Pirfenidone Alleviates Choroidal Neovascular Fibrosis through TGF-β/Smad Signaling Pathway by Chuang Gao, Xin Cao, Lili Huang, Yueqi Bao, Tao Li, Yue Di, Liucheng Wu, Yu Song

“…The results of this study suggest that TGF-β2 represents a target to prevent or treat choroidal neovascular fibrosis, and PFD may provide an alternative to traditional methods for Wet Age-related macular degeneration (wAMD) treatment.…”
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Enhancing cracking resistance in semi-flexible pavements using an interfacial immersion method by Xiaoyu Liu, Kuanghuai Wu, Giovanni Giacomello, Yunpeng Yue, Fengming Ren, Xu Cai, Marco Pasetto

“…To enhance the cracking resistance of SFP, an interfacial immersion method is proposed to immerse the porous asphalt mixture (PAM) specimens using a silane coupling agent (SCA) in this paper. Compared to traditional methods. this method directly improves the crack resistance of SFP by strengthening the interface. …”
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A perspective on the current state of smartphone-based mobile applications for scar assessment by Peter Moortgat, Jill Meirte, Mieke Anthonissen, Koen Maertens, Thibau Demarbaix, Ulrike Van Daele

“…Scars can have a significant impact on the physical and psychosocial well-being, so the assessment of scars is crucial for accurate diagnosis, monitoring, and treatment. Traditionally, these assessments required specialized, bulky equipment that needed a wired connection to computers, making these assessment tools less accessible and efficient. …”
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Multi-thermal recovery layout for a sustainable power and cooling production by biomass-based multi-generation system: Techno-economic-environmental analysis and ANN-GA optimizatio... by Ma Zihao, Naeim Farouk, Pradeep Kumar Singh, Azher M. Abed, Sarminah Samad, Samah G. Babiker, Iskandar Shernazarov, Ahmed Hendy, Ahmad Almadhor, Belgacem Bouallegue, Abdul Rahman Afzal

“…Additionally, employing the sCO2 cycle provides high thermal efficiency, cost-effectiveness, and lower environmental impacts compared to traditional power generation methods. Extensive evaluations, including techno-economic and environmental analyses, confirm the system's practicality and potential for future commercial application. …”
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Comparison of the effectiveness of the helmet interface using flow meters versus the mechanical ventilator for non-invasive ventilation in patients with coronavirus disease 2019. C... by Fernanda dos Reis Ferreira, João Carlos Ferrari Correa, Eduardo Storopoli, Diego Restivo Faria, Karina Cassaro, Natália Feitosa da Hora, Raphael Ritti, Rafael Akira Becker, Simone Dal Corso, Ivan Peres Costa, Luciana Maria Malosá Sampaio

“…Introduction This study aimed to compare the effectiveness of two methods for non-invasive mechanical ventilation in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – using a helmet interface with a flow meter and positive end-expiratory pressure valve versus a traditional mechanical ventilator. Material and methods We conducted a single-center randomized clinical trial involving 100 adult SARS-CoV-2 patients in a specialized private hospital. …”
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Seed Protein Content Estimation with Bench-Top Hyperspectral Imaging and Attentive Convolutional Neural Network Models by Imran Said, Vasit Sagan, Kyle T. Peterson, Haireti Alifu, Abuduwanli Maiwulanjiang, Abby Stylianou, Omar Al Akkad, Supria Sarkar, Noor Al Shakarji

“…Convolutional neural networks (CNNs) with attention mechanisms were proposed along with traditional machine learning models based on feature engineering including Random Forest (RF) and Support Vector Machine (SVM) regression for comparative analysis. …”
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A state of the art review on geotechnical reinforcement with end life tires by M. Shariati, M. Afrazi, H. Kamyab, S. Rouhanifar, E. Toghroli, M. Safa, Sh. Chelliapan, H. Afrazi

