The role of NF-κB in diabetic cardiomyopathy by Huang-Jun Liu, Le-Kun Gui, Han Wei, Xing-Yu Zhou, Zhen-Lan Liu, Li-Jun Jin

“…Diabetic cardiomyopathy (DCM), a major risk factor contributing to diabetes-related morbidity and mortality, manifests as a pathophysiologic condition in humans independently of coronary artery disease or hypertension. Several transcription factors intricately participate in the initiation and progression of associated processes. …”
Get full text

A Short Report on the Markov Property of DNA Sequences on 200-bp Genomic Units of ENCODE/Broad ChromHMM Annotations: A Computational Perspective by Hyun-Seok Park

“…The non-coding DNA in eukaryotic genomes encodes a language which programs chromatin accessibility, transcription factor binding, and various other activities. …”
Get full text

The involvement of Elf5 in regulating keratinocyte proliferation and differentiation processes in skin. by Anhua Hu, Maximilian E Pickup, Maryam A Lawal, Hetal J Patel, Mohammed I Ahmed

“…Here, we have identified E74-like factor 5 (Elf5) transcription factor, as a novel regulator of keratinocyte proliferation and differentiation processes in skin. …”
Get full text

NLRP3 inflammasome-modulated angiogenic function of EPC via PI3K/ Akt/mTOR pathway in diabetic myocardial infarction by Jia-Peng Li, Shu Qiu, Guang-Jie Tai, Yi-Ming Liu, Wei Wei, Meng-Meng Fu, Pan-Qi Fang, Joseph Nicolao Otieno, Tungalag Battulga, Xiao-Xue Li, Ming Xu

“…Chip and Luciferase assay revealed CEBPB regulated the transcriptional expression of Nlrp3 as a transcription factor in EPC stimulated by high glucose (HG) or advanced glycation end products (AGEs). …”
Get full text

Deciphering the safeguarding role of cysteine residues in p53 against H2O2-induced oxidation using high-resolution native mass spectrometry by Manuel David Peris-Díaz, Artur Krężel, Perdita Barran

“…Abstract The transcription factor p53 is exquisitely sensitive and selective to a broad variety of cellular environments. …”
Get full text

Midregion PTHrP and Human Breast Cancer Cells by Claudio Luparello

“…In addition, midregion PTHrP appears to be imported in the nucleoplasm of cultured MDA-MB231 cells and in vitro, it can bind chromatin of metaphase spread preparations and also an isolated 20-mer oligonucleotide, thereby appearing endowed with a putative transcription factor–like DNA-binding ability. The object of this review is to discuss collectively and critically both precedent and more updated data obtained in the lab, the latter arising from assays on DNA status, and gene and protein expression patterns of treated cells, aiming to check whether the cytotoxicity of the peptide may result from a reprogramming of gene expression towards apoptotic death or, instead, it is to be ascribed to an unprogrammed perturbation of cell functions.…”
Get full text

New Insights into the Androgen-Targeted Therapies and Epigenetic Therapies in Prostate Cancer by Abhijit M. Godbole, Vincent C. O. Njar

“…The androgen receptor (AR), a receptor of nuclear family and a transcription factor, is the most important target in this disease. …”
Get full text

Belzutifan for the treatment of renal cell carcinoma by Xiancheng Wu, David Lazris, Risa Wong, Scott S. Tykodi

“…By inhibiting the HIF-2α transcription factor, belzutifan prevents HIF-2α from dimerizing with HIF-1β, thereby preventing the transcription of downstream oncogenes. …”
Get full text

Genetic Architecture of Transcription and Chromatin Regulation by Kwoneel Kim, Hyoeun Bang, Kibaick Lee, Jung Kyoon Choi

“…DNA microarray and next-generation sequencing provide data that can be used for the genetic analysis of multiple quantitative traits such as gene expression levels, transcription factor binding profiles, and epigenetic signatures. …”
Get full text

Diverse Roles of Inhibitor of Differentiation 2 in Adaptive Immunity by Lucille Rankin, Gabrielle T. Belz

“…The helix-loop-helix (HLH) transcription factor inhibitor of DNA binding 2 (Id2) has been implicated as a regulator of hematopoiesis and embryonic development. …”
Get full text

Resolving the Two “Bony” Faces of PPAR-γ by Beata Lecka-Czernik, Larry J. Suva

“…The adipocyte-specific transcription factor peroxisome proliferator-activated receptor-gamma (PPAR-γ) acts as a critical positive regulator of marrow adipocyte formation and as a negative regulator of osteoblast development. …”
Get full text

