The Beneficial Role of Nrf2 in the Endothelial Dysfunction of Atherosclerosis by Zixia Huang, Mingyue Wu, Lijin Zeng, Deming Wang

“…Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor with antioxidant effects that is strongly connected to several CVDs. …”
Get full text

A Short Report on the Markov Property of DNA Sequences on 200-bp Genomic Units of Roadmap Genomics ChromHMM Annotations: A Computational Perspective by Hyun-Seok Park

“…The non-coding DNA in eukaryotic genomes encodes a language that programs chromatin accessibility, transcription factor binding, and various other activities. …”
Get full text

Development of <i>Aspergillus oryzae</i> BCC7051 as a Robust Cell Factory Towards the Transcriptional Regulation of Protease-Encoding Genes for Industrial Applications by Sarocha Panchanawaporn, Chanikul Chutrakul, Sukanya Jeennor, Jutamas Anantayanon, Kobkul Laoteng

“…The AoPrtR protein, which is classified into the Zn(II)2-Cys6-type transcription factor family, manipulates both intra- and extracellular proteolytic enzymes. …”
Get full text

THE CHARACTERISTICS OF MIRNA BINDING SITES IN MRNA OF ZFHX3 GENE AND ITS ORTHOLOGS by A. М. Kondybayeva, A. N. Akimniyazova, S. U. Kamenova, A. Т. Ivashchenko

“…Transcription factor gene ZFHX3 is one of the candidate genes involved in stroke development. …”
Get full text

Integrated bioinformatics analysis of the effects of chronic pain on patients with spinal cord injury by Jinlong Zhang, Jinlong Zhang, Longju Qi, Yuyu Sun, Yuyu Sun, Shiyuan Chen, Jinyi Liu, Jiaxi Chen, Fangsu Yan, Wenqi Wang, Qinghua Wang, Liang Chen

“…This analysis uncovered shared pathways, proteins, transcription factor networks, hub genes, and potential therapeutic drugs. …”
Get full text

Activity-Dependent NPAS4 Expression and the Regulation of Gene Programs Underlying Plasticity in the Central Nervous System by José Fernando Maya-Vetencourt

“…Here, I discuss the role of the recently discovered neuronal-specific and activity-dependent transcription factor NPAS4 as a critical mediator of plasticity in the nervous system. …”
Get full text

Antioxidant Functions of the Aryl Hydrocarbon Receptor by Cornelia Dietrich

“…The aryl hydrocarbon receptor (AhR) is a transcription factor belonging to the basic helix-loop-helix/PER-ARNT-SIM family. …”
Get full text

Therapeutic Effects of PPARα on Neuronal Death and Microvascular Impairment by Elizabeth P. Moran, Jian-xing Ma

“…Peroxisome-proliferator activated receptor-alpha (PPARα) is a broadly expressed nuclear hormone receptor and is a transcription factor for diverse target genes possessing a PPAR response element (PPRE) in the promoter region. …”
Get full text

A Role for PPARγ in the Regulation of Cytokines in Immune Cells and Cancer by Xiao Yi Yang, Li Hua Wang, William L. Farrar

“…Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated transcription factor and a member of the nuclear receptor superfamily. …”
Get full text

Evidence for a Potential Role of Metallothioneins in Inflammatory Bowel Diseases by Anouk Waeytens, Martine De Vos, Debby Laukens

“…MTs exert a central position in zinc homeostasis, modulate the activation of the transcription factor nuclear factor (NF)-𝜅B, and serve as antioxidants. …”
Get full text

GABAergic Neuron Specification in the Spinal Cord, the Cerebellum, and the Cochlear Nucleus by Kei Hori, Mikio Hoshino

“…Although the machinery to specify GABAergic neurons was first studied in the telencephalon, identification of key molecules, such as pancreatic transcription factor 1a (Ptf1a), as well as recently developed genetic lineage-tracing methods led to the better understanding of GABAergic specification in other brain regions, such as the spinal cord, the cerebellum, and the cochlear nucleus.…”
Get full text

PPARγ and Its Role in Cardiovascular Diseases by Mini Chandra, Sumitra Miriyala, Manikandan Panchatcharam

“…Peroxisome proliferator-activated receptor Gamma (PPARγ), a ligand-activated transcription factor, has a role in various cellular functions as well as glucose homeostasis, lipid metabolism, and prevention of oxidative stress. …”
Get full text

Side-stepping the guardian of the genome: current cancer therapeutics targeting mutant p53 by Iulianna C. Taritsa, Eric T. Fossel

“…Cancer therapies have attempted to target the transcription factor p53, a gene also described as the “guardian of the genome,” for decades. …”
Get full text

The Role of Mitochondrial Damage-Associated Molecular Patterns in Chronic Neuroinflammation by Ekta Bajwa, Caitlin B. Pointer, Andis Klegeris

“…In this review, we highlight the mitochondrial DAMPs cytochrome c (CytC), mitochondrial transcription factor A (TFAM), and cardiolipin and explore their potential role in the central nervous system disorders including Alzheimer’s disease and Parkinson’s disease, which are characterized by neurodegeneration and chronic neuroinflammation.…”
Get full text

The role of NF-κB in diabetic cardiomyopathy by Huang-Jun Liu, Le-Kun Gui, Han Wei, Xing-Yu Zhou, Zhen-Lan Liu, Li-Jun Jin

“…Diabetic cardiomyopathy (DCM), a major risk factor contributing to diabetes-related morbidity and mortality, manifests as a pathophysiologic condition in humans independently of coronary artery disease or hypertension. Several transcription factors intricately participate in the initiation and progression of associated processes. …”
Get full text

A Short Report on the Markov Property of DNA Sequences on 200-bp Genomic Units of ENCODE/Broad ChromHMM Annotations: A Computational Perspective by Hyun-Seok Park

“…The non-coding DNA in eukaryotic genomes encodes a language which programs chromatin accessibility, transcription factor binding, and various other activities. …”
Get full text

Deciphering the safeguarding role of cysteine residues in p53 against H2O2-induced oxidation using high-resolution native mass spectrometry by Manuel David Peris-Díaz, Artur Krężel, Perdita Barran

“…Abstract The transcription factor p53 is exquisitely sensitive and selective to a broad variety of cellular environments. …”
Get full text

Midregion PTHrP and Human Breast Cancer Cells by Claudio Luparello

“…In addition, midregion PTHrP appears to be imported in the nucleoplasm of cultured MDA-MB231 cells and in vitro, it can bind chromatin of metaphase spread preparations and also an isolated 20-mer oligonucleotide, thereby appearing endowed with a putative transcription factor–like DNA-binding ability. The object of this review is to discuss collectively and critically both precedent and more updated data obtained in the lab, the latter arising from assays on DNA status, and gene and protein expression patterns of treated cells, aiming to check whether the cytotoxicity of the peptide may result from a reprogramming of gene expression towards apoptotic death or, instead, it is to be ascribed to an unprogrammed perturbation of cell functions.…”
Get full text

New Insights into the Androgen-Targeted Therapies and Epigenetic Therapies in Prostate Cancer by Abhijit M. Godbole, Vincent C. O. Njar

“…The androgen receptor (AR), a receptor of nuclear family and a transcription factor, is the most important target in this disease. …”
Get full text

Belzutifan for the treatment of renal cell carcinoma by Xiancheng Wu, David Lazris, Risa Wong, Scott S. Tykodi

“…By inhibiting the HIF-2α transcription factor, belzutifan prevents HIF-2α from dimerizing with HIF-1β, thereby preventing the transcription of downstream oncogenes. …”
Get full text