Stochastic dynamics and survival analysis of a cell population model with random perturbations by Cristina Anton, Alan Yong

“…We consider a model based on the logistic equation and linear kinetics to study the effect of toxicants with various initial concentrations on a cell population. …”
Get full text

Direct and Indirect Drug Design Approaches for the Development of Novel Tricyclic Antipsychotics: Potential 5-HT2A Antagonist by Mahantesh Namdev Jadhav, Ganesh Rajendra Kokil, Shilpa Sudhakar Harak, Sanjay Baburao Wagh

“…Given the therapeutic and toxic limitations of clinically available drugs, it is clear that there is still a need for the development of new generation antipsychotic agents with an improved clinical profile. …”
Get full text

Dynamic Analysis of DNA Damage by Flow Cytometry and FISH by Demetrios P. Matthopoulos

“…Although it is the test that can be used to assess agents' toxicity, it cannot provide information on the molecular events that result in the induction of micronuclei. …”
Get full text

Congenital Defects in Neutrophil Dynamics by Marton Keszei, Lisa S. Westerberg

“…Their high turnover rate, their fine-tuned killing machinery, and their arsenal of toxic vesicles leave them particularly vulnerable to various genetic deficiencies. …”
Get full text

Anti-VEGF Cancer Therapy in Nephrology Practice by Hassan Izzedine

“…Then, in nephrology practice, should we continue to perform kidney biopsy, and what should be done with the anti-VEGF agents in case of renal toxicity?…”
Get full text

BRAF inhibitor monotherapy in BRAFV600E-mutated pediatric low-grade glioma: a single center’s experience by S. S. McThenia, S. S. McThenia, S. S. McThenia, K. M. Reddy, K. M. Reddy, E. Damaraju, E. Castellino, Z. He, R. Beer, F. Chien, F. Chien, F. Chien, R. C. Castellino, R. C. Castellino, R. C. Castellino, A. E. Goldman-Yassen, A. E. Goldman-Yassen, J. R. Fangusaro, J. R. Fangusaro, J. R. Fangusaro, T. MacDonald, T. MacDonald, T. MacDonald

“…Overall, patients tolerated treatment well with Grade 1 rash being the most common toxicity. Two of 15 patients (13%) discontinued therapy due to toxicities, and 2 other patients switched within drug class from vemurafenib to dabrafenib due to toxicities.DiscussionIn this small cohort of incompletely resected BRAFV600E mutated pLGGs, BRAFi monotherapy was effective and well tolerated with an ORR comparable to published prospective outcomes of dual MEK/BRAF inhibitor therapy. …”
Get full text

Related Pentacyclic Triterpenes Have Immunomodulatory Activity in Chronic Experimental Visceral Leishmaniasis by Jéssica Adriana de Jesus, Márcia Dalastra Laurenti, Leila Antonangelo, Caroline Silvério Faria, João Henrique Ghilardi Lago, Luiz Felipe Domingues Passero

“…This is the first comparative work showing the in vitro activity, toxicity, and therapeutic activity of Lu and UA in the chronic model of visceral leishmaniasis caused by L. …”
Get full text

Synthesis, characterization and biological profile of some new dihydropyrimidinone derivaties by Madiha Kanwal, Humaira Nadeem, Sumra Malik, Saima Maqsood

“…The selected derivatives exhibited no toxicity profile with 99 % and 98 % cell survival rate using compound 4a and 4b. …”
Get full text

Safety profile of sacituzumab govitecan in patients with breast cancer: A systematic review and meta-analysis by Maria Inez Dacoregio, Isabella Michelon, Caio Ernesto do Rego Castro, Francisco Cezar Aquino de Moraes, Guilherme Rossato de Almeida, Lis Victória Ravani, Maysa Vilbert, Ricardo Lima Barros Costa

“…We highlight the need for protocols establishing prophylactic measures and strategies to mitigate SG-related toxicity.…”
Get full text

L-selenomethionine inhibits small intestinal ferroptosis caused by ammonia exposure through regulating ROS-mediated iron metabolism by Xinxin Zhang, Lepeng Gu, Ying Chen, Tianqi Wang, Houjuan Xing

“…However, the potential toxicity mechanism of ammonia exposure to the intestine remains unclear. …”
Get full text

Role of the two-component system AmgRS in early resistance of Pseudomonas aeruginosa to cinnamaldehyde by Eline Dubois, Vladimir Spasovski, Patrick Plésiat, Catherine Llanes

