Interleukin-33 in cutaneous wound healing by Bei Liu

“…Following skin injury, IL-33 alerts immune cells via its receptor ST2, modulating the inflammatory response and acting as a nuclear transcription factor to regulate target cell function. Multiple studies have verified the vital function of IL-33 in cutaneous wound healing; however, the mechanisms remain contentious. …”
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Mechanism of <italic>Hindu Datura</italic> in the Treatment of Rheumatoid Arthritis from the Perspective of Network Pharmacology by Changlong FU, Yangyang MEI, Xihai LI, Zhiwei QIU, Changxing CHEN, Chunsong ZHENG

“…Objective:To construct the active component target of <italic>Hindu datura</italic> and the disease target of rheumatoid arthritis by using network pharmacology, to predict the specific molecular signal and pathway of <italic>hindu datura</italic> in the treatment of rheumatoid arthritis, and to analyze its potential therapeutic target and molecular mechanism.Methods:All the chemical components of <italic>hindu datura</italic> were summarized and screened through Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP)database, retrieval was performed with the preset oral bioavailability(OB)≥30%and drug like(DL)≥0.18.Uniprot database was used to screen the entire correlation basis of the effective chemical compound.After screening the disease target with"rheumatoid arthritis"as the retrieval word using GeneCards and OMIM database, the superimposed target area between the drug target of <italic>hindu datura</italic> and the disease target of rheumatoid arthritis was summarized and analyzed, and it could be used as the prediction target gene of <italic>hindu datura</italic> for treating rheumatoid arthritis.Network targets were constructed and analyzed for the exported data based on Cytoscape 3.7.1 software and STRING 7.8 database.Finally, GO functional enrichment analysis and KEGG signal pathway analysis were performed to further screen the main targets and signal pathways.Results:①Through screening and analysis, 27 effective compounds, 318 corresponding target genes and 125 predicted target genes were obtained for the treatment of rheumatoid arthritis.②The core genes in PPI network mainly included JUN, AKT1, RELA, MAPK1, etc.③GO functional enrichment analysis showed that the biological process(BP)for the treatment of rheumatoid arthritis by <italic>hindu datura</italic> mainly involves response to lipopolysaccharide, response to lipopolysaccharide, response to molecule of bacterial origin, response to metalion, response to oxidative stress, response to steroid hormone, cellular response to oxidative stress, reactive oxygen species metabolic process, response to oxygen levels, etc..The cell component(CC)consisted of membrane raft, membrane region, plasma membrane raft and presynaptic membrane; molecular functions(MF)mainly involved the nuclear receptor activity, transcription factor activity(direct ligand regulated sequence-specific DNA binding), steroid hormone receptor activity, cytokine receptors, cytokine activity, DNA-binding transcription activator activity, RNA polymeraseⅡtranscription factor binding, kinase regulator activity, receptor ligand activity, etc.The analysis of KEGG signaling pathway showed that the obvious pathway of <italic>hindu datura</italic> in the treatment of rheumatoid arthritis may involve IL-17 signaling pathway, TNF signal pathway, HIF-1signalpathway, Toll-like receptor signal pathway, etc.Conclusion:The potential mechanism of <italic>hindu datura</italic> for the treatment of rheumatoid arthritis is to exert anti-inflammatory, analgesic and antioxidant effects, which involve a number of interactive signal pathways.…”
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OsWRKY26 negatively regulates bacterial blight resistance by suppressing OsXa39 expression by Win Tun, Kieu Thi Xuan Vo, Behnam Derakhshani, Jinmi Yoon, Lae-Hyeon Cho, Kay Tha Ye Soe Win, Sang-Won Lee, Ki-Hong Jung, Jong-Seong Jeon, Gynheung An

“…In this study, we report the identification and characterization of OsWRKY26, a sucrose-inducible transcription factor, that plays a role in the plant defense responses following Xoo infection. …”
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TEAD1‐Mediated Trans‐Differentiation of Vascular Smooth Muscle Cells into Fibroblast‐Like Cells Contributes to the Stabilization and Repair of Disrupted Atherosclerotic Plaques... by Ming Zhai, Zhijun Lei, Yefei Shi, Jiayun Shi, Yanxi Zeng, Shiyu Gong, Weixia Jian, Jianhui Zhuang, Qing Yu, Mark W. Feinberg, Wenhui Peng

“…Further investigation identified TEA domain transcription factor 1 (TEAD1) as the key transcription factor driving the trans‐differentiation of VSMCs into fibroblast‐like cells. …”
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PPAR𝛾, PTEN, and the Fight against Cancer by Rosemary E. Teresi, Kristin A. Waite

“…Peroxisome proliferator-activated receptor gamma (PPAR𝛾) is a ligand-activated transcription factor, which belongs to the family of nuclear hormone receptors. …”
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PU.1 and Haematopoietic Cell Fate: Dosage Matters by Ka Sin Mak, Alister P. W. Funnell, Richard C. M. Pearson, Merlin Crossley

