The efficacy and safety of a taxane-based chemotherapy regimen combined with a PD-1 inhibitor in HNSCC: a multicenter real-world study by Min Ouyang, Hanquan Sun, Xiaoyu Liu, Haijun Wu, Feilong Deng, Erdong Shen, Guozheng Peng, Hanbing Wu, Yinshan Zhao, Hui Xiong, Bin Liu, Shasha He, Ying Hu, Ping Liu

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Unveiling and validating biomarkers related to the IL-10 family in chronic sinusitis with nasal polyps: insights from transcriptomics and single-cell RNA sequencing analysis by Xinghong Liu, Yi Peng, Ling Guo, Weilan Xiong, Weijiang Liao, Jiangang Fan

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Pembingkaian Perjuangan Tanah Orang Mentawai Dalam Konflik Kehutanan by Nurhayati Nurhayati, Afrizal Afrizal, Jendrius Jendrius

“…Researchers collected and analyzed data in the form of words, human actions, interviewed Traditional Leaders, Village Heads, Sikebukkat Uma, land cultivators, and sympathizers of the Saliguma Village people. …”
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Shengxue Busui Decoction activates the PI3K/Akt and VEGF pathways, enhancing vascular function and inhibiting osteocyte apoptosis to combat steroid-induced femoral head necrosis by Manting Liu, Jiexiang Ye, Runtian Wu, Dongqiang Luo, Tao Huang, Dandan Dai, Kexin Wang, Yanping Du, Junwen Ou

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Characteristics of e-scooter and bicycle injuries at a university hospital in a large German city – a one-year analysis by Frederik Hartz, Philipp Zehnder, Tobias Resch, Gregor Römmermann, Victoria Hartmann, Markus Schwarz, Chlodwig Kirchhoff, Peter Biberthaler, Michael Zyskowski

“…Methods All patients who presented to the emergency department of our level I university trauma center after an accident involving a traditional bicycle without electric assistance or an e-scooter in 2022 were recorded. …”
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TUBA1B as a novel prognostic biomarker correlated with immunosuppressive tumor microenvironment and immunotherapy response by Juntao Qi, Juntao Qi, Mingming Zhou, Na Yang, Huiyun Ma, Min He, Gujie Wu, Chang Ge, Liuyin Jin, Lin Cheng, Wei Liao, Hefei Ren, Caiyun Lei

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A method for evaluating the accessibility of underground auxiliary transportation vehicles in coal mines based on multi feature fusion by Fan JIANG, Yifan LIU, Zhencai ZHU, Chaofan ZHANG, Gongbo ZHOU, Yuxing PENG

“…Progressive probability Hough transform and Catmull Rom spline curve with improved feature point selection are used to fit the straight track and curved track separately, forming a railway track detection method based on a switchable model; Secondly, based on the color attributes of coal mine underground tunnel wall pipelines, a pipeline feature detection strategy is constructed through HSV color space transformation, edge detection, and least squares fitting algorithms; Once again, a weighted fusion method based on pipeline and rail feature points is proposed to extract the centerline trajectory of auxiliary transportation vehicles, and to construct rules for generating safe passage areas for auxiliary transportation vehicles; Then, for the over-segmentation problem in the traditional watershed algorithm, two-dimensional edge and area feature extraction of static obstacles is carried out by using improved watershed segmentation based on markers and GraphCut algorithm, and a small-sample classification support vector mechanism is selected to build a pedestrian detection model based on the fusion of HOG (Histograms of Oriented Gradients)features and LBP(Local Binary Pattern) features for underground coal mine, so as to realize the comprehensive detection of dynamic and static obstacles in front of auxiliary transportation vehicles; Finally, the positional relationship between obstacles and safe passage area is judged by Euclidean distance to determine the obstacle invasion, and the results of auxiliary transportation vehicle passability assessment are obtained. …”
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Fufang E’jiao Jiang’s effect on immunity, hematopoiesis, and angiogenesis via a systematic “compound-effect-target” analysis by Xiang Li, Xiao Xu, Ying Dong, Shusheng Fan, Xueyang Ren, Yuan Zheng, Jiamu Ma, Feng Zhang, Qingyue Deng, Xianxian Li, Yingyu He, Mengyu Sun, Wei Liu, Mengxia Li, Qing Xia, Yan Zhang, Gaimei She

