Plant-Mediated Green Synthesis of Ag NPs and Their Possible Applications: A Critical Review by Darbin Kumar Poudel, Purushottam Niraula, Himal Aryal, Biplab Budhathoki, Sitaram Phuyal, Rishab Marahatha, Kiran Subedi

“…This review focuses on the contribution of plant-mediated Ag NPs in different applications and their toxicity in the aquatic system.…”
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Hsp104 suppresses polyglutamine-induced degeneration post onset in a drosophila MJD/SCA3 model. by Mimi Cushman-Nick, Nancy M Bonini, James Shorter

“…Importantly, in staging experiments, Hsp104 suppressed toxicity of a C-terminal MJD fragment when expressed after the onset of PolyQ-induced degeneration, whereas Hsp70 was ineffective. …”
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Remarkable Presentation: Anaplastic Thyroid Carcinoma Arising from Chronic Hyperthyroidism by Habib G. Zalzal, Jeffson Chung, Jessica A. Perini

“…She had been taking methimazole for chronic hyperthyroidism due to toxic thyroid nodules, previously biopsied as benign. …”
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A Phase I/II Study of Ultra-Hypofractionated Carbon-ion Radiation therapy for Low- and Intermediate-Risk Localized Prostate Cancer by Noriyuki Okonogi, MD, PhD, Hiroshi Tsuji, MD, PhD, Kana Kobayashi, MD, PhD, Mio Nakajima, MD, PhD, Shuri Aoki, MD, PhD, Takanobu Utsumi, MD, PhD, Hiroyoshi Suzuki, MD, PhD, Koichiro Akakura, MD, PhD, Tomohiko Ichikawa, MD, PhD, Hitoshi Ishikawa, MD, PhD

“…Eligible patients were randomly assigned (1:1) to a 1- or 2-week schedule. Dose-limiting toxicities (DLTs) were defined as any genitourinary (GU) or gastrointestinal (GI) toxicity grade 3 or higher within 90 days of beginning CIRT. …”
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CD4 CAR-T cells targeting CD19 play a key role in exacerbating cytokine release syndrome, while maintaining long-term responses by Alice Bergamini, Barbara Camisa, Attilio Bondanza, Fabio Ciceri, Chiara Bonini, Monica Casucci, Beatrice Greco, Camilla Bove, Silvia Arcangeli, Laura Falcone, Rita El Khoury, Anna De Lucia

“…However, treatment failures are common and the occurrence of severe toxicities, such as cytokine release syndrome (CRS), still limits the full exploitation of this approach. …”
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A Comparative Review: Biological Safety and Sustainability of Metal Nanomaterials Without and with Machine Learning Assistance by Na Xiao, Yonghui Li, Peiyan Sun, Peihua Zhu, Hongyan Wang, Yin Wu, Mingyu Bai, Ansheng Li, Wuyi Ming

“…However, nanomaterials have been identified as potentially toxic, with the toxicity of metal nanoparticles posing significant risks to both human health and the environment. …”
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A compendium of Amplification-Related Gain Of Sensitivity genes in human cancer by Veronica Rendo, Michael Schubert, Nicholas Khuu, Maria F. Suarez Peredo Rodriguez, Declan Whyte, Xiao Ling, Anouk van den Brink, Kaimeng Huang, Michelle Swift, Yizhou He, Johanna Zerbib, Ross Smith, Jonne Raaijmakers, Pratiti Bandopadhayay, Lillian M. Guenther, Justin H. Hwang, Amanda Iniguez, Susan Moody, Ji-Heui Seo, Elizabeth H. Stover, Levi Garraway, William C. Hahn, Kimberly Stegmaier, René H. Medema, Dipanjan Chowdhury, Maria Colomé-Tatché, Uri Ben-David, Rameen Beroukhim, Floris Foijer

“…Additionally, we analyze 17 cancer open reading frame screens to identify genes toxic to cancer cells when overexpressed. Combining these approaches, we propose a class of ‘Amplification-Related Gain Of Sensitivity’ (ARGOS) genes located in commonly amplified regions, yet expressed at lower levels than expected by their copy number, and toxic when overexpressed. …”
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Optimal timing of organs-at-risk-sparing adaptive radiation therapy for head-and-neck cancer under re-planning resource constraints by Fatemeh Nosrat, Cem Dede, Lucas B. McCullum, Raul Garcia, Abdallah S.R. Mohamed, Jacob G. Scott, James E. Bates, Brigid A. McDonald, Kareem A. Wahid, Mohamed A. Naser, Renjie He, Aysenur Karagoz, Amy C. Moreno, Lisanne V. van Dijk, Kristy K. Brock, Jolien Heukelom, Seyedmohammadhossein Hosseinian, Mehdi Hemmati, Andrew J. Schaefer, Clifton D. Fuller

“…Materials and methods: A novel Markov decision process (MDP) model was developed to determine optimal timing of re-planning based on the patient’s expected toxicity, characterized by normal tissue complication probability (NTCP), for four toxicities. …”
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Transcriptome analysis unveils the mechanisms of oxidative stress, immunotoxicity and neurotoxicity induced by benzotriazole UV stabilizer-328 in zebrafish embryos by Xinlu Yang, Yijing Gan, Menghuan Zhang, Shaolin Xie, Mingfu Lin, Lixiang Zhong, Mengke Song, Jun Wang, Yumei Huang

