The Good, the Bad, and the Ugly: What the Future Could Hold for Bs2 Tomatoes by Samuel F. Hutton, John W. Scott, Jeffrey B. Jones, Robert E. Stall, Gary E. Vallad, B. J. Staskawicz, D. M. Horvath

“… Bs2 tomatoes are transgenic tomatoes that have been engineered to contain the Bs2 gene from pepper. …”
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Validation of a mouse model with Apoe gene knockout by Petr R. Lebedev

“…Introduction: The research focuses on the ApoE-/- transgenic mouse model. This model enhances the understanding of the mechanisms underlying disease progression and allows for the testing of new therapeutic strategies. …”
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Repeated Long-Term DT Application in the DEREG Mouse Induces a Neutralizing Anti-DT Antibody Response by Junhua Wang, Myriam Siffert, Markus Spiliotis, Bruno Gottstein

“…Genetic tools exploiting the foxp3 locus including bacterial artificial chromosome- (BAC-) transgenic DEpletion of REGulatory T cells (DEREG) mice have provided essential information on Treg biology and the potential therapeutic modulation of tolerance. …”
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Modeling of Chronic Myeloid Leukemia: An Overview of In Vivo Murine and Human Xenograft Models by Pallavi Sontakke, Jenny Jaques, Edo Vellenga, Jan Jacob Schuringa

“…These models range from (conditional) transgenic models, knock-in models, and murine bone marrow retroviral transduction models followed by transplantation. …”
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Advances in Murine Models of Diabetic Nephropathy by Li-li Kong, Hao Wu, Wen-peng Cui, Wen-hua Zhou, Ping Luo, Jing Sun, Hang Yuan, Li-ning Miao

“…Although a large number of murine models of DN including artificially induced, spontaneous, and genetically engineered (knockout and transgenic) animal models have been developed, none of them develops renal changes sufficiently reflecting those seen in humans. …”
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Expression of a mammalian RNA demethylase increases flower number and floral stem branching in Arabidopsis thaliana by Kasey Markel, Lucas Waldburger, Patrick M. Shih

“…We also performed RNA‐seq of our FTO‐transgenic plants, which we analyzed in conjunction with previously published datasets to detect several previously unrecognized patterns in the functional and structural classification of the upregulated and downregulated genes. …”
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Molecular insights into the unique properties of the blood‐circulating proteasome by Yegor Leushkin, David Morgenstern, Shifra Ben‐Dor, Rebecca Haffner‐Krausz, Katharina Zittlau, Gili Ben‐Nissan, Michal Sharon

“…Our study investigates the freely circulating proteasome in blood, to uncover its unique molecular characteristics, compared to its intracellular counterparts. Using a transgenic mouse model, mass spectrometry, and biochemical tools, we show that the predominant proteasome in serum is the free uncapped 20S particle, which seems to assemble intracellularly before entering the bloodstream. …”
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Silk Protein Gene Engineering and Its Applications: Recent Advances in Biomedicine Driven by Molecular Biotechnology by Ji X, Li Y, Wang J, Wang G, Ma B, Shi J, Cui C, Wang R

“…Notably, modified silk proteins expressed by transgenic silkworms demonstrate significant advantages in enhancing drug bioavailability and promoting cell proliferation and differentiation. …”
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A conserved element in the first intron of Cd4 has a lineage specific, TCR signal-responsive, canonical enhancer function that matches the timing of cell surface CD4 upregulation r... by Gregory A. Swan, Gregory A. Swan, Chika Fujii, Mia E. Guzynski, Sheridan M. Page, Isabelle V. Meyers, Yordan P. Penev, Sejiro Littleton, Sejiro Littleton, Adinda Azzahra, Christine Richardson, Sophia D. Sarafova, Sophia D. Sarafova

“…To avoid developmental alterations from direct manipulation of the endogenous Cd4 locus in vivo, BAC-transgenic reporter mice were generated with the locus modified to express EGFP in the presence or absence of NCE. …”
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C-Reactive Protein (CRP) and Autoimmune Disease: Facts and Conjectures by Alexander J. Szalai

“…Coincident with a now decade-long resurgence in clinical interest in associations of CRP with disease, our laboratory has been investigating the biology of CRP in vivo using human CRP transgenic mice (CRPtg). At that time we confirmed that CRP affects a host defense function mediated at least in part through the elimination of pathogens. …”
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The Role of TGFβ Signaling in Squamous Cell Cancer: Lessons from Mouse Models by Adam B. Glick

“…The mouse skin carcinogenesis model has been a useful tool to dissect the function of this pathway in cancer pathogenesis, with transgenic and null mice as well as small molecule inhibitors to alter the function of the TGFβ1 pathway and assess the effects on cancer development. …”
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Lignin: Characterization of a Multifaceted Crop Component by Michael Frei

“…Both mapping of quantitative trait loci and transgenic approaches have been adopted to modify lignin in crops. …”
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Beneficial Effects of Prebiotic Saccharomyces cerevisiae Mannan on Allergic Asthma Mouse Models by D. Betty Lew, Christie F. Michael, Tracie Overbeck, W. Scout Robinson, Erin L. Rohman, Jeffrey M. Lehman, Jennifer K. Patel, Brandi Eiseman, Kim S. LeMessurier, Amali E. Samarasinghe, M. Waleed Gaber

