Transcriptomic data reveals MYC as an upstream regulator in laying hen follicular recruitment by Ashley E Kramer, Kathryn M Ellwood, Nicole Guarino, Cong-Jun Li, Aditya Dutta

“…The study highlights the intricate regulatory network involving MYC and other transcription factors such as CTNNB1, crucial for follicular development. …”
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Comparative Transcriptome Analysis Reveals Molecular Defensive Mechanism of Arachis hypogaea in Response to Salt Stress by Hao Zhang, Xiaobo Zhao, Quanxi Sun, Caixia Yan, Juan Wang, Cuiling Yuan, Chunjuan Li, Shihua Shan, Fengzhen Liu

“…Of these DEGs, 141 transcription factors (TFs) mainly consisting of MYB, AP2/ERF, WRKY, bHLH, and HSF were identified in response to salinity stress. …”
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Changing of expression actinbinding proteins in the kidney under dehydration by I. I. Khegay

“…The most probable molecular mechanism of changing the expression of the genes for alpha-actinin and tropomyosin is transduction of the V2-mediated vasopressin hormonal signal to protein kinase A, phosphorylation of the cAMPresponsible transcriptional factor CREB, and nuclear CREB interaction with gene CRE sites sensitive to it.…”
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Elotuzumab Enhances CD16-Independent NK Cell-Mediated Cytotoxicity against Myeloma Cells by Upregulating Several NK Cell-Enhancing Genes by Yan-Hua Wang, Shotaro Hagiwara, Hiroshi Kazama, Yuki Iizuka, Norina Tanaka, Junji Tanaka

“…The enhanced NK cell function could also be attributed to the increased expression of the transcription factors T-BET and EOMES. Furthermore, the augmentation of the antitumor effects of CD16-independent NK cells upon pretreatment with Elo enhanced the expression of CRTAM, TNFRSF9, EAT-2, and FOXP3 genes and reduced the expression of HSPA6. …”
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Metastatic melanoma: An integrated analysis to identify critical regulators associated with prognosis, pathogenesis and targeted therapies. by Zeinab Chaharlashkar, Yousof Saeedi Honar, Meghdad Abdollahpour-Alitappeh, Sepideh Parvizpour, Abolfazl Barzegar, Effat Alizadeh

“…After exploration of DEGs of NS and metastatic-melanoma, identification of relevant transcription factors (TFs) and kinases, the Gene Ontology (GO), and pathways analyses of DEGs were performed. …”
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Transcriptional Activity of PGC-1α and NT-PGC-1α Is Differentially Regulated by Twist-1 in Brown Fat Metabolism by Hee-Jin Jun, Thomas W. Gettys, Ji Suk Chang

“…Brown fat expresses two PGC-1α isoforms (PGC-1α and NT-PGC-1α) and both play a central role in the regulation of cellular energy metabolism and adaptive thermogenesis by interacting with a wide range of transcription factors including PPARγ, PPARα, ERRα, and NRF1. …”
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Genetic Analysis of Cytokine Promoters in Nonhuman Primates: Implications for Th1/Th2 Profile Characteristics and SIV Disease Pathogenesis by Pavel Bostik, Melanie Watkins, Francois Villinger, Aftab A. Ansari

“…In addition, several variable regions within the promoters of IL-12 p40, IL-10 and TNF-alpha in the two species contain polymorphisms in sequences that constitute binding sites of known transcription factors (TF). Such differences are likely to differentially bind TF and thus either qualitatively and/or quantitatively affect the regulation of cytokine synthesis in these two species and potentially contribute to disease progression and/or resistance.…”
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Differentially Expressed MicroRNAs in the Development of Early Diabetic Retinopathy by Qiaoyun Gong, Jia’nan Xie, Yang Liu, Ying Li, Guanfang Su

“…Therefore, miRNA modulation and the targeting of miRNA effects on transcription factors could represent novel and effective DR-treatment strategies.…”
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α-Lipoic Acid Inhibits Helicobacter pylori-Induced Oncogene Expression and Hyperproliferation by Suppressing the Activation of NADPH Oxidase in Gastric Epithelial Cells by Eunyoung Byun, Joo Weon Lim, Jung Mogg Kim, Hyeyoung Kim

“…The aim of this study is to investigate the effect of α-LA on H. pylori-induced hyperproliferation and oncogene expression in gastric epithelial AGS cells by determining cell proliferation (viable cell numbers, thymidine incorporation), levels of reactive oxygen species (ROS), NADPH oxidase activation (enzyme activity, subcellular levels of NADPH oxidase subunits), activation of redox-sensitive transcription factors (NF-κB, AP-1), expression of oncogenes (β-catenin, c-myc), and nuclear localization of β-catenin. …”
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Cytogenetic impact of gamma radiation and its effects on growth, yield and drought tolerance of maize (Zea mays L.) by Walaa M. Al-Sayed, Hanaa H. El-Shazly, Awatif I. El-Nahas, Ahmed A. A. Omran

