Protection against the Phytotoxic Effect of Mercury Chloride by Catechin and Quercetin by Yedda M. L. S. de Matos, Daniel L. M. Vasconcelos, Antonio C. H. Barreto, Janaína E. Rocha, José B. de Araújo-Neto, Fábia F. Campina, Maria Milene C. da Silva, Tássia T. Al Yafawi, Celestina E. Sobral-Souza, Jacqueline C. A. Pinheiro, Saulo R. Tintino, Amanda K. Sousa, Raimundo N. P. Teixeira, Juan C. Alvarez-Pizarro, João H. da Silva, Abolghasem Siyadatpanah, Bonglee Kim, Henrique D. M. Coutinho

“…Plants when exposed to toxic levels of metals can suffer morphological or physiological damage because toxic metals can interact with several vital molecules in the plant. …”
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Preliminary efficacy and safety analysis: 12-month results in 83 patients using a novel approach of widefield radiation therapy for extensive skin field cancerization with or witho... by Andrew E. Potter, Christopher Baker, Stephen Shumack, Robert Sinclair, Walter J. Curran, David Christie, Bradley Wong, Peter Foley, Peter O’Brien, Lynda Spelman

“…The frequency of Grade 3 acute skin toxicities was low.Conclusions Registry data demonstrate the potential for widefield RT to treat patients with significant skin pathology who have exhausted other therapies and require durable, minimally invasive treatment options. …”
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The Role of AChE in Swimming Behavior of Daphnia magna: Correlation Analysis of Both Parameters Affected by Deltamethrin and Methomyl Exposure by Qing Ren, Ruibin Zhao, Cheng Wang, Shangge Li, Tingting Zhang, Zongming Ren, Meiyi Yang, Hongwei Pan, Shiguo Xu, Jianping Zhu, Xun Wang

“…The unpredictable toxicity of insecticides may cause behavior disorder of biological organisms. …”
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RETRACTED ARTICLE: A novel, bioactive and antibacterial scaffold based on functionalized graphene oxide with lignin, silk fibroin and ZnO nanoparticles by Reza Eivazzadeh-Keihan, Ensiye Zare-Bakheir, Hooman Aghamirza Moghim Aliabadi, Mostafa Ghafori Gorab, Hossein Ghafuri, Ali Maleki, Hamid Madanchi, Mohammad Mahdavi

“…As a result, the synthesized structure has a hemolysis percentage below 12% and its toxicity effect on Hu02 cells is below 9%.…”
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M1 and M2 Functional Imprinting of Primary Microglia: Role of P2X7 Activation and miR-125b by Chiara Parisi, Giulia Napoli, Pablo Pelegrin, Cinzia Volonté

“…At present, the mechanisms by which microglia actively participate to both toxic and neuroprotective actions in ALS constitute an important matter of research. …”
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Impairment of Hepatic and Renal Functions by 2,5-Hexanedione Is Accompanied by Oxidative Stress in Rats by Isaac A. Adedara, Amos O. Abolaji, Blessing E. Odion, Isioma J. Okwudi, Abiola A. Omoloja, Ebenezer O. Farombi

“…2,5-Hexanedione (2,5-HD) is the toxic metabolite of n-hexane which is widely used as solvent in numerous industries. …”
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Safety and Tolerance of Donor-Derived Mesenchymal Stem Cells in Pediatric Living-Donor Liver Transplantation: The MYSTEP1 Study by Steffen Hartleif, Michael Schumm, Michaela Döring, Markus Mezger, Peter Lang, Marc H. Dahlke, Joachim Riethmüller, Alfred Königsrainer, Rupert Handgretinger, Silvio Nadalin, Ekkehard Sturm

“…Calcineurin inhibitors (CNI) have significantly improved patient and graft survival in pediatric liver transplantation (pLT). However, CNI toxicity leads to significant morbidity. Moreover, CNIs cannot prevent long-term allograft injury. …”
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Silver nanoparticle induced immunogenic cell death can improve immunotherapy by Ara Sargsian, Xanthippi Koutsoumpou, Hermon Girmatsion, Can Egil, Kiana Buttiens, Carla Rios Luci, Stefaan J. Soenen, Bella B. Manshian

“…Here, we set out to screen a variety of metallic nanoparticles and explored their in vitro toxicity against a series of tumor and non-tumor cell lines. …”
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Traditional Uses, Bioactive Compounds, and Pharmacological Investigations of Calendula arvensis L.: A Comprehensive Review by Aya Khouchlaa, Aicha El Baaboua, Hamza El Moudden, Fatima Lakhdar, Saad Bakrim, Naoual El Menyiy, Omar Belmehdi, Hicham Harhar, Nasreddine El Omari, Abdelaali Balahbib, Moon Nyeo Park, Gokhan Zengin, Bonglee Kim, Abdelhakim Bouyahya

“…Nevertheless, pharmacokinetic validation and toxicological examinations are required to detect any possible toxicity for future clinical trials.…”
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Chemical test and cellular bioactivities and flavor enhancer properties of mung bean protein via glycation reaction by Srisukpachin Nuttakarn, Tabtimmai Lueacha, Sedtananun Saranya, Laohakunjit Natta, Sonklin Chanikan