“…We have previously reported that ASM cells express a mannose receptor (ASM-MR) and that mannan derived from Saccharomyces cerevisiae (SC-MN) inhibits mannosyl-rich lysosomal hydrolase-induced bovine ASM cell proliferation. Using a humanized transgenic mouse strain (huASM-MRC2) expressing the human MRC2 receptor in a SM tissue-specific manner, we have demonstrated that ASM hyperplasia/hypertrophy can occur as early as 15 days after allergen challenge in this mouse model and this phenomenon is preventable with SC-MN treatment. …”
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Knockdown of Zebrafish Blood Vessel Epicardial Substance Results in Incomplete Retinal Lamination by Yu-Ching Wu, Ruei-Feng Chen, Chia-Yang Liu, Fung Rong Hu, Chang-Jen Huang, I-Jong Wang

“…In the current study, we generated a transgenic zebrafish Bves (zbves) promoter-EGFP zebrafish line to investigate the expression pattern of Bves in the retina and to study the role of zbves in retinal lamination. …”
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A synthetic chronogenetic gene circuit for programmed circadian drug delivery by Lara Pferdehirt, Anna R. Damato, Kristin L. Lenz, Maria F. Gonzalez-Aponte, Daniel Palmer, Qing-Jun Meng, Erik D. Herzog, Farshid Guilak

“…Using a combination of synthetic biology and tissue engineering, we developed circadian-based gene circuits, termed “chronogenetics”, that express a prescribed transgene downstream of the core clock gene promoter, Period2 (Per2). …”
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Single-cell transcriptome atlas of lamprey exploring Natterin- induced white adipose tissue browning by Yue Pang, Yating Qin, Zeyu Du, Qun Liu, Jin Zhang, Kai Han, Jiali Lu, Zengbao Yuan, Jun Li, Shanshan Pan, Xinrui Dong, Mengyang Xu, Dantong Wang, Shuo Li, Zhen Li, Yadong Chen, Zhisheng Zhao, Zhe Zhang, Shunqin Chuan, Yue Song, Mingjie Sun, Xiaodong Jia, Zhangyong Xia, Liping Zhan, Zhen Yue, Wei Cui, Jun Wang, Ying Gu, Ming Ni, Huanming Yang, Xun Xu, Xin Liu, Qingwei Li, Guangyi Fan

“…Moreover, we developed a transgenic mouse model expressing Natterin to elucidate the role of NATTERIN in lipid metabolism, whereas the browning of white adipose tissue was induced. …”
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Extracellular vesicles contribute to the beneficial effects of exercise training in APP/PS1 mice by Oliver K. Fuller, Emma D. McLennan, Casey L. Egan, Nimna Perera, Lauren V. Terry, Jae Pyun, Mariana de Mendonca, Guilherme Defante Telles, Benoit Smeuninx, Emma L. Burrows, Ghizal Siddiqui, Darren J. Creek, John W. Scott, Michael A. Pearen, Pamali Fonseka, Joseph A. Nicolazzo, Suresh Mathivanan, Anthony J. Hannan, Grant A. Ramm, Martin Whitham, Mark A. Febbraio

“…Here, we first examined the effect of voluntary exercise training (VET) on energy metabolism and cognitive function in the APP/PS1 transgenic mouse (Tg) model of familial AD. Next, we profiled extracellular vesicles (EVs) and examined whether they may play a role in the protective effects of VET via intranasal administration of EVs, purified from the blood of sedentary (sEV) and/or acutely exercised (eEV) donor wild-type mice into APP/PS1Tg mice. …”
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Spontaneous Type 2 Diabetic Rodent Models by Yang-wei Wang, Guang-dong Sun, Jing Sun, Shu-jun Liu, Ji Wang, Xiao-hong Xu, Li-ning Miao

“…On the basis of their strains, features, advantages, and disadvantages, various types of animal models of T2DM can be divided into spontaneously diabetic models, artificially induced diabetic models, and transgenic/knockout diabetic models. Among these models, the spontaneous rodent models are used more frequently because many of them can closely describe the characteristic features of T2DM, especially obesity and insulin resistance. …”
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New Insight on the Sublethal Effect of Bt-Cry1Ab in <i>Spodoptera litura</i> (Fabricius): Tissular Distribution of Cry1Ab, Ultrastructural Alterations and the Lysosomal Response by Yan-Jue Wang, Ya-Qin Shen, Ying-Dan Xiao, Xue Yang, Shao-Peng Hao, Jian-Qiu Liu, Xiao-Xue Yang, Kazuei Mita, Ya-Jing Xu

“…Bt has been applied as a gene source for insect-resistant transgenic crops, which represents efficient control of insect pests. …”
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The Class III Peroxidase gene TaPRX-2A controls grain number per spike in common wheat (Triticum aestivum L.) by Dongtian Zang, Wenjia You, Yangyang Wu, Pengyue Wang, Zhiyu Wang, Qingyun Yang, Shatong Chi, Peisen Su, Peisen Su

“…In our study, we cloned a wheat PRX gene TaPRX-2A and identified its function in controlling GNS by generating transgenic overexpression lines. The results showed that TaPRX-2A overexpression displayed lower GNS and shorter SL, compared with the wild-type plants. …”
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