Effect of Silver Nanoparticles on Tropical Freshwater and Marine Microalgae by Thanh-Luu Pham

“…The results suggested that AgNPs presented different toxicity mechanisms for microalgae and showed to be more toxic in freshwater than in marine environment. …”
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Once-Daily Dosing of Aminoglycosides by William A Craig

“…Similar efficacy and toxicity were observed in all the oilier studies. CONCLUSIONS: Once-daily dosing of aminoglycosides has the potential to enhance efficacy, reduce toxicity and lower administration costs for this drug class. …”
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Evaluation of phenylethylamine type entactogens and their metabolites relevant to ecotoxicology – a QSAR study by Takač Milena Jadrijević-Mladar, Magina Joao Daniel Casimiro, Takač Tin

“…The impact of the selected entactogens and their o-quinone metabolites on the environment was explored in QSAR studies by the use of predicted molecular descriptors, ADMET properties and environmental toxicity parameters, i.e., acute toxicity in Tetrahymena pyriformis (TOX_ATTP) expressed as Th_pyr_pIGC50/mmol L−1, acute toxicity in Pimephales promelas, the fathead minnow (TOX_FHM) expressed as Minnow LC50/mg L−1, the acute toxicity in Daphnia magna (TOX_DM) expressed as Daphnia LC50/mg L−1 and bioconcentration factor (BCF).…”
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PREDICCIÓN DE TOXICIDAD ACUÁTICA MEDIANTE QSAR TOOLBOX: UN ENFOQUE IN SILICO PARA LA EVALUACIÓN DE RIESGOS QUÍMICOS EN LA FRACTURACIÓN HIDRÁULICA by Adolfo E. Ensuncho, Diana B. Ramírez, Jesús M. López

“…The results show that QSAR toolbox can predict aquatic toxicity, using the log Kow hydrophobicity descriptor and through this it’s observed that, in the three aquatic species, aldrin exhibits a high degree of toxicity compared to the other chemicals. …”
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Severe Neurotoxicity due to Atropa belladonna Poisoning: A Case Report and Literature Review by Seyed Javad Boskabadi, Sima Ramezaninejad, Zakaria Zakariaei

“…These cases highlight the importance of awareness regarding the potential toxicity of A. belladonna and the necessity of prompt and appropriate management of its toxicity. …”
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Two- and Three-Dimensional Culture Systems: Respiratory In Vitro Tissue Models for Chemical Screening and Risk-Based Decision Making by Joanne Wallace, Mary C. McElroy, Mitchell Klausner, Richard Corley, Seyoum Ayehunie

“…Here we review 2D and 3D lung models in terms of their application for inhalation toxicity assessment. We highlight a key case study for the Organization for Economic Cooperation and Development (OECD), in which a 3D model was used to assess human toxicity and replace the requirement for a 90-day inhalation toxicity study in rats. …”
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Phytochemical and toxicological evaluation of aqueous leaf extract of Premna integrifolia L. in male balb/c mice by Suman, Pratibha Gaurav, Rajesh Saini, Kavindra Nath Tiwari, Gautam Geeta Jiwatram

“…The acute and subacute toxicity studies of the ALEPI provided a comprehensive evaluation of its safety profile. …”
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Perfluorooctane sulfonate (PFOS) induced bone loss by inhibiting FoxO1-mediated defense against oxidative stress in osteoblast by Liming Xue, Jiale Xu, Ping Xiao, Yiping Jiang, Yuanjie Lin, Chao Feng, Yu’e Jin, Zhijun Zhou, Guoquan Wang, Dasheng Lu

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Application of iron on improving antimony tolerance in Salvia spinosa by Shakiba Rajabpoor, Soghra Kiani, Shokoofeh Hajihashemi

“…Antimony (Sb) is a potential threat to living organisms, but very little is known on strategies manage its toxicity in plants. This study aimed to clarify the role of Fe on alleviation Sb toxicity in a metallicolous population of Salvia spinose and its mechanisms. …”
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Standardization of Alternative Methods for Nanogenotoxicity Testing in Drosophila melanogaster Using Iron Nanoparticles: A Promising Link to Nanodosimetry by Venkatachalam Deepa Parvathi, Kalyanaraman Rajagopal, Ravindran Sumitha

