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Transcription factor networks de-liver insight into improving organoid-derived hepatocyte culture
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Targeting immune cellular populations and transcription factors: unraveling the therapeutic potential of JQF for NAFLD
Published 2025-01-01“…Further SCENIC analysis additionally uncovered the essential transcription factors that regulate these cell subclusters, such as Stat2, Mta3, Eomes, and Etv5.ConclusionOverall, our research suggests a promising potential therapeutic agent and identifies critical cell populations and transcription factors that contribute to its therapeutic effects, thereby revealing potential therapeutic targets for NAFLD.…”
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Human-genome single nucleotide polymorphisms affecting transcription factor binding and their role in pathogenesis
Published 2023-11-01Subjects: Get full text
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Circular RNA circ-Olfm1 induces progression of Alzheimer’s disease by regulating FOXO3a
Published 2025-01-01Subjects: Get full text
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Maneuvering the role of midnolin in oral cancer
Published 2024-03-01Subjects: Get full text
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Mutations to transcription factor MAX allosterically increase DNA selectivity by altering folding and binding pathways
Published 2025-01-01“…Towards this end, we study how variants of the promiscuous transcription factor (TF) MAX (H. sapiens) alter DNA specificity and selectivity, yielding >1700 K ds and >500 rate constants in complex with multiple DNA sequences. …”
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Genome-wide identification, characterization, and expression analysis of BZR transcription factor family in Gerbera hybrida
Published 2025-02-01Subjects: “…BZR transcription factor…”
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The GbbZIP41 transcription factor participates in terpene trilactones biosynthesis in Ginkgo biloba L.
Published 2025-03-01“…Here, we screened the transcription factor GbbZIP41 that may be involved in the biosynthesis of TTLs and verified its function by transgenic technology. …”
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Identification and characteristics of MYB4 transcription factor related to regulation of abiotic stress tolerance in peanut
Published 2024-06-01“….), an economically valuable crop, provides protein and oil for human and animal consumption. The transcription factor MYB4 has been identified as a potential drought tolerance gene in peanut. …”
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Establishment of a CRISPR-Based Lentiviral Activation Library for Transcription Factor Screening in Porcine Cells
Published 2024-12-01Subjects: Get full text
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Graph pangenome reveals the regulation of malate content in blood-fleshed peach by NAC transcription factors
Published 2025-01-01“…Pangenome analysis reveals a long terminal repeat retrotransposon insertion in the promoter of the NAC transcription factor (TF) PpBL in blood-fleshed peaches, which enhances PpBL expression. …”
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Footprint-C reveals transcription factor modes in local clusters and long-range chromatin interactions
Published 2024-12-01“…Here we present Footprint-C, which yields high-resolution chromatin contact maps built upon intact and genuine footprints protected by transcription factor (TF) binding. When analyzed at one-dimensional level, the billions of chromatin contacts from Footprint-C enable genome-wide analysis at single footprint resolution, and reveal preferential modes of local TF co-occupancy. …”
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The glucose-sensing transcription factor MLX balances metabolism and stress to suppress apoptosis and maintain spermatogenesis.
Published 2021-10-01“…Here, we show that the glucose-sensing transcription factor (TF) MAX-Like protein X (MLX) and its binding partner MondoA are both required for male fertility in the mouse, as well as survival of human tumor cells derived from the male germ line. …”
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Significance of Glutathione Peroxidase 1 and Caudal-Related Homeodomain Transcription Factor in Human Gastric Adenocarcinoma
Published 2013-01-01“…To investigate the expressions of glutathione peroxidase 1 (GPX1) and caudal-related homeodomain transcription factor (CDX2) in GAC and their correlation with clinicopathological features and tumor cell proliferation. …”
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RLS-associated MEIS transcription factors control distinct processes in human neural stem cells
Published 2024-11-01“…Abstract MEIS1 and MEIS2 encode highly conserved homeodomain transcription factors crucial for developmental processes in a wide range of tissues, including the brain. …”
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