Th9 Cells in Peripheral Blood Increased in Patients with Immune-Related Pancytopenia by Qing Shao, Yangyang Wang, Zhaoyun Liu, Hui Liu, Yihao Wang, Yang Zhao, Lijuan Li, Rong Fu

“…CD4+ lymphocytes were sorted by magnetic beads, and the mRNA expression levels of Th9 cells related transcription factors PU.1 and BATF were detected by RT-PCR. …”
Get full text

Bioinformatics insights into mitochondrial and immune gene regulation in Alzheimer's disease by Tian Meng, Yazhou Zhang, Yuan Ye, Hui Li, Yongsheng He

“…Subsequently, we further analyzed the signaling pathways and potential biological mechanisms of the biomarkers through gene set enrichment analysis, prediction of transcription factors (TFs), miRNAs, and drug prediction. …”
Get full text

Gibberellin-3 induced dormancy and suppression of flower bud formation in pitaya (Hylocereus polyrhizus) by Kamran Shah, Xiaoyue Zhu, Tiantian Zhang, Jiayi Chen, Jiaxuan Chen, Yonghua Qin

“…Abstract Background Flowering is a complex, finely regulated process involving multiple phytohormones and transcription factors. However, flowering regulation in pitaya (Hylocereus polyrhizus) remains largely unexamined. …”
Get full text

Transcriptome and Metabolome Analysis Unveil Anthocyanin Metabolism in Pink and Red Testa of Peanut (Arachis hypogaea L.) by Qiqin Xue, Xiurong Zhang, Hui Yang, Huadong Li, Yuying Lv, Kun Zhang, Yongguang Liu, Fengzhen Liu, Yongshan Wan

“…X8EVF3) may be the key functional genes controlling the formation of pink and red testa in peanut. Transcription factors MYB (arahy.A2IWKV, arahy.US2SKM, arahy.SJGE27, arahy.H8DJRL, and arahy.PR7AYB), bHLH (arahy.26781N, arahy.HM1IVV, and arahy.MP3D3D), and WD40 (arahy.L6JJW9) in the biosynthetic pathway of anthocyanin were significantly upregulated in Zhonghua 12 which may be the key regulatory genes in testa pigment formation. …”
Get full text

Genome-wide identification and characterization of WRKYs family involved in responses to Cylindrocarpon destructans in Panax notoginseng by Manqiao Li, Xiaoli Che, Qiwen Liang, Kuixiu Li, Guisheng Xiang, Xuyan Liu, Yan Zhao, Fugang Wei, Shengchao Yang, Guanze Liu

“…Abstract Background WRKY transcription factors (TFs) are key regulators of plant responses to biotic and abiotic stresses. …”
Get full text

RamA upregulates the ATP-binding cassette transporter mlaFEDCB to mediate resistance to tetracycline-class antibiotics and the stability of membranes in Klebsiella pneumoniae by Xiaoyu Zhao, Yixin Zhang, Mohan Ju, Yang Yang, Haoqi Liu, Xiaohua Qin, Qingqing Xu, Min Hao

“…ABSTRACT RamA is an intrinsic regulator in Klebsiella pneumoniae, belonging to the AraC family of transcription factors and conferring a multidrug resistance phenotype, especially for tetracycline-class antibiotics. …”
Get full text

Inhibition of programmed cell death by melanoma cell subpopulations reveals mechanisms of melanoma metastasis and potential therapeutic targets by Yuepeng An, Fu Zhao, Hongling Jia, Siyu Meng, Ziwei Zhang, Shuxiao Li, Jiusi Zhao

“…Through analyzing metabolic pathways, stemness genes, and transcription factors (TFs) among cells in different phases (G1, G2/M, and S) as well as between primary and metastatic foci cells, we investigated the specific mechanisms underlying melanoma metastasis. …”
Get full text

Integrative bioinformatic approach reveals novel melatonin-related biomarkers for Alzheimer’s disease by Hua-xiong Zhang, Dilmurat Hamit, Qing Li, Xiao Hu, San-feng Li, Fu Xu, Ming-yuan Wang, Guo-qing Bao, Hong-yan Li

“…Moreover, T helper type 17 cells, natural killer cells and CD56dim natural killer cells were significantly correlated with biomarkers. Transcription factors (GATA2, POU2F2, NFKB1, etc.) can regulate the expression of biomarkers. …”
Get full text

Comparative transcriptomic analysis and identification of candidate genes related to Verticillium wilt resistance in Gossypium barbadense and Gossypium hirsutum by Jieyin Zhao, Xingui Hu, Yuxiang Wang, Jiaxin Lu, Wenju Gao, Xuening Su, Quanjia Chen, Yanying Qu

