PPARγ and Its Agonists in Chronic Kidney Disease by Yuhua Ma, Manman Shi, Yuxin Wang, Jian Liu

“…Peroxisome proliferator-activated receptor γ (PPARγ) is one of the ligand-activated transcription factor superfamily members and is globally expressed in human tissues. …”
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Role of aryl hydrocarbon receptor in toxic effects of emerging environmental pollutants by Mingxuan ZHANG, Baoqiang FU, Jinhao LI, Kang WANG, Yan JIANG, Tao CHEN

“…The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor traditionally known to be activated by dioxins and polycyclic aromatic hydrocarbons (PAHs) and is involved in the metabolism of exogenous chemicals. …”
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Natural regulatory T cells increase significantly in pediatric patients with parasitic infections: Flow cytometry study by Nadeem Kizilbash, Nida Suhail, A. Khuzaim Alzahrani, W. Jamith Basha, Mohamed Soliman

“…Background: The most accepted definition of regulatory T cells (Tregs) relies on the expression of several biomarkers, including CD4, CD25, and transcription factor, Foxp3. The Tregs maintain tolerance to self-antigens and prevent autoimmune diseases. …”
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Decitabine-Induced Changes in Human Myelodysplastic Syndrome Cell Line SKM-1 Are Mediated by FOXO3A Activation by Wen Zeng, Hanjun Dai, Ming Yan, Xiaojun Cai, Hong Luo, Min Ke, Zeming Liu

“…We investigated the effects of DAC treatment on the myeloid MDS cell line SKM-1 and investigated the role of FOXO3A, a potentially tumor-suppressive transcription factor, by silencing its expression prior to DAC treatment. …”
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Regulation of modular Cyclin and CDK feedback loops by an E2F transcriptionoscillator in the mammalian cell cycle by Orit Lavi, Doron Ginsberg, Yoram Louzoun

“…The cell cycle is regulated by a large number of enzymes and transcription factors. We have developed a modular description of the cell cycle, based on a set of interleaved modular feedback loops, each leading to a cyclic behavior. …”
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Role of BMP-4 and Its Signaling Pathways in Cultured Human Melanocytes by Hee-Young Park, Christina Wu, Mina Yaar, Christina M. Stachur, Marita Kosmadaki, Barbara A. Gilchrest

“…Then the activated MAPK/ERK caused an acute phosphorylation of MITF, followed by proteosome-mediated degradation of MITF, the key transcription factor for melanogenic proteins [Wu et al. (2000) Gene & Development:14]. …”
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Urinary Bladder Adenocarcinoma Metastatic to the Abdominal Wall: Report of a Case with Cytohistologic Correlation by Vikas Nath, Mithra Baliga

“…Immunohistochemistry revealed positivity for CK7, membranous/cytoplasmic β-catenin, caudal-type homeobox transcription factor 2 (CDX2), and α-methylacyl coenzyme A racemase and negativity for CK20, p63, prostate-specific antigen (PSA), and prostate-specific acid phosphatase (PSAP). …”
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The Role of the Enterohepatic Circulation of Bile Salts and Nuclear Hormone Receptors in the Regulation of Cholesterol Homeostasis: Bile Salts as Ligands for Nuclear Hormone Recept... by Richard N Redinger

“…The coordinated effect of lipid activated nuclear hormone receptors; liver X receptor (LXR), bound by oxysterol ligands and farnesoid X receptor (FXR), bound by bile acid ligands, act as genetic transcription factors to cause feed-forward cholesterol catabolism to bile acids and feedback repression of bile acid synthesis, respectively. …”
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Sodium aescinate-induced hepatotoxicity via ATF4/GSH/GPX4 axis-mediated ferroptosis by Chen Xi, Jie Zhou, Xin Zheng, Xiaoyi Fu, Minjuan Xie

“…In addition, SA inhibited transcriptional activity of activating transcription factor 4 (ATF4) and subsequently reduced the expression of the downstream genes xCT (solute carrier family 7a member 11, SLC7A11) and Cystathionine gamma-lyase (CTH) which play vital roles in GSH biosynthesis. …”
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Genome-wide association study and candidate gene identification for the cold tolerance at the seedling stage of rapeseed (Brassica napus L.) by Guangyu Wu, Yanda Zhou, Jingyi Zhang, Mengjie Gong, Lixi Jiang, Yang Zhu

