The Ongoing Challenge of Hematopoietic Stem Cell-Based Gene Therapy for β-Thalassemia by Ekati Drakopoulou, Eleni Papanikolaou, Nicholas P. Anagnou

“…Gene therapy, on the other hand, is promising, and its success lies primarily on designing efficient globin vectors that can effectively and stably transduce HSCs. The major breakthrough in β-thalassemia gene therapy occurred a decade ago with the development of globin LVs. …”
Get full text

Extracellular NM23 Protein as a Therapeutic Target for Hematologic Malignancies by Junko Okabe-Kado, Takashi Kasukabe, Yasuhiko Kaneko

“…The growth and survival promoting activity to AML cells is associated with cytokine production and activation of mitogen-activated protein kinases (MAPKs) and signal transducers and activators of transcription (STAT) signaling pathways. …”
Get full text

Health Status Monitoring of Cuplock Scaffold Joint Connection Based on Wavelet Packet Analysis by Liuyu Zhang, Chenyu Wang, Gangbing Song

“…In order to detect the looseness of cuplock connection, three stress PZTs and three shear PZTs used as transducers are mounted onto vertical bar and cross bars of cuplok scaffold. …”
Get full text

Revisiting 310-helices: biological relevance, mimetics and applications by Diego Núñez-Villanueva

“…In the last section, the use of 310-helices as scaffolds of interest in the development of bioactive compounds, catalysts for enantioselective reactions, supramolecular receptors, and membrane-embedded signal transducers are discussed. The present work aims to highlight the relevance, sometimes underestimated, of 310-helices in chemical biology and protein science, providing the tools to develop functional biomimetics with a wide range of potential applications.…”
Get full text

The role of order and disorder in thermal and material sciences part 2: Scientific world and new insights by Šesták Jaroslav

“…Exploitation of fire and its conscious use as a manufacturing power are analyzed in terms of generalized engines to act in the sense of as the information transducers. The part 2 reveals the impact of mathematics as explained on some simple cases showing development of basic ideas (vibration, topology, bifurcations etc). …”
Get full text

CCAAT/Enhancer-Binding Protein β Mediates Oxygen-Induced Retinal Neovascularization via Retinal Vascular Damage and Vascular Endothelial Growth Factor by Tingting Li, Xuan Cai, Xiangning Wang, Xueyan Zhang, Hui Zhang, Biwei Xu, Shiwei Li, Jianyan Hu, Qiang Wu

“…The retinal C/EBP β level was significantly reduced in tissues from rats with OIR transduced with LV.shC/EBP β compared with tissues from those transduced with LV.shScrambled (P<0.01). …”
Get full text

A synthetic chronogenetic gene circuit for programmed circadian drug delivery by Lara Pferdehirt, Anna R. Damato, Kristin L. Lenz, Maria F. Gonzalez-Aponte, Daniel Palmer, Qing-Jun Meng, Erik D. Herzog, Farshid Guilak

“…Gene circuits were transduced into induced pluripotent stem cells that were tissue-engineered into cartilage constructs. …”
Get full text

CRMP2 and CRMP4 Are Differentially Required for Axon Guidance and Growth in Zebrafish Retinal Neurons by Zhi-Zhi Liu, Jian Zhu, Chang-Ling Wang, Xin Wang, Ying-Ying Han, Ling-Yan Liu, Hong A. Xu

“…Many axon guidance cues have been discovered; however, much less known is about how the growth cones transduce the extracellular guidance cues to intracellular responses. …”
Get full text

Differential Evolutionary Constraints in the Evolution of Chemoreceptors: A Murine and Human Case Study by Ricardo D’Oliveira Albanus, Rodrigo Juliani Siqueira Dalmolin, José Luiz Rybarczyk-Filho, Mauro Antônio Alves Castro, José Cláudio Fonseca Moreira

“…Our findings suggest that chemosensory receptor genes are less constrained than their signal transducing machinery, resulting in greater receptor diversity and conservation of information processing pathways. …”
Get full text

Polydiacetylene (PDA) Embedded Polymer-Based Network Structure for Biosensor Applications by Huisoo Jang, Junhyeon Jeon, Mingyeong Shin, Geonha Kang, Hyunil Ryu, Sun Min Kim, Tae-Joon Jeon

“…Biosensors, which combine physical transducers with biorecognition elements, have seen significant advancement due to the heightened interest in rapid diagnostic technologies across a number of fields, including medical diagnostics, environmental monitoring, and food safety. …”
Get full text

Compound ultrasonic vibration systems with a complex disk tool: Local resonance characteristics, FEM-based modal analysis, and design method by Cunying Zhang, Wenbo Bie, Yu Liu, Fan Chen

