Phase I study of pembrolizumab in combination with ibrutinib for the treatment of unresectable or metastatic melanoma by Yuan Yao, Yiyi Yan, Vera J. Suman, Allan B. Dietz, Courtney L. Erskine, Anastasios Dimou, Svetomir N. Markovic, Svetomir N. Markovic, Robert R. McWilliams, Heather N. Montane, Matthew S. Block, Matthew S. Block

“…BackgroundImmune checkpoint inhibitors (ICIs) have been transformative in the treatment of patients with metastatic melanoma, but primary and secondary resistance to ICI treatment is common. …”
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Cooling and Sterile Inflammation in an Oxygen-Glucose-Deprivation/Reperfusion Injury Model in BV-2 Microglia by Jana Lücht, Nele Rolfs, Sylvia J. Wowro, Felix Berger, Katharina R. L. Schmitt, Giang Tong

“…Furthermore, inducible nitric oxide synthase (iNOS), ionized calcium-binding adaptor molecule 1 (Iba1), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β), interleukin-1α (IL-1α), monocyte chemotactic protein 1 (MCP-1), transforming growth factor β (TGFβ), CIRBP, and RBM3 gene expressions were assessed via reverse transcription polymerase chain reaction, and TNF-α, IL-6, and IL-1β releases into the cultured supernatants were assessed via enzyme-linked immunosorbent assays (ELISA). …”
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Assessing Mental Illness Referral Request Acceptance: A Nationwide E-Referral Data From Saudi Arabia by Alharbi AA, Aljerian NA, Alghamdi HA, Binhotan MS, Alsultan AK, Arafat MS, Aldhabib A, Aloqayli AI, Alwahbi EB, Horner RD

“…Saudi Arabia has implemented an innovative nationwide electronic referral system (SMARC) as part of its digital health transformation strategy to enhance mental healthcare accessibility. …”
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Network and systems biology approaches help investigate gene regulatory interactions between Salmonella disease and host in chickens: Model‐based in silico evidence combined with g... by Reza Tohidi, Hoda Javaheri Bargourooshi, Arash Javanmard

“…These include inducible nitric oxide synthase, NRAMP1, immunoglobulin light chain (IgL), transforming growth factor B family (TGFb2, TGFb3 and TGFb4), interleukin 2 (IL2), apoptosis inhibitor protein 1 (IAP1), TLR4, myeloid differentiation protein 2 (MD2), IFNγ, caspase 1 (CASP1), lipopolysaccharide‐induced tumour necrosis factor (LITAF), cluster of differentiation 28 (CD28) and prosaposin (PSAP). …”
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Biodiversity Patterns of Rocky Coastal and Human-Made Structures in Gheshm Shorelines; Role of Slope and Tidal Levels Characteristics in Determining Patterns of Biodiversity by Marzieh Razaghi, Ali Nasrolahi, Ehsan Kamrani, Mohammad Sharif Ranjbar, Amir Vazirizadeh

“…Human-made constructions such as breakwaters, piers, and seawalls have become characteristic features alongside shallow habitats in intertidal and subtidal zones. This transformation accelerates in response to exponential population growth and climate change impacts, such as rising sea levels and the need to mitigate natural disasters like storm surges. …”
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Lipoleiomyoma of the uterus in a woman of reproductive age (clinical case) by V.V. Talash, Ya.V. Palyokha, A.M. Gromova, V.V. Talash, V.B. Martynenko, N.O. Prylutska, N.I. Mityunina

“…Im­munohistochemically, a positive reaction for caldesmon, desmin, smooth muscle actin alpha of tumor cells and for S.100 (DAKO, polyclonal) fatty cells was detected, which confirmed the hypothesis of direct transformation of smooth muscle cells existing in the leiomyoma of the uterus into fatty cells. …”
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Progress of research on aviation kerosene preparation using bioethanol by Pan LI, Yu ZHAO, Xingguo WU, Lulu ZHANG, Junhao HU, Wei CHEN, Jing BAI, Chun CHANG, Shuqi FANG

“…In achieving this goal, the petrochemical industry is experiencing the urgent challenge regarding its development and transformation vis energy conservation and emission reduction. …”
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Effectiveness of Massive Open Online Course on Risk Communication Knowledge in Global Health Emergencies Among Nurses by Khin Thandar Aung, Rafiza Abdul Razak, Muhammad Fadli Zulkafley

“…Massive Open Online Courses (MOOCs) have transformed education. The minimal usage of MOOCs in nursing education reveals a lack of continuous healthcare professional development. …”
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Reims antique, acquis et perspectives by Magalie Cavé, Philippe Rollet, Régis Bontrond

“…Though initially open, the city was transformed around 80-70 BC into an oppidum of 80 ha. …”
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Desain Interaksi Aplikasi Zero Waste dengan Menerapkan Gamifikasi Menggunakan Pendekatan Player-Centered Design by Adi Mulyanto, Nadija Herdwina Putri Soerojo

“…In earlier research shows gamification applied to a system could lead to improve an individual motivation toward studying by also transform their behavior. This research intends to develop zero waste application design interaction to escalate people motivation for applying zero waste fundamental by using gamification appliance. …”
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SMART SPECIALISATION AS A BASIC COMPONENT OF SOCIO-ECONOMIC DEVELOPMENT by Olena Guzenko, Svitlana Nikolaichuk, Dmytro Ivanenko

