Evaluation and Comparison of Iodine-Based and Biosynthesized Gold Nanoparticles as X-Ray Contrast Agent and Their Effects on Renal Functions in Male Wistar Rats by Paul Ayanlola, Gbadebo Isola, Waidi Saka, Margaret Akinloye, Abraham Aremu, Mustapha Lawal

“…Introduction: Gold nanoparticles (AuNPs) have gained significant attention as a promising contrast agent to overcome the challenges of iodine-based contrast agents (ICAs), such as poor contrast, and renal toxicity. However, studies have associated toxicity with AuNPs synthesized through chemical methods, thereby raising concerns regarding the safety of such AuNPs. …”
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DNA-loaded targeted nanoparticles as a safe platform to produce exogenous proteins in tumor B cells by Maria Cristina Grimaldi, Sara Bozzer, Dick J. Sjöström, Dick J. Sjöström, Linnea I. Andersson, Tom Eirik Mollnes, Tom Eirik Mollnes, Per H. Nilsson, Per H. Nilsson, Luca De Maso, Federico Riccardi, Michele Dal Bo, Daniele Sblattero, Paolo Macor

“…In the human/zebrafish lymphoma xenograft model, no evidence of toxicity was observed, and targeted NPs demonstrated the capacity to enhance exogenous pDNA expression.ConclusionOur findings provide a rationale for the use of targeted NPs as a DNA delivery system for the local expression of therapeutic proteins.…”
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Impact of thoracic radiotherapy on first‐line treatment outcomes in ES‐SCLC patients by Xiaoli Mu, Yixin Zhou, Qing Liu, Jiantao Wang, Feng Xu, Feng Luo, Ke Wang, Lu Li, Panwen Tian, Yalun Li, Jiewei Liu, Yan Zhang, Jiyan Liu, Yan Li

“…Conclusions Thus, weconfirmed that the addition of tRT to the conventional regimen of first‐linechemotherapy and immunotherapy yields better survival outcomes without asignificant increase in toxicity.…”
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Anti-allergic potentials of Ceriops decandra leaves in TDI-induced allergic mice: Comprehensive in-vivo and in-silico studies by Aishwarja Dey, Subarna Rani, Rabindra Nath Acharyya, Apurba Kumar Barman, Khondoker Shahin Ahmed, Nripendra Nath Biswas, Shrabanti Dev, Asish Kumar Das

“…Here we investigated the safety and anti-allergic potential of C. decandra leaves. Method: The toxicity was screened by mortality rate, and behavioral changes in mice. …”
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CPT1 deficiency blocks autophagic flux to promote lipid accumulation induced by co-exposure to polystyrene microplastic and cadmium by Zhixuan Chen, Huayi Qu, Jian Sun, Tao Wang, Yan Yuan, Yan Yuan, Yan Yuan, Jianhong Gu, Jianhong Gu, Jianhong Gu, Jianchun Bian, Jianchun Bian, Jianchun Bian, Zongping Liu, Zongping Liu, Zongping Liu, Hui Zou, Hui Zou, Hui Zou

“…IntroductionCadmium (Cd) and polystyrene microplastics (PS-MPs), two ubiquitous environmental contaminants, produce unique synergistic toxicity when co-existing. Key unanswered questions include specific effects on liver function and potential mechanisms.MethodsIn this study, C57BL/6 mice and AML12 cells were used to establish in vivo and in vitro models to elucidate the effects of combined exposure to PS-MPs and Cd on the liver and their mechanisms.ResultsThe results showed that the combined effects of PS-MPs and Cd caused significantly more liver damage than exposure alone. …”
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PHARMACEUTICAL GELS by Syeda Yamna Zia

“…They are non-invasive, less greasy, non-toxic, and inert to food and drugs. They have minimum side effects, hence becoming a reason for increasing patient compliance and topic of interest over the last few decades. …”
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Citrus Leaf Sampling Procedures for Nutrient Analysis by Tripti Vashisth, Jamie D Burrow, Davie Kadyampakeni, Rhuanito Ferrarezi

“…These assessments help prevent any nutrient deficiency or toxicity from compromising tree health and yield or reducing revenue. …”
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Citrus Leaf Sampling Procedures for Nutrient Analysis by Tripti Vashisth, Jamie D Burrow, Davie Kadyampakeni, Rhuanito Ferrarezi

“…These assessments help prevent any nutrient deficiency or toxicity from compromising tree health and yield or reducing revenue. …”
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Successful Treatment of Fanconi Anemia and T-Cell Acute Lymphoblastic Leukemia by Terrie Flatt, Kathleen Neville, Karen Lewing, Jignesh Dalal

