Fragment optimized chalcone derivatives targeting OmpA protein as a therapeutic approach against multidrug resistant Acinetobacter baumannii by Muhammad Naveed, Amina Abid, Tariq Aziz, Ayesha Saleem, Arooj Arshad, Khushbakht Javed, Hafiz Muzzammel Rehman, Ghulam Nabi, Mitub Al-harbi, Abdullah F. Alasmari

“…Furthermore, for a more potent compound, fragment optimization was performed and led to a new lead compound fragment optimized isobavachalcone (FOI) which shows increased binding energy −6 kcal/mol. ADMET and toxicity analysis was performed of both the compounds isobavachalcone and FOI which revealed favorable pharmacokinetic profiles for both compounds, but toxicity analysis showed discrepancies, with the isobavachalcone exhibiting toxicity but FOI compound showing no detectable toxicity. …”
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Neurotoxic Effect of Myricitrin in Copper-Induced Oxidative Stress Is Mediated by Increased Intracellular Ca²⁺ Levels and ROS/p53/p38 Axis by Ignacija Vlašić, Antonio Krstačić-Galić, Anđela Horvat, Nada Oršolić, Anja Sadžak, Lucija Mandić, Suzana Šegota, Maja Jazvinšćak Jembrek

“…At non-toxic concentrations, myricitrin exacerbated copper’s toxic effects. …”
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Influence of soil type on bacterial growth and tolerance to experimentally added human antibiotics by Laura Rodríguez-González, Montserrat Díaz-Raviña, Beatriz Sevilla-Morán, Elena García-Campos, Juan José Villaverde, Manuel Arias-Estévez, David Fernández-Calviño, Vanesa Santás-Miguel

“…The lack of studies on CXM and AZI in soils hinders our understanding of their potential toxic effects on soil bacterial communities and ecosystem services. …”
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Clinical Practice Guidelines for Exogenous Poisoning. by Alexis Díaz Mesa, Eddy Pereira Valdés, Alba Enseñat Álvarez, Carlos Alberto Rodríguez Armada

“…It includes the classification of toxic substances, clinical diagnosis (main syndromes), and description of therapeutic variations (vital support, antidotes, absorption measurements and increase of elimination and depuration of the toxic substance). …”
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Deciphering the interactome of Ataxin-2 and TDP-43 in iPSC-derived neurons for potential ALS targets. by Yuan Tian, Nicolette Heinsinger, Yinghui Hu, U-Ming Lim, Yi Wang, Aaron Zefrin Fernandis, Sophie Parmentier-Batteur, Becky Klein, Jason M Uslaner, Sean M Smith

“…To identify alternative therapeutic targets that can mitigate TDP-43 toxicity, we examined the interaction between Ataxin-2 and TDP-43. …”
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Assessing the Ecological Risk of Polycyclic Aromatic Hydrocarbons in Sediments at Langkawi Island, Malaysia by Essam Nasher, Lee Yook Heng, Zuriati Zakaria, Salmijah Surif

“…The contamination and toxicity levels of polycyclic aromatic hydrocarbon (PAH) in the sediments of Langkawi were evaluated using sediment quality guidelines (SQGs) and toxic equivalent factors. …”
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Antihyperlipidemic Potential of Polyphenol and Glycoside Rich Nerium oleander Flower against Triton WR-1339-Induced Hyperlipidemia in Experimental Sprague Dawley Rats by V. Gayathri, S. Ananthi, Hannah R. Vasanthi

“…In the present study, we have evaluated the toxicity profile of the 50% hydroethanolic extracts of Nerium oleander flowers (ENO) using in vitro brine shrimp lethality assay and MTT cytotoxicity assay and in vivo acute toxicity test as per the OECD guidelines. …”
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Attempted Suicide by Massive Warfarin Ingestion Conservatively Managed Using Phytonadione by Katherine L. March, Kruti S. Patel, Jennifer D. Twilla

“…Treatment strategies for acute toxicity following massive ingestion of warfarin are not well described in the literature. …”
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A critical assessment of ionic liquid-based aqueous biphasic systems for biomolecules extraction and CO2 absorption by Viggy Wee Gee Tan, Yazan Abuhasheesh, Doris Ying Ying Tang, Yongyu Zhang, Zengling Ma, Lin Chen, Rambabu Krishnamoorthy, Pau Loke Show

“…The prospects of ILs as green solvents and their toxicity and applicability in carbon dioxide (CO2) capture are discussed. …”
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Effect of spirulina supplementation on growth, immunity, antioxidant status and pathomorphological perspectives in broilers exposed to dietary aflatoxin B1 by Ayman S. Salah, Antonia Lestingi, Mahmoud S. El-Tarabany, Marwa Mostafa, Rania Samir Zaki, Mahmoud M. Azzam, Alessandro Di Cerbo, Mahmoud Alagawany, Ahmed Fotouh

“…AFB1 toxicity reduced the activity of SOD and GPx (P < 0.05). …”
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Dynamics of two phytoplankton populations under predation by Jean-Jacques Kengwoung-Keumo

