Therapeutic benefit of the dual ALK/FAK inhibitor ESK440 in ALK-driven neuroblastoma by Seema Chugh, Jean C. Tien, Jennifer Hon, Carson Kenum, Rahul Mannan, Yunhui Cheng, Chi Chiang Li, Zainab I. Taher, Andrew D. Delekta, Pushpinder Singh Bawa, Ingrid J. Apel, Stephanie J. Miner, Xuhong Cao, Rohit Mehra, Saravana M. Dhanasekaran, Yuanyuan Qiao, Rajen Mody, Arul M. Chinnaiyan

“…Standard therapy involves highly toxic chemotherapy, surgery, radiation, and immunotherapy, and less toxic, more specific targeted therapies are urgently needed. …”
Get full text

Impact of the Number of Administered Systemic Treatment Lines on Local Response to Radiation Therapy for Multiple Myeloma by Andrea Emanuele Guerini, MD, Eneida Mataj, MD, Paolo Borghetti, MD, Luca Triggiani, Ludovica Pegurri, MD, Stefania Nici, Stefano Riga, Alessandra Tucci, MD, Angelo Belotti, MD, Marco Lorenzo Bonù, MD, Giorgio Facheris, MD, Stefano Maria Magrini, Luigi Spiazzi, Michela Buglione

“…Disease control after RT was optimal, and instances of severe toxicities during treatment were rare.…”
Get full text

Spatial-temporal distribution of phytoplankton HAB species and contamination status of oyster toxins under intensive oyster farming in Jiangmen coasts, the South China Sea by Jian Zou, Yayuan Xiao, Jiaqi Su, Yang Liu, Peng Wu, Teng Wang, Lin Lin, Chunhou Li, Yu Liu, Yong Liu

“…The total average abundances of toxic HAB species were 269, 265, 321 and 2.6 × 103 cells L−1 in winter, spring, summer and autumn, respectively. …”
Get full text

Long-term Prospective Comparative Analysis of Ototoxic and Survival Outcomes of Sequential Boost and Simultaneous Integrated Boost of Volumetric Modulated Arc Therapy for Head-Neck... by Nidhin Das, Sri Harsha Kombathula, Vidhu Sharma, Puneet Pareek, Kapil Soni, Amit Goyal

“…We also investigated other significant late toxicities that led to dysphagia, voice changes, and xerostomia. …”
Get full text

Social context affects tissue-specific copper distribution and behaviour of threespine stickleback (Gasterosteus aculeatus) by Sienna L. Overduin, Shaun S. Killen, Alex M. Zimmer, Jenelle D. McCuaig, Lucy Cotgrove, Isabel Aragao, Kelly J. Rozanitis, Kurt O. Konhauser, Daniel S. Alessi, Tamzin A. Blewett

“…Our results illustrate the differences in physiology and behaviour that can arise when social contexts are manipulated and stress the importance of considering sociality when conducting toxicity tests with social organisms.…”
Get full text

Salvage Magnetic Resonance Imaging–guided Transurethral Ultrasound Ablation for Localized Radiorecurrent Prostate Cancer by Mikael Anttinen, Pietari Mäkelä, Pertti Nurminen, Heikki Pärssinen, Simona Malaspina, Teija Sainio, Mikael Högerman, Pekka Taimen, Roberto Blanco Sequeiros, Peter J. Boström

“…Background and objective: Toxicity from local salvage therapy for radiorecurrent prostate cancer (PCa) remains a concern. …”
Get full text

Phytochemical Analysis, Antioxidant Activity, Antimicrobial Activity, and Cytotoxicity of Chaptalia nutans Leaves by Letiele Bruck de Souza, Amanda Leitão Gindri, Thainara de Andrade Fortes, Thais Felli Kubiça, Jefferson Enderle, Rafael Roehrs, Sidnei Moura e Silva, Vanusa Manfredini, Elton Luís Gasparotto Denardin

“…TBARS, carbonyl protein, and DCFH demonstrate that the extract has the ability to protect the cell from protein and lipid damage, as well as the inhibition of oxygen-derived radicals at the three concentrations tested: 0.1, 1, and 10 mg/mL. Regarding the toxicity of C. nutans extract against D. melanogaster, it was found that until the concentration of 15 mg/mL, the extract showed no toxicity and that the LC50 obtained was 24 mg/mL. …”
Get full text

Biochemical Constituent of Ginkgo biloba (Seed) 80% Methanol Extract Inhibits Cholinesterase Enzymes in Javanese Medaka (Oryzias javanicus) Model by Ibrahim Hassan, Wan Norhamidah Wan Ibrahim, Ferdaus Mohamat Yusuf, Siti Aqlima Ahmad, Syahida Ahmad

“…High anticholinesterase activities and low toxicity effect of this plant show its benefit to be used as natural medicine or supplements.…”
Get full text

RETRACTED ARTICLE: Novel magnetic organic–inorganic hybrids based on aromatic polyamides and ZnFe2O4 nanoparticles with biological activity by Reza Eivazzadeh-Keihan, Mostafa Ghafori Gorab, Hooman Aghamirza Moghim Aliabadi, Mohammad mahdavi, Ali Reza Akbarzadeh, Ali Maleki, Hossein Ghafuri

“…So, the prepared hybrid is biocompatible and non-toxic to Hu02 cells. Also, it has antibacterial ability against gram-positive and gram-negative bacteria. …”
Get full text