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Design of an Ultra Compact 180-Degree Ring Coupler With Harmonic Suppression Using Composite Lines for Modern RF Systems by Saeed Roshani, Farid Zubir, Mohsen Karimi, Muhammad Akmal Chaudhary, Maher Assaad, Fawwaz Hazzazi, Noorlindawaty Md Jizat, Sobhan Roshani

“…This paper presents lumped reactive capacitors and inductors to create a compact filtering hybrid ring coupler (HRC) with a broad suppression band. The traditional 180-degree ring coupler has six long <inline-formula> <tex-math notation="LaTeX">$\lambda $ </tex-math></inline-formula>/4 branches. …”
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Investigating the Role of the basic Components of Smart Governance in Realizing a Smart City with the ISM Method (Case Study: Tehran) by ALi Asghar Pourezzat, Tayebeh Abbasi, Shahryar Maghsoodi Kenari, Mohammad Mehdi Namdar Joybari

“…The focus is on understanding the specific factors that enable the transformation of a traditional city into a smart city, with a particular emphasis on the city of Tehran. …”
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Machine learning based on blood test biomarkers predicts fast progression in advanced NSCLC patients treated with immunotherapy by Jie Yang, Jian-Guo Zhou, Benjamin Frey, Hu Ma, Haitao Wang, Markus Hecht, Rainer Fietkau, Udo Gaipl, Xiaofei Chen, Ada Hang-Heng Wong, Fangya Tan, Si-Si He, Gang Shen, Yun-Jia Wang, Wenzhao Zhong

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Harmony in Diversity in Border Areas: Dayak Iban Tribe and Migrants in Badau by I Nyoman Yoga Segara, Kustini Kustini, Mustolehudin Mustolehudin, Siti Muawanah, R. Adang Nofandi

“…The primary motivation for examining the socio-cultural and religious life in Badau stems from the region's challenges, including limited religious guidance and services, the establishment of places of worship, the roles of traditional and religious leaders, and interfaith relationships. …”
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Association between the hemoglobin A1c/High-density lipoprotein cholesterol ratio and stroke incidence: a prospective nationwide cohort study in China by Chaojuan Huang, Hongtao You, Yuyang Zhang, Ligang Fan, Xingliang Feng, Naiyuan Shao

“…The predictive value of the HbA1c/HDL-C in stroke risk assessment have been significantly improved compared to the traditional HDL-C and HbA1c. Consistent associations were observed across most stratified subgroups. …”
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Nursery of bonylip barb fish Osteochilus hasselti in an aquaponics system by Yani Hadiroseyani, Iis Diatin, Miftah Fajri Faozar, Apriana Vinasyiam

“… Bonylip barb fish Osteochilus hasselti is traditionally cultivated as a by-product in a polyculture system due to the problem of seed availability. …”
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Malaria prevalence, transmission potential and efficacy of artemisinin-based combination therapy in the Kenyan Central highlands: a zone previously characterized as malaria-free by Francis T. Kimani, Kelvin K. Thiongó, Maureen A. Otinga, Lewis K. Mbabu, Mary N. Ombati, Stanley K. Kitur, Sarah A. Ochieng’, Lucy N. Wachira, Damaris K. Matoke-Muhia, Luna Kamau

“…Abstract Background The current study sought to re-evaluate malaria prevalence, susceptibility to artemisinin-based combination therapy (ACT), transmission patterns and the presence of malaria vectors in the Kikuyu area of the Kenyan Central highlands, a non-traditional/low risk malaria transmission zone where there have been anecdotal reports of emerging malaria infections. …”
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Suberosin attenuates rheumatoid arthritis by repolarizing macrophages and inhibiting synovitis via the JAK/STAT signaling pathway by Huan Liu, Qianwei Li, Yuehong Chen, Min Dong, Hongjiang Liu, Jiaqian Zhang, Leiyi Yang, Geng Yin, Qibing Xie