“…MRP demonstrated both low cytotoxicity and significant anti-inflammatory effects. MRP exhibited non-toxic in Vero cells at 10 mg/mL and it significantly suppressed nitric oxide (NO) release to 18.62 µM with non-toxicity in the murine macrophage; RAW 264.7 at a concentration of 1 mg/mL.…”
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Effects and Impact of Selenium on Human Health, A Review by Song Bai, Miaohe Zhang, Shouying Tang, Miao Li, Rong Wu, Suran Wan, Lijun Chen, Xian Wei, Shuang Feng

“…Despite its critical importance to human health, the range between selenium’s nutritional and toxic doses is very narrow. Insufficient daily selenium intake can lead to selenium deficiency, while excessive intake carries the risk of selenium toxicity. …”
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Effect of the Mg/Al Ratio on Activated Sol-Gel Hydrotalcites for Photocatalytic Degradation of 2,4,6-Trichlorophenol by Esthela Ramos-Ramírez, Norma L. Gutiérrez-Ortega, Francisco Tzompantzi-Morales, Gloria A. Del Ángel, Claudia Martínez-Gómez, Elizabeth Pabón-Gelves

“…Chlorophenols are extremely toxic, especially 2,4,6-trichlorophenol, which is potentially carcinogenic. …”
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Biochemical and histopathological profiling of Wistar rat treated with Brassica napus as a supplementary feed by Kazi Md. Mahmudul Hasan, Nasrin Tamanna, Md. Anwarul Haque

“…Noticeable tissue injury observed in this study is a sign of the relative toxicity of erucic acid containing rapeseed oil to mammalian species. …”
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A CDFT-Based Computational Peptidology (CDFT-CP) Study of the Chemical Reactivity and Bioactivity of the Marine-Derived Alternaramide Cyclopentadepsipeptide by Norma Flores-Holguín, Juan Frau, Daniel Glossman-Mitnik

“…The ADMET indices confirm this assertion through the absence of toxicity and good absorption and distribution properties.…”
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Safety evaluation of the food enzyme protein‐glutamine γ‐glutamyltransferase from the non‐genetically modified Streptomyces mobaraensis strain AE‐BTG by EFSA Panel on Food Enzymes (FEZ), Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L. M. Solano, Monika Sramkova, Henk Van Loveren, Laurence Vernis, Jaime Aguilera, Magdalena Andryszkiewicz, Natalia Kovalkovicova, Giulio diPiazza, Yi Liu

“…Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by means of a repeated dose 90‐day oral toxicity study in rats. …”
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Eradication of Krebs-2 primary ascites via a single-injection regimen of cyclophosphamide and double-stranded DNA by E. A. Potter, E. V. Dolgova, A. M. Minkevich, V. P. Nikolin, N. A. Popova, Ya. R. Efremov, S. I. Baiborodin, V. A. Rogachev, A. S. Proskurina, O. S. Taranov, E. I. Vereschagin, A. A. Ostanin, E. R. Chernykh, N. A. Kolchanov, S. S. Bogachev

“…We observed an increase in the average life span of Krebs-2- transplanted mice on a single-injection regimen, which was consistent with reduced toxicity of such treatment.…”
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Exploring the microbiome-gut-testis axis in testicular germ cell tumors by Sona Ciernikova, Aneta Sevcikova, Michal Mego

“…This review explores the emerging role of the microbiome-gut-testis axis in the context of testicular cancer, highlighting its implications for disease onset, progression, treatment efficacy, and toxicity. Identifying potential microbial biomarkers, followed by microbiota modulation to restore a balanced microbial community, might offer a novel supportive strategy for improving treatment efficacy in refractory TGCT patients while reducing chemotherapy-induced toxicity. …”
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Development of Safe and Non-Self-Immunogenic Mucosal Adjuvant by Recombinant Fusion of Cholera Toxin A1 Subunit with Protein Transduction Domain by Byoung-Shik Shim, In Su Cheon, Eugene Lee, Sung-Moo Park, Youngjoo Choi, Dae-Im Jung, Eunji Yang, Jung-ah Choi, June Young Chun, Jae-Ouk Kim, Cheol-Heui Yun, Cecil Czerkinsky, Man Ki Song

“…However, native CT is highly toxic to be used as a mucosal adjuvant in humans. …”
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Antileishmanial Effect of 5,3′-Hydroxy-7,4′-dimethoxyflavanone of Picramnia gracilis Tul. (Picramniaceae) Fruit: In Vitro and In Vivo Studies by Sara M. Robledo, Wilson Cardona, Karen Ligardo, Jéssica Henao, Natalia Arbeláez, Andrés Montoya, Fernando Alzate, Juan M. Pérez, Victor Arango, Iván D. Vélez, Jairo Sáez

“…(V.) panamensis (EC50 17.0 + 2.8 mg/mL, 53.7 μM) and low toxicity on mammalian U-937 cells, with an index of selectivity >11.8. …”
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High Content Analysis of Human Pluripotent Stem Cell Derived Hepatocytes Reveals Drug Induced Steatosis and Phospholipidosis by Arvind Pradip, Daniella Steel, Susanna Jacobsson, Gustav Holmgren, Magnus Ingelman-Sundberg, Peter Sartipy, Petter Björquist, Inger Johansson, Josefina Edsbagge

“…Recent advances in differentiating human induced pluripotent stem cells (hiPSCs) into pure cultures of hepatocyte-like cells expressing functional drug metabolizing enzymes open up possibilities for novel, more relevant human cell based toxicity models. The present study aimed to investigate the use of hiPSC derived hepatocytes for conducting mechanistic toxicity testing by image based high content analysis (HCA). …”
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