“…It has been demonstrated that the benefits of this approach for Ukraine include the accession of regions to the EU network of regions, attracting investors to the region, increasing the number of joint projects with the EU, supporting regions in the process of economic transformation and aligning professional potential with market requirements. …”
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Outcome evaluation and cost-effectiveness analysis for an integrated multidisciplinary diabetic limb salvage program: a combined observational and simulation study by Yan Sun, Xiaoli Zhu, Jaime Lin, John Abisheganaden, Zhiwen Joseph Lo, Lixia Ge, Joseph Molina, Elaine Tan, Huiling Liew, Jeremy Hoe, Gary Ang, Kai Qiang Low, Theophilus Yap, Nur Aberleen Syafirah Binte Azmi, Enming Yong, Tiffany Chew, Hui Yan Koo, Chelsea Law, Dexter Yak Seng Chan, Claris Shi, Julia Choo, Wai Han Hoi, Sadhana Chandraskear, Jo Ann Lim, Jemes Siow, Sabariah Binte Kaspon, Subramaniam Tavintharan, Daniel Chew

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A Phenologically Simplified Two-Stage Clumping Index Product Derived from the 8-Day Global MODIS-CI Product Suite by Ge Gao, Ziti Jiao, Zhilong Li, Chenxia Wang, Jing Guo, Xiaoning Zhang, Anxin Ding, Zheyou Tan, Sizhe Chen, Fangwen Yang, Xin Dong

“…In this study, we applied the discrete Fourier transform and an improved dynamic threshold method to estimate the start of season (SOS) and end of season (EOS) from the CI time series and indicated that the CI exhibits significant seasonal variation characteristics that are generally consistent with the MODIS land surface phenology (LSP) product (MCD12Q2), although seasonal differences between them probably exist. …”
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Impactos ambientales en la ciudad de Manaus: una búsqueda de comprensión Ambient impacts in the city of Manaus: an understanding search by Eveline Maria Damasceno do Nascimento, Iraildes Caldas Torres

“…The process of reproduction of the urban space leads us in front of deep transformations because each citizen points out in to a space wich determines, in the level of the daily life, the collective construction of the city, what it strengthens the necessity to identify the roles and the responsibilities of the diverse actors in face to the environmental issues and to the necessity reading consensus around them. …”
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Three different methods for ZnO-RGO nanocomposite synthesis and its adsorption capacity for methylene blue dye removal in a comparative study by Safaa A. Hussein, Gharib M. Taha, F. A. Adam, Marwa A. Moghazy

“…X-ray diffraction (XRD), Burnauer-Emmett-Teller (BET), Fourier transform infrared (FTIR), Zeta potential, transmittance electron microscope (TEM) and scanning electron microscope (SEM) analyses are conducted for synthesized sample characterization. …”
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A Mixed Project-and-Stock Portfolio Optimization Model with Mean-SemiVariance-SemiEntropy Approach by Amirhosein Khayyatian, Majid Shakhsi-Niaei

“…The innovative mixed project-and-stock portfolio problem has the potential to positively transform society using fostering innovation, stimulating economic growth, and enhancing financial knowledge. …”
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Therapeutic Potential of <i>Cajanus cajan</i> (L.) <i>Millsp</i>. Leaf Extract in Modulating Gut Microbiota and Immune Response for the Treatment of Inflammatory Bowel Disease by Mingzhang Lin, Linghua Piao, Zhendong Zhao, Li Liao, Dayong Wang, Haiwen Zhang, Xiande Liu

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Prediksi Kelulusan Tepat Waktu Berdasarkan Riwayat Akademik Menggunakan Metode K-Nearest Neighbor by Imam Riadi, Rusydi Umar, Rio Anggara

“…The research phase begins with data collection, attribute selection, data cleaning, data transformation, selection of testing data and training data. …”
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Identifying factors affecting the creation of brand identity in Iran's banking industry by Seyed Mahdi Saatchi, farzad asayesh, Sedighe Tootian Esfahani, Seyed Mahmood Hashemi

“…Also, part of the bank's recruitment can be done with new mechanisms with the aim of attracting the country's scientific elites and using them in the direction of innovative and transformational movements in the banking industry. In the field of organizational culture, it is necessary to promote value-oriented behaviors based on concepts such as loyalty and commitment to the bank, customer-orientedness, honesty and ethics in dealing with customers and employees. …”
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hBMSC-EVs alleviate weightlessness-induced skeletal muscle atrophy by suppressing oxidative stress and inflammation by Mengyuan Chang, Ruiqi Liu, Bingqian Chen, Jin Xu, Wei Wang, Yanan Ji, Zihui Gao, Boya Liu, Xinlei Yao, Hualin Sun, Feng Xu, Yuntian Shen

“…Conclusions Our findings indicate that hBMSC-EVs are capable of inhibiting excessive activation of the UPS and autophagy lysosome pathway, suppressing oxidative stress and inflammatory response, reversing muscle fiber type transformation, effectively delaying hindlimb unloading-induced muscle atrophy and enhancing muscle function. …”
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