“…Suberosin (SBR), isolated from Plumbago zeylanica—a medicinal plant traditionally used to treat RA in Asia—possesses notable biological activities. …”
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Elevated Circulating Adipocyte-Fatty Acid Binding Protein Levels Predict Incident Ischemic Cardiovascular Events in a Longitudinal and Prospective AMI Aging Study by Zhao X, Zhao H, Chen R, Zhou J, Li N, Li J, Yan S, Liu C, Zhou P, Chen Y, Song L, Yan H

“…Initially, participants were stratified into three groups according to the tertile levels of FABP4, followed by further categorization based on various lipid profiles and specific inflammatory markers.Results: On follow-up (median 751 days, maximum 1506 days), a total of 158 ischemic events were recorded. 1) In multivariable models meticulously adjusted for age, gender, traditional coronary heart disease factors, Killip classification, and discharge medications, the association of elevated levels of FABP4 (Tertile 3 HR 1.618 [1.061 to 2.468], p=0.026), augmented concentrations of PTX3 (Tertile 3 HR 1.811 [1.211 to 2.710], p=0.004), or LL-37 (Tertile 3 HR 0.651 [0.433 to 0.981], p=0.040) with ischemic risk was markedly intensified. 2) Multivariate HRs associated with 1 standard deviation (SD) (mg/dL) increase in the FABP4 parameters were as follows in different subgroups. 1-SD difference in FABP4 was associated with a 23%, 23%, 21 and 29% increase in ischemic events over after fully adjusted the confounding risk factors among male, patients with hyperlipidemia, hypertension and diabetes respectively. 3) The Kaplan-Meier curve demonstrated significant differences between the tertiles of FABP4 index levels among all enrolled participants (p=0.0180).Conclusion: This study reinforces the utility of FABP4 for enhancing risk stratification specifically among older patients diagnosed with ST-elevation myocardial infarction.Keywords: FABP4, lipid profile, PTX3, LL-37, ischemic vascular events…”
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Building a Digital Health Research Platform to Enable Recruitment, Enrollment, Data Collection, and Follow-Up for a Highly Diverse Longitudinal US Cohort of 1 Million People in the... by Dave Klein, Aisha Montgomery, Mark Begale, Scott Sutherland, Sherilyn Sawyer, Jacob L McCauley, Letheshia Husbands, Deepti Joshi, Alan Ashbeck, Marcy Palmer, Praduman Jain

“… BackgroundLongitudinal cohort studies have traditionally relied on clinic-based recruitment models, which limit cohort diversity and the generalizability of research outcomes. …”
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Mapping mycological ignorance – checklists and diversity patterns of fungi known for West Africa by Meike Piepenbring, Jose G. Maciá-Vicente, Jean Evans I. Codjia, Carola Glatthorn, Paul Kirk, Yalemwork Meswaet, David Minter, Boris Armel Olou, Kai Reschke, Marco Schmidt, Nourou Soulemane Yorou

“…Here, information for West African countries about species diversity of fungi and fungus-like organisms (other organisms traditionally studied by mycologists) is compiled from literature and analysed in its historical context for the first time. …”
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Low versus high initial oral glucocorticoid dose for lupus nephritis: a pooled analysis of randomised controlled clinical trials by Amit Saxena, Peter Izmirly, Jill P Buyon, Cristina Sorrento, Janine Sullivan, Monica Gamez-Perez, Jammie Law, Howard Michael Belmont

“…Objective Traditional initial treatment regimens for lupus nephritis (LN) used oral glucocorticoids (GC) in starting doses up to 1.0 mg/kg/day prednisone equivalent with or without a preceding intravenous methylprednisolone pulse. …”
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