“…The ETS family transcription factor PU.1 is a key regulator of haematopoietic differentiation. …”
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The Beneficial Role of Nrf2 in the Endothelial Dysfunction of Atherosclerosis by Zixia Huang, Mingyue Wu, Lijin Zeng, Deming Wang

“…Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor with antioxidant effects that is strongly connected to several CVDs. …”
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A Short Report on the Markov Property of DNA Sequences on 200-bp Genomic Units of Roadmap Genomics ChromHMM Annotations: A Computational Perspective by Hyun-Seok Park

“…The non-coding DNA in eukaryotic genomes encodes a language that programs chromatin accessibility, transcription factor binding, and various other activities. …”
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Development of <i>Aspergillus oryzae</i> BCC7051 as a Robust Cell Factory Towards the Transcriptional Regulation of Protease-Encoding Genes for Industrial Applications by Sarocha Panchanawaporn, Chanikul Chutrakul, Sukanya Jeennor, Jutamas Anantayanon, Kobkul Laoteng

“…The AoPrtR protein, which is classified into the Zn(II)2-Cys6-type transcription factor family, manipulates both intra- and extracellular proteolytic enzymes. …”
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THE CHARACTERISTICS OF MIRNA BINDING SITES IN MRNA OF ZFHX3 GENE AND ITS ORTHOLOGS by A. М. Kondybayeva, A. N. Akimniyazova, S. U. Kamenova, A. Т. Ivashchenko

“…Transcription factor gene ZFHX3 is one of the candidate genes involved in stroke development. …”
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Integrated bioinformatics analysis of the effects of chronic pain on patients with spinal cord injury by Jinlong Zhang, Jinlong Zhang, Longju Qi, Yuyu Sun, Yuyu Sun, Shiyuan Chen, Jinyi Liu, Jiaxi Chen, Fangsu Yan, Wenqi Wang, Qinghua Wang, Liang Chen

“…This analysis uncovered shared pathways, proteins, transcription factor networks, hub genes, and potential therapeutic drugs. …”
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Activity-Dependent NPAS4 Expression and the Regulation of Gene Programs Underlying Plasticity in the Central Nervous System by José Fernando Maya-Vetencourt

“…Here, I discuss the role of the recently discovered neuronal-specific and activity-dependent transcription factor NPAS4 as a critical mediator of plasticity in the nervous system. …”
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Antioxidant Functions of the Aryl Hydrocarbon Receptor by Cornelia Dietrich

“…The aryl hydrocarbon receptor (AhR) is a transcription factor belonging to the basic helix-loop-helix/PER-ARNT-SIM family. …”
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Therapeutic Effects of PPARα on Neuronal Death and Microvascular Impairment by Elizabeth P. Moran, Jian-xing Ma

“…Peroxisome-proliferator activated receptor-alpha (PPARα) is a broadly expressed nuclear hormone receptor and is a transcription factor for diverse target genes possessing a PPAR response element (PPRE) in the promoter region. …”
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A Role for PPARγ in the Regulation of Cytokines in Immune Cells and Cancer by Xiao Yi Yang, Li Hua Wang, William L. Farrar

“…Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated transcription factor and a member of the nuclear receptor superfamily. …”
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Evidence for a Potential Role of Metallothioneins in Inflammatory Bowel Diseases by Anouk Waeytens, Martine De Vos, Debby Laukens

“…MTs exert a central position in zinc homeostasis, modulate the activation of the transcription factor nuclear factor (NF)-𝜅B, and serve as antioxidants. …”
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GABAergic Neuron Specification in the Spinal Cord, the Cerebellum, and the Cochlear Nucleus by Kei Hori, Mikio Hoshino

“…Although the machinery to specify GABAergic neurons was first studied in the telencephalon, identification of key molecules, such as pancreatic transcription factor 1a (Ptf1a), as well as recently developed genetic lineage-tracing methods led to the better understanding of GABAergic specification in other brain regions, such as the spinal cord, the cerebellum, and the cochlear nucleus.…”
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PPARγ and Its Role in Cardiovascular Diseases by Mini Chandra, Sumitra Miriyala, Manikandan Panchatcharam

“…Peroxisome proliferator-activated receptor Gamma (PPARγ), a ligand-activated transcription factor, has a role in various cellular functions as well as glucose homeostasis, lipid metabolism, and prevention of oxidative stress. …”
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Side-stepping the guardian of the genome: current cancer therapeutics targeting mutant p53 by Iulianna C. Taritsa, Eric T. Fossel

“…Cancer therapies have attempted to target the transcription factor p53, a gene also described as the “guardian of the genome,” for decades. …”
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The Role of Mitochondrial Damage-Associated Molecular Patterns in Chronic Neuroinflammation by Ekta Bajwa, Caitlin B. Pointer, Andis Klegeris

“…In this review, we highlight the mitochondrial DAMPs cytochrome c (CytC), mitochondrial transcription factor A (TFAM), and cardiolipin and explore their potential role in the central nervous system disorders including Alzheimer’s disease and Parkinson’s disease, which are characterized by neurodegeneration and chronic neuroinflammation.…”
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