, Enhances Salt Tolerance in Rice by Xiaojue Peng, Xia Ding, Tianfang Chang, Zhoulong Wang, Rong Liu, Xin Zeng, Yaohui Cai, Youlin Zhu

“…Herein, we isolated a vesicle trafficking gene, OsRab7, from rice. Transgenic rice over-expressing OsRab7 exhibited enhanced seedling growth and increased proline content under salt-treated conditions. …”
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Bioluminescence Imaging of Gene Expression in Utero by Meera T. Saxena, Sara J. Aton, Charles Hildebolt, Julie L. Prior, Ute Abraham, David Piwnica-Worms, Erik D. Herzog

“…Using rats carrying a Per1::luc transgene, we repetitively imaged fetuses in utero throughout gestation. …”
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Calcineurin, Synaptic Plasticity, and Memory by Carl Weitlauf, Danny Winder

“…Isabelle Mansuy and colleagues used an inducible and reversible transgene expression system in which transgene expression could be controlled on a week-to-week timescale to assess the effects of genetic reduction of the activity of a protein phosphatase known as calcineurin or PP2B in adult mouse forebrain[3,4].…”
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Leaf-Encapsulated Vaccines: Agroinfiltration and Transient Expression of the Antigen Staphylococcal Endotoxin B in Radish Leaves by Pei-Feng Liu, Yanhan Wang, Robert G. Ulrich, Christopher W. Simmons, Jean S. VanderGheynst, Richard L. Gallo, Chun-Ming Huang

“…Transgene introgression is a major concern associated with transgenic plant-based vaccines. …”
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Environnement politique et réglementaire des pharmacultures au Canada : la contamination pharmaceutique à l’horizon ? by Marie-Hélène Bacon

“…Within these multiple fields of GM crops grows, since 1994, transgenic plants which could eventually produce pharmaceutical molecules.  …”
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Genetic Factors in Animal Models of Intestinal Inflammation by R Balfour Sartor

“…The dominant role of genetic background in induction of intestinal inflammation is further documented by spontaneous colitis which develops in spontaneously mutant mice, cotton-top tamarins, human leukocyte antigen-B27/ β2 microglobulin transgenic rats and mice with targeted deletions of certain immunoregulatory cytokine and T lymphocyte genes. …”
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