“…The accumulation of discarded tires poses significant environmental and economic concerns globally, with traditional disposal methods often leading to environmental degradation, fire hazards, and increased land use. …”
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Development and evaluation of the recombinant BP26 protein-based C-ELISA for human brucellosis diagnosis by Yujia Xie, Shaoqing Lin, Liping Guo, Xinru Qi, Shiqi Zhao, Qichuan Pei, Yixiao Chen, Qi Wu, Yun Wang, Meixue Yao, Dehui Yin, Dehui Yin

“…This study aimed to develop and evaluate a competitive enzyme-linked immunosorbent assay (C-ELISA) utilizing monoclonal antibodies against BP26 for the diagnosis of human brucellosis, thereby providing a more accurate and specific diagnostic approach.MethodsThe study produced monoclonal antibody (mAb) against the BP26 protein through traditional mouse hybridoma technology and developed the C-ELISA method, and compared with a C-ELISA method based on LPS mAb. …”
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Transfer from long-term care to acute care and risk of new permanent cognitive or physical disability among long-term care residents in Canada: protocol for a retrospective cohort... by Sharon Kaasalainen, Daniel I McIsaac, Steven Hawken, Daniel Kobewka, Peter Tanuseputro, Amy Hsu, Robert Talarico, Colleen Webber, Ramtin Hakimjavadi, Celeste Fung, Mary M Scott, Doug Manuel, Christina Y Yin, Jackie Kierulf, Frank Molnar, Sandy Shamon, Aliza Moledina

“…We will fit marginal structural models (MSMs) to account for the known shortcomings of traditional regression modelling, such as collider bias. …”
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State Estimation in Power Systems Under False Data Injection Attack Using Total Least Squares by Bamrung Tausiesakul, Krissada Asavaskulkiet, Chuttchaval Jeraputra, Ittiphong Leevongwat, Thamvarit Singhavilai, Supun Tiptipakorn

“…For the problem size solvability point of view, the traditional low-rank methods suffer from the trivial solution caused by too many unknown convex optimization variables due to a large number of time samples, whereas the proposed TLS-based algorithms can handle a large power distribution system with a large number of time samples.…”
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The MyFlex-ζ Foot: A Variable Stiffness ESR Ankle-Foot Prosthesis by Johnnidel Tabucol, Vera G. M. Kooiman, Marco Leopaldi, Ruud Leijendekkers, Giacomo Selleri, Marcello Mellini, Nico Verdonschot, Magnus Oddsson, Raffaella Carloni, Andrea Zucchelli, Tommaso M. Brugo

“…Overall, these findings suggest MyFlex-<inline-formula> <tex-math notation="LaTeX">$\zeta $ </tex-math></inline-formula> offers adaptability and performance improvements over traditional ESR feet. With further actuation and control system development, MyFlex-<inline-formula> <tex-math notation="LaTeX">$\zeta $ </tex-math></inline-formula> could mark significant progress in prosthesis technology.…”
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Egg freshness during storage: the effect of laying hen age and shelf life prediction using a novel hybrid modeling method by Yifeng Lu, Jing Li, Zihao He, Linyun Chen, Huixin Tian, Chen Xu, Xinglian Xu, Minyi Han

“…The model used solved the problem that the traditional BP-ANN tends to fall into local minima. …”
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Design and fabrication of a device for cleaning greenhouse roofs by Ahmed Amin, Xiaochan Wang, Zhao Lianyuan, Yinyan Shi, Ren Xiaoyan, Mahmoud Okasha, Reda Hassanien Emam Hassanien

“…Dust, algae, mold, lichen, and moss accumulation on the greenhouse cover materials could hinder sun lights and decrease the internal light intensity in greenhouses. Moreover, the traditional way of cleaning greenhouse roofs using ladders is laborious and time-consuming, requires a lot of water, and puts too much pressure on the roof. …”
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The prevalence and burden of musculoskeletal disorders amongst Indigenous people in Pimicikamak, northern Manitoba, Canada: A community health survey by André Bussières, Melissa Atkinson-Graham, Jennifer Ward, Muriel Scott, Jean Moss, Patricia Tavares, Deborah Kopansky-Giles, Jacqueline Ladwig, Cheryl Glazebrook, David A. Monias, Helga Hamilton, Donald Z. Mckay, Randall Smolinski, Scott Haldeman, Sheilah Hogg-Johnson, Steven Passmore