“…Research studies (in vitro model) have demonstrated the lack of toxicity in nanoiron. The present study design involves in vivo toxicity assessment of nanoiron at specific concentrations of 0.1 mM, 1 mM, 5 mM, and 10 mM in Drosophila. …”
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The development and evaluation of a tublysine-based antibody-drug conjugate with enhanced tumor therapeutic efficacy by Huihui Guo, Hongsheng Xie, Yuanyuan Huang, Junxiang Jia, Xiangfei Kong, Qingliang Yang, Shun Gai, Wenjun Li, Lu Bai, Lingli Zhang, Xiaoxiao Chen, Zhicang Ye, Hangbo Ye, Linyao Zhao, Yifang Xu, Yong Du, Xiuzhen Zhang, Miaomiao Chen, Xiaomai Zhou, Robert Y. Zhao

“…In repeated-dose toxicity studies, DX126-262 was well tolerated in rats at doses up to 200 mg/kg, with the highest non-severely toxic dose (HNSTD) established at 100 mg/kg. …”
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Preparation and In Vitro Evaluation of Alginate Microparticles Containing Amphotericin B for the Treatment of Candida Infections by Merlis P. Alvarez-Berrios, Lisa M. Aponte-Reyes, Lourdes Diaz-Figueroa, Juan Vivero-Escoto, Alexis Johnston, David Sanchez-Rodriguez

“…Our results demonstrated that the platform developed in this work was able to induce antifungal toxicity against Candida albicans yeast cells at the same level of free AmB with minimal toxicity to lung cells, which is one of the main side effects induced by commercial drug delivery systems containing AmB. …”
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Cadmium Uptake and Distribution in Fragrant Rice Genotypes and Related Consequences on Yield and Grain Quality Traits by Adam Sheka Kanu, Umair Ashraf, Zhaowen Mo, Issaka Fuseini, Lamin R. Mansaray, Meiyang Duan, Shenggan Pan, Xiangru Tang

“…Cadmium (Cd) toxicity has varying consequences on plants growth and development. …”
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Antagonistic Effects of Sublethal Concentrations of Certain Mixtures of Metal Oxide Nanoparticles and the Bulk (Al2O3, CuO, and SiO2) on Gill Histology in Clarias gariepinus by Amaeze Henry Nnamdi, Tam-Miette Dawarri Briggs, Oluwaseun Olusola Togunde, Henry Ebele Obanya

“…The joint actions of nano Al2O3 and CuO with SiO produced a low toxic effect, unlike the high toxicity of their single trials; this also indicates that nano Al2O3 and CuO are antagonists. …”
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NeuTox 2.0: A hybrid deep learning architecture for screening potential neurotoxicity of chemicals based on multimodal feature fusion by Xudi Pang, Xuejun He, Ying Yang, Ling Wang, Yuzhen Sun, Huiming Cao, Yong Liang

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What is the Significance of a Part Per Million? by Frederick M. Fishel, Mark Mossler

“… The health effects of toxic substances are related to their doses—the amount of exposure to the toxic substance. …”
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Evaluation of Type III Adhesive Mortar (ACIII) and Gypsum as Precipitating Agents of Copper and Lead by Jefferson Luiz Alves Marinho, Henrique Douglas Melo Coutinho, Raimundo Nonato Pereira Teixeira, Jorge Marcell Coelho Menezes, Francisco José de Paula Filho, Francisco Assis Bezerra da Cunha

“…Heavy metals exhibit characteristics such as nonbiodegradable nature, toxic character, bioaccumulation capability, and ability to transit over long distances. …”
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Euodiae Fructus: a review of botany, application, processing, phytochemistry, quality control, pharmacology, and toxicology by Yule Hao, Jiawen Qi, Xinggui Huang, Chenhao Liu, Yi Liu

“…Further in-depth research is necessary to explore the mechanisms underlying EF’s pharmacological and toxicological mechanisms and to develop strategies for quality control and toxicity mitigation. The toxicity of EF can be reduced by processing, but this aspect is rarely discussed, and the quality control needs to be further standardized. …”
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Toxicological Evaluation and Protective Effects of Ethanolic Leaf Extract of Cassia spectabilis DC on Liver and Kidney Function of Plasmodium berghei-Infected Mice by Wiwied Ekasari, Anisah Mahardiani, Nindya T. Putri, Tutik S. Wahyuni, Heny Arwati

“…The acute and subacute toxicity tests were carried out on healthy mice that were given EECS at a dose of 150 mg/kg BW. …”
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Anticancer Activity of Rhizophora mucronata Leaves Extract on Sprague–Dawley Rats: In Vivo Model by Asbin Mary X, Syed Ali Mohamed Yacoob, Anuradha Venkatraman, Ruban Packiasamy, Meivelu Moovendhan, Murugesan Gnanadesigan, Yogananth Nagarajan

“…In acute toxicity trials, the dose of 1000 mg/kg body weight was determined to be safe and nontoxic even at high dose levels and did not result in any indicators of toxicity or death in the tested groups compared to controls for 14 days. …”
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