High-affinity promotor binding of YhaJ mediates a low signal leakage for effective DNT detection by Myeongbin Kim, Ryun Kang, Hye Min Park, Eun Bi Cho, Hye Rim Lee, Seong Eon Ryu

“…The YhaJ transcription factor responds to dinitrophenol (DNT) and its metabolic products. …”
Get full text

Genetic Associations in Acquired Immune-Mediated Bone Marrow Failure Syndromes: Insights in Aplastic Anemia and Chronic Idiopathic Neutropenia by Irene Mavroudi, Helen A. Papadaki

“…Various alleles and haplotypes of human leucocyte antigen (HLA) molecules have been implicated in the predisposition of developing the above diseases, as well as polymorphisms of inhibitory cytokines such as interferon-γ, tumor necrosis factor-α, and transforming growth factor-β1 along with polymorphisms on molecules of the immune system including the T-bet transcription factor and signal transducers and activators of transcription. …”
Get full text

Cyclin-Dependent Kinase 5/p35/p39: A Novel and Imminent Therapeutic Target for Diabetes Mellitus by Danish Ahmed, Manju Sharma

“…Inhibition of CDK5 averts the decrease of insulin gene expression through the inhibition of nuclear translocation of PDX-1 which is a transcription factor for the insulin gene. The present pieces of evidence designate that CDK5 might be a potential drug target for the regulation of glucose-stimulated insulin secretion in the treatment of diabetes mellitus.…”
Get full text

Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age. by Amanda L Kauffman, Jasmine M Ashraf, M Ryan Corces-Zimmerman, Jessica N Landis, Coleen T Murphy

“…We find that crh-1, the C. elegans homolog of the CREB transcription factor, is required for long-term associative memory, but not for learning or short-term memory. …”
Get full text

Regulatory role of PPAR in colorectal cancer by Cong Wang, Tingcong Lv, Binghui Jin, Yang Li, Zhe Fan

“…With the deepening of research, it has been revealed that PPARs, as a transcription factor, are inextricably linked to CRC. This article outlines the mechanisms by which PPARs are involved in CRC development. …”
Get full text

Review of the Structural and Dynamic Mechanisms of PPARγ Partial Agonism by Alice J. Kroker, John B. Bruning

“…PPARγ (peroxisome proliferator activated receptor γ) is a ligand activated transcription factor of the nuclear receptor superfamily that controls the expression of a variety of genes involved in fatty acid metabolism, adipogenesis, and insulin sensitivity. …”
Get full text

Unraveling the AMPK-SIRT1-FOXO Pathway: The In-Depth Analysis and Breakthrough Prospects of Oxidative Stress-Induced Diseases by Guangqi Guan, Yaoxing Chen, Yulan Dong

“…In oxidative stress conditions, AMPK, an energy sensor, activates SIRT1, which in turn stimulates the FOXO transcription factor. This cascade enhances mitochondrial function, reduces mitochondrial damage, and mitigates OS-induced cellular injury. …”
Get full text

The miR-23a/27a/24 − 2 cluster drives immune evasion and resistance to PD-1/PD-L1 blockade in non-small cell lung cancer by Hao Luo, Bin Hu, Xiang-Rong Gu, Jing Chen, Xiao-Qing Fan, Wei Zhang, Ren-Tao Wang, Xian-Dong He, Wei Guo, Nan Dai, Dan Jian, Qing Li, Cheng-Xiong Xu, Hua Jin

“…The overexpression of all miRNAs in the miR-23a/27a/24 − 2 cluster upregulated PD-L1 expression by targeting Cbl proto-oncogene B (CBLB) and downregulated MHC-I expression by increasing the level of eukaryotic initiation factor 3B (eIF3B) via the targeting of microphthalmia-associated transcription factor (MITF). In addition, we demonstrated that the expression of the miR-23a/27a/24 − 2 cluster of miRNAs is maintained in NSCLC through increased Wnt/β-catenin signaling-regulated interaction of transcription factor 4 (TCF4) and the miR-23a/27a/24 − 2 cluster promoter. …”
Get full text

The miR-1269a/PCDHGA9/CXCR4/β-catenin pathway promotes colorectal cancer invasion and metastasis by Haitao Mei, Qingshan Luo, Junyong Weng, Jialing Hao, Jinfeng Cai, Runkai Zhou, Ce Bian, Yingzi Ye, Shengzheng Luo, Yugang Wen

“…PCDHGA9’s interaction with HOXA1 downregulated CXCR4, a transcription factor, leading to accumulation of β-catenin and further promoting invasion, migration, and EMT of CRC cells. …”
Get full text