Cloning, Structural Characterization, and Phylogenetic Analysis of Flower MADS-Box Genes from Crocus (Crocus sativus L.) by Athanasios S. Tsaftaris, Alexios N. Polidoros, Konstantinos Pasentsis, Apostolos Kalivas

“…In order to uncover and understand the molecular mechanisms controlling flower development in cultivated crocus and its relative wild progenitor species, and characterize a number of crocus flower mutants, we have cloned and characterized different, full-length, cDNA sequences encoding MADS-box transcription factor proteins involved in flower formation.…”
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Inhibitors of nuclear factor kappa B cause apoptosis in cultured macrophages by E. E. Mannick, J. Mishra, J. Marque, M. Clavell, M. J. S. Miller, P. D. Oliver

“…The precise role of the transcription factor nuclear factor kappa B (NF- κB) in the regulation of cell survival and cell death is still unresolved and may depend on cell type and position in the cell cycle. …”
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Imaging Reporters for Proteasome Activity Identify Tumor- and Metastasis-Initiating Cells by Amanda C. Stacer, Hanxiao Wang, Joseph Fenner, Joseph S. Dosch, Anna Salomonnson, Kathryn E. Luker, Gary D. Luker, Alnawaz Rehemtulla, Brian D. Ross

“…Patient-derived glioblastoma cells with low proteasome activity measured by the HaloTag reporter show key phenotypes associated with tumor-initiating cells, including expression of a stem cell transcription factor, reconstitution of the original starting population, and enhanced neurosphere formation. …”
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MLLT11 siRNA Inhibits the Migration and Promotes the Apoptosis of MDA-MB-231 Breast Cancer Cells by Xiangrong Liu, Wenqi Bai, Jianrong Li, Jinfeng Ma, Yan Liu, Zhixiang Wang, Linjie Hu, Zheng Li, Dimitri Papukashvili, Nino Rcheulishvili, Fusheng Wang, Xiaoqing Lu

“…Through the bioinformatics analysis, the transcription factor 7 cofactor (MLLT11) as the target gene was obtained. …”
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Predicting CTCF cell type active binding sites in human genome by Lu Chai, Jie Gao, Zihan Li, Hao Sun, Junjie Liu, Yong Wang, Lirong Zhang

“…Our analysis reveals that transcription factors RAD21/SMC3 and chromatin accessibility are more predictive compared to sequence motifs and histone modifications. …”
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Dysregulation of REST and its target genes impacts the fate of neural progenitor cells in down syndrome by Tan Huang, Sharida Fakurazi, Pike-See Cheah, King-Hwa Ling

“…REST, the Repressor Element-1 Silencing Transcription factor, regulates the differentiation and development of neural cells. …”
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Expression of GPR43 in Brown Adipogenesis Is Enhanced by Rosiglitazone and Controlled by PPARγ/RXR Heterodimerization by Jiamiao Hu, Arong Zhou, Peter C. K. Cheung, Baodong Zheng, Shaoxiao Zeng, Shaoling Lin

“…The PPARγ/RXR heterodimerization was found to be the key transcription factor for this enhancing effect of rosiglitazone on GPR43 expression. …”
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How Bacteria-Induced Apoptosis of Intestinal Epithelial Cells Contributes to Mucosal Inflammation by Martin Hausmann

“…TNF is the major target gene of the transcription factor nuclear factor-kappa B with both pro- and anti-apoptotic effects. …”
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Functional and Practical Insights Into the Genetic Basis of Takayasu Arteritis by Desiré Casares‐Marfil, Amr H. Sawalha

“…The analysis of transcription factor motifs within TAK‐associated loci revealed enrichment of the STAT and RUNX families, both characterized by their role in immune functions and inflammatory responses. …”
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Conditional Inactivation of HIF-1 Using Intrabodies by Arjan J. Groot, Eelke H. Gort, Elsken van der Wall, Paul J. van Diest, Marc Vooijs

