Multitasking muscle: engineering iPSC-derived myogenic progenitors to do more by Mark Stephen Hamer, Fabio M. V. Rossi

“…Notably absent from recent reviews on iMPs is the concept of engineering these cells to perform functions post-transplantation that non-transgenic cells cannot. Here, we highlight protocols to enhance the generation, purification, and maturation of iMPs, and introduce the idea of engineering these cells to perform functions beyond their normal capacities, envisioning novel therapeutic applications.…”
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CD93 blockade promotes effector T-cell infiltration and facilitates adoptive cell therapy in solid tumors by Yi Sun, Eduardo Davila, YuJie Guo, Richard D Schulick, Elliott Yee, Yuki Fujiwara, Kaitlyn Dickinson, Zhiwei Sun, Junyi Hu, Yuwen Zhu

“…Different sources of effector T cells were used, including pre-activated CD8+OT-1, pmel-1 transgenic T cells, and CAR-T cells. Rip-OVA and Rip-TAG-OVA transgenic mice were used to evaluate the selective impact of CD93 blockade on effector T-cell infiltration in tumors. …”
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Cardiovascular Development and the Colonizing Cardiac Neural Crest Lineage by Paige Snider, Michael Olaopa, Anthony B. Firulli, Simon J. Conway

“…Although it is well established that transgenic manipulation of mammalian neural crest-related gene expression and microsurgical removal of premigratory chicken and Xenopus embryonic cardiac neural crest progenitors results in a wide spectrum of both structural and functional congenital heart defects, the actual functional mechanism of the cardiac neural crest cells within the heart is poorly understood. …”
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Transcriptional Control of Synaptic Plasticity by Transcription Factor NF-κB by Christian Engelmann, Ronny Haenold

“…Recent research on transgenic mice with impaired or hyperactivated NF-κB gave important insights into plasticity-related target gene expression that is regulated by NF-κB. …”
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Gene Therapy for Glioblastoma Multiforme by Smit Shah, Joshua Green, Shantelle A. Graff, Qi Li, John D. Heiss

“…It reviews promising DNA transgenes, RNA inhibitors, and vectors for anti-GBM therapy. …”
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Advances in Gene Therapy for Neurologic Disorders: An Overview by Pallavi Chand, K. Trideva Sastri, Ashish Singh Chauhan, Souvik Chakraborty, Vikash Jakhmola

“…Several efforts to enhance gene therapy rely on discovering novel vectors, recent curative targets, and the dependability of transgenic delivery paths. These viral and non-viral vectors techniques are carefully screened through preclinical and clinical levels and eventually render patients with effective therapies. …”
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Noncoding RNA in the Regulation of Acute Aortic Dissection: From Profile to Mechanism by Ruibin Wei, Yingqing Feng

“…However, with the development of gene sequencing and transgenic technology, genetic methods are being used for the diagnosis and treatment of diseases, including acute aortic dissection. …”
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Plant Growth-Promoting Bacteria: Mechanisms and Applications by Bernard R. Glick

“…This includes both the increasing use of transgenic plants and plant growth-promoting bacteria as a part of mainstream agricultural practice. …”
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Noninvasive in Vivo Imaging of Protein Kinase a Activity by Jan Øivind Moskaug, Harald Carlsen, Rune Blomhoff

“…The PKA-sensitive luciferase, termed luciferase PKA , was incorporated into the mouse genome, and transgenic animals exhibited a rapid β-adrenergic response, that is, reduced luminescence, in various organs, including the pancreas, muscle, liver, and fat, after isoproterenol injection. …”
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Identification and functional characterization of AsWRKY9, a WRKY transcription factor modulating alliin biosynthesis in garlic (Allium sativum L.) by Jiaying Wu, Min Li, Wanni Wang, Yiren Su, Jie Li, Jiaxin Gong, Xianfeng Meng, Chenyuan Lin, Qiantong Zhang, Yanyan Yang, Chunyan Xu, Limei Zeng, Jihong Jiang, Xuqin Yang

