What is the Significance of a Part Per Million? by Frederick M. Fishel, Mark Mossler

“… The health effects of toxic substances are related to their doses—the amount of exposure to the toxic substance. …”
Get full text

Prediction-based prompt levothyroxine replacement to prevent a hypothyroid state after immune-related adverse events involving the thyroid gland by Ichiro Yamauchi, Takuro Hakata, Taku Sugawa, Daisuke Kosugi, Haruka Fujita, Kentaro Okamoto, Yohei Ueda, Toshihito Fujii, Daisuke Taura, Norio Harada, Nobuya Inagaki

“…The Toxic-Hypo group developed thyroid irAEs earlier than the Toxic group (26 vs. 91 days; p < 0.001), and had higher serum free T4 levels (3.210 vs. 1.880 ng/dL; p = 0.011). …”
Get full text

Comparison of Transfection Agents in Forming Complexes with Ferumoxides, Cell Labeling Efficiency, and Cellular Viability by Ali Syed Arbab, Gene Thomus Yocum, Lindsey Bashaw Wilson, Ashari Parwana, Elaine Kay Jordan, Heather Kalish, Joseph Alan Frank

“…Lipofectamine2000 showed toxicity at lowest dose (1 μg/mL), whereas FuGENE6 and low molecular weight poly- L -lysine (PLI.) showed the least toxicity. …”
Get full text

Toxicological effects of the environmental pollutant perfluoronanoic acid on the ground-dwelling arthropod Solenopsis invicta by Wenxuan Wang, Mingrong Liang, Yangting Ou, Xiangrui Wang, Yunbo Song, Huimei Chen, Jingxin Hong, Yuling Liang, Yongyue Lu

“…Perfluorononanoic acid (PFNA), widely employed in surfactants, coatings, plastics, corrosion inhibitors, and fire-extinguishing agents, is less regulated than PFOS or PFOA but displays higher bioaccumulation and potential toxicity. Most toxicity assessments have focused on mammals, fish, and algae, with limited research on ground-dwelling arthropods, especially ants. …”
Get full text

Research Progress of Programmed Cell Death Induced by Acrylamide by Jing Wang, Jinfeng Yu, Man Wang, Liangliang Fang, Wenjuan Yang, Wenbo Yao, Nan Li, Pin Gong

“…This review may provide basic data for further research of acrylamide and prevention of its toxicity.…”
Get full text

Methotrexate Induced Pancytopenia by Fernando Gonzalez-Ibarra, Sahar Eivaz-Mohammadi, Shiri Surapaneni, Hazem Alsaadi, Amer K. Syed, Simon Badin, Valentin Marian, Mazhar Elamir

“…The well-reported methotrexate (MTX) toxicities are based on the duration and cumulative dosing of drug. …”
Get full text

Vitamin E and N-Acetylcysteine as Antioxidant Adjuvant Therapy in Children with Acute Lymphoblastic Leukemia by Youssef Al-Tonbary, Mohammad Al-Haggar, Rasha EL-Ashry, Sahar EL-Dakroory, Hanan Azzam, Ashraf Fouda

“…Although cancer therapies have experienced great success nowadays, yet the associated toxic response and free radicals formation have resulted in significant number of treatment-induced deaths rather than disease-induced fatalities. …”
Get full text

Bioactivity of Powder and Extracts from Garlic, Allium sativum L. (Alliaceae) and Spring Onion, Allium fistulosum L. (Alliaceae) against Callosobruchus maculatus F. (Coleoptera: Br... by Abiodun A. Denloye

“…On the basis of 48 hr median lethal toxicity (LC50), test plant powders and extracts from A. sativum were more toxic to C. maculatus adults than those from A. fistulosum. …”
Get full text

Mycoremediation of pesticide-contaminated soil: A review by Pujiati, Fatimah, Ramadhan Rico, Ni’matuzahroh

“…Pesticide contamination in soil presents significant environmental and health risks due to toxic residues. Traditional physical and chemical remediation methods are often expensive, ineffective at low concentrations, and generate toxic by-products. …”
Get full text

Clinical Results after High-Dose Intensity-Modulated Radiotherapy for High-Risk Prostate Cancer by Valérie Fonteyne, Nicolaas Lumen, Geert Villeirs, Piet Ost, Gert De Meerleer

“…In this paper we report on (i) late toxicity and (ii) biochemical (bRFS) and clinical relapse-free survival (cRFS) of this combined treatment. …”
Get full text

Research Progress on Effects and Treatment of Microplastic Pollution in Freshwater Ecosystems by TANG Hongliang, MA Jinlong, XU Chenchen, PENG Songyao, FENG Lijuan

“…Due to their widespread distribution, being difficult to degrade, and toxic properties to organisms, they pose a serious threat to the health of freshwater ecosystems. …”
Get full text