“…Based on the local resonance characteristics of the system and the simulation results, the horn, transducers, and other components were designed. The node position of the compound ultrasound system can be accurately determined, leading to the acquisition of a cutting disc with a disc-shaped cutting edge that exhibits equal center distance and amplitude longitudinal vibration in the ultrasonic vibration system. …”
Get full text

Sparse Signal Representations of Bearing Fault Signals for Exhibiting Bearing Fault Features by Wei Peng, Dong Wang, Changqing Shen, Dongni Liu

“…For bearing faults’ diagnosis, bearing faults signals collected from transducers are often overwhelmed by strong low-frequency periodic signals and heavy noises. …”
Get full text

Elastic Membrane That Undergoes Mechanical Deformation Enhances Osteoblast Cellular Attachment and Proliferation by G. K. Toworfe, R. J. Composto, M. H. Lee, P. Ducheyne

“…We concluded from this preliminary data obtained that the engineered surface transduced applied mechanical forces directly to the adherent osteoblast cells via integrin binding tripeptide receptors, present in the FN molecules, resulting in the enhanced cellular attachment and proliferation.…”
Get full text

PAI-1: An Integrator of Cell Signaling and Migration by Ralf-Peter Czekay, Cynthia E. Wilkins-Port, Stephen P. Higgins, Jennifer Freytag, Jessica M. Overstreet, R. Matthew Klein, Craig E. Higgins, Rohan Samarakoon, Paul J. Higgins

“…It is now apparent that several proteases and protease inhibitors, most notably urokinase plasminogen activator (uPA) and plasminogen activator inhibitor type-1 (PAI-1), also interact with several cell surface receptors transducing intracellular signals that significantly affect both motile and proliferative programs. …”
Get full text

Intratumoral pan-ErbB targeted CAR-T for head and neck squamous cell carcinoma: interim analysis of the T4 immunotherapy study by Fiona Reid, Sophie Papa, John Maher, Jean-Pierre Jeannon, James Spicer, Victoria Gibson, Selvam Thavaraj, Michael Metoudi, Christopher Fisher, Nicholas Beckley-Hoelscher, Andrew Hope, Maria Elstad, Antonella Adami, Richard Beatson, Molly Sarah George, Daniela Achkova, Evangelia Williams, Sefina Arif, Abdel Douri, Marc Delord, Mike Lyne, Dharshene Shivapatham, Sakina Gooljar, Arindam Mitra, Linda Gomm, Cienne Morton, Rhonda Henley-Smith, Alice Santambrogio, Cynthia Andoniadou, Sarah Allen, Gary J R Cook, Ana C Parente-Pereira, David M Davies, Farzin Farzaneh, Anna Schurich, Teresa Guerrero-Urbano

“…Patient-derived T-cells are engineered by retroviral transduction to coexpress a panErbB-specific CAR called T1E28ζ and an IL-4-responsive chimeric cytokine receptor, 4αβ, which allows IL-4-mediated enrichment of transduced cells during manufacture. These cells elicit preclinical antitumor activity against HNSCC and other carcinomas. …”
Get full text

Intermittent Flow Regimes in a Transonic Fan Airfoil Cascade by J. Lepicovsky, E. R. McFarland, R. V. Chima, V. R. Capece, J. Hayden

“…Flush-mounted, high-frequency response pressure transducers indicated large local jumps in the pressure in the leading edge area, which generates large intermittent loading on the blade leading edge. …”
Get full text

Gab Docking Proteins in Cardiovascular Disease, Cancer, and Inflammation by Yoshikazu Nakaoka, Issei Komuro

“…Through these interactions, the Gab proteins transduce signals from activated receptors into pathways with distinct biological functions, thereby contributing to signal diversification. …”
Get full text

Volatolomics for Anticipated Diagnosis of Cancers with Chemoresistive Vapour Sensors: A Review by Abhishek Sachan, Mickaël Castro, Jean-François Feller

“…Nanocomposite chemo-resistive transducers have unique prospects to enhance both the selectivity and sensitivity to volatile biomarkers. …”
Get full text

Structural Health Monitoring of Steel Pipes under Different Boundary Conditions and Choice of Signal Processing Techniques by Rais Ahmad, Tribikram Kundu

“…Cylindrical Guided waves are generated by piezo-electric transducers and propagated through the pipe wall boundaries in a pitch-catch system. …”
Get full text

Experimental application of gliders communication system in South China Sea by Shuyang Jia, Shuyang Jia, Shuyang Jia, Baoheng Liu, Baoheng Liu, Sichen Zou, Xiaochuan Zhang, Xiaochuan Zhang, Xiaochuan Zhang

“…The glider consists of three cabins connected in sequence and is capable of diving to a depth of over 1,000 m. Two acoustic transducers are fixed separately at the bow and stern of the underwater glider to ensure that the energy transmission range and angle remain consistent to the surface wave energy glider even if the glider’s attitude changes. …”
Get full text