Demografic analysis of biopesticide effects on the two-spotted spider mite (Acari: Tetranychidae) following egg treatment by Međo Irena

“…These concentrations were within 95% confidence limits of the LC50s estimated in acute toxicity bioassays. The mites that hatched from treated eggs completed their juvenile development on the same leaf discs, i.e. the toxic effect was caused by topical treatment and residual exposure. …”
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Antifilarial Activity of the Methanolic Extract of Indigofera tinctoria (Fabaceae) on Bovine Parasites (Onchocerca ochengi) by Enock Enock Rakwa, Benoît Bargui Koubala, Bertrand Ndou Mando, Mathieu Djongra, Francis Nveikoueing, Dieudonné Ndjonka

“…The promising plant extract’s acute and subacute oral toxicity were evaluated on both mice and rats. The result revealed a highest antifilarial activity of the methanolic extract (LC50=12.28 μg/mL) compared to ivermectin (LC50=26.50 μg/mL) after 72 h of treatment. …”
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Computational design of potent dimeric phenylthiazole NS5A inhibitors for hepatitis C virus by Wissal Liman, Mehdi Oubahmane, Nouhaila Ait Lahcen, Ismail Hdoufane, Driss Cherqaoui, Rachid Daoud, Achraf El Allali

“…Finally, the absorption, distribution, metabolism, excretion, and toxicity analysis were performed to assess the pharmacokinetic and toxicity profiles of the inhibitor candidates. …”
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Therapeutic potential of phytocompounds of Bacopa monnieri (L.) Wettst (literature review) by O.O. Nikitina, D.S. Tsyba

“…Considering the amphiphilicity of bacosides and the non-toxicity of extracts, they can be involved in the development of various dosage forms with a wide range of therapeutic applications. …”
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Anthracycline-induced arrhythmias in breast cancer therapy: A meta-analysis of single-arm trials. by Tao Ran, Jinyao Chen, Qiurui She, Yi Mu, Min Zhang, Min Mao, Zhong Zuo, Juan Li

“…However, these anthracycline-based drugs are associated with cardiac toxicity. This study represents the first clinical quantitative analysis aimed at accurately determining the incidences of arrhythmia and abnormal electrocardiogram (ECG) changes, thereby providing valuable data to bolster clinical drug usage and monitoring.…”
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Treatment With Avacopan in Patients With Respiratory Tract Manifestations of Antineutrophil Cytoplasmic Antibody–Associated Vasculitis by Ulrich Specks, Robert F. Spiera, Lynn A. Fussner, Robert Lebovics, Sarah Bray, Rachel E. Gurlin, Darcy Trimpe, David R. W. Jayne, Peter A. Merkel, for the ADVOCATE Study Group

“…The relapse rate, glucocorticoid toxicity, and measures of HRQoL favored avacopan for both respiratory tract manifestation groups. …”
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Current status and perspectives of hematopoietic cell transplantation in patients with paroxysmal nocturnal hemoglobinuria by Marek Ussowicz, Dawid Przystupski, Patrycja Mensah-Glanowska, Agnieszka Piekarska

“…In the case of severe aplastic anemia with an associated PNH clone, immunoablative protocols based on anti-thymocyte globulin serotherapy with fludarabine and cyclophosphamide are recommended. The use of reduced toxicity protocols with fludarabine has been well-documented in patients with classic PNH. …”
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Vancomycin population pharmacokinetic models: Uncovering pharmacodynamic divergence amid clinicobiological resemblance by Peggy Gandia, Sahira Chaiben, Nicolas Fabre, Didier Concordet

“…Thus, it is fundamental to evaluate the impact of these differences on both efficacy/toxicity.…”
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Actinomycete-Derived Pigments: A Path Toward Sustainable Industrial Colorants by Blanca Hey Díez, Cristiana A. V. Torres, Susana P. Gaudêncio

“…Pigment production has a substantial negative impact on the environment, since mining for natural pigments causes ecosystem degradation, while synthetic pigments, derived from petrochemicals, generate toxic by-products that accumulate and persist in aquatic systems due to their resistance to biodegradation. …”
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Nanoformulation of Polymyxin E Through Complex Coacervation: A Pharmacokinetic Analysis by Xiaobao Chen, Li Liu, Weidan Wang, Yuan Yuan, Wei Wang

“…The positive charge inherent in PME causing its toxicity was mitigated after complex coacervation.…”
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MEDICAL AND SOCIAL CHARACTERISTICS OF MODERN INFERTILE WOMEN ACCORDING TO THE REGISTRY OF INFERTILITY COUPLES IN THE TRANSBAIKAL REGION by Татьяна Евгеньевна Белокриницкая, Наталия Ивановна Фролова, Дмитрий Владимирович Малько

“…No differences were found in frequency of such factors as regular taking medications, drinking alcohol, living near a source of toxic substances (landfill, mine, etc.). The proportion of smoking women was higher among rural residents: 19.4 % vs 34.1 % (p = 0.022). …”
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Pretreatment with serine protease inhibitors impairs Leishmania amazonensis survival on macrophages by Patrícia de Almeida Machado, Pollyanna Stephanie Gomes, Elaine Soares Coimbra, Herbert Leonel de Matos Guedes

