IONPs-induced neurotoxicity via cascade of neuro-oxidative stress, parthanatos-mediated cell death, neuro-inflammation and neurodegenerative changes: Ameliorating effect of rosemar... by Arwa A. Elsheikh, Noha Ali Abd-Almotaleb, Mona Mostafa Ahmed, Eman El-Sayed Khayal

“…Iron oxide nanoparticles (IONPs) are widely used in various fields, particularly in medicine, where they can be directly injected for diagnostic and therapeutic purposes, although they may induce certain types of toxicity. Therefore, the present work aimed to estimate the potential protective role of the oral extract of rosemary (RO)against the toxic effects of injected IONPs on the brain tissues of adult male rats, and to explore the potential underlying mechanisms involved in reversing such toxicity. …”
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Effect of <I>Andrographis paniculata</I> Leaf Crude Extract Against <I>Edwardsiella tarda</I> Bacteria and Histopathological Profile of the Liver of <I>Osphronemus gouramy</I> Juve... by Giri Pratama, Arief Prajitno, Titik Dwi Sulistiyati

“…The Lethal Dosage (LD50) was 106 CFU/ml, and a toxicity test showed a dose of 250 mg/L caused the most death compared to other treatments. …”
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Enhancing oral cancer treatment via photodynamic therapy: Gold nanoparticle-based delivery system for 5-aminolevulinic acid (5-ALA) by Romesa Soomro, Mohamed Abdelmonem, Bachren Azra Saputra, Che Azurahanim Che Abdullah

“…Traditional treatments, including surgery, radiation, and chemotherapy, often lead to severe side effects such as physical disfigurement, functional loss, and systemic toxicity. These limitations have spurred the search for alternative therapies, with photodynamic therapy (PDT) gaining recognition for its reduced invasiveness, improved targeting, and better cosmetic outcomes. …”
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Galectin-1-Dependent Mitochondria Apoptosis Plays an Essential Role in the Potential Protein Targets of DBDCT-Induced Hepatotoxicity as Revealed by Quantitative Proteomic Analyses by Jiayu Song, Yuan Ren, Lihua Liu, Yixin Wang, Chuandao Shi, Xiaoqing Ji, Yunlan Li, Qingshan Li

“…Similar to platinum compounds, it also showed toxicity. However, the effective targets and mechanisms for specific toxicity and biological activity are still unclear. …”
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Species Differences in the Biotransformation of Aflatoxin B1: Primary Determinants of Relative Carcinogenic Potency in Different Animal Species by David L. Eaton, David E. Williams, Roger A. Coulombe

“…It was also evident early on that AFB1 itself was not toxic but required bioactivation to a reactive form. …”
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Crushed Capsicum chacoense Hunz Fruits: A Food Native Resource of Paraguay with Antioxidant and Anthelmintic Activity by Eva Coronel, Laura Mereles, Silvia Caballero, Nelson Alvarenga

“…The nutritional composition and toxicity of native plants with food potential like Capsicum chacoense are important for the safe use of populations and could be used as a source for searching for new drug candidates. …”
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Gastrointestinal side effects in hepatocellular carcinoma patients receiving transarterial chemoembolization: a meta-analysis of 81 studies and 9495 patients by Nathalie Arendt, Maria Kopsida, Jaafar Khaled, Markus Sjöblom, Femke Heindryckx

“…Objectives: Quantify the prevalence of key GI complications (diarrhea, nausea, GI toxicity, abdominal pain) following TACE. Design: Systematic review was performed following Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines, focusing on studies that reported side effects of TACE. …”
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Silver nanoparticles immobilized on crosslinked vinyl polymer for catalytic reduction of nitrophenol: experimental and computational studies by Elsayed Elbayoumy, Ashraf A. El-Bindary, Tamaki Nakano, Mohamed M. Aboelnga

“…Abstract The removal of toxic nitrophenols from the industrial wastewater is urgently needed from health, environmental and economic aspects. …”
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High content analysis of primary macrophages hosting proliferating Leishmania amastigotes: application to anti-leishmanial drug discovery. by Nathalie Aulner, Anne Danckaert, Eline Rouault-Hardoin, Julie Desrivot, Olivier Helynck, Pierre-Henri Commere, Hélène Munier-Lehmann, Gerald F Späth, Spencer L Shorte, Geneviève Milon, Eric Prina

“…Based on their intramacrophagic leishmanicidal activity and their toxicity against host cells, compounds were classified as irrelevant or relevant for entering the next step in the drug discovery pipeline.…”
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Cytotoxic and Antioxidant Effects of Antimalarial Herbal Mixtures by Isaac Dadzie, Shaibu Adams Avorgbedo, Regina Appiah-Opong, Obed Cudjoe