An Overview of the Environmental Applicability of Vermicompost: From Wastewater Treatment to the Development of Sensitive Analytical Methods by Madson de Godoi Pereira, Lourdes Cardoso de Souza Neta, Maurício Paulo Ferreira Fontes, Adriana Nascimento Souza, Thaionara Carvalho Matos, Raquel de Lima Sachdev, Arnaud Victor dos Santos, Marluce Oliveira da Guarda Souza, Marta Valéria Almeida Santana de Andrade, Gabriela Marinho Maciel Paulo, Joselito Nardy Ribeiro, Araceli Verónica Flores Nardy Ribeiro

“…Finally, the use of vermicompost in sensitive analytical methods for quantifying toxic metals is the newest application of this adsorbent.…”
Get full text

Pituranthos chloranthus Oil as an Antioxidant-Based Adjuvant Therapy against Cisplatin-Induced Nephrotoxicity by Aida Lahmar, Zaineb Dhaouefi, Rihab Khlifi, Fairouz Sioud, Leila Chekir- Ghedira

“…Significant mitigation of cisplatin-induced toxicity was confirmed by lowered levels of serum biomarkers and reduced DNA damage in liver and kidney. …”
Get full text

Molecular Docking, Dynamics Simulations, ADMET, and DFT Calculations: Combined In Silico Approach to Screen Natural Inhibitors of 3CL and PL Proteases of SARS-CoV-2 by Sugumar Mohanasundaram, Porkodi Karthikeyan, Venkatesan Sampath, M. Anbazhagan, Sundramurthy Venkatesa Prabhu, Jamal M. Khaled, Muthu Thiruvengadam

“…There is no significant toxicity identified.…”
Get full text

N-acetylcysteine use in a cocaine-induced liver failure: a case report by Vanessa Biering, Ronan Bellouard, Ronan Bellouard, Maëlle Martin, Éric Dailly, Éric Dailly, Catherine Monteil-Ganière, Edouard Charles Le Carpentier

“…The toxicokinetics of major cocaine metabolites and clinical chemistry concentrations were monitored.ConclusionIn addition to the usual management measures for acute hepatitis, the administration of N-acetylcysteine should be investigated further, although it is currently used only in cases of acetaminophen acute toxic hepatitis.…”
Get full text

Study of adsorption behavior of HCN and H2S molecules over undoped and Al-doped zinc oxide monolayer: A DFT approach by Dipak Oli, Om Shree Rijal, Ravi Kiran Neupane, Pitamber Shrestha, Shriram Sharma, Leela Pradhan Joshi, Rajendra Parajuli

“…Gas adsorption sensors are of immense importance for detecting and measuring of the presence of toxic gases to prevent health hazards, industrial accidents etc. …”
Get full text

Assessing the Proteomic Activity of the Venom of the Ant Ectatomma tuberculatum (Hymenoptera: Formicidae: Ectatomminae) by Juliana Rocha da Silva, Aline Zanotelli de Souza, Carlos Priminho Pirovani, Helena Costa, Aline Silva, João Carlos Teixeira Dias, Jacques Hubert Charles Delabie, Renato Fontana

“…Ectatomma tuberculatum has one of the most toxic venoms known among ants but there is no detailed study on its characteristics. …”
Get full text

Evaluation on Genotoxicity and Teratogenicity of Aqueous Extract from Cyclocarya paliurus Leaves by Lihong Deng, Jiandu Lei, Jing He, Jing Liu, Luying Wang, Rui Zhang, Xinhua Liu, Yun Liu

“…In this study, we have conducted the genotoxicity assay (including Ames test, bone marrow polychromatic erythrocyte micronucleus test, and sperm abnormality test in mice) and traditional teratogenicity assay in rats (maternal toxicity, embryo toxicity, and teratogenicity test) to assess the genetic and teratogenic safety of aqueous extracts from C. paliurus leaves. …”
Get full text

Modeling and optimal regulation of erythropoiesis subject to benzene intoxication by H. T. Banks, Cammey E. Cole, Paul M. Schlosser, Hien T. Tran

“…The exposure-dose-response relationship of benzene in humans is expected to be nonlinear becausebenzene undergoes a series of metabolic transformations, detoxifying and activating, resulting in various metabolites that exert toxic effects on the bonemarrow. &nbsp Since benzene is a known human leukemogen, the toxicity of benzene in thebone marrow is of most importance. …”
Get full text

“I’m Seeing Dead People”: A Case Report on Salicylate Poisoning in a Patient with Hallucinations by Jessica Meyers, Sean McCormick, Phillip D. Levy, Michael J. Twiner

“…Conclusion: This case serves as a reminder for physicians to have a high index of suspicion for chronic toxicities including salicylates in patients who present as acute psychosis or altered mental status of unknown etiology.…”
Get full text

Methylene blue at recommended concentrations alters metabolism in early zebrafish development by Niepukolie Nipu, Lai Wei, Lauren Hamilton, Hyojin Lee, Jith Thomas, Jan A. Mennigen

“…The Organisation for Economic Co-operation and Development zebrafish embryo toxicity test guideline omits MB recommendations, leading to inconsistent MB use in zebrafish research. …”
Get full text

Development of Cutaneous Bioadhesive Ureasil-Polyether Hybrid Films by João Augusto Oshiro Junior, Flávia Chiva Carvalho, Christiane Pienna Soares, Marlus Chorilli, Leila Aparecida Chiavacci

“…The hybrids formed by more hydrophilic PEO chains are more bioadherent, since they can interact more efficiently with the water present in the stratum corneum increasing the bioadhesion. Due to their low toxicity and high bioadhesion, the ureasil-PEO films obtained by using HCl as catalyst agent are good candidates for application to the skin as bioadhesive films.…”
Get full text