“…Patients are sensitive to the toxic effects of chemotherapy. We report the case of a patient with Fanconi anemia who developed T-cell acute lymphoblastic leukemia. …”
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Nonconvulsive Status Epilepticus Complicating Epstein-Barr Virus Encephalitis in a Child by Filippo Greco, Maria Donatella Cocuzza, Pierluigi Smilari, Giovanni Sorge, Lorenzo Pavone

“…Pediatric NCSE is a heterogeneous clinical entity with poor outcome and different etiologies, including central nervous system infection, stroke, toxic-metabolic syndrome, and epileptic syndrome. …”
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New Insights into Artesunate as a Pleiotropic Regulator of Innate and Adaptive Immune Cells by Lixian Lin, Zengqi Tang, Zhenrui Shi, Qing Guo, Hui Xiong

“…Artesunate, one of the derivatives of artemisinin (“qinghaosu” in Chinese), is known as an antimalarial drug with high efficiency and low toxicity. Of interest, emerging evidences suggest that artesunate also possesses an immunomodulatory effect during innate and adaptive immune responses in cell types and context-dependent manner. …”
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Arsenic Exposure and the Induction of Human Cancers by Victor D. Martinez, Emily A. Vucic, Daiana D. Becker-Santos, Lionel Gil, Wan L. Lam

“…Millions of individuals worldwide are chronically exposed through drinking water, with consequences ranging from acute toxicities to development of malignancies, such as skin and lung cancer. …”
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Is It Safe to Restart Antivascular Endothelial Growth Factor Therapy in Patients with Renal Cell Carcinoma after Cardiac Ischemia? by Bo Zhao, Laura S. Wood, Karen James, Brian I. Rini

“…Studies have shown that sunitinib and axitinib can be associated with cardiac toxicity. Whether these agents should be restarted in patients who experience cardiac ischemia remains uncertain. …”
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Abnormalities in Glutamate Metabolism and Excitotoxicity in the Retinal Diseases by Makoto Ishikawa

“…However, excessive glutamate can be toxic to retinal neurons by overstimulation of the glutamate receptors. …”
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Severe pulmonary-renal syndrome in honeybee sting envenomation – A case report by Alan Shaji, Malik Parvez, Naresh Kumar Chirumamilla, Nalin Sharma, Ashok Kumar Pannu

“…Honeybee stings with features of envenomation (either local or allergic and rarely systemic toxicity) are often seen in agriculture workers. An initial presentation with severe diffuse alveolar hemorrhage or pulmonary-renal syndrome is rare and only confined to a few case reports. …”
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Nonceliac Diaphragm Disease of the Duodenum by Hugh J Freeman

“…Further studies are needed to evaluate potential toxicity or protective effects of different ethnic diets and their relationship with the development of different intestinal diseases.…”
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The theory of oxidative stress as a direct cause of cell aging by Milagros Lisset León Regal, Raúl Cedeño Morales, Rodolfo Javier Rivero Morey, Jeisy Rivero Morey, Diana Laura García Pérez, Leissay Bordón González

“…It is concluded that oxygen which is necessary for cell viability and other exogenous substances show toxicity since they lead to the formation of free radicals whose action is the main cause of aging. …”
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Hashish Body Packing: A Case Report by Manuel Jesus Soriano-Perez, Jose Luis Serrano-Carrillo, Inmaculada Marin-Montin, Alfonso Cruz-Caballero

“…Body packers may present to the emergency department because of drug toxicity, intestinal obstruction, or more commonly, requested by law-enforcement officers for medical confirmation or exclusion of suspected body packing.…”
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Crosstalk between Gut Microbiota and Cancer Immunotherapy: Present Investigations and Future Perspective by Yuhui Tang, Qiaoting Cai, Zhi Tian, Wenkuan Chen, Hailin Tang

“…Increasing evidence unravel the intricate role of gut microbiota in reshaping tumor microenvironment and affecting the efficacy and toxicities of immunotherapy, which shed more light on the future applications of gut microbiota in efficacious biomarker and combination treatment of immunotherapy. …”
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Resveratrol and its derivates improve inflammatory bowel disease by targeting gut microbiota and inflammatory signaling pathways by Ming Li, Ping Li, Rongxue Tang, Hui Lu

“…Conventional treatments for IBD include antibiotics, immunosuppressive agents, 5-aminosalicylic acid, steroids and surgery, which have high toxic side effects. Resveratrol is a natural polyphenol, and its various derivatives have anti-oxidation and anti-inflammatory properties. …”
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