“…The herbal mixtures may be potential sources of toxic agents to host cells. Therefore, further toxicity studies must be performed to safeguard health of the public. …”
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CD19-directed chimeric antigen receptor T-cell therapy: what can we learn from the haematologist? by Marie José Kersten, Maria Theresa Kuipers

“…This article reviews the key principles learnt in haematology, the results and the mechanisms behind its efficacy, toxicities, and the challenges that need to be addressed for its broader application in clinical practice.…”
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Hepatoprotective effect of leaf extracts from Citrus hystrix and C. maxima against paracetamol induced liver injury in rats by Arumugam Abirami, Gunasekaran Nagarani, Perumal Siddhuraju

“…The present investigation is aimed to evaluate the hepatoprotective effects of Citrus hystrix and Citrus maxima (Red and White variety) methanolic leaf extracts on paracetamol induced toxicity. Leaf extracts were given in the dose of 200 mg/kg body weight for 7 days and toxicity was induced by paracetamol (2 g/kg) on day 5. …”
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Nanoexposure, Unusual Diseases, and New Health and Safety Concerns by Yuguo Song, Shichuan Tang

“…Accumulating studies in animals have shown that nanoparticles could cause unusual rapid lung injury and extrapulmonary toxicity. Whether exposure of workers to nanoparticles may result in some unexpected damage as seen in animals is still a big concern. …”
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The Redox System in C. elegans, a Phylogenetic Approach by Andrew D. Johnston, Paul R. Ebert

“…Oxidative stress is a toxic state caused by an imbalance between the production and elimination of reactive oxygen species (ROS). …”
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In Vitro and In Silico Anthelmintic Activity of Extracts of Lannea kerstingii and Ficus thonningii on Heligmosomoides polygyrus by Ndjinkeu Ntcheuzing Serena, Masoud Besati, Noumedem Anangmo Christelle Nadia, Mahdi Yaghoobi, Yamssi Cédric, Claire Ciancia, Ngouyamsa Nsapkain Aboubakar Sidiki, Vincent Khan Payne, Mpoame Mbida, Haibo Hu

“…However, more research is required, especially on the acute toxicity and in vivo anthelmintic efficacy to validate this scientific investigation.…”
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Fluconazole-Pyridoxine Bis-Triazolium Compounds with Potent Activity against Pathogenic Bacteria and Fungi Including Their Biofilm-Embedded Forms by Marsel R. Garipov, Roman S. Pavelyev, Svetlana A. Lisovskaya, Elena V. Nikitina, Airat R. Kayumov, Alina E. Sabirova, Oksana V. Bondar, Albina G. Malanyeva, Alexander M. Aimaletdinov, Alfia G. Iksanova, Konstantin V. Balakin, Yurii G. Shtyrlin

“…The leading compound was significantly less toxic than miramistin and benzalkonium chloride and more toxic than the reference antifungal drugs. …”
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Review on Cement Stabilization/Solidification of Municipal Solid Waste Incineration Fly Ash by Chengcheng Fan, Baomin Wang, Tingting Zhang

“…Municipal solid waste incineration (MSWI) fly ash must be treated properly prior to being disposed in the security landfill due to its serious pollution toxicity. Nowadays, lots of studies have demonstrated that cement-based stabilization/solidification could reduce the toxicity pollution effectively by encapsulating the heavy metals into cement matrix, which leads to greater capacity and weight. …”
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Detecting Methotrexate in Pediatric Patients Using Artificial Neural Networks by Alejandro Medina Santiago, Jorge Iván Bermúdez Rodríguez, Jorge Antonio Orozco Torres, Julio Alberto Guzmán Rabasa, José Manuel Villegas Izaguirre, Gladys Falconi Alejandro

“…However, there is evidence of an association between methotrexate and toxicity risks, which influences the personalization of treatment, particularly in the case of childhood ALL. …”
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Green synthesis of silver nanoparticles derived from algae and their larvicidal properties to control Aedes aegypti by Matheus Alves Siqueira de Assunção, Douglas Dourado, Daiane Rodrigues dos Santos, Gabriel Bezerra Faierstein, Mara Elga Medeiros Braga, Severino Alves Junior, Rosângela Maria Rodrigues Barbosa, Herminio José Cipriano de Sousa, Fábio Rocha Formiga

“…In addition, assessment of toxicity of these nanomaterials in non-target species is discussed.…”
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Sulfurous Gases As Biological Messengers and Toxins: Comparative Genetics of Their Metabolism in Model Organisms by Neal D. Mathew, David I. Schlipalius, Paul R. Ebert

“…As gases with potent biological activities, they are toxic as air pollutants, and the sulfurous compounds are used as fumigants. …”
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