“…The aim of this paper is to investigate the manner in which predation and single-nutrient competition affect the dynamics of a non-toxic and a toxic phytoplankton species in a homogeneous environment (such as a chemostat). …”
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Mechanisms underlying the effects of cyanogenesis on development and reproduction of Tetranychus urticae: Insights from enzyme activity and gene expression aspects by Mufeng Wu, Xiao Liang, Ying Liu, Chunling Wu, Xingkui An, Zihua Zhao, Guifeng Hao, Ijiti Oluwole Gregory, Zhihong Li, Qing Chen

“…Numerous studies have speculated this CNG-mediated toxicity by a plant-pest interaction manner. However, the specific toxic effect of HCN was not well-demonstrated because of the interference of other ingested metabolites. …”
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Toxicological Assessment of Pseudospondias microcarpa (A. Rich.) Engl. Hydroethanolic Leaf Extract in Rats: Haematological, Biochemical, and Histopathological Studies by Donatus Wewura Adongo, Priscilla Kolibea Mante, Kennedy Kwami Edem Kukuia, Charles Kwaku Benneh, Robert Peter Biney, Eric Boakye-Gyasi, Nicholas Akinwale Titiloye, Eric Woode

“…However, although parts of the plant are extensively used in African traditional medicine, no scientific study has been reported on its toxicity. Therefore, this study evaluated the acute and subacute toxicity studies of the ethanolic extract of P. microcarpa in rats. …”
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N-3 Polyunsaturated Fatty Acids Stimulate Bile Acid Detoxification in Human Cell Models by Anna Cieślak, Jocelyn Trottier, Mélanie Verreault, Piotr Milkiewicz, Marie-Claude Vohl, Olivier Barbier

“…Cholestasis is characterized by the accumulation of toxic bile acids (BAs) in liver cells. The present study aimed to evaluate the effects of n-3 polyunsaturated fatty acids (n-3 PUFAs), such as docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids, on BA homeostasis and toxicity in human cell models. …”
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Oxidative stress caused by 3-monochloro-1,2-propanediol provokes intestinal stem cell hyperproliferation and the protective role of quercetin by Zongzhong Liu, Yanfei He, Yuhan Wang, Kefeng Ren, Pengpeng Xia, Binbin Xie, Tian Wei

“…Recently, the contaminant 3-monochloropropane-1,2-diol (3-MCPD) found in food and the environment has garnered significant global attention due to its detrimental health effects on animals, including reproductive toxicity, neurotoxicity, and nephrotoxicity. However, the specific impacts and mechanisms of 3-MCPD on intestinal health remain elusive. …”
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Three-Dimensional Conformal Radiotherapy for Hepatocellular Carcinoma in Patients Unfit for Resection, Ablation, or Chemotherapy: A Retrospective Study by Vassilis Kouloulias, Eftychia Mosa, John Georgakopoulos, Kalliopi Platoni, Ilias Brountzos, Anna Zygogianni, Christos Antypas, Paraskevas Kosmidis, Kyriaki Mystakidou, Maria Tolia, Ivelina Beli, Athanasios Gouliamos, John Kouvaris, Nikoalos Kelekis

“…The purpose is to evaluate the feasibility, efficacy, and the toxicity of three-dimensional conformal radiotherapy (3DCRT) in patients with advanced hepatocelluar carcinoma (HCC) and inferior vena cava tumor thrombosis (IVCTT). …”
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Combined BPA and DIBP Exposure Induced Intestinal Mucosal Barrier Impairment Through the Notch Pathway and Gut Microbiota Dysbiosis in Mice by Mengge Duan, Yuting Wang, Shiyu Chen, Jiawen Lu, Ruihong Dong, Qiang Yu, Jianhua Xie, Yi Chen

“…However, little research has investigated the combined toxicity of BPA and DIBP, particularly their intestinal toxicity. …”
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The mechanisms of fiber flax adaptation to high soil acidity (a review) by N. V. Kishlyan, N. V. Melnikova, T. A. Rozhmina

“…On strongly acid soils (pHKCl less than 4.5) with threshold values of the toxic aluminum (Al3+) content, 10–11 mg/100 g, a decrease in the flax yield is over 50%. …”
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Effect of Mercury on Seed Germination and Seedling Growth of Mungbean (<i>Vigna radiata</i> (L.) Wilczek) by ZI Muhammad, KS Maria, A Mohammad, S Muhammad, F Zia-ur-Rehman, K Muhammad

“…Among the toxic elements release in the environment, mercury is considered highly toxic to the growth of plants. …”
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Effect of Mercury on Seed Germination and Seedling Growth of Mungbean (<i>Vigna radiata</i> (L.) Wilczek) by ZI Muhammad, KS Maria, A Mohammad, S Muhammad, F Zia-ur-Rehman, K Muhammad

“…Among the toxic elements release in the environment, mercury is considered highly toxic to the growth of plants. …”
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