The pharmacology, toxicology, and detoxification of Aconitum kusnezoffii Reichb., traditional and modern views by Kenneth Happy, Sungyu Yang, Chang Ho Kang, Youngmin Kang

“…Abstract Aconitum kusnezoffii Reichb. is a medicinal plant widely used in traditional Asian medicine, especially in Korea, for its potent pharmacological effects. However, its toxic alkaloids pose significant risk, making careful processing essential to reduce its toxicity. …”
Get full text

Evaluating the Impact of Commonly Used Pesticides on Honeybees (Apis mellifera) in North Gonder of Amhara Region, Ethiopia by Zewdie Abay, Amssalu Bezabeh, Alemayehu Gela, Asaminew Tassew

“…On the other hand, agro-2, 4-D and its mixture with glycel 41% EC are moderately toxic, and mancozeb 80% WP and glycel 41% EC were slightly toxic to honeybees as compared to the positive control (dimethoate 40% EC). …”
Get full text

Real‐World Study of EGFR‐TKI Rechallenge With Another TKI After First‐Line Osimertinib Discontinuation in Patients With EGFR‐Mutated Non‐Small Cell Lung Cancer: A Subset Analysis o... by Kei Sonehara, Kazunari Tateishi, Kiyotaka Yoh, Kazuhiro Usui, Yukio Hosomi, Kazuma Kishi, Go Naka, Kageaki Watanabe, Shu Tamano, Kohei Uemura, Hideo Kunitoh

“…In clinical practice, rechallenge therapy with another EGFR‐tyrosine kinase inhibitor (TKI) is often performed after first‐line TKI discontinuation owing to resistance or toxicity; however, the efficacy and toxicity of EGFR‐TKI rechallenge after first‐line osimertinib have not been adequately investigated. …”
Get full text

Antifungal Activity of Coumarin Mammeisin Isolated from Species of the Kielmeyera Genre (Family: Clusiaceae or Guttiferae) by Helcio Cassemiro Marcondes, Tânia T. de Oliveira, Jason G. Taylor, Moisés Hamoy, Arman do Leonel Neto, Vanessa Joia de Mello, Tanus J. Nagem

“…Coumarin mammeisin isolated from Kielmeyera elata was evaluated for its toxicity and antifungal activities. The toxicity of mammeisin was investigated by utilizing the Artemia salina methodology to determine its LD50 value. …”
Get full text

An Initial Evaluation on the Adsorption of SO2 and NO2 over Porous Fe3O4 Nanoparticles Synthesized by Facile Scalable Method by Xuan-Manh Pham, Duy Linh Pham, Nguyen Thi Hanh, Tuyet Anh Dang Thi, Le Nhat Thuy Giang, Hoang Thi Phuong, Nguyen Tuan Anh, Hac Thi Nhung, Giang Truong Le, Mai Ha Hoang, Tuyen Van Nguyen

“…In this study, Fe3O4 nanoparticles used as an adsorbent for the removal of toxic gases were successfully synthesized via the facile coprecipitation method. …”
Get full text

Acute Liver and Renal Failure: A Rare Adverse Effect Exclusive to Intravenous form of Amiodarone by Robin Paudel, Prerna Dogra, Saurav Suman, Saurav Acharya, Jyoti Matta

“…The mechanism of acute liver and renal toxicity is not clearly known but is believed to be secondary to amiodarone induced (relative) hypotension, idiosyncratic reaction to the drug, and toxicity of the vector that carries the medication, polysorbate-80. …”
Get full text

Synthesis and Evaluation of Some New Isoquine Analogues for Antimalarial Activity by Chandra Nath Saha, Sanjib Bhattacharya, Dipak Chetia

“…Amodiaquine is a 4-aminoquinoline antimalarial that can cause adverse side effects including hepatic and haematological toxicity. The drug toxicity involves the formation of an electrophilic metabolite, amodiaquine quinoneimine (AQQI), which binds to cellular macromolecules leading to hepatotoxicity and agranulocytosis. …”
Get full text

Effects of Cu(Ⅱ) stress on embryonic development, oxidative stress response, cholinergic system and energy metabolism in the Sepiella maindroni by Qilong Huang, Jiawen Yu, Ruibing Peng, Maowang Jiang, Qingxi Han, Xiamin Jiang

“…In conclusion, when the concentration of Cu(Ⅱ) in the environment is ≥ 0.01 mg/L, it causes significant lethality toxicity, developmental toxicity and teratogenicity in S. maindroni embryos. …”
Get full text

Safety Evaluation of Artocarpus altilis as Pharmaceutical Agent in Wistar Rats by Sudha Sairam, Asna Urooj

“…This study was designed to elucidate the acute toxicity of Artocarpus altilis leaf and bark extracts. …”
Get full text