“…Additionally, molecular polymorphism induced by both gamma irradiation and drought stress was analyzed using Real-Time quantitative PCR techniques for DREB2, ERF, and EF transcription factors. Also, under a field condition experiment, maize plants were subjected to the same gamma irradiation doses and drought stress by reducing the number of irrigations, with subsequent evaluations of yield attributes to assess the overall impact of treatments on plant performance. …”
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Integrated Metabolome and Transcriptome Analysis Uncovers the Role of Anthocyanin Metabolism in Michelia maudiae by Xiaoan Lang, Na Li, Lingfei Li, Shouzhou Zhang

“…Additionally, several coloration-related repressor R2R3-MYB transcription factors showed different expression levels in the tepals of the rubellis mutant. …”
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Comparative gametogenesis and genomic signatures associated with pollen sterility in the seedless mutant of grapevine by Siddhi Chavan, Satish Phalake, Sujata Tetali, Vitthal T. Barvkar, Ravindra Patil

“…Conclusion The study showed the downregulation of transcription factors and their target genes involved in cell division, gibberellin biosynthesis and signalling, cell wall development, organization, and pollen germination. …”
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Multiple Roles of the Y Chromosome in the Biology of Drosophila melanogaster by Roberto Piergentili

“…Nonetheless, a more accurate analysis reveals that this chromosome can influence several complex phenotypes: (1) it has a role in the fertility of both sexes and viability of males when over-represented; (2) it can unbalance the intracellular nucleotide pool; (3) it can interfere with the gene expression either by recruiting proteins involved in chromatin remodeling (PEV) or, to a higher extent, by influencing the expression of up to 1,000 different genes, probably by changing the availability of transcription factors; (4) it plays a major role (up to 50%) in the resistance to heat-induced male sterility; (5) it affects the behavior; and (6) it plays a role in genetic imprinting. …”
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Networking Salt Inducible Kinase 1 Regulatory Perturbations on Type 2 Diabetes- Breast Cancer Co-Morbidity Associated Molecular Bridge by Durrani I.A., John P., Bhatti A.

“…Gene mutations, and transcription factors (TF), hub proteins and microRNA (miRNA) associated with SIK1 and its protein-protein interactions (PPIs) were extracted from MuTarget and EnrichR, respectively. …”
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Comparison of Immunosuppressive and Angiogenic Properties of Human Amnion-Derived Mesenchymal Stem Cells between 2D and 3D Culture Systems by Vitale Miceli, Mariangela Pampalone, Serena Vella, Anna Paola Carreca, Giandomenico Amico, Pier Giulio Conaldi

“…However, during culture, MSCs rapidly lose the expression of key transcription factors associated with multipotency and self-renewal, as well as the ability to produce functional paracrine factors. …”
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Starch metabolism in potato <i>Solanum tuberosum</i> L. by E. M. Sergeeva, K. T. Larichev, E. A. Salina, A. V. Kochetov

“…It is a complex process, requiring the orchestrated work of many enzymes, transporter and targeting proteins, transcription factors, and other regulators. Two types of starch are recognized with regard to their biological functions. …”
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Altered Protein Structures and Neoepitopes in Lupus Neutrophils From Dysregulated Splicing of Messenger RNA by Rayan Najjar, Xiaoxing Wang, Jose Mario Bello Pineda, Hugh Alessi, Alison Bays, Robert K. Bradley, James N. Jarvis, Tomas Mustelin

“…Results Neutrophils from patients with SLE contained 521 statistically significant altered mRNA splicing events compared with healthy donor neutrophils, many of them affecting important immunologic pathways, myeloid function, transcription factors, and proteins involved in mRNA splicing. …”
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An In Vitro and In Vivo Comparison of Osteogenic Differentiation of Human Mesenchymal Stromal/Stem Cells by Jamie Mollentze, Chrisna Durandt, Michael S. Pepper

“…The osteogenic process is a complex network of transcription factors, stimulators, inhibitors, proteins, etc., and in vivo experiments are helpful in evaluating the various aspects of this osteogenic process without distractions and confounding variables. …”
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Generation of American mink induced pluripotent stem cells: a protocol by I. E. Pristyazhnyuk, A. G. Menzorov

“…Shinya Yamanaka produced induced pluripotent stem (iPS) cells from mouse fibroblasts by the use of just four transcription factors in 2006: Oct4, Klf4, Sox2, and c-Myc. …”
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Gene Expression Profiling of the Sciatic Nerve in Streptozotocin-Induced Diabetic Rats with Peripheral Neuropathy by Yiji Tu, Zenggan Chen, Feng Zhang, Zhenglin Di, Junhui Zhang, Li Cai

“…Thirteen genes were identified as the hub DEGs in the PPI network. Eleven transcriptional factors (TFs) targeting 9 of the 13 hub DEGs were predicted. …”
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