“…Hypoxia is a hallmark of solid cancers and triggers the transcription of genes responsible for cell survival. The transcription factor Hypoxia-Inducible Factor 1 (HIF-1) is a key regulator in this response and frequently activated in human cancer. …”
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Comparative transcriptome analysis in two contrasting genotypes for Sclerotinia sclerotiorum resistance in sunflower. by Mingzhu Zhao, Bing Yi, Xiaohong Liu, Dexing Wang, Dianxiu Song, Enyu Sun, Liangji Cui, Jingang Liu, Liangshan Feng

“…Most of DEGs were enriched in cell wall organisation, protein kinase activity, hormone, transcription factor activities, redox homeostasis, immune response, and secondary metabolism. …”
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Peroxisome Proliferator-Activated Receptor Alpha Target Genes by Maryam Rakhshandehroo, Bianca Knoch, Michael Müller, Sander Kersten

“…The peroxisome proliferator-activated receptor alpha (PPARα) is a ligand-activated transcription factor involved in the regulation of a variety of processes, ranging from inflammation and immunity to nutrient metabolism and energy homeostasis. …”
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Viral mimicry evasion: a new role for oncogenic KRAS mutations by Raymond Chen, Aobo He, Daniel D. De Carvalho

“…Oncogenic KRASG12D mutations downregulate the RNA‐binding protein DDX60 by activating the AKT signaling pathway, which inhibits STAT3, a critical transcription factor regulating DDX60 and other interferon‐stimulated genes. …”
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Comparative transcriptome analysis revealed gene expression differences in fruits between two Actinidia chinensis cultivars by Lina Guo, Kai Yan, Dan Li, Wanxing Li

“…To analyze the DEGs using functional categorization, some regulated processes were significantly changed, and 52 TF (transcription factor) families were detected. This study revealed the change in gene expression level at maturity through the analysis of DEGs data, and these data can provide valuable clues for exploring the molecular mechanism between two kiwifruit varieties, and will be helpful for molecular breeding in Actinidia plants.…”
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A Liver Transplant for Local Control in a Pediatric Patient with Metastatic TFE3-Associated Perivascular Epithelioid Cell Tumor (PEComa) to the Liver by Whayoung Lee, Josephine HaDuong, Aaron Sassoon, Tuan Dao, Ali Nael

“…Recently, a subset of these tumors has been reported to harbor Transcription Factor E3 (TFE3) gene rearrangement with distinct morphologic and immunophenotypic features. …”
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SOX2 Is Regulated Differently from NANOG and OCT4 in Human Embryonic Stem Cells during Early Differentiation Initiated with Sodium Butyrate by Ade Kallas, Martin Pook, Annika Trei, Toivo Maimets

“…Transcription factors NANOG, OCT4, and SOX2 regulate self-renewal and pluripotency in human embryonic stem (hES) cells; however, their expression profiles during early differentiation of hES cells are unclear. …”
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Neurturin Evokes MAPK-Dependent Upregulation of Egr4 and KCC2 in Developing Neurons by Anastasia Ludwig, Pavel Uvarov, Christophe Pellegrino, Judith Thomas-Crusells, Sebastian Schuchmann, Mart Saarma, Matti S. Airaksinen, Claudio Rivera

“…We have previously shown that BDNF upregulates KCC2 in immature neurons through the transcription factor Egr4. The effect of BDNF on Egr4 and KCC2 was shown to be dependent on the activation of ERK1/2. …”
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Epigenetics and Breast Cancers by An T. Vo, Richard M. Millis

“…This makes the chromatin accessible for transcription factors and enzymes.…”
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Regulation of pyroptosis by NF-κB signaling by Ling Yang, Yan Zhang, Zhuodong Chai, Yuqi Zhou, Zhenyu Li, Yinan Wei

“…Nuclear factor-κB (NF-κB), a prototypical pro-inflammatory transcription factor, plays a critical role in immune system regulation. …”
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Enrichment of rare alleles within epigenetic chromatin marks in the first intron by Shin-Sang Jo, Sun Shim Choi

“…As expected, rare alleles were found to be significantly enriched in most of the regulatory sites located in the first introns. Meanwhile, transcription factor binding sites were significantly more enriched in the 2-kb upstream regions (i.e., the regions of putative promoters of genes) than in the first introns. …”
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