“…As an emerging pollutant, ultraviolet stabilizer-328 (UV-328) has been frequently detected in aquatic environments and attracted great attention. Nevertheless, the toxicity and mechanisms of UV-328 to aquatic organisms are still not fully understood. …”
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Antibacterial Activity of Traditional Medicinal Plants Used for the Treatment of Acute Diarrheal Diseases in Chiapas, Mexico by Jesús Mauricio Ernesto Hernández-Méndez, Israel Peña-Hernández, Mariela Tapia-Nazario, Gerardo Leyva-Padrón, Abumalé Cruz-Salomón, María Emperatriz Domínguez-Espinosa, Héctor Armando Esquinca-Avilés, Maritza del Carmen Hernández-Cruz, Rocío Magdalena Sánchez-Albores, Kelly del Carmen Cruz-Salomón, Rosa Isela Cruz-Rodríguez, Martha Guadalupe Gómez-Santos

“…With rising antibiotic resistance, plants offer promising antibacterial compounds with low toxicity. This study evaluated the antibacterial activity, minimum inhibitory concentration (MIC), and toxicity of ethanolic (EE) and aqueous (AE) extracts from five Mexican medicinal plants traditionally used in Chiapas for treating acute diarrheal diseases (ADD). …”
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Delphi study to identify consensus on patient selection for hydrogel rectal spacer use during radiation therapy for prostate cancer in the UK by Amit Bahl, Suneil Jain, Albert Edwards, Rhodri Saunders, Clive Peedell, Heather Ann Payne, James Andrew Thomas, Prantik Das, Amanda Hansson Hedblom, Emily Woodward

“…There was agreement that despite meeting rectal dose constraints, too many patients experience rectal toxicity and that rectal hydrogel spacers in eligible patients significantly reduces toxicity-related adverse events. …”
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Mild hyperthermia with magnetic resonance- guided high intensity focused ultrasound combined with salvage chemoradiation for recurrent rectal cancer by Jonathan Peng, Ari Partanen, Samuel Pichardo, Robert Staruch, Kaitlyn Perry, Merrylee McGuffin, Yuexi Huang, Kelvin KW. Chan, Shun Wong, Greg Czarnota, Kullervo Hynynen, William Chu

“…There were no complications on the day of the MR-HIFU procedure and all acute toxicities (no grade >/=3 toxicities) resolved after completion of treatment. …”
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Staphylococcus aureus Infections in the Paediatric Intensive Care Unit: Illustrated Cases by Kam Lun Hon, Ronald C. M. Fung, Karen K. Y. Leung, Alexander K.C. Leung, Wun Fung Hui, Wing Lum Cheung

“…Staphylococcus aureus is known to be one of the most common gram-positive microorganisms and an important pathogen associated with sepsis and toxic shock. We present four anonymized consecutive cases in a paediatric intensive care unit (PICU) to illustrate the different clinical manifestations of staphylococcal infections, including local infection versus systemic infection, toxic shock versus septic shock, and osteomyelitis. …”
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Green Silver Nanoparticles: An Antibacterial Mechanism by Ekaterina O. Mikhailova

“…The mechanism of antibacterial activity is also discussed in detail with special attention given to anti-biofilm and anti-quorum sensing activities. The toxicity of silver nanoparticles is considered in light of their further biomedical applications.…”
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Acute enteritis with pelvic SBRT: Influence of bowel delineation methods by Akshay Dinesan, Maneesh Singh, Prachi Mehta, Priyamvada Maitre, Vedang Murthy

“…Patients with acute bowel toxicity (CTCAE v5.0) were included as cases while those without were controls. …”
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Analysis of HIV therapy in the liver using optimal control and pharmacokinetics by Hasifa Nampala, Matylda Jabłońska-Sabuka, Martin Singull

“…An objective function is defined with an aim to investigate the optimal control strategy that minimises toxicity, viral load and cost of first-line and second-line HIV regimen. …”
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Bioassays and virtual screening to identify potent natural antifouling compounds from the brown macroalga Dictyota dichotoma by Ba-akdah Mohammad Abdulaziz, Satheesh Sathianeson

“…The metabolites also showed positive for crustacean and fish toxicity in toxicity prediction using an in silico method.…”
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Biosorptive Removal of Cadmium(II) and Copper(II) Using Microwave-Assisted Thiourea-Modified Sorghum bicolor Agrowaste by Muhammad Salman, Rabia Rehman, Umar Farooq, Anum Tahir, Liviu Mitu

“…Sorghum bicolor (S.B.) is used in this work for preparing chemically modified adsorbent for toxic metal ions, i.e., cadmium(II) and copper(II). …”
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Expression, Purification, and Functional Analysis of Novel RelE Operon from X. nematophila by Jitendra Singh Rathore, Lalit Kumar Gautam

“…The expression of recombinant Xn-relE under tightly regulated ara promoter in E. coli Top 10 cells confirms its toxic nature in endogenous toxicity assay. The neutralization activity in endogenous toxicity assay by Xn-relEAT antitoxin confirms its antidote nature when studying the whole TA operon under ara regulated promoter. …”
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Outcome differences by sex in oncology clinical trials by Ashwin V. Kammula, Alejandro A. Schäffer, Padma Sheila Rajagopal, Razelle Kurzrock, Eytan Ruppin

“…Abstract Identifying sex differences in outcomes and toxicity between males and females in oncology clinical trials is important and has also been mandated by National Institutes of Health policies. …”
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