“…A total of 18,138 differentially expressed genes (DEGs), including 1470 transcription factors (TFs). Further analysis of the expression of hormone biosynthesis- and signal transduction-related genes revealed that most of the genes in the salicylic acid (SA), jasmonic acid (JA) and ethylene (ET) biosynthesis pathways were highly expressed in Hai7124; the expression of SA and JA biosynthesis genes began to be significantly upregulated in the early stage of Verticillium wilt stress, while the expression of ET biosynthesis genes was upregulated mainly in the later stage. …”
Get full text

Genome-wide identification and expression analysis of phytochrome gene family in Aikang58 wheat (Triticum aestivum L.) by Zhu Yang, Zhu Yang, Wenjie Kan, Wenjie Kan, Ziqi Wang, Caiguo Tang, Yuan Cheng, Yuan Cheng, Dacheng Wang, Dacheng Wang, Yameng Gao, Lifang Wu, Lifang Wu

“…Additionally, the least absolute shrinkage and selection operator (LASSO) regression algorithm in machine learning was used to screen transcription factors such as bHLH, WRKY, and MYB that influenced the expression of TaAkPHY genes. …”
Get full text

Investigating intra‐tumoural heterogeneity and microenvironment diversity in primary cardiac angiosarcoma through single‐cell RNA sequencing by Jingyuan Huo, Zhen Wang, Wenting Zhao, Miao Chen, Haoyang Li, Fengpu He, Xiao Tian, Yaqi Ma, Firyuza Husanova, Liang Ma, Yiming Ni, Hongda Ding, Weidong Li, Hongfei Xu

“…The SCENIC analysis identified three primary transcription factors' clusters (CEBPB, MYC and TAL1). T‐cell subset analysis showed exhausted antigen‐specific T‐cells, complicating the efficacy of immune checkpoint blockade. …”
Get full text

Lower Circulating miR-122 Level in Patients with HNF1A Variant-Induced Diabetes Compared with Type 2 Diabetes by Xiuting Huang, Siqian Gong, Yumin Ma, Xiaoling Cai, Lingli Zhou, Yingying Luo, Meng Li, Wei Liu, Simin Zhang, Xiuying Zhang, Qian Ren, Yu Zhu, Xianghai Zhou, Rui Zhang, Ling Chen, Xueying Gao, Fang Zhang, Yanai Wang, Xueyao Han, Linong Ji

“…miR-122, the expression of which is regulated by several transcription factors, such as HNF1A, was recently reported to be associated with type 2 diabetes (T2DM) and hepatocellular carcinoma. …”
Get full text

Integrated physiological and transcriptomic analysis uncovers the mechanism of moderate nitrogen application on promoting the growth and (-)-borneol accumulation of Blumea balsamif... by Yuan Yuan, Wei-Jie Tang, Wei-Jie Tang, Jia-Yuan Cao, Ke Zhong, Ke Zhong, Ze-Jun Mo, Ying Zhou, Yu-Xin Pang, Yu-Xin Pang

“…Moreover, potential transcription factors (TFs) that may link N nutrition with the synthesis of medicinal components were identified. …”
Get full text

MAZ-mediated tumor progression and immune evasion in hormone receptor-positive breast cancer: Targeting tumor microenvironment and PCLAF+ subtype-specific therapy by Gaofeng Ni, Yuwei Sun, Hongling Jia, Zhikai Xiahou, Yumeng Li, Fu Zhao, Hongyan Zang

“…The pySCENIC package was utilized to analyze transcription factors regulatory networks in the identified tumor cell subtypes. …”
Get full text

A murine model of acute and prolonged abdominal sepsis, supported by intensive care, reveals time-dependent metabolic alterations in the heart by Bart Jacobs, Inge Derese, Sarah Derde, Sarah Vander Perre, Lies Pauwels, Greet Van den Berghe, Jan Gunst, Lies Langouche

“…Key metabolic transcription factors PPARα and PGC-1α were downregulated in acute, but upregulated in prolonged, sepsis (p ≤ 0.05 for both). …”
Get full text

Identification of WDR74 and TNFRSF12A as biomarkers for early osteoarthritis using machine learning and immunohistochemistry by Yiwei Chen, Yiwei Chen, Jiali Lin, Detong Shi, Yu Miao, Yu Miao, Feng Xue, Feng Xue, Kexin Liu, Kexin Liu, Xiaotao Wang, Changqing Zhang, Changqing Zhang

“…The ChEA3 database was utilized to predict the transcription factors regulated by core ubiquitination-related genes. …”
Get full text

Development of the early fetal human thalamus: from a protomap to emergent thalamic nuclei by Maznah Alhesain, Ayman Alzu’bi, Ayman Alzu’bi, Ayman Alzu’bi, Niveditha Sankar, Niveditha Sankar, Charles Smith, Charles Smith, Janet Kerwin, Ross Laws, Susan Lindsay, Gavin J. Clowry

“…This was also the case for post-mitotic transcription factors ZIC4, GBX2, FOXP2 and OTX2 which marked thalamic boundaries but also exhibited opposing gradients with ZIC4 expression higher anterior/lateral, and GBX2, FOXP2 and OTX2 higher in posterior/medial. …”
Get full text