Expanding Yarrowia lipolytica’s metabolic potential for detoxification of cyanogenic glycosides in edible plants by Fidelis Azi, Zhiyu Li, Peng Xu

“…Abstract Cyanides are highly toxic chemicals in several edible plants that threaten food safety and human health. …”
Get full text

Plants with known antagonistic properties against pests: how they influence non-target free-living soil fauna? by Kassimira Ilieva-Makulec, Michał Bielecki, Grzegorz Makulec

“…The toxicity of the hemp extract showed a clear dependence on its concentration. …”
Get full text

Preparation of Ca-Mg Double-Doped Mesoporous Silica Nanoparticles and Their Drug-Loading and Drug-Releasing Properties by Qian Zhang, Jiamin Huang, Chao Liu, Ruihua Chen, Tao Jiang, Yusufu Hailili, Telieke Bahetibieke, Xiaohui Tang, Mei Wang

“…Therefore, developing low-toxicity MSNs with good biocompatibility, biodegradability, and rapid release at the tumor site is a key scientific issue to be addressed. …”
Get full text

Application of Hyphenated Techniques in Speciation Analysis of Arsenic, Antimony, and Thallium by Rajmund Michalski, Sebastian Szopa, Magdalena Jabłońska, Aleksandra Łyko

“…Arsenic, antimony, and thallium are important examples of such toxic elements. Their speciation is especially important in the environmental and biomedical fields because of their toxicity, bioavailability, and reactivity. …”
Get full text

Cybertoxicology, molecular docking, and experimental verification reveal the mechanism of action of chlorpyrifos on skin damage by Weibin Du, Wenxiang Zeng, Zhenwei Wang, Huahui Hu, Hongfeng Ruan, Gang Qu

“…However, there is currently no relevant research revealing the toxic effects of CPF exposure on the skin, then it is necessary to comprehensively understand the toxic effects and mechanisms. …”
Get full text

Hepatic sinusoidal obstruction syndrome (SOS) associated with checkpoint inhibitor therapy by Marianna Litterio, Nicole Marchetti, Francesco Carubbi, Marianna Tudini, Luciano Mutti, Claudio Ferri

“…Furthermore, as their use has become more widespread, rare toxicities have emerged. The difficulty lies in diagnosing these unusual toxicities with an incidence of as low as less than 1% hence defined as SOS. …”
Get full text

Gonadal health benefits of black cumin (Nigella sativa) seed oil on chronic lead-exposed male Wistar rats by Afrina Mustari, Mahabub Alam, Samia Rashid, A.G.M.Sofi Uddin Mahamud, Mohammad Alam Miah, Emdadul Hauqe Chowdhury

“…Lead (Pb) is a highly toxic heavy metal that can cause harm even at extremely low concentrations and damage various organs, including those of reproduction. …”
Get full text

Prevalence, Dispersion and Nature of Bioaerosols over a Solid Landfill Site in Central India by Priyanka D. Bhoyar, Pooja Kamdi, Amit Bafana, Panuganti C. S. Devara, Saravanadevi Sivanesan, Amrit Kumar, Kannan Krishnamurthi

Get full text

The Effects of Polystyrene Microplastics and Copper Ion Co-Contamination on the Growth of Rice Seedlings by Huiyu Jin, Guohe Lin, Mingzi Ma, Lin Wang, Lixiang Liu

“…While PS-MPs can alleviate Cu toxicity by reducing its bioavailability, they also compromise antioxidant activity, potentially affecting plant resilience to stress. …”
Get full text

Temperature effects on the hormetic response of Myzus persicae after sublethal exposure to insecticides by Ana Paula Nascimento Silva, Camila Faria Chagas, Emanuel Lucas de Andrade Alves, Vinícius de Castro Carvalho, Khalid Haddi

“…It can also affect the toxicity and relative efficacy of insecticides that are used in agricultural fields. …”
Get full text

Diversity and functions of fungal VOCs with special reference to the multiple bioactivities of the mushroom alcohol by Guohua Yin, Geromy G. Moore, Joan Wennstrom Bennett

“…When Drosophila was cultivated in an atmosphere shared with VOC mixtures released from growing cultures of several medically important fungi, including Aspergillus fumigatus, toxicity was observed. Additionally, we propose that components of the genetic immune system of D. melanogaster are engaged in the toxicity of fungal VOCs mainly via the elicitation of the Toll pathway. …”
Get full text