“…The current chemotherapy available for the treatment of leishmaniasis presents several problems, such as adverse effects, toxicity, long treatment time, and parasite resistance. …”
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Understanding the Relationship Between Cerebrovascular Disease and the Gut Microbiome by William Roth, Elaine Lo, Orlando De Leon, Sajid Suriya, Farima Fakhri, James R. Brorson, Sean Polster, Tareq Kass‐Hout, Shyam Prabhakaran, James E. Siegler

“…The individualized targeting of one's microbiome, and perhaps more generalized targeting of toxic microbial metabolites, has the potential to revolutionize the treatment of vascular disease. …”
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Protective effects of resveratrol on the expression of catalase, glutathione peroxidase, and superoxide dismutase genes in the ovary and their activity in the serum of rats exposed... by Mohammad Karimian, Mozhdeh Ghadiri, Seyedeh Mahsa Poormoosavi, Hossein Najafzadehvarzi

“… Background: Lead (Pb) could be toxic to the female reproductive system, and resveratrol (Res) may overcome this toxicity. …”
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Neoadjuvant programmed death ligand-1 with chemotherapy versus chemotherapy alone for limited-stage small-cell lung cancer: a retrospective study by Zhi Yang, Yan-qing Wang, Xiujun Chang

“…There were no perioperative deaths.ConclusionsNeoadjuvant immunotherapy shows lower toxicity and fewer perioperative complications. ICI combined chemotherapy can achieve more pathological relief and clinical benefits in the neoadjuvant treatment of LS-SCLC without increased irAE and perioperative complications. …”
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Investigating the research landscape of chlorinated paraffins over the past ten decades by Chinemerem Ruth Ohoro, Chijioke Olisah, Victor Wepener

“…Despite having similar toxicity to short-chain chlorinated paraffin (SCCP), long-chain chlorinated paraffin (LCCP) has received less attention. …”
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The triphenylmethane dye brilliant blue G is only moderately effective at inhibiting amyloid formation by human amylin or at disaggregating amylin amyloid fibrils, but interferes w... by Rehana Akter, Alexander Zhyvoloup, Bingqian Zheng, Surita R Bhatia, Daniel P Raleigh

“…BBG also remodels preformed h-amylin amyloid fibrils if added in excess, however BBG has no significant effect on h-amylin induced toxicity towards cultured β-cells or cultured CHO-T cells except at high concentrations. …”
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Immunogenicity and vaccine efficacy of Actinobacillus pleuropneumoniae-derived extracellular vesicles as a novel vaccine candidate by Su Hyun Park, Yun Hye Kim, Hyeon Jin Lee, Jeong Moo Han, Byoung-Joo Seo, Gyeong-Seo Park, Chonghan Kim, Young Bae Ryu, Woo Sik Kim

“…APP-EVs predominantly elicited Th1-mediated IgG responses in immunized mice without significant liver and kidney toxicity. Contrarily, unlike Coglapix, which induced stronger Th2-mediated responses and notable toxicity. …”
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Effect of Cd–Zn compound contamination on the physiological response of broad bean and aphids by Liya Chen, Sijing Wan, Qintian Shen, Keting Zhao, Yanlan He, Yexin Xie, Shiyu Tao, Shuchang Zheng, Yi Zhang, Shigui Wang, Bin Tang, Yan Li, Yan Li

“…However, research on the toxic effect of the Cd–Zn combination is still lacking, and the underlying toxic mechanisms remain unclear.MethodsTherefore, in this experiment, we established four treatment groups with different ratios of Cd–Zn compound stress for the broad bean, Vicia faba L., and aphids, Megoura crassicauda, to explore the growth and physiological adaptation mechanisms under different levels of mixed heavy metal stress.ResultsBy measuring the germination rate, seedling height, and chlorophyll content of broad beans, we found that Cd–Zn-mixed stress has a synergistic inhibitory effect on the growth and development of broad beans. …”
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Long-Term Effects of Ozone Treatment in Patients with Persistent Numbness and Tingling Secondary to Chemotherapy-Induced Peripheral Neuropathy. A Retrospective Study by Bernardino Clavo MD, PhD, Delvys Rodríguez-Abreu MD, PhD, Saray Galván-Ruiz MD, Mario Federico MD, PhD, Angeles Cánovas-Molina RN, Yolanda Ramallo-Fariña MSc, Carla Antonilli MD, Gretel Benítez MD, Himar Fabelo BEng MSc, PhD, Carla García-Lourve RN, MRes, Damián González-Beltrán CNS, MSc, Ignacio J. Jorge MD, PhD, Francisco Rodríguez-Esparragón BSc, PhD, Gustavo M. Callico MEng, PhD

“…Before and after ozone treatment, and at 3- and 6- months after the end of treatment, they were assessed (i) the grade of CIPN-toxicity, and (ii) the self-reported decrease in numbness and tingling. …”
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