“…Future preferred care included self-care (88.5 %), over-the- counter medication (64.6 %), seeing an allied care provider (45.4 %), a traditional healer (26.2 %), a nurse or a medical doctor (22.3 %). …”
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Puerariae Radix protects against ulcerative colitis in mice by inhibiting NLRP3 inflammasome activation by Yu Ga, Yuanyuan Wei, Qingyu Zhao, Yimeng Fan, Yannan Zhang, Zhifang Zhang, Sijia Hao, Lixia Wang, Zhifen Wang, Jinlong Han, Shuang Wu, Zhihui Hao

“…Ulcerative colitis (UC) is a common infl ammatory disease of the gastrointestinal tract. Traditional Chinese medicine (TCM) has long been used in Asia as a treatment for UC and Puerariae Radix (PR) is a reliable anti-diarrheal therapy. …”
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Game mechanics in eHealth interventions promoting self-management in young people with chronic diseases: a protocol for a systematic review and meta-analyses from the eHealth Junio... by Sanne L Nijhof, Elise van de Putte, Fernando Estévez-López, Wichor M Bramer, Lisa Levelt, Job van ’t Veer, Micah M Hrehovcsik, Valentijn Visch, Manon H. J. Hillegers, Remco C Veltkamp

“…In comparison with traditional face-to-face care, interventions delivered through the internet and related technologies (eHealth) are less stigmatising and more accessible. …”
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Interactive effect of phenylalanine with duration of diabetes on the risk of small vessel disease in Chinese patients with T2DM by Jun Zheng, Wei Zhang, Yu-Yang Miao, Xue-Rui Li, Wei-Ming Luo, Xi-Lin Yang, Zhong-Ze Fang, Qiang Zhang

“…The inclusion of phenylalanine and duration of T2DM into a traditional risk factor model substantially increased the area under the receiver operating characteristic curve from 0.67 to 0.71 (95% CI 0.70 to 0.75) (P &lt;0.05).ConclusionsIn Chinese patients with T2DM, phenylalanine &lt;42μmol/L was associated with an increased risk of SVD, which was further amplified by a duration of T2DM of ≥5 years.…”
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Diagnostic Accuracy of Shear Wave Elastography in Predicting Malignant Origins of Pleural Effusions in Emergency Departments by Rune Wiig Nielsen, Casper Falster, Stefan Posth, Niels Jacobsen, August Emil Licht, Rahul Bhatnagar, Christian Borbjerg Laursen

“…Two index tests were applied: (i) traditional B-mode TUS examination registering the presence of diaphragmatic nodules, pleural thickenings and other findings associated with malignancy and (ii) an SWE examination of different regions of interest. …”
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Artificial intelligence-driven fuzzy logic approach for optimal well selection in gas lift design: A brown field case study by Nnaemeka Princewill Ohia, Chadi Paul, Emmanuel Asolo, Taiwo Adetomiwa Adewa, Chidimma Favour Chukwu, Paschal Ateb Ubi, Daniel Hogan Itam, Daniel Ugochukwu Nnaji

“…However, selecting suitable wells for gas lift is complex due to the inherent uncertainty and variability in petroleum production data. Traditional decision-making approaches often struggle with this uncertainty, leading to suboptimal choices that can reduce efficiency and increase operational costs. …”
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Influence of substituted quinones on the excretory function of the rat kidney and evaluation of the prospects of their use as potential diuretics by K.V. Sokolova, O.A. Podpletnya, S.О. Konovalova, A.P. Avdeenko, S.I. Kovalenko

“…However, the development of side effects during their long-term use remains a problem of traditional treatment regimens. The search for diuretics that would be aimed at inhibiting a key target molecule that is involved in the regulation of salt or water balance in the kidney, and certainly have a low level of toxicity and side effects, is an urgent task for researchers. …”
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