Understanding Epistatic Interactions between Genes Targeted by Non-coding Regulatory Elements in Complex Diseases by Min Kyung Sung, Hyoeun Bang, Jung Kyoon Choi

“…We showed that epistatic single-nucleotide polymorphisms (SNPs) were enriched in enhancers, as well as in DNase I footprints (the Encyclopedia of DNA Elements [ENCODE] Project Consortium 2012), which suggested that the disruption of the regulatory regions where transcription factors bind may be involved in the disease mechanism. …”
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Dual Inhibition of Activin/Nodal/TGF-β and BMP Signaling Pathways by SB431542 and Dorsomorphin Induces Neuronal Differentiation of Human Adipose Derived Stem Cells by Vedavathi Madhu, Abhijit S. Dighe, Quanjun Cui, D. Nicole Deal

“…Indeed, dual inhibition of activin/nodal/TGF-β and BMP pathways using SB431542 and dorsomorphin, respectively, induced neuronal differentiation of human adipose derived stem cells (hADSCs) as evidenced by formation of neurite extensions, protein expression of neuron-specific gamma enolase, and mRNA expression of neuron-specific transcription factors Sox1 and Pax6 and matured neuronal marker NF200. …”
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Single-cell RNA sequencing reveals tumor heterogeneity in small cell neuroendocrine cervical carcinoma by Xuesong Xiang, Xiang Tao, Keqin Hua, Hua Jiang, Jingxin Ding

“…Within four epithelial cell clusters, the key transcription factors ASCL1, NEUROD1, POU2F3, and YAP1 defined molecular subtypes. …”
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Utility of Lymphoblastoid Cell Lines for Induced Pluripotent Stem Cell Generation by Satish Kumar, Joanne E. Curran, David C. Glahn, John Blangero

“…Here, we report a new optimized LCL-to-iPSC reprogramming protocol using episomal plasmids encoding pluripotency transcription factors and mouse p53DD (p53 carboxy-terminal dominant-negative fragment) and commercially available reprogramming media. …”
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Effect of the B chromosome-located long non-coding RNAs on gene expression in maize by Xin Liu, Wenjie Yue, Shiqi Lin, Yuxian Yang, Tong Chen, Xiaowen Shi

“…Regulatory networks constructed in this study suggest that B-located lncRNAs may drive the differential expression of A chromosome-located transcription factors and genes associated with circadian rhythm regulation, indicating their regulatory role in A chromosome gene expression.…”
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KYNU as a Biomarker of Tumor-Associated Macrophages and Correlates with Immunosuppressive Microenvironment and Poor Prognosis in Gastric Cancer by Kaiyu Shen, Binyu Chen, Liu Yang, Wencang Gao

“…KYNU-overexpressing macrophages drove GC progression through unique ligand-receptor pairs and transcription factors and were associated with adverse clinical phenotypes in GC. …”
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Analysis of the Neurogenesis: Prepattern gene network сontrolling the first stage in Drosophila melanogaster bristle pattern development by D. P. Furman, T. A. Bukharina

“…They are induced by prepattern factors, identified with the transcription factors driving expression of their target genes in certain disc regions. …”
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The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis. by David G Ransom, Nathan Bahary, Knut Niss, David Traver, Caroline Burns, Nikolaus S Trede, Noelle Paffett-Lugassy, Walter J Saganic, C Anthoney Lim, Candace Hersey, Yi Zhou, Bruce A Barut, Shuo Lin, Paul D Kingsley, James Palis, Stuart H Orkin, Leonard I Zon

“…During development, hematopoietic progenitor cells in mon mutants fail to express normal levels of hematopoietic transcription factors, including gata1, and undergo apoptosis. …”
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The Maize Corngrass1 miRNA-Regulated Developmental Alterations Are Restored by a Bacterial ADP-Glucose Pyrophosphorylase in Transgenic Tobacco by Ayalew Ligaba-Osena, Kay DiMarco, Tom L. Richard, Bertrand Hankoua

“…The transcript level of miRNA156 target SQUAMOSA promoter binding-like (SPL) transcription factors was suppressed severely in Cg1-expressing lines as compared to the wild type. …”
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Unraveling the Molecular Nexus between GPCRs, ERS, and EMT by Niti Kumari, Somrudee Reabroi, Brian J. North