“…Compared to the control, the alliin content in the transgenic callus overexpressing AsWRKY9 was significantly increased, thus confirming the activation of the alliin biosynthesis pathway and enhancing the accumulation of alliin in garlic. …”
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The regulatory role of cystatin C in autophagy and neurodegeneration by T. A. Korolenko, A. B. Shintyapina, A. B. Pupyshev, A. A. Akopyan, G. S. Russkikh, M. A. Dikovskaya, V. A. Vavilin, E. L Zavjalov, M. A. Tikhonova, T. G. Amstislavskaya

“…Autophagy has been shown to be suppressed in the striatum of a transgenic mouse model of Parkinson’s disease. Cystatin C is one of the potent regulators of autophagy. …”
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Neuroprotection by chronic administration of Fluoroethylnormemantine (FENM) in mouse models of Alzheimer's disease by Allison Carles, Aline Freyssin, Sarra Guehairia, Thomas Reguero, Michel Vignes, Hélène Hirbec, Gilles Rubinstenn, Tangui Maurice

“…Conclusion These data confirmed the neuroprotective potential of FENM in the pharmacological Aβ25–35 and transgenic APP/PS1 mouse models of AD, with a superiority to MEM, and showed that the drug can be efficiently infused chronically.…”
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Transcription factors MhyFIL1 and MhyFIL3 <i>(Monotropa hypopitys)</i> determine the asymmetric development of above-ground lateral organs in plants by A. V. Shchennikova, A. M. Kamionskaya, A. V. Nezhdanova, K. S. Gavrilova, M. A. Filyushin, E. Z. Kochieva, K. G. Skryabin

“…Also, changes in the architecture of the aerial part and the root system of transgenic plants, including aberrant phyllotaxis and arrest of the shoot and root apical meristem development, were noted. …”
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E. coli-Produced BMP-2 as a Chemopreventive Strategy for Colon Cancer: A Proof-of-Concept Study by Saravanan Yuvaraj, Sa’ad H. Al-Lahham, Rajesh Somasundaram, Patrick A. Figaroa, Maikel P. Peppelenbosch, Nicolaas A. Bos

“…We propose that prevention and treatment of colorectal cancer using transgenic bacteria is feasible.…”
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Rapid Heterotrophic Ossification with Cryopreserved Poly(ethylene glycol-) Microencapsulated BMP2-Expressing MSCs by Jennifer Mumaw, Erin T. Jordan, Corinne Sonnet, Ronke M. Olabisi, Elizabeth A. Olmsted-Davis, Alan R. Davis, John F. Peroni, Jennifer L. West, Franklin West, Yangqing Lu, Steven L. Stice

“…Poly(ethylene glycol) (PEG) microencapsulation and BMP2 transgene delivery are being developed together to induce rapid bone formation. …”
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Recent Advances in Application of Male Germ Cell Transplantation in Farm Animals by Ali Honaramooz, Yanfei Yang

“…The application of this method in farm animals has been the subject of an increasing number of studies, mostly because of its potential as an alternative strategy in producing transgenic livestock with higher efficiency and less time and capital requirement than the current methods. …”
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Optimization of photosynthesis for sustainable crop production by Seid Hussen Muhie

“…Further work should be done on transgenic crops with modified photosynthesis. Optimization of the activity of Rubisco may not be successful in some moisture stress areas, and consideration of photoprotection could offer some advantages. …”
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The Ongoing Challenge of Hematopoietic Stem Cell-Based Gene Therapy for β-Thalassemia by Ekati Drakopoulou, Eleni Papanikolaou, Nicholas P. Anagnou

“…Since then, researchers focused on designing efficient and safe vectors, which can successfully deliver the therapeutic transgene, demonstrating no insertional mutagenesis. …”
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The Good, the Bad, and the Ugly: What the Future Could Hold for Bs2 Tomatoes by Samuel F. Hutton, John W. Scott, Jeffrey B. Jones, Robert E. Stall, Gary E. Vallad, B. J. Staskawicz, D. M. Horvath

“… Bs2 tomatoes are transgenic tomatoes that have been engineered to contain the Bs2 gene from pepper. …”
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FGF21 as an Endocrine Regulator in Lipid Metabolism: From Molecular Evolution to Physiology and Pathophysiology by Yusuke Murata, Morichika Konishi, Nobuyuki Itoh

“…Experiments with Fgf21 transgenic mice and cultured cells indicate that FGF21 exerts pharmacological effects on glucose and lipid metabolism in hepatocytes and adipocytes via cell surface FGF receptors. …”
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