A Bayesian phase 2 model based adaptive design to optimise antivenom dosing: Application to a dose-finding trial for a novel Russell's viper antivenom in Myanmar. by James A Watson, Thomas Lamb, Jane Holmes, David A Warrell, Khin Thida Thwin, Zaw Lynn Aung, Min Zaw Oo, Myat Thet Nwe, Frank Smithuis, Elizabeth A Ashley

“…The design formalises the optimal initial dose of antivenom as the dose closest to that giving a pre-specified desired efficacy, but resulting in less than a pre-specified maximum toxicity. For Daboia siamensis envenoming, efficacy is defined as the restoration of blood coagulability within six hours, and toxicity is defined as anaphylaxis. …”
Get full text

Optimization of anthracene biodegradation by indigenous Trichoderma lixii and Talaromyces pinophilus using response surface methodology by Samson O. Egbewale, Ajit Kumar, Mduduzi P. Mokoena, Ademola O. Olaniran

“…Despite reduced toxicity, both strains were classified as harmful based on effective concentration (EC50) and toxicity unit (TU) (20.92±1.32 mg/L and 4.78 % for TlFLU1 and 35.29±1.55 mg/L and 2.83 % for TpFLU12). …”
Get full text

How to use monoclonal antibody-based therapy in ALL by Erica Brivio, Sujith Samarasinghe

“…Acute Lymphoblastic Leukemia (ALL) represents a significant challenge in haematology, particularly due to its aggressive nature, high relapse rates in adults and toxicity of treatment. Over the past decade, monoclonal antibody (MoAb)-based therapies have emerged as a promising approach to target specific antigens on leukemic cells, offering higher specificity, reduced toxicity, and improved response rates. …”
Get full text

Role of Radiotherapy in Modern Treatment of Hodgkin's Lymphoma by Kheng-Wei Yeoh, N. George Mikhaeel

“…The differing toxicities of radiotherapy and chemotherapy has promoted ongoing research to identify the utility of each of these modalities in the modern management of Hodgkin's Lymphoma. …”
Get full text

Health effects, environmental impacts, and photochemical degradation of selected surfactants in water by Sarah Hatfield Venhuis, Mehrab Mehrvar

“…It has been found that although certain surfactants may not be directly toxic, when their concentrations are high in soil, they can act as agents to release toxic pollutants such as polychlorinated biphenyls (PCBs). …”
Get full text

Second-Line Irinotecan, Leucovorin, and 5-Fluorouracil for Gastric Cancer Patients after Failed Docetaxel and S-1 by Joo Young Jung, Min-Hee Ryu, Baek-Yeol Ryoo, Boram Han, Ji Woong Cho, Man Sup Lim, Hyun Lim, Ho Suk Kang, Min-Jeong Kim, Hong Il Ha, Hunho Song, Jung Han Kim, Hyeong Su Kim, Yoon-Koo Kang, Dae Young Zang

“…The major grade 3/4 toxicity was neutropenia (8.6%). Conclusion. FOLFIRI/IFL chemotherapy showed modest antitumour activity and tolerable toxicities in DS/DOS-treated MGC patients.…”
Get full text

Comprehensive Insight of Neurodegenerative Diseases and The Role of Neurotoxin Agents — Glutamate by Hui-Min Yap, Kwan-Liang Lye, Loh Teng-Hern Tan

“…Whereas non-receptor mediated oxidative toxicity involved the breakdown of the cystine/glutamate antiporter (xc - ) mechanism, which leads to the depletion of glutathione (GSH) and causes oxidative stress and cell death. …”
Get full text

Adjuvant Bidirectional Chemotherapy with Intraperitoneal Pemetrexed Combined with Intravenous Cisplatin for Diffuse Malignant Peritoneal Mesothelioma by Lana Bijelic, O. Anthony Stuart, Paul Sugarbaker

“…The primary endpoint of the study was treatment related toxicity. From July 2007 until July 2009 ten patients were enrolled. …”
Get full text

On the Environmental Factors Affecting the Structural and Cytotoxic Properties of IAPP Peptides by Marianna Flora Tomasello, Alessandro Sinopoli, Giuseppe Pappalardo

“…Other open questions are related to the nature of the IAPP toxic species and how exactly β-cells die. …”
Get full text