“…By regulating downstream signaling pathways such as NF-κB, MAPK/ERK, PI3K/AKT, TGF-β, and Wnt/β-catenin, GPCRs also upregulate mesenchymal transcription factors including Snail, ZEB, and Twist superfamilies which regulate cell polarity, cytoskeleton remodeling, migration, and invasion. …”
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A Foxf1-Wnt-Nr2f1 cascade promotes atrial cardiomyocyte differentiation in zebrafish. by Ugo Coppola, Bitan Saha, Jennifer Kenney, Joshua S Waxman

“…Nr2f transcription factors (TFs) are conserved regulators of vertebrate atrial cardiomyocyte (AC) differentiation. …”
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Potential Biomarkers and Signaling Pathways Associated with the Pathogenesis of Primary Ameloblastoma: A Systems Biology Approach by Zeynab Bayat, Azin Mirzaeian, Amir Taherkhani

“…This study aimed to determine potential signaling pathways and biological processes, critical genes and their regulating transcription factors (TFs), and miRNAs, as well as protein kinases involved in the etiology of primary ameloblastoma. …”
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Mechanisms of transcriptional regulation of ecdysone response by M. Yu. Mazina, N. E. Vorobyeva

“…Likely, certain DNA-binding transcription factors that are involved in the ecdysonedependent response together with the EcR/Usp heterodimer are responsible for cell-type specificity. …”
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Chromatin remodeling in oligodendrogenesis by E. V. Antontseva, N. P. Bondar

“…These changes require precisely spatially and temporally coordinated interactions of various transcription factors and epigenetic events that determine the regulatory landscape of chromatin. …”
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Isolation and Characterization of Multipotent Turkey Tendon-Derived Stem Cells by Qian Liu, Yaxi Zhu, Peter C. Amadio, Steven L. Moran, Anne Gingery, Chunfeng Zhao

“…Turkey TDSCs also expressed transcription factors PouV, Nanog, and Sox2, which are critically involved in the regulation of stemness. …”
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Use of a Sendai virus-based vector for effcient transduction of pinniped fbroblasts by V. R. Beklemisheva, A. G. Menzorov

“…There are several ways to deliver reprogramming transcription factors: RNA, proteins, plasmids, viral vectors etc. …”
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Proinflammatory Cytokines IL-6 and TNF-α Increased Telomerase Activity through NF-κB/STAT1/STAT3 Activation, and Withaferin A Inhibited the Signaling in Colorectal Cancer Cells by Seyung S. Chung, Yong Wu, Quincy Okobi, Debbie Adekoya, Mohammad Atefi, Orette Clarke, Pranabananda Dutta, Jaydutt V. Vadgama

“…Combined treatment of IL-6 and TNF-α phosphorylated transcription factors STAT3 in a synergistic manner. STAT3, STAT1, and NF-κB physically interacted upon the cytokine stimulation. …”
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Omega-3 Polyunsaturated Fatty Acids Enhance Neuronal Differentiation in Cultured Rat Neural Stem Cells by Masanori Katakura, Michio Hashimoto, Toshiyuki Okui, Hossain Md Shahdat, Kentaro Matsuzaki, Osamu Shido

“…In the present study, we examined the effect of eicosapentaenoic acid (EPA) and arachidonic acid (AA) on differentiation, expression of basic helix-loop-helix transcription factors (Hes1, Hes6, and NeuroD), and the cell cycle of cultured NSCs. …”
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Novel histone deacetylase-5 inhibitor T2943 exerts an anti-depressive effect in mice by enhancing GRID1 expression by Juan Du, Ruyun Liu, Lin Ma, Yue Liu, Wei Wei, Ning Liu, Qiuhua Cao, Jianqiang Yu

“…This modification loosens the chromatin structure, allowing transcription factors to bind to the Grid1 promoter region and enhance its transcription and expression. …”
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Differentiation-Associated MicroRNA Alterations in Mouse Heart-Derived Sca-1+CD31− and Sca-1+CD31+ Cells by Qiong Wu, Jinxi Zhan, Yun Li, Xiaoxia Wang, Lu Xu, Juan Yu, Shiming Pu, Zuping Zhou

“…In particular, mmu-miR-322-5p had more targeted and inversely associated genes and transcription factors and might have higher potential for CSC/CPCs differentiation.…”
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