“…Altogether, these data suggest that efflux-dependent and -independent mechanisms are activated in the early phase of CNA exposure, allowing for progressive enzymatic reduction of the biocide to non-toxic cinnamic alcohol.IMPORTANCEExposure of Pseudomonas aeruginosa to cinnamaldehyde (CNA), an antimicrobial used in self-medication, induces overproduction of the MexAB-OprM efflux system, leading to multidrug resistance. …”
Get full text

Dimethomorph induces heart and vascular developmental defects by disrupting thyroid hormone in zebrafish embryos by You Wei, Yunlong Meng, Kun Jia, Weijian Lu, Yushan Huang, Huiqiang Lu

“…In this study, we utilized zebrafish as an animal model to assess the toxicity of DMT induced by exposure 5.5–72 hours post-fertilization (hpf). …”
Get full text

Ochratoxin A induces immunotoxicity by targeting Annexin A1 mediated neutrophil apoptosis in zebrafish by Yihong Zheng, Yinuo Liu, Jin Tian, Shuhong Liu, Gaowei Ma, Yupeng Xie, Chenhua Zheng, Zekai Wu

“…IntroductionOchratoxin A (OTA) is a toxic secondary metabolite produced by Aspergillus and Penicillium species, posing a significant threat to global food safety. …”
Get full text

Decitabine Compared with Low-Dose Cytarabine for the Treatment of Older Patients with Newly Diagnosed Acute Myeloid Leukemia: A Pilot Study of Safety, Efficacy, and Cost-Effectiven... by Linu A. Jacob, S. Aparna, K. C. Lakshmaiah, D. Lokanatha, Govind Babu, Suresh Babu, Sandhya Appachu

“…Our study has shown that both of these agents have similar OS and toxicity. Low-dose cytarabine scores over decitabine in developing countries as it is more cost-effective.…”
Get full text

Foliar spraying melatonin reduces the threat of chromium-contaminated water to wheat production by improving photosynthesis, limiting Cr translocation and reducing oxidative stress by Chuanjiao Sun, Libing Xu, Qiang Gao, Shuzhen Sun, Xiaoxue Liu, Zigang Zhang, Zhongwei Tian, Tingbo Dai, Jianyun Sun

“…This study aimed to investigate the effects of foliar spraying MT on alleviating Cr toxicity and accumulation in wheat irrigated with K2Cr2O7 solution at concentrations of 5, 10, and 20 mg/kg Cr in the soil. …”
Get full text

Analysing the effect of Quinalphos pesticide on fish health through molecular docking studies and their eradication by photocatalytic degradation using Fe/S/TiO2 nanocomposite by Anisha Russelraj, Sibmah Stalin, Kirupa Jino

“…Furthermore, the reduction in toxicity level of the effluent was examined by using aquatic organisms. …”
Get full text

Exploring northeast India’s culturable soil Actinomycetia for potent antibacterial agents against gram-positive bacterial pathogens of clinical importance by Aditya Narayan Konwar, Surajit Basak, Shalini Gurumayum, Jagat Chandra Borah, Debajit Thakur

“…Chemical analyses using FTIR and GC-MS identified key bioactive compounds, including Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-3-(2-methylpropyl)- and Phenol 3,5-bis(1,1-dimethylethyl), known for their antimicrobial properties. Toxicity studies against animal liver cell lines indicated that the ethyl acetate extract was non-toxic at concentrations below 125 µg/mL, compared to Vancomycin, which was found to be hepatotoxic at similar concentrations. …”
Get full text

Degradation of Benzotriazole from aqueous solutions: A synergistic effect of nano- Fe2O3@Alg-TiO2 on UV/Fe2O3@Alg-TiO2 process by Seyedeh Elahe Badiei Khairabadi, Hasan Rahmani, Mohammad Bagher Miranzadeh, Rouhullah Dehghani, Fatemeh Atoof

“…The results showed that the toxicity decreased in 200 minutes that if sufficient time is provided to complete the reaction toxicity can be reduced. …”
Get full text

Microplastics on the growth of plants and seed germination in aquatic and terrestrial ecosystems by Y.S.K. De Silva, U.M. Rajagopalan, H. Kadono

“…Several research studies have been conducted as well as reviewed to investigate the toxic effects of microplastics on aquatic systems, but studies that investigate the toxic effect of microplastics on the terrestrial systems are limited. …”
Get full text

Dimethoate Induced Behavioural Changes in Juveniles of Cyprinus carpio var. communis under Temperate Conditions of Kashmir, India by Imtiyaz Qayoom, Feroz A. Shah, Malik Mukhtar, Masood H. Balkhi, Farooz A. Bhat, Bilal A. Bhat

“…The present study was designed to investigate acute toxicity of dimethoate on juvenile Cyprinus carpio var. communis. …”
Get full text