“…A genome-wide association study (GWAS) of cold tolerance grades identified four significant loci in the genomic region of one MYB transcription factor BnaA8.MYB60. Furthermore, field accessions with BnaA8.MYB60 Hap1 exhibited significantly higher cold tolerance and lower expression of BnaA8.MYB60 compared to the majority of accessions with BnaA8.MYB60 Hap2. …”
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The Nrf2/ARE Pathway: A Promising Target to Counteract Mitochondrial Dysfunction in Parkinson's Disease by Kemal Ugur Tufekci, Ezgi Civi Bayin, Sermin Genc, Kursad Genc

“…Nrf2 activates the antioxidant response element (ARE) pathway, including a battery of cytoprotective genes such as antioxidants and anti-inflammatory genes and several transcription factors involved in mitochondrial biogenesis. …”
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HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo. by Yorifumi Satou, Jun-Ichirou Yasunaga, Tiejun Zhao, Mika Yoshida, Paola Miyazato, Ken Takai, Kei Shimizu, Koichi Ohshima, Patrick L Green, Naganari Ohkura, Tomoyuki Yamaguchi, Masahiro Ono, Shimon Sakaguchi, Masao Matsuoka

“…Approximately 60% of ATL cases indeed harbor leukemic cells that express FoxP3, a key transcription factor for T(reg) cells. HTLV-1 encodes an antisense transcript, HTLV-1 bZIP factor (HBZ), which is expressed in all ATL cases. …”
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System Review about Function Role of ESCC Driver Gene KDM6A by Network Biology Approach by Jihua Ran, Hui Li, Huiwu Li

“…The biology themes of clusters 1, 2, and 3 are chromatin modification, regulation of gene expression by transcription factor complex, and control of cell cycle, respectively. …”
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Regulation of meristem and hormone function revealed through analysis of directly-regulated SHOOT MERISTEMLESS target genes by Tamara Lechon, Nicholas A. Kent, James A. H. Murray, Simon Scofield

“…Abstract The Arabidopsis Knotted1-like homeobox (KNOX) gene SHOOT MERISTEMLESS (STM) encodes a homeodomain transcription factor that operates as a central component of the gene regulatory network (GRN) controlling shoot apical meristem formation and maintenance. …”
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Lipopolysaccharide alters CEBPβ signaling and reduces estradiol production in bovine granulosa cells by Mackenzie J. Dickson, I. Martin Sheldon, John J. Bromfield

“…Although treating granulosa cells with LPS in vitro decreases the expression of the estradiol synthesis enzyme CYP19A1 and reduces estradiol secretion, the molecular mechanisms are unclear. The transcription factor CCAAT enhancer binding protein beta (CEBPβ) not only facilitates the transcription of LPS regulated cytokines, but also binds to the promoter region of CYP19A1 in humans, mice, and buffalo. …”
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Fasting Upregulates PPAR𝛼 Target Genes in Brain and Influences Pituitary Hormone Expression in a PPAR𝛼 Dependent Manner by Bettina König, Christine Rauer, Susann Rosenbaum, Corinna Brandsch, Klaus Eder, Gabriele I. Stangl

“…PPAR𝛼 is a lipid-activable transcription factor that mediates the adaptive response to fasting. …”
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lncRNA NORAD modulates STAT3/STAT1 balance and innate immune responses in human cells via interaction with STAT3 by Amir Argoetti, Dor Shalev, Galia Polyak, Noa Shima, Hadas Biran, Tamar Lahav, Tamar Hashimshony, Yael Mandel-Gutfreund

“…Here we reveal an interaction between the lncRNA NORAD, noted for its role in DNA stability, and the immune related transcription factor STAT3 in embryonic and differentiated human cells. …”
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Activating Mutation (V617F) in the Tyrosine Kinase JAK2 is Absent in Locally-Confined or Castration-Resistant Prostate Cancer by Lei Gu, Xian-Hua Zhu, Tapio Visakorpi, Kalle Alanen, Tuomas Mirtti, Tina Bocker Edmonston, Marja T. Nevalainen

“…Background: Transcription factor Stat5a/b is highly critical for the viability of human prostate cancer cells in vitro and for prostate tumor growth in vivo. …”
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A computational and structural approach to identify malignant non-synonymous FOXM1 single nucleotide polymorphisms in triple-negative breast cancer by Prarthana Chatterjee, Satarupa Banerjee

“…Abstract The proliferation-specific oncogenic transcription factor, FOXM1 is overexpressed in primary and recurrent breast tumors across all breast cancer (BC) subtypes. …”
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Trichostatin A Promotes the Generation and Suppressive Functions of Regulatory T Cells by Cristian Doñas, Macarena Fritz, Valeria Manríquez, Gabriela Tejón, María Rosa Bono, Alejandra Loyola, Mario Rosemblatt

“…The forkhead box P3 transcription factor (Foxp3) is a crucial molecule